Article
Immunology
Makoto Iwasaki, Junya Kanda, Hidenori Tanaka, Takero Shindo, Takahiko Sato, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Yuta Katayama, Keisuke Kataoka, Takahide Ara, Shuichi Ota, Makoto Onizuka, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Satoko Morishima
Summary: This study retrospectively examined the identification of non-permissive HLA mismatching patterns in hematopoietic stem cell transplantation. The results suggest that HLA-C EMM might be associated with a higher risk of grade III-IV GVHD, leading to increased non-relapse mortality and decreased overall survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Betty K. Hamilton, Lisa A. Rybicki, Hong Li, Taylor Lucas, Donna Corrigan, Matt Kalaycio, Ronald Sobecks, Rabi Hanna, Seth J. Rotz, Robert M. Dean, Aaron T. Gerds, Deepa Jagadeesh, Claudio Brunstein, Craig S. Sauter, Edward A. Copelan, Navneet S. Majhail
Summary: This study compared the efficacy of two different prophylaxis regimens for graft-versus-host disease (GVHD) prevention after allogeneic hematopoietic cell transplantation. The results showed that the reduced-dose MTX/MMF regimen had a similar incidence of grade 2-4 acute GVHD compared to standard MTX, but with fewer toxicities. Further research is needed to optimize this regimen.
Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, General & Internal
Jeremy Epah, Gabriele Spohn, Kathrin Preiss, Markus M. Mueller, Johanna Doerr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwaeble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schaefer
Summary: This study found that the collection efficiency of bone marrow (BM) samples varies greatly worldwide. The implementation of a small volume aspirate policy improved the total nucleated cell yields in BM products. The impact of the BM collection technique on the quality of hematopoietic progenitor cell-manufacture was assessed.
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Hematology
Itaru Kato, Hirotoshi Sakaguchi, Shunichi Kato, Maho Sato, Maiko Noguchi, Nao Yoshida, Katsuyoshi Koh, Takashi Koike, Masakatsu Yanagimachi, Keisuke Kato, Yoshiyuki Takahashi, Naoto Fujita, Atsushi Sato, Yoshiko Hashii, Ken Tabuchi, Yoshiko Atsuta, Satoko Morishima, Junya Kanda
Summary: This study analyzed data from paediatric patients with haematological malignancies who underwent unrelated bone marrow transplantation in Japan. The results showed that HLA mismatching was associated with a low relapse rate but higher non-relapse mortality. While HLA-C mismatching had a negative impact on overall survival in adults, it did not have the same effect in paediatric patients. However, recent cases showed weakened HLA mismatch effects.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Pietro Crivello, Esteban Arrieta-Bolanos, Meilun He, Tao Wang, Stephanie Fingerson, Shahinaz M. Gadalla, Sophie Paczesny, Steven G. E. Marsh, Stephanie L. J. Lee, Stephen R. Spellman, Yung-Tsi Bolon, Katharina Fleischhauer
Summary: This study found that immunopeptidome divergence is a determinant of T-cell alloreactivity and clinical tolerability in single class I HLA-mismatched unrelated donor hematopoietic cell transplantation. Using hierarchical clustering of peptide-binding motifs, the authors classified 68.1% of the HLA-mismatched transplants as matched or mismatched. Mismatched transplants were associated with lower overall survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Hematology
Curtis Marcoux, David Marin, Jeremy Ramdial, Gheath AlAtrash, Amin M. Alousi, Betul Oran, Partow Kebriaei, Uday R. Popat, Katayoun Rezvani, Richard E. Champlin, Elizabeth J. Shpall, Rohtesh S. Mehta
Summary: Optimal donor selection is crucial in allogeneic hematopoietic cell transplantation, and this study compares the outcomes of patients who received transplants from younger haploidentical donors or older matched unrelated donors. The use of younger haploidentical donors was associated with improved survival and lower rates of GVHD compared to older MUDs. These findings support the use of younger haploidentical donors with post-transplant cyclophosphamide in patients with MDS or AML.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Amy E. DeZern, Marianna Zahurak, Heather J. Symons, Kenneth R. Cooke, Carol Ann Huff, Tania Jain, Lode J. Swinnen, Philip H. Imus, Nina D. Wagner-Johnston, Richard F. Ambinder, Mark Levis, Leo Luznik, Javier Bolanos-Meade, Ephraim J. Fuchs, Richard J. Jones, Robert A. Brodsky
Summary: Severe aplastic anemia (SAA) is a marrow failure disorder with high morbidity and mortality. This study found that reduced-intensity conditioning HLA-haploidentical bone marrow transplantation (BMT) with posttransplantation cyclophosphamide (PTCy)-based graft-versus-host (GVHD) prophylaxis resulted in 100% overall survival and minimal GVHD in patients with SAA. This approach not only avoids the adverse effects of immunosuppressive therapy, but also expands access to BMT across all populations.
Article
Medicine, General & Internal
Aurore Douge, Aurelie Ravinet, Alexandrine Corriger, Aurelie Cabrespine, Mathieu Wasiak, Bruno Pereira, Harry Sokol, Stephanie Nguyen, Jacques-Olivier Bay
Summary: This study aims to evaluate the effect of fecal microbiota transplantation (FMT) on toxicity in patients undergoing myeloablative allo-HSCT. The study will include 60 male and female patients, randomly assigned to two groups, one receiving FMT and one as a control group. The primary endpoint is the GvHD-free relapse-free survival rate at 1 year after allo-HSCT. The results of this study will be disseminated through peer-reviewed publications and conferences.
Article
Biophysics
Jana Jabbour, Batoul Manana, Ammar Zahreddine, Laila Al-Shaar, Ali Bazarbachi, Didier Blaise, Jean El-Cheikh
Summary: This study found that individualized nutritional counseling for patients with hematological malignancies receiving hematopoietic stem cell transplant (HSCT) was associated with improved intake of certain micronutrients, but vitamin D intake remained low regardless of counseling.
BONE MARROW TRANSPLANTATION
(2021)
Article
Oncology
Hidekazu Takahashi, Naoko Okayama, Natsu Yamaguchi, Moe Nomura, Yuta Miyahara, M. H. Mahbub, Ryosuke Hase, Yasuo Morishima, Yutaka Suehiro, Takahiro Yamasaki, Koji Tamada, Satoshi Takahashi, Arinobu Tojo, Tsuyoshi Tanabe
Summary: Unrelated bone marrow transplantation (uBMT) is a treatment for blood disorders using bone marrow from an unrelated donor, with the importance of HLA matching well-established. However, the significance of other genetic factors, such as SNPs, remains unclear. While immune checkpoint gene SNPs did not correlate with post-uBMT outcomes, the recipient's EZH2 gene SNP showed potential value in predicting acute GVHD.
Article
Urology & Nephrology
Nuria Lloberas, Josep M. Grinyo, Helena Colom, Anna Vidal-Alabro, Pere Fontova, Raul Rigo-Bonnin, Ariadna Padro, Oriol Bestard, Edoardo Melilli, Nuria Montero, Ana Coloma, Anna Manonelles, Maria Meneghini, Alex Fava, Joan Torras, Josep M. Cruzado
Summary: This study developed and validated a population pharmacokinetic model for tacrolimus dosing, which was found to be superior to traditional labeling-based dosing in achieving therapeutic targets. The model showed faster attainment of therapeutic levels and reduced dosage adjustments compared to the standard approach.
KIDNEY INTERNATIONAL
(2023)
Article
Hematology
Antonio Jimenez Jimenez, Krishna Komanduri, Samantha Brown, Trent Wang, Denise Pereira, Mark Goodman, Amer Beitinjaneh, Lazaros Lekakis, Stephanie Chinapen, Sean Devlin, Doris Ponce, Craig Sauter, Miguel-Angel Perales, Brian C. Shaffer
Summary: This study compared the graft-versus-host disease-free, relapse-free survival (GRFS) in patients who underwent allogeneic hematopoietic cell transplantation from an HLA-mismatched unrelated donor using different prophylactic measures. The results showed that the use of posttransplant cyclophosphamide resulted in superior GRFS and overall survival after one year.
Article
Pharmacology & Pharmacy
Benedetta C. Sallustio, Benjamin D. Noll, Rong Hu, Daniel T. Barratt, Jonathan Tuke, Janet K. Coller, Graeme R. Russ, Andrew A. Somogyi
Summary: Recipient and donor CYP3A5 and ABCB1 3435C>T genotypes do not determine allograft tacrolimus exposure in kidney transplant recipients. However, tacrolimus dose and C-0Blood are significant predictors of C-Graft, and the relationship between C-0Blood and C-Graft appears to differ in the presence or absence of acute nephrotoxicity.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Letter
Biophysics
Saiko Kurosawa, Takuhiro Yamaguchi, Kumi Oshima, Atsumi Yanagisawa, Takahiro Fukuda, Heiwa Kanamori, Takehiko Mori, Satoshi Takahashi, Tadakazu Kondo, Shin Fujisawa, Yasushi Onishi, Shingo Yano, Makoto Onizuka, Yoshinobu Kanda, Ishikazu Mizuno, Shuichi Taniguchi, Takuya Yamashita, Yoshihiro Inamoto, Shinichiro Okamoto, Yoshiko Atsuta
BONE MARROW TRANSPLANTATION
(2019)
Article
Hematology
Chikako Ohwada, Emiko Sakaida, Aiko Igarashi, Takeshi Kobayashi, Noriko Doki, Takehiko Mori, Jun Kato, Yuya Koda, Heiwa Kanamori, Masatsugu Tanaka, Takayoshi Tachibana, Shin Fujisawa, Yuki Nakajima, Ayumi Numata, Masako Toyosaki, Yasuyuki Aoyama, Makoto Onizuka, Maki Hagihara, Satoshi Koyama, Yoshinobu Kanda, Hideki Nakasone, Hiroaki Shimizu, Seiko Kato, Reiko Watanabe, Katsuhiro Shono, Rika Sakai, Takeshi Saito, Chiaki Nakaseko, Shinichiro Okamoto
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Hematology
Shinichi Kako, Hirohito Yamazaki, Kazuteru Ohashi, Yukiyasu Ozawa, Shuichi Ota, Yoshinobu Kanda, Tetsuo Maeda, Jun Kato, Ken Ishiyama, Ken-ichi Matsuoka, Toshihiro Miyamoto, Hiroatsu Iida, Kazuhiro Ikegame, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Takehiko Mori
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Biophysics
Kohei Shiroshita, Takehiko Mori, Jun Kato, Masatoshi Sakurai, Yuya Koda, Ryohei Abe, Koichi Murakami, Chieko Sumiya, Shinya Fujita, Kentaro Yamaguchi, Rie Yamazaki, Hitomi Nakayama, Shigeaki Suzuki, Jin Nakahara, Shinichiro Okamoto
BONE MARROW TRANSPLANTATION
(2020)
Article
Infectious Diseases
Takehiko Mori, Taku Kikuchi, Jun Kato, Yuya Koda, Masatoshi Sakurai, Osamu Kikumi, Rika Inose, Mitsuru Murata, Naoki Hasegawa, Hitomi Nakayama, Rie Yamazaki, Shinichiro Okamoto
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2020)
Article
Hematology
Shinichi Kako, Yoshinobu Kanda, Makoto Onizuka, Nobuyuki Aotsuka, Kensuke Usuki, Takayoshi Tachibana, Takeshi Kobayashi, Jun Kato, Shingo Yano, Hiroaki Shimizu, Katsuhiro Shono, Masatsugu Tanaka, Shokichi Tsukamoto, Takehiko Mori, Etsuko Yamazaki, Yuho Najima, Akira Hangaishi, Takumi Hoshino, Reiko Watanabe, Kenji Matsumoto, Shinichiro Okamoto
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Article
Hematology
Saiko Kurosawa, Ayako Mori, Mayumi Tsukagoshi, Yasushi Onishi, Chikako Ohwada, Takehiko Mori, Hideki Goto, Yuki Asano-Mori, Yuichiro Nawa, Masayuki Hino, Tomoko Fukuchi, Yasuo Mori, Reiko Yamahana, Yoshihiro Inamoto, Takahiro Fukuda
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Hematology
Takayoshi Tachibana, Junya Kanda, Takuma Ishizaki, Yuho Najima, Masatsugu Tanaka, Noriko Doki, Shin-ichiro Fujiwara, Shun-ichi Kimura, Makoto Onizuka, Satoshi Takahashi, Takeshi Saito, Takehiko Mori, Shin Fujisawa, Emiko Sakaida, Kenji Matsumoto, Nobuyuki Aotsuka, Moritaka Gotoh, Reiko Watanabe, Katsuhiro Shono, Kensuke Usuki, Nobuhiro Tsukada, Heiwa Kanamori, Yoshinobu Kanda, Shinichiro Okamoto
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Biophysics
Motohiro Kato, Hideki Nakasone, Nobuaki Nakano, Shigeo Fuji, Akihito Shinohara, Hisayuki Yokoyama, Kazuo Sakashita, Tsukasa Hori, Satoshi Takahashi, Miho Nara, Yoshinobu Kanda, Takehiko Mori, Junko Takita, Hiroshi Kawaguchi, Toshiro Kawakita, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, Masao Ogata
BONE MARROW TRANSPLANTATION
(2020)
Article
Oncology
Takehiko Mori, Souichi Shiratori, Junji Suzumiya, Mineo Kurokawa, Motohiro Shindo, Uchida Naoyuki, Takenaka Katsuto, Toshihiro Miyamoto, Satoshi Morishige, Makoto Hirokawa, Takahiro Fukuda, Yoshiko Atsuta, Ritsuro Suzuki
HEMATOLOGICAL ONCOLOGY
(2020)
Review
Oncology
M. Elvira P. Correa, Karis Kin Fong Cheng, Karen Chiang, Abhishek Kandwal, Charles L. Loprinzi, Takehiko Mori, Carin Potting, Tanya Rouleau, Juan J. Toro, Vinisha Ranna, Anusha Vaddi, Douglas E. Peterson, Paolo Bossi, Rajesh Lalla, Sharon Elad
SUPPORTIVE CARE IN CANCER
(2020)
Article
Oncology
Tomohiro Horio, Eriko Morishita, Shohei Mizuno, Kaori Uchino, Ichiro Hanamura, J. Luis Espinoza, Yasuo Morishima, Yoshihisa Kodera, Makoto Onizuka, Koichi Kashiwase, Takahiro Fukuda, Noriko Doki, Koichi Miyamura, Takehiko Mori, Shinji Nakao, Akiyoshi Takami
Article
Biophysics
Masamitsu Yanada, Takahiro Fukuda, Masatsugu Tanaka, Shuichi Ota, Takashi Toya, Takehiko Mori, Naoyuki Uchida, Yukiyasu Ozawa, Hirohisa Nakamae, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, Shingo Yano
BONE MARROW TRANSPLANTATION
(2020)
Article
Immunology
Takaaki Toyama, Takehiko Mori, Jun Kato, Kayoko Sugita, Naoki Hasegawa, Noboru Nakata, Yoshihiko Hoshino, Shinichiro Okamoto
TRANSPLANT INFECTIOUS DISEASE
(2020)
Meeting Abstract
Hematology
Masatomo Kuno, Satoshi Yamasaki, Takahiro Fukuda, Takehiko Mori, Naoyuki Uchida, Yuta Katayama, Makoto Onizuka, Tatsuo Ichinohe, Yoshiko Atsuta, Yoshihiro Inamoto
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)