Emerging insights into symmetry breaking in centriole duplication: updated view on centriole duplication theory

SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL

(2019) Andrew Kodani et al.   JOURNAL OF CELL BIOLOGY

HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates

(2019) Satoko Yoshiba et al.   JOURNAL OF CELL SCIENCE

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

(2019) Shohei Yamamoto et al.   Nature Communications

A theory of centriole duplication based on self-organized spatial pattern formation

(2019) Daisuke Takao et al.   JOURNAL OF CELL BIOLOGY

Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

(2019) Daisuke Takao et al.   Biology Open

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

(2019) Jung-Eun Park et al.   Nature Communications

Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis

(2018) Kayla Carpenter et al.   DEVELOPMENTAL CELL

An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly

(2018) Tiffany A. McLamarrah et al.   JOURNAL OF CELL BIOLOGY

Once and only once: mechanisms of centriole duplication and their deregulation in disease

(2018) Erich A. Nigg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physical principles of intracellular organization via active and passive phase transitions

(2018) Joel Berry et al.   REPORTS ON PROGRESS IN PHYSICS

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

(2018) Midori Ohta et al.   Cell Reports

Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state

(2018) Cody J. Boese et al.   MOLECULAR BIOLOGY OF THE CELL

Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress

(2017) Shady Saad et al.   NATURE CELL BIOLOGY

Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation

(2017) Nikola S. Dzhindzhev et al.   Open Biology

Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication

(2017) Nina Peel et al.   PLoS Genetics

The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Octanol-assisted liposome assembly on chip

(2016) Siddharth Deshpande et al.   Nature Communications

It's all relative: Centromere- versus pole-based error correction

(2015) Anna A Ye et al.   CELL CYCLE

PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space

(2015) Carla A.M. Lopes et al.   DEVELOPMENTAL CELL

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Historical roots of centrosome research: discovery of Boveri's microscope slides in Wurzburg

(2014) U. Scheer   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

Polo-like Kinase 4 Autodestructs by Generating Its Slimb-Binding Phosphodegron

(2013) Joseph E. Klebba et al.   CURRENT BIOLOGY

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

Actin polymerization or myosin contraction: two ways to build up cortical tension for symmetry breaking

(2013) K. Carvalho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-cycle-regulated expression of STIL controls centriole number in human cells

(2012) C. Arquint et al.   JOURNAL OF CELL SCIENCE

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

(2011) Christopher W. Brownlee et al.   JOURNAL OF CELL BIOLOGY

From centriole biogenesis to cellular function: Centrioles are essential for cell division at critical developmental stages

(2010) Ana Rodrigues-Martins et al.   CELL CYCLE

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Plk4 trans-autophosphorylation regulates centriole number by controlling  TrCP-mediated degradation

(2010) G. Guderian et al.   JOURNAL OF CELL SCIENCE

Sensing centromere tension: Aurora B and the regulation of kinetochore function

(2010) Michael A. Lampson et al.   TRENDS IN CELL BIOLOGY

Mutations in STIL, Encoding a Pericentriolar and Centrosomal Protein, Cause Primary Microcephaly

(2009) Arun Kumar et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL