Article
Andrology
Sheini Ruturi Sanchez Gonzalez, Esperanza Mata Martinez, Jorge Arturo Torres Juarez, Rodolfo Jose Arias, Gerardo Andres De Blas, Ana Alicia Sanchez Tusie
Summary: Background stress and elevated cortisol levels have negative effects on fertility. The effect of cortisol on human sperm has been controversial, thus this study evaluated the effects of different concentrations of hydrocortisone on human sperm physiology using various approaches and techniques.
Article
Environmental Sciences
Chen Chen, Bingqian Li, Rongzu Huang, Shijue Dong, Yang Zhou, Jian Song, Xuhui Zeng, Xiaoning Zhang
Summary: Nickel toxicity impairs human sperm motility and penetration ability, possibly by interfering with intracellular Ca2+ signaling and inducing excessive oxidative stress. These findings are of important value for evaluating the fertility of males exposed to occupational nickel environments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Chemistry, Multidisciplinary
Sonia Santander Ballestin, Maria Jose Luesma Bartolome
Summary: Some chemical components in sun cream filters have potential risks to health and the environment. This study compares conventional commercial sunscreens with natural products in terms of their endocrine-disrupting effects. Different sun cream filters were evaluated and compared, considering safety assessments from Environmental Working Group and the EU Registration, Evaluation, Authorization and Restriction of Chemicals Regulation. While some organic sun cream filters pose risks, inorganic filters like titanium dioxide and zinc oxide have very low risk as they are not absorbed through intact or damaged tissues. However, the legislation does not require manufacturers to specify the concentration of each substance, providing limited information for consumers.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Julia Korobkin, Fedor A. Balabin, Sergey A. Yakovenko, Ekaterina Yu Simonenko, Anastasia N. Sveshnikova
Summary: The study identified three types of calcium responses in human spermatozoa induced by progesterone: a single transient rise, a steady elevation, or low-frequency oscillations. The computational models provided insights into the mechanisms behind these responses, showing that the calcium diffusion coefficient affects the occurrence of calcium oscillations. Additionally, the spatial distribution of calcium signaling enzymes was found to govern the appearance of calcium oscillations in progesterone-activated human spermatozoa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Heidi Birch, Alexandre Teixeira, Roger van Egmond, Philipp Mayer
Summary: The aim of this study was to design a sample preparation procedure that is compatible with LC-MS and SPME, and to determine the biodegradation kinetics of diverse chemicals in closed batch tests with activated sludge. The results showed that ethanol could effectively stop biodegradation and extract sorbed chemicals from activated sludge under low cosolvent concentrations. This study demonstrated a 'cold' alternative to an OECD 314b test and provided an approach to determine biodegradation kinetics for mixtures of diverse chemicals.
Article
Biochemistry & Molecular Biology
Mengyun Wang, Yang Yu, Yunbing Tang, Chengshuang Pan, Qianjin Fei, Zhiyan Hu, Huitao Li, Yang Zhu, Yiyan Wang, Ren-shan Ge
Summary: This study found that benzophenone ultraviolet filters inhibit gonadal steroidogenesis, and BP-1 and BP-2 are the most potent inhibitors of human, rat, and mouse gonadal 38-HSDs. The 4-hydroxyl substitution in the benzene ring plays a key role in enhancing the inhibitory effect.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Rita Rahban, Anders Rehfeld, Christian Schiffer, Christoph Brenker, Dorte Louise Egeberg Palme, Tao Wang, Johannes Lorenz, Kristian Almstrup, Niels E. Skakkebaek, Timo Struenker, Serge Nef
Summary: The study found that the SSRI antidepressant Sertraline affects human sperm function by inhibiting the sperm-specific Ca2+ channel CatSper, potentially impairing the fertilization process. This was an in vitro study, and further research is needed to assess the physiological relevance in vivo.
HUMAN REPRODUCTION
(2021)
Article
Cell Biology
Anatoliy Shmygol, Jan J. Brosens
Summary: Embryo implantation is a complex and tightly regulated process in humans, where uterine luminal epithelium functions as a biosensor to gauge embryo quality and transmit information to the endometrial stromal cells, ensuring only high quality embryos are implanted. Trypsin, secreted by the blastocyst, has been implicated in this crosssignaling, triggering intracellular calcium signaling in uterine epithelium through protease-activated G-protein coupled receptors and activation of epithelial sodium channels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang, Ying-Pu Sun
Summary: This study reveals that HB-EGF can enhance the luteal function in humans by inducing StAR expression and progesterone production through the activation of the ERK1/2 signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Reproductive Biology
Patrick R. Hannon, James W. Akin, Thomas E. Curry Jr
Summary: Exposure to phthalates disrupts ovarian function and inhibits PGR signaling in human granulosa cells, but supplementation with cAMP can restore PGR signaling and potentially alleviate the ovulatory dysfunction caused by phthalate exposure.
BIOLOGY OF REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Maria Pachetti, Francesco D'Amico, Luisa Zupin, Stefania Luppi, Monica Martinelli, Sergio Crovella, Giuseppe Ricci, Lorella Pascolo
Summary: This study aimed to use UV resonance Raman spectroscopy to monitor molecular modifications in nucleic acids and support the selection of high-quality sperm samples in ART. The results suggest that UVRR can be utilized as an inexpensive tool for semen quality assessment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lanlan Fang, Yanjie Guo, Yiran Li, Qiongqiong Jia, Xiaoyu Han, Boqun Liu, Jiaye Chen, Jung-Chien Cheng, Ying-Pu Sun
Summary: EGCG, the most abundant catechins from green tea, has been studied for its health benefits, including its role in ovarian steroidogenesis. In human granulosa-like tumor cell line KGN, EGCG upregulates StAR expression and enhances P4 production, without affecting other steroidogenesis-related enzymes. The effects of EGCG on steroidogenesis require 67LR-mediated activation of the PKA-CREB signaling pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Noemi Toth, Xiao-Hua Zhang, Alexandra Zamaro, Martin Morad
Summary: Mutations in the S4938F-RyR2 gene have been found to cause abnormal Ca2+ signaling and arrhythmia in cardiomyocytes, which may lead to sudden cardiac death or heart failure. The mutations result in smaller L-type Ca2+ currents and activated Ca2+ transients, despite larger caffeine-triggered Ca2+ release signals. This study suggests that the mutations compromise the normal function of Ca2+ release channels and increase the risk of arrhythmia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Gi Ho Lee, Chae Yeon Kim, Chuanfeng Zheng, Sun Woo Jin, Ji Yeon Kim, Seung Yeon Lee, Mi Yeon Kim, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Summary: The study demonstrates that RUT promotes NO synthesis and eNOS phosphorylation by increasing intracellular Ca2+ concentration and kinase phosphorylation. Inhibition of TRPV1 attenuates RUT-induced effects, and blocking downstream signaling pathways suppresses eNOS phosphorylation and NO generation. These findings indicate that RUT can prevent endothelial dysfunction and benefit cardiovascular health through specific signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Marine & Freshwater Biology
Laura Anido-Varela, Marta Seoane, Marta Esperanza, Angeles Cid, Carmen Rioboo
Summary: This study analyzed the cytotoxicity of benzophenone-3 (BP-3) and benzophenone-4 (BP-4) on microalgae and found that both UV filters can pose a serious threat to non-target photosynthetic microorganisms in aquatic environments, with BP-3 having a more pronounced effect.
AQUATIC TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Anders Rehfeld, Dorte Louise Egeberg Palme, Kristian Almstrup, Anders Juul, Niels Erik Skakkebaek
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Environmental Sciences
Hanne Frederiksen, Marianna Krause, Niels Jorgensen, Anders Rehfeld, Niels E. Skakkebaek, Anna-Maria Andersson
Summary: Recent studies have found that some chemical UV filters can mimic the effects of progesterone in human sperm and are present in men's seminal fluid. Benzophenone (BP), benzophenone-1 (BP-1), and benzophenone-3 (BP-3) are the most frequently detected UV filters in seminal fluid, albeit at levels one to two orders of magnitude lower than those in urine.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Anders Rehfeld, A. M. Andersson, N. E. Skakkebaek
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Clinical Neurology
Claire Prener Miller, Martin Prener, Steen Dissing, Olaf B. Paulson
ACTA NEUROLOGICA SCANDINAVICA
(2020)
Article
Biochemistry & Molecular Biology
Lasse Bollehuus Hansen, Jovana Kaludjerovic, John Erik Nielsen, Anders Rehfeld, Nadia Nicholine Poulsen, Noriko Ide, Niels Erik Skakkebaek, Hanne Frederiksen, Anders Juul, Beate Lanske, Martin Blomberg Jensen
Article
Physiology
Anders Rehfeld, Noelia Mendoza, Raquel Ausejo, Niels Erik Skakkebaek
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Developmental Biology
Anders Rehfeld
MOLECULAR HUMAN REPRODUCTION
(2020)
Article
Endocrinology & Metabolism
Ida Marie Boisen, Anders Rehfeld, Iris Mos, Nadia Nicholine Poulsen, John Erik Nielsen, Peter Schwarz, Lars Rejnmark, Steen Dissing, Pernille Bach-Mortensen, Anders Juul, Hans Brauner-Osborne, Beate Lanske, Martin Blomberg Jensen
Summary: This study elucidates the important role of CaSR in human sperm, particularly in sensing calcium, magnesium, and bicarbonate ions, and participating in sperm activation and the acrosome reaction.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Developmental Biology
Michala Rosa Birch, Steen Dissing, Niels E. Skakkebaek, Anders Rehfeld
Summary: Finasteride caused a minor transient rise in intracellular Ca2+ concentration in human sperm, potentially affecting Ca2+ signalling through interaction with the PGE(1)-binding site. It did not interfere with progesterone-induced Ca2+ signalling, acrosome reaction, or sperm viability. Finasteride decreased PGE(1)-induced penetration into viscous medium at concentrations higher than those typically found in blood or seminal fluids. Further investigation is needed to determine the extent to which finasteride may impact successful fertilization and potential side effects on prostaglandin signalling in other parts of the human body.
Article
Obstetrics & Gynecology
Rita Rahban, Anders Rehfeld, Christian Schiffer, Christoph Brenker, Dorte Louise Egeberg Palme, Tao Wang, Johannes Lorenz, Kristian Almstrup, Niels E. Skakkebaek, Timo Struenker, Serge Nef
Summary: The study found that the SSRI antidepressant Sertraline affects human sperm function by inhibiting the sperm-specific Ca2+ channel CatSper, potentially impairing the fertilization process. This was an in vitro study, and further research is needed to assess the physiological relevance in vivo.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
A. Rehfeld, H. Frederiksen, R. H. Rasmussen, A. David, J. Chaker, B. S. Nielsen, J. E. Nielsen, A. Juul, N. E. Skakkebaek, D. M. Kristensen
Summary: The study found that while paracetamol itself does not affect Ca2+ signalling in human sperm, its metabolite AM404 interferes with sperm Ca2+ signalling and function through a CatSper-dependent action. This suggests a potential explanation for the negative association between urinary paracetamol concentrations in males and sperm motility.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Michala R. Birch, Mathias Johansen, Niels E. Skakkebaek, Anna-Maria Andersson, Anders Rehfeld
Summary: This study found that various pesticides can interfere with normal Ca2+ signaling in human sperm cells, affecting sperm function and viability. These effects can occur at low nanometer concentrations and when pesticides are used alone or in combination with other environmental chemicals.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Frederikke Hyldahl, Elisabeth Hem-Jensen, Ulrik L. Rahbek, Katerina Tritsaris, Steen Dissing
Summary: The study found that external pulsed electric fields can activate microglia cells and affect capillary function. By applying transcranial pulsed electromagnetic fields identical to those produced by neurons, the synthesis of mRNA for VEGF, IL-8, IL-6 and the proglucagon gene as well as the PC1/3 enzyme can be enhanced. Additionally, the combined effects of transcranial pulsed electromagnetic fields and purinergic transmitters can enhance microglia secretion. Applying these electric fields can effectively treat refractory depressions and show promise for treating neurodegenerative brain diseases.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Meeting Abstract
Clinical Neurology
R. H. Rasmussen, S. L. Christensen, K. Callo, A. Rehfeld, T. E. Taylor-Clark, K. A. Haanes, O. Taboureau, K. Audouze, D. Klaerke, J. Olesen, D. M. Kristensen
JOURNAL OF HEADACHE AND PAIN
(2022)