ID4 controls luminal lineage commitment in normal mammary epithelium and inhibitsBRCA1function in basal-like breast cancer

Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer

(2016) Aruna Korlimarla et al.   PLoS One

Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity

(2015) Pankaj Sharma et al.   BIOCHIMIE

Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival

(2015) Aye A. Thike et al.   HISTOPATHOLOGY

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

(2015) Simon Junankar et al.   Nature Communications

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

(2015) Fabio Valenti et al.   Oncotarget

Molecular features of the basal-like breast cancer subtype based on BRCA1 mutation status

(2014) Aleix Prat et al.   BREAST CANCER RESEARCH AND TREATMENT

Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary

(2014) S. A. Best et al.   DEVELOPMENT

ID Proteins Regulate Diverse Aspects of Cancer Progression and Provide Novel Therapeutic Opportunities

(2014) Radhika Nair et al.   MOLECULAR THERAPY

Identification of multipotent mammary stem cells by protein C receptor expression

(2014) Daisong Wang et al.   NATURE

In situ identification of bipotent stem cells in the mammary gland

(2014) Anne C. Rios et al.   NATURE

miR-342 Regulates BRCA1 Expression through Modulation of ID4 in Breast Cancer

(2014) Elisabetta Crippa et al.   PLoS One

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(2014) C. Blanpain et al.   SCIENCE

p53 in breast cancer subtypes and new insights into response to chemotherapy

(2013) Philippe Bertheau et al.   BREAST

Triple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers

(2013) E H Lips et al.   BRITISH JOURNAL OF CANCER

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

Analysis of colorectal cancers in British Bangladeshi identifies early onset, frequent mucinous histotype and a high prevalence of RBFOX1 deletion

(2013) Neel Sengupta et al.   Molecular Cancer

Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer

(2013) A. Prat et al.   ONCOLOGIST

Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation

(2012) Yong Hannah Wen et al.   BREAST CANCER RESEARCH AND TREATMENT

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(2012) Daniel C. Koboldt et al.   NATURE

FoxM1 Regulates Mammary Luminal Cell Fate

(2012) Janai R. Carr et al.   Cell Reports

Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer

(2012) Pankaj Sharma et al.   Cancer Medicine

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(2012) M T Branham et al.   Oncogenesis

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

ID4 regulates mammary gland development by suppressing p38MAPK activity

(2011) J. Dong et al.   DEVELOPMENT

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct stem cells contribute to mammary gland development and maintenance

(2011) Alexandra Van Keymeulen et al.   NATURE

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

(2011) A. Aly et al.   Journal of Molecular Cell Biology

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

(2010) Pierfrancesco Tassone et al.   CANCER BIOLOGY & THERAPY

BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells

(2010) Gemma Molyneux et al.   Cell Stem Cell

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue

(2010) L. Bai et al.   GENES & DEVELOPMENT

BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer

(2010) Renaud Sabatier et al.   GENES CHROMOSOMES & CANCER

Gene Expression Profile ofBRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer

(2010) Panagiotis A. Konstantinopoulos et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

(2010) Daniel P. Silver et al.   JOURNAL OF CLINICAL ONCOLOGY

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

(2010) Sunil Badve et al.   MODERN PATHOLOGY

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(2010) Nasim Mavaddat et al.   Molecular Oncology

Deconstructing the molecular portraits of breast cancer

(2010) Aleix Prat et al.   Molecular Oncology

The role of BRCA1 in DNA damage response

(2010) Jiaxue Wu et al.   Protein & Cell

Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer

(2009) Jason PW Carey et al.   BMC CANCER

Correlations between RNA and protein expression profiles in 23 human cell lines

(2009) Marcus Gry et al.   BMC GENOMICS

An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers

(2009) Rachael Natrajan et al.   BREAST CANCER RESEARCH AND TREATMENT

Defective Repair of Oxidative DNA Damage in Triple-Negative Breast Cancer Confers Sensitivity to Inhibition of Poly(ADP-Ribose) Polymerase

(2009) E. Alli et al.   CANCER RESEARCH

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis

(2009) Jane E. Visvader   GENES & DEVELOPMENT

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

Mammary development in the embryo and adult: a journey of morphogenesis and commitment

(2008) C. J. Watson et al.   DEVELOPMENT

Transcriptional Response of the Murine Mammary Gland to Acute Progesterone Exposure

(2008) Rodrigo Fernandez-Valdivia et al.   ENDOCRINOLOGY

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

(2008) S. R. Oakes et al.   GENES & DEVELOPMENT

Basal-Like Breast Cancer: A Critical Review

(2008) Emad A. Rakha et al.   JOURNAL OF CLINICAL ONCOLOGY

A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair

(2008) Alan Ashworth   JOURNAL OF CLINICAL ONCOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

BRCA1 regulates human mammary stem/progenitor cell fate

(2008) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells

(2008) Na Li et al.   STEM CELLS