Review
Biochemistry & Molecular Biology
Jordan Swiderski, Laura Kate Gadanec, Vasso Apostolopoulos, Graham J. J. Moore, Konstantinos Kelaidonis, John M. M. Matsoukas, Anthony Zulli
Summary: Cardiovascular diseases (CVDs) and COVID-19 share overlapping pathophysiological complications. CVDs have been identified as major risk factors for severe and fatal COVID-19 states. Dysregulation of the renin-angiotensin system (RAS) in CVDs contributes to the development of COVID-19. Inhibiting RAS signaling through angiotensin receptor blockers (ARBs) has been indicated as a promising therapeutic approach for COVID-19 treatment.
Article
Respiratory System
Evdokia Gavrielatou, Katerina Vaporidi, Vasiliki Tsolaki, Nikos Tserlikakis, George E. Zakynthinos, Eleni Papoutsi, Aikaterini Maragkuti, Athina G. Mantelou, Dimitrios Karayiannis, Zafeiria Mastora, Dimitris Georgopoulos, Epaminondas Zakynthinos, Christina Routsi, Spyros G. Zakynthinos, Edward J. Schenck, Anastasia Kotanidou, Ilias I. Siempos
Summary: Rapidly improving ARDS is not prevalent and is not associated with good prognosis among patients with COVID-19. Persistent severe ARDS has a higher prevalence and mortality rate.
RESPIRATORY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Luis F. Angel, Nancy E. Amoroso, Samaan Rafeq, Brian Mitzman, Ronald Goldenberg, Saketh Palasamudram Shekar, Andrea B. Troxel, Yan Zhang, Stephanie H. Chang, Paul Kwak, Milan R. Amin, Kimberly Sureau, Heidi B. Nafday, Sarun Thomas, Zachary Kon, Philip M. Sommer, Leopoldo N. Segal, William H. Moore, Robert Cerfolio
Summary: This study found that early modified percutaneous dilational tracheostomy was safe for both patients with coronavirus disease 2019 on mechanical ventilation and healthcare providers, and it was associated with improved clinical outcomes. Specifically, patients who underwent early procedures had a higher probability of successful weaning off mechanical ventilation and lower mortality rates.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Karuna Wongtangman, Peter Santer, Luca J. Wachtendorf, Omid Azimaraghi, Elias Baedorf Kassis, Bijan Teja, Kadhiresan R. Murugappan, Shahla Siddiqui, Matthias Eikermann
Summary: Compared to patients with acute respiratory distress syndrome of other causes, patients with COVID-19 received higher doses of hypnotics, leading to prolonged coma and higher mortality.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Julien Lopinto, Romain Arrestier, Bastien Peiffer, Antoine Gaillet, Guillaume Voiriot, Tomas Urbina, Charles-Edouard Luyt, Raphael Bellaiche, Tai Pham, Zakaria Ait-Hamou, Damien Roux, Raphael Clere-Jehl, Elie Azoulay, Stephane Gaudry, Julien Mayaux, Armand Mekontso Dessap, Florence Canoui-Poitrine, Nicolas de Prost
Summary: High doses of corticosteroids (HDCT) in critically ill COVID-19 patients with nonresolving acute respiratory distress syndrome (ARDS) leads to an increased 90-day mortality.
CRITICAL CARE MEDICINE
(2023)
Review
Pediatrics
Lea C. Steffes, David N. Cornfield
Summary: In the pediatric population, COVID-19 respiratory disease is distinct from adult illness, characterized by a milder phenotype. Recent findings have shown an expanded knowledge of the clinical presentation and pathophysiology of COVID-19 pneumonia. The differences in viral cell entry efficiency and immune response timing between children and adults are key areas of ongoing research.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Ivor S. Douglas, Chester A. Rosenthal, Diandra D. Swanson, Terra Hiller, Judy Oakes, Jamie Bach, Christopher Whelchel, Jennifer Pickering, Tobias George, Mark Kearns, Michael Hanley, Kara Mould, Sarah Roark, Jason Mansoori, Anuj Mehta, Eric P. Schmidt, Anna Neumeier
Summary: This study demonstrates that prolonged prone position ventilation for patients with coronavirus disease 2019 acute respiratory distress syndrome is feasible and relatively safe, with implications for wider adoption in treating critically ill coronavirus disease 2019 patients and acute respiratory distress syndrome of other etiologies.
CRITICAL CARE MEDICINE
(2021)
Review
Medical Laboratory Technology
Yang Liu, Huanzhong He, Huilian Huang
Summary: This article discusses the importance of ACE2 in drug development and COVID-19 treatment, as well as the key amino acid positions for ACE2 binding to SARS-CoV-2-RBD. The study suggests that the development and optimization of ACE2 peptides may effectively block 2019-nCoV infection and treat COVID-19.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Medicine, General & Internal
Nicolas Dognon, Alexandre Gaudet, Erika Parmentier-Decrucq, Sylvain Normandin, Andre Vincentelli, Mouhamed Moussa, Julien Poissy, Thibault Duburcq, Lille Intensive Care COVID Grp
Summary: The study aimed to compare outcomes of COVID-19 patients with Acute Respiratory Distress Syndrome treated with V-V ECMO during the first and second waves. While the 90-day mortality did not significantly differ between waves, more patients in the second wave received steroid treatment, had longer non-invasive ventilation support duration, and exhibited poorer lung mechanical properties. The second wave also saw more bacterial co-infections and less encouraging outcomes despite evidence-based critical care management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jiazhao Yang, Kerong Wu, Ao Ding, Li Li, Hui Lu, Wanbo Zhu, Kai Xie, Ziqin Yao, Shiyuan Fang
Summary: This study described the epidemiology, clinical characteristics, treatment, and prognosis of 74 hospitalized patients with COVID-19. Findings showed that fever was the most common symptom, followed by cough, fatigue, and expectoration. ICU patients had higher inflammatory indicators and CD4/CD8 ratio compared to non-ICU patients.
Article
Critical Care Medicine
Sara C. Auld, Kristin R. Harrington, Max W. Adelman, Chad J. Robichaux, Elizabeth C. Overton, Mark Caridi-Scheible, Craig M. Coopersmith, David J. Murphy
Summary: This study aims to explore the association between time period of hospitalization and hospital mortality among critically ill adults with coronavirus disease 2019. The study found that the risk of death was highest for patients admitted during the fall and winter of 2020. Hospital mortality was associated with preexisting risk factors, clinical status at ICU admission, and ICU interventions.
CRITICAL CARE MEDICINE
(2022)
Review
Microbiology
Chao Quan, Caiyan Li, Han Ma, Yisha Li, Huali Zhang
Summary: This review summarizes the epidemiology, clinical features, virology, and host immune responses of SARS-CoV, MERS-CoV, and SARS-CoV-2, highlighting the potential immunopathological effects of highly pathogenic coronaviruses and discussing potential therapeutic implications for combating severe coronavirus infections.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Review
Critical Care Medicine
Fernando Jose da Silva Ramos, Flavio Geraldo Rezende de Freitas, Flavia Ribeiro Machado
Summary: Severe COVID-19 should be considered sepsis due to both viral toxicity and dysregulated host response. Co-infection and secondary infection aggravate the condition, particularly in resource-poor settings. Mortality rates are influenced by factors such as hospital strain, HAI incidence, and organizational aspects.
CURRENT OPINION IN CRITICAL CARE
(2021)
Review
Critical Care Medicine
Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou, Ilias I. Siempos
Summary: This study suggests that the timing of intubation may not affect the mortality and morbidity of critically ill patients with COVID-19, supporting a wait-and-see approach which might lead to fewer intubations. Relevant guidelines may therefore need to be updated.
Article
Medicine, General & Internal
Ilker Inanc Balkan, Harika Oyku Dinc, Gunay Can, Ridvan Karaali, Dogukan Ozbey, Bilge Caglar, Ayse Nur Beytur, Elif Keskin, Beyhan Budak, Okan Aydogan, Bilgul Mete, Sevgi Ergin, Bekir Kocazeybek, Nese Saltoglu
Summary: Despite high vaccination rates, increasing cases continue to be reported, and the durability of vaccine-induced immune response remains a hot topic. This study investigated the changes in antibodies after the second dose of the CoronaVac vaccine at different time points. The results showed that while antibody positivity remained above 90% in the 6th month after vaccination, the median antibody titers decreased rapidly, especially in individuals with no prior history of COVID-19 infection.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Infectious Diseases
Afsin Ipekci, Serap Biberoglu, Ibrahim Ikizceli, Fatih Cakmak, Yonca Senem Akdeniz, Altug Kanbakan, Dildar Konukoglu, Ibrahim Murat Bolayirli, Sermin Borekci, Seval Urkmez, Seda Ozkan
Summary: This study analyzed the ACE2 and AngII levels in patients with suspected COVID-19 and examined their relationship with disease severity. The results showed that decreased ACE2 levels were associated with lung damage, while decreased AngII levels were associated with severe diseases such as ARDS and mortality.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2022)
Article
Medicine, General & Internal
Yusuf Emre Ozdemir, Meryem Sahin Ozdemir, Osman Faruk Bayramlar, Serkan Surme, Sibel Yildiz Kaya, Ridvan Karaali, Ilker Inanc Balkan, Bilgul Mete, Nese Saltoglu, Fehmi Tabak
Summary: Oral antiviral agents can achieve similar complete virological responses in the treatment of HBeAg-negative chronic hepatitis B. Younger age and low baseline viral load are the main factors for virological response. However, drug resistance and virological breakthrough in the lamivudine group, as well as side effects in the telbivudine group, were observed during long-term follow-up. The effectiveness of oral antiviral agents in achieving HBsAg seroclearance is low.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Pediatrics
Seha Saygili, Nur Canpolat, Rumeysa Yasemin Cicek, Ayse Agbas, Esra Karabag Yilmaz, Ayse Ayzit Kilinc Sakalli, Deniz Aygun, Gulsen Akkoc, Kaan Can Demirbas, Dildar Konukoglu, Haluk Cokugras, Salim Caliskan, Lale Sever
Summary: The study reveals that even children with mild or moderate COVID-19 disease course have an increased risk of developing AKI. The association between neutrophil count and AKI suggests the role of inflammation in the development of AKI.
PEDIATRIC RESEARCH
(2023)
Article
Immunology
Yesim Tuyji Tok, Rabia Can Sarinoglu, Seyhan Ordekci, Serife Yilmaz, Gunes Ozcolpan, Aysen Bayram, Okan Kadir Nohut, Ipek Kocer, Ufuk Hasdemir, Mert Ahmet Kuskucu, Dildar Konukoglu, Aysegul Gozalan, Kenan Midilli, Gulden Celik
Summary: This study aimed to evaluate the immunogenicity of heterologous boosts by BioNTech against homologous boosts by CoronaVac in two groups of health care workers over a one-year period. The study found that there was a significant difference in antibody levels between individuals with and without prior COVID-19 infection at three months after receiving two doses of CoronaVac, but this difference was not observed in subsequent follow-ups. Those who received BioNTech as a third dose had higher antibody levels and neutralizing antibody responses against Wuhan and Omicron compared to those who received CoronaVac. The study suggests that continuing heterologous CoronaVac/BioNTech vaccination with at least a six-month interval booster could be an effective and safe strategy for protection against COVID-19, particularly in health care workers.
Article
Otorhinolaryngology
Aysegul Batioglu-Karaaltin, Ozgur Yigit, Dogan Cakan, Ozer Akgul, Enes Yigit, Yetkin Zeki Yilmaz, Kays-i Burak Cakir, Gamze Ciftci, Nihal Seden Boyoglu, Abdurrahman Cagliyan, Efe Can, Ozgur Dikme, Yalcin Hacioglu, Ilker Inanc Balkan, Ozgur Enver, Hasan Ahmet Ozdogan
Summary: This study investigated the effectiveness of nasal irrigation with saline, povidone-iodine (PVP-I) 1%, and a combination of hypertonic alkaline and 1% PVP-I against SARS-CoV-2. The results showed that the use of the combination of hypertonic alkaline and 1% PVP-I solution was more effective in reducing the nasal viral load.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Endocrinology & Metabolism
C. Sulu, G. B. Senel, O. Koca, M. Alaylioglu, A. N. Demir, E. Durcan, D. G. Ak, E. Dursun, D. Konukoglu, H. M. Ozkaya, D. Karadeniz, P. Kadioglu
Summary: This study aimed to evaluate the sleep architecture of patients with Cushing's disease (CD) and investigate the role of agouti-related peptide (AgRP) and/or leptin in sleep alterations in patients with active CD. Polysomnography was performed on 26 patients with active CD and compared with age and sex-matched control subjects. The results showed that patients with CD had reduced sleep efficiency and increased wake after sleep onset, and their serum levels of AgRP and leptin were elevated. These findings suggest that CD is associated with impaired sleep efficiency and continuity, which may be influenced by elevated levels of AgRP and leptin.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Cem Boluk, Merve Hazal Ser, Mehmet Aslan, Ridvan Karaali, Sermin Borekci, Ilker Inanc Balkan, Nurten Uzun, Meral Kiziltan, Aysegul Gunduz
Summary: The aim of this study was to determine the prevalence of skeletal muscle injury in COVID-19 patients using creatine kinase (CK) levels. Medical records of COVID-19 patients were retrospectively analyzed and divided into high CK levels and normal CK levels groups. Results showed that the use of favipiravir and hospitalization in the intensive care unit were risk factors for high CK levels. CK levels were positively correlated with age, hospitalization duration, intensive care duration, and levels of liver function tests, serum urea, D-dimer, and ferritin levels, and negatively correlated with oxygen saturation and thrombocyte levels.
TURKISH JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Mehmet Hamza Guktekin, Goktug Kalender, Kadir Can Sahin, Sami Berk Ozden, Ilker Inanc Balkan, Muhammed Fatih Simsekoglu, Bulent Onal, Ahmet Erozenci
Summary: The aim of this study was to compare the effectiveness of two drugs in preventing infectious complications after prostate biopsy. The results showed that, when used for prophylaxis, patients receiving FT had significantly lower risks of developing lower urinary tract symptoms, having positive urine cultures, and requiring hospitalization for antibiotic treatment compared to patients receiving CIP.
HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
(2023)
Article
Infectious Diseases
Ridvan Karaali, Harika Oyku Oyku Dinc, Ilker Inanc Balkan, Gunay Can, Elif Keskin, Hatice Colak, Ferhat Osman Dasdemir, Okan Aydogan, Beyhan Budak, Sibel Yildiz Kaya, Bekir Kocazeybek, Nese Saltoglu
Summary: This study compares neutralizing antibody levels and side effects in different vaccination schemes. The results show that administration of booster doses with mRNA vaccines leads to higher antibody levels and fewer side effects. Therefore, for those at risk of contracting severe COVID-19 and healthcare workers caring for this population, administration of booster doses with mRNA vaccines is the most accurate strategy.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Burcu Isler, Cansel Vatansever, Berna Ozer, Gule Cinar, Abdullah Tarik Aslan, Caitlin Falconer, Michelle J. J. Bauer, Brian Forde, Funda Simsek, Necla Tulek, Hamiyet Demirkaya, Sirin Menekse, Halis Akalin, Ilker Inanc Balkan, Mehtap Aydin, Elif Tukenmez Tigen, Safiye Koculu Demir, Mahir Kapmaz, Siran Keske, Ozlem Dogan, Cigdem Arabaci, Serap Yagci, Gulsen Hazirolan, Veli Oguzalp Bakir, Mehmet Gonen, Nese Saltoglu, Alpay Azap, Ozlem Azap, Murat Akova, Onder Ergonul, Fusun Can, David L. L. Paterson, Patrick N. A. Harris
Summary: This study tested carbapenem-resistant Klebsiella spp. (CRK) isolates and compared cefiderocol susceptibilities using EUCAST and CLSI interpretive criteria. The results showed that cefiderocol resistance rates among NDM producers are high using EUCAST criteria, while lower using CLSI criteria.
INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Ahmet Numan Demir, Zehra Kara, Emre Durcan, Cem Sulu, Oznur Aydin Atar, Guldana Zulfaliyeva, Cebrail Karaca, Hande Mefkure Ozkaya, Nurhan Seyahi, Dildar Konukoglu, Mustafa Sait Gonen
Summary: This study aimed to investigate the prevalence of microalbuminuria and associated factors in patients with Graves' Disease (GD). The results showed that the prevalence of microalbuminuria in GD patients was 12.1%. There was a significant correlation between microalbuminuria and the level of thyroid-stimulating hormone receptor antibody (TRAb) in GD patients, suggesting that autoimmunity may be one of the underlying mechanisms of microalbuminuria in GD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Hazal Cansu Culpan, Sumeyye Nur Aydin, Abdulkerim Uygur, Ugurcan Sayili, Erkam Seker, I'lker Inanc Balkan, Ridvan Karaali, Beyhan Budak, Yilmaz Keskindemirci, Nese Saltoglu, Gunay Can
Summary: This study evaluated the effectiveness of COVID-19 vaccines among healthcare workers, finding that receiving two doses of CoronaVac and two doses of BNT162b2 showed the highest effectiveness, while receiving two doses of CoronaVac alone had the lowest effectiveness. The effectiveness of two doses of CoronaVac was not significant, but increased significantly with a booster dose of CoronaVac or BNT162b2. The results suggest the need for booster doses, with heterologous boosting using BNT162b2 potentially offering higher effectiveness for individuals who received two doses of CoronaVac.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Medicine, General & Internal
Altug Kanbakan, Fatih Cakmak, Afsin Ipekci, Yonca S. Akdeniz, Ibrahim Ikizceli
Summary: This study aimed to determine the factors affecting the mortality of geriatric patients presenting to the emergency department with non-traumatic abdominal pain, as well as the associations of these factors with mortality. The results showed that neurological diseases, a history of surgery, and anemia were associated with increased risk of mortality.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2023)