Review
Immunology
Arduino A. Mangoni, Angelo Zinellu
Summary: This study evaluated the pathophysiological role of neopterin in patients with rheumatic diseases through systematic review and meta-analysis. The results showed that neopterin concentrations were significantly higher in patients with RD compared to healthy controls. However, there were no significant associations found between neopterin concentrations and factors such as age and gender ratio, but associations were observed with geographical area and type of RD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Elisabetta Zinellu, Alessandro G. Fois, Elisabetta Sotgiu, Sabrina Mellino, Arduino A. Mangoni, Ciriaco Carru, Angelo Zinellu, Pietro Pirina
Summary: This systematic review and meta-analysis revealed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls, indicating a deficiency in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hamed Mohammadi, Sepide Talebi, Abed Ghavami, Masoumeh Rafiei, Shima Sharifi, Zahra Faghihimani, Golnaz Ranjbar, Maryam Miraghajani, Gholamreza Askari
Summary: This study found through systematic review and meta-analysis that zinc supplementation may have beneficial anti-inflammatory and antioxidative effects in adults.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alireza Jafari, Saeed Ghobadi
Summary: The meta-analysis on the effects of Zinc supplementation on inflammation and oxidative stress markers has raised concerns about inadequate search strategy, methodological flaws, data interpretation, and reporting, which may lead to biased results.
Review
Medicine, Research & Experimental
Stefania Bassu, Arduino A. Mangoni, Dario Argiolas, Ciriaco Carru, Pietro Pirina, Alessandro G. Fois, Angelo Zinellu
Summary: Our meta-analysis has shown that serum PON-1 concentrations are significantly lower in patients with asthma, suggesting the presence of an impaired antioxidant defense in this group.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Xiaogang Luo, Dongli Xie, Jianchen Hu, Jing Su, Zhebin Xue
Summary: This meta-analysis study suggests that exposure to nanomaterials causes significant changes in various biomarkers, indicating the importance of oxidative stress and inflammation in nanomaterial-induced toxicity.
Review
Pharmacology & Pharmacy
Amir Hossein Faghfouri, Meysam Zarezadeh, Baharak Aghapour, Azimeh Izadi, Helya Rostamkhani, Amin Majnouni, Ahmed Abu-Zaid, Hamed Kord Varkaneh, Zohreh Ghoreishi, Alireza Ostadrahimi
Summary: Zinc supplementation did not have beneficial effects on glutathione peroxidase (GPx) activity, but had significant increasing effects on glutathione (GSH), total antioxidant capacity (TAC) levels, and superoxide dismutase (SOD) activity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Monika Mittal, Poonam Mehta, Swati Rajput, Singh Rajender, Naibedya Chattopadhyay
Summary: Resveratrol has shown significant efficacy in mitigating experimental rheumatoid arthritis in animal models, reducing paw swelling, arthritis symptoms, and improving histopathological damage and cartilage loss. It also decreases oxidative stress markers and pro-inflammatory cytokines while increasing anti-inflammatory cytokines.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Gholamreza Askari, Abed Ghavami, Farnaz Shahdadian, Amir Reza Moravejolahkami
Summary: The study found that supplementation with synbiotics and probiotics has a significant effect on certain inflammatory and oxidative stress markers, but further research is needed to confirm these findings.
CLINICAL NUTRITION
(2021)
Review
Neurosciences
Abbas F. Almulla, Thitiporn Supasitthumrong, Arisara Amrapala, Chavit Tunvirachaisakul, Al-Karrar Kais Abdul Jaleel, Gregory Oxenkrug, Hussein K. Al-Hakeim, Michael Maes
Summary: This study aimed to investigate the activity of the TRYCAT pathway and the levels of TRP and TRYCATs in AD patients. The results showed a significant decrease in TRP in AD patients, while the overactivity of the TRYCAT pathway was not a key factor in the pathophysiology of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Immunology
Hossein Bahari, Hossein Rafiei, Kian Goudarzi, Kosar Omidian, Omid Asbaghi, Kosar Sadat Hosseini Kolbadi, Moslem Naderian, Ali Hosseini
Summary: This study aimed to evaluate the effects of pomegranate consumption on oxidative stress and inflammation biomarkers in adults. A meta-analysis of 33 eligible randomized controlled trials showed that pomegranate consumption significantly reduced CRP, IL-6, TNF-α, and MDA, and increased TAC. Pomegranate can be consumed as an effective dietary approach to attenuate oxidative stress and inflammation in patients with cardiovascular diseases.
INFLAMMOPHARMACOLOGY
(2023)
Review
Sport Sciences
Kenji Doma, Daniel Gahreman, Akhilesh Kumar Ramachandran, Uktarsh Singh, Jonathan Connor
Summary: This study found that leaf plant extracts can reduce exercise-induced muscle damage and improve muscle performance, especially within 24 hours post-exercise. While the effect of leaf plant extracts on antioxidant status remains equivocal, their ingestion as tea beverages may be an effective recovery strategy following strenuous exercises.
JOURNAL OF SPORTS SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Pablo Salmon, Pablo Burraco
Summary: Human-driven environmental changes are impacting wildlife, but the extent of their impact varies among different species. Telomere length has been proposed as a potential biomarker for animal health and fitness, but its use in ecological studies is limited. A systematic review and meta-analysis found a small negative association between anthropogenic disturbances and telomere length in wild animals. However, further research is needed to fully understand the causal relationship and implications of telomere length in anthropogenically disturbed scenarios.
Review
Biochemistry & Molecular Biology
Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim
Summary: Vitamin E supplementation significantly decreased inflammation and oxidative stress biomarkers in adult patients receiving hemodialysis, suggesting that it may help alleviate endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Wu Sun, Yuwei Zhao, Liang Liao, Xueyao Wang, Qiping Wei, Guojun Chao, Jian Zhou
Summary: This meta-analysis found that acupuncture can improve the clinical efficacy and visual acuity of patients with age-related macular degeneration (AMD), especially for dry AMD patients. However, there is currently no high-quality evidence to support the effectiveness of acupuncture in treating AMD, and more rigorously designed randomized controlled trials are needed to verify its efficacy.
Review
Chemistry, Medicinal
Mohammad Jalali, Marzieh Mahmoodi, Seyedeh Parisa Moosavian, Ronak Jalali, Gordon Ferns, Abdolhamid Mosallanezhad, Mohammad Hadi Imanieh, Zahra Mosallanezhad
PHYTOTHERAPY RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Mohammad Jalali, Navid Jamali, Shahla Rezaei, Kamran Hessami, Pedram Keshavarz, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
Summary: Intake of diacerein may lead to significant reductions in hemoglobin A1c and body mass index in patients with type 2 diabetes mellitus, but has no significant effects on other cardiometabolic parameters.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Razieh Hosseini, Farzaneh Montazerifar, Elham Shahraki, Mansour Karajibani, Ali Mohammad Mokhtari, Ali Reza Dashipour, Gordon A. Ferns, Mohammad Jalali
Summary: Zinc sulfate supplementation has favorable effects on serum copeptin, hs-CRP, FBG, and renal function in zinc-deficient diabetic hemodialysis patients, without affecting QUICKI, HOMA-IR, and serum insulin levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Integrative & Complementary Medicine
Zahra Mosallanezhad, Marzieh Mahmoodi, Sara Ranjbar, Razieh Hosseini, Cain C. T. Clark, Kristin Carson-Chahhoud, Zahra Norouzi, Ali Abbasian, Zahra Sohrabi, Mohammad Jalali
Summary: The results of the study indicate that soy intake is associated with improvements in systolic and diastolic blood pressure in adults. The effects were more pronounced in younger participants with lower baseline diastolic blood pressure and shorter intervention durations.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Peyman Nowrouzi-Sohrabi, Shahla Rezaei, Mohammad Jalali, Mahkameh Ashourpour, Ahmad Ahmadipour, Pedram Keshavarz, Hamed Akbari
Summary: This study found that GLP-1 receptor agonists have certain therapeutic effects on patients with T2DM and NAFLD, significantly reducing body mass index, waist circumference, and body weight, while decreasing postprandial glucose levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Razieh Hosseini, Gordon A. Ferns, Amirhossein Sahebkar, Mohammad Ali Mirshekar, Mohammad Jalali
Review
Endocrinology & Metabolism
Zahra Mosallanezhad, Marzieh Mahmoodi, Razieh Hosseini, Sara Ranjbar, Mohammad Ali Mirshekar, Cain C. T. Clark, Kamyar Kiamarzi, Faezeh Barzegar, Zahra Motamed, Mohammad Jalali
Summary: This study found that chamomile intake can significantly reduce total cholesterol levels in diabetics, but does not have a significant effect on triglycerides, high density lipoproteins cholesterol, and low density lipoprotein cholesterol. Further large-scale and well-designed randomized controlled trials are needed to confirm these findings.
CLINICAL DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Razieh Hosseini, Mansour Karajibani, Farzaneh Montazerifar, Elham Shahraki, Khatereh Babakhani, Ali Mohammad Mokhtari, Amirhossein Sahebkar
Summary: This study aimed to investigate the association between zinc sulfate supplementation and serum levels of galectin-3 and cardiometabolic parameters in zinc-deficient diabetic patients on hemodialysis. The results showed that daily intake of 220 mg zinc sulfate for 8 weeks had beneficial effects on galectin-3 and metabolic profiles in zinc-deficient DHPs.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Review
Endocrinology & Metabolism
Asma Kazemi, Sung Ryul Shim, Navid Jamali, Zahra Hassanzadeh-Rostami, Sepideh Soltani, Najmeh Sasani, Mohammad Ali Mohsenpour, Donya Firoozi, Reyhane Basirat, Razieh Hosseini, Cain C. T. Clark, Siavash Babajafari, Mozhgan Soltanmohammadi
Summary: This systematic review and network meta-analysis examined the effects of nutritional supplements on glycemic control in individuals with type 2 diabetes. The results showed that vitamin D supplementation was the most effective in improving HbA1c, FBS, and HOMA-IR.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Pharmacology & Pharmacy
Elham Shahreki, Mahmoud Ali Kaykhaei, Zahra Mosallanezhad, Zahra Adineh, Ali Mohammad Mokhtari, Mahdi Mohammadi, Razieh Hosseini, Aliyeh Bazi
Summary: This study investigated the effect of selenium and/or N-acetyl-cysteine (NAC) on nonthyroidal illness syndrome (NTIS) parameters in hemodialysis patients. The results showed that selenium and/or NAC can decrease reverse T3 levels. However, long-term clinical trials with a larger sample size using more appropriate biomarkers are needed to evaluate the efficacy and safety of selenium and/or NAC in hemodialysis patients.
Article
Integrative & Complementary Medicine
Farzaneh Montazerifar, Shadi Shourestani, Razieh Hosseini, Mansour Karajibani, Sasan Amanat, Gohar Sedaghat, Hamed Fanaei
Summary: This study aimed to investigate the effects of Berberis vulgaris (B. vulgaris) supplementation on patients with type 2 diabetes mellitus (T2DM). The results showed that B. vulgaris supplementation had positive effects on lipid profile and serum visfatin in T2DM patients. These findings suggest that B. vulgaris may be beneficial for T2DM management.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Ali Shamsi-Goushki, Zinat Mortazavi, Fatemeh Behrasi, Ali Ebrahimkhani, Razieh Hosseini
Summary: This study aimed to investigate the effects of curcumin and nano-curcumin on serum levels of BDNF, fasting blood sugar, water and food intake, and body weight in T2DM rats. The results showed that nano-curcumin had a superior effectiveness in increasing serum BDNF levels compared to curcumin. Thus, curcumin and nano-curcumin can be considered as beneficial agents for adjunctive diabetes therapies.
NANOMEDICINE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Mona M. Watany, Marwa M. Elhosary
Summary: Circulating TWEAK and CD163 appear to be promising biomarkers for monitoring myocardial iron overload and predicting iron-induced cardiac decompensation in TDTM patients.
Article
Biochemistry & Molecular Biology
Lixin Xiao, Kang Tang, Ting Fu, Xiaojie Yuan, Samuel Seery, Weilu Zhang, Zhaohua Ji, Zhen He, Yan Yang, Wenhua Zhang, Wenling Jia, Chunhui Liang, Haitao Tang, Fengmei Wang, Yancheng Ye, Lihua Chen, Zhongjun Shao
Summary: This study investigated the characteristics of cytokine/chemokine profiles during chronic hepatitis B virus infection and the effects of nucleotide analogues antiviral therapy on cytokine profiles. The results suggest that specific cytokines and virological markers may serve as potential indicators of different immune statuses in chronic HBV infection, while nucleotide analogues antiviral therapy has limitations in altering cytokine profiles.
Article
Biochemistry & Molecular Biology
Desiree Gutmann, Melanie Dressler, Olaf Eickmeier, Eva Herrmann, Marta Kirwil, Ralf Schubert, Stefan Zielen, Ulrich M. Zissler
Summary: This study found that obese adolescents have increased bronchial inflammation, which may be caused by the pro-inflammatory effects of obesity itself. This finding is important for understanding the relationship between obesity and airway diseases.
Article
Biochemistry & Molecular Biology
Wei Liu, Hui Zeng
Summary: IGF2BP2 enhances the expression of GPX4 through m6A modification, thereby suppressing ferroptosis and attenuating inflammation and pathological changes in ulcerative colitis.
Article
Biochemistry & Molecular Biology
Xiaohua Li, Junping Xu, Xin Lin, Qiong Lin, Tianxing Yu, Lin Chen, Lifang Chen, Xiaoqing Huang, Xueping Zhang, Geng Chen, Liyu Xu
Summary: Macrophages play a significant role in the progression of cryptococcosis. This study investigated the potential involvement of macrophage-derived exosomes in the pathogenesis of cryptococcosis. The study analyzed the changes of microRNAs in macrophage exosomes and explored the effects of highly expressed exo-miRNAs on human endothelial cell permeability, ROS accumulation, and pyroptosis in bronchial epithelioid cells. The results showed that exo-miR-4449 plays a crucial role in the pathogenesis of cryptococcosis and holds promise as a significant biomarker for treatment.
Article
Biochemistry & Molecular Biology
E. Melinda Mahabee-Gittens, Georg E. Matt, Matthew J. Mazzella, John T. Doucette, Parita Ratnani, Ashley L. Merianos
Summary: This study examined the associations between inflammatory markers and pediatric illnesses related to children's exposure to tobacco smoke. The results showed that parent-reported child tobacco smoke exposure was associated with increased levels of C-reactive protein (CRP) in children, while children with bacterial diagnoses had higher levels of IL-8.
Article
Biochemistry & Molecular Biology
Jin-Yu Liang, Hai-Jun Wei, Yi-Yun Tang
Summary: Isthmin is a polypeptide secreted by adipocytes that plays important biological functions in growth and development, angiogenesis, and metabolism. ISM-1, as a regulator of cell proliferation, migration, angiogenesis, and immune microenvironments, plays a crucial role in the occurrence and development of cancer. Furthermore, ISM-1 acts as a regulator of adipocyte glucose uptake and hepatic lipid synthesis.
Article
Biochemistry & Molecular Biology
Abhishek Singh, Baishakhi Mahapatra, Arpita Banerjee, Samer Singh, Sangram Singh, Vikash K. Dubey, Pradeep Das, Rakesh K. Singh
Summary: In Leishmania infection, antigen-activated CD4+ T cells expressing CD200R receptors are the main source of IL-10 production. The expression of CD200R helps T cells acquire the ability to produce IL-10 as a survival strategy in leishmaniasis pathogenesis.
Article
Biochemistry & Molecular Biology
Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Duan
Summary: Failure of bone healing after fracture often results in nonunion, but the underlying mechanism of nonunion pathogenesis is poorly understood. This study reveals that the inflammatory microenvironment in atrophic nonunion inhibits the expression of DNA methyltransferases, resulting in overexpression of CtBP1/2. The increased CtBP1/2 acts as transcriptional corepressors that suppress the expression of six genes involved in bone healing. The disruption of this signaling may represent a new therapeutic strategy to prevent nonunion incidence after bone fracture.
Review
Biochemistry & Molecular Biology
Yuwei Peng, Meng Zhang, Jiangkang Hu
Summary: This review article provides an overview of the pivotal role of non-coding RNAs (ncRNAs) in the activity and pathogenesis of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). These ncRNAs regulate various FLS activities including metastasis, proliferation, and cytokine production. Additionally, the study discusses potential therapeutic approaches involving modulation of ncRNAs to regulate FLS activity.
Review
Biochemistry & Molecular Biology
Milad Khorasani
Summary: This review discusses the role of the cGAS-STING pathway in CRC and highlights the potential therapeutic benefits of targeting this pathway.
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Biochemistry & Molecular Biology
Oznur Copur, Havva Yazici, Erhan Canbay, Burak Durmaz, Ebru Canda, Sema Kalkan Ucar, Mahmut Coker, Eser Yildirim Sozmen
Summary: This study explores the oxidative stress, antioxidant parameters, and pro-inflammatory cytokine levels in MPS patients. The results suggest that inflammation plays a role in MPS patients, especially in untreated MPS III and MPS VI patients. The study also highlights potential targets for treatment development.
Article
Biochemistry & Molecular Biology
Saikat Fakir, Nektarios Barabutis
Summary: GHRHAnt have been shown to have protective effects on endothelial cells, opposing interferon-gamma-induced inflammation and barrier disruption.