Article
Biotechnology & Applied Microbiology
Caio H. N. Barros, Dishon W. Hiebner, Stephanie Fulaz, Stefania Vitale, Laura Quinn, Eoin Casey
Summary: Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with intrinsic antibacterial activity, showing enhanced penetration into biofilms and improved antibacterial activity compared to free curcumin. These nanoparticles are also efficient at disrupting mature biofilms and inhibiting bacterial growth within biofilms, suggesting their potential for drug delivery applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chaemin Lim, Duhyeong Hwang, Mostafa Yazdimamaghani, Hannah Marie Atkins, Hyesun Hyun, Yuseon Shin, Jacob D. Ramsey, Patrick D. Raedler, Kevin R. Mott, Charles M. Perou, Marina Sokolsky-Papkov, Alexander V. Kabanov
Summary: The presence of immunosuppressive immune cells in tumors is a barrier to therapeutic immune responses. This study used polymeric micelles to enhance the adaptive T cell immunity against triple-negative breast cancers (TNBCs) by delivering the small molecule drugs paclitaxel (PTX) and CSF1R inhibitor PLX3397. The combination therapy repolarized the immunosuppressive tumor microenvironment, resulting in inhibited primary tumor growth and metastasis.
Article
Chemistry, Multidisciplinary
Yun-Chang Zhang, Lan She, Zi-Yue Xu, Ze-Kun Wang, Zhiqiang Ma, Feng Yang, Zhan-Ting Li
Summary: Photodynamic therapy (PDT) is a promising non-invasive and targeted treatment approach. However, the hypoxic microenvironment in tumor tissue limits its effectiveness. In this study, a novel photosensitizer-loaded polymer system was developed, which significantly inhibited tumor proliferation, demonstrating its potential as an effective photo therapeutic system for cancer treatment.
CHINESE CHEMICAL LETTERS
(2022)
Review
Pharmacology & Pharmacy
Genada Sinani, Meltem Ezgi Durgun, Erdal Cevher, Yildiz Ozsoy
Summary: Nucleic acids can regulate gene expression specifically and have huge potential in disease prevention and treatment. However, their clinical translation is challenging due to rapid clearance, low stability, and limited cellular uptake. Polymeric micelles have emerged as suitable delivery vehicles for nucleic acids, with their versatile structures and ability to overcome barriers and enhance therapeutic efficacy. Various strategies, such as stimuli-sensitive groups and specific ligands, can be used to improve delivery, targeting, and cellular uptake of nucleic acids. Additionally, polymeric micelles can deliver both chemotherapeutic drugs and nucleic acid therapeutics simultaneously, achieving synergistic combination treatment.
Article
Materials Science, Multidisciplinary
Dongshi Liang, Meiqian Yu, Shuaishuai Huang, Jinglin Wang, Zijin Xu, Daai Li, Zhongyu Li, Huamin Wang
Summary: This study developed a new approach to address the limitations of magnolol as an anti-tumor agent, by creating an acid-responsive polymeric prodrug that can self-assemble into polymeric micelles. In vitro and in vivo studies showed that these micelles released magnolol selectively at an acidic pH, demonstrated superior inhibition of tumor growth, and had increased accumulation in tumor tissues. Pharmacokinetic analysis also showed a longer half-life and extended duration of action for these prodrugs. These findings indicate the potential of this synthesized prodrug as a promising therapeutic option for gastric cancer.
MATERIALS & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Lauren Repp, Sarah L. Skoczen, Morteza Rasoulianboroujeni, Stephan T. Stern, Glen S. Kwon
Summary: PTX is a commonly used chemotherapy drug for treating various solid tumors. o(LA)(8)-PTX prodrug-loaded PEG-b-PLA micelles have higher loading, slower release, and greater antitumor efficacy compared to PTX-loaded PEG-b-PLA micelles. This study investigates the plasma stability and pharmacokinetics of o(LA)(8)-PTX-loaded PEG-b-PLA micelles in rats. The prodrug is metabolized into o(LA)(1)-PTX and PTX in rat plasma, while in human plasma, it is metabolized into o(LA)(2)-PTX, o(LA)(1)-PTX, and PTX. The abundance of metabolites in rat plasma after IV injection follows the order: o(LA)(1)-PTX > o(LA)(2)-PTX > o(LA)(4)-PTX > o(LA)(6)-PTX. Bile metabolite profiles are similar to plasma metabolite profiles. Compared to Abraxane, plasma exposure to PTX is 100 times higher for Abraxane, and plasma exposure to o(LA)(1)-PTX is five times higher, indicating enhanced antitumor efficacy.
Article
Pharmacology & Pharmacy
Xiaohui Tang, Munire Kurban, Ipargul Hafiz, Qi Shen, Mei Wang
Summary: In this study, hyaluronic acid-loaded Harmine polymeric micelles with CD44 targeting properties were prepared, and their anti-breast cancer effects were investigated in vitro. The prepared micelles had a uniform particle size of about 200 nm, good dispersion, high encapsulation rate, and drug loading. They showed dose-dependent toxicity to both CD44-positive MDA-MB-231 and CD44-negative MCF-7 cells, with increased uptake by MDA-MB-231 cells and significant effects on apoptosis and cell cycling in both cell types.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Chae Eun Jin, Moon Sup Yoon, Min Jeong Jo, Seo Yeon Kim, Jae Min Lee, Su Jeong Kang, Chun-Woong Park, Jin-Seok Kim, Dae Hwan Shin
Summary: Ovarian cancer has a high mortality rate due to difficult early detection, necessitating the development of a novel anti-cancer treatment with improved efficacy and reduced toxicity. Micelles encapsulating paclitaxel and sorafenib were prepared using the freeze-drying method, and the optimal polymer was selected based on various factors. The PTX/SRF micelles demonstrated slower release, improved bioavailability, and enhanced anticancer effects compared to single-drug therapy in ovarian cancer.
Article
Biochemistry & Molecular Biology
Maryam Gharehasanloo, Mansoor Anbia, Fatemeh Yazdi
Summary: Developing a facile and green strategy, researchers used biocompatible polylactic acid polymer foam modified by nanochitosan and stearic acid to remove petroleum and organic contaminants in water. The foam exhibited super hydrophobicity, with high absorption capacity for oil pollutants and maintained its efficiency for more than 15 hours during continuous water-oil pumping test, making it a promising solution for large-scale oil pollution cleaning.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Linqi Yun, Kai Li, Cancan Liu, Ligao Deng, Jianbin Li
Summary: This study successfully synthesized biocompatible dual-modified starch micelles and demonstrated their potential as drug delivery vehicles. The results provide reference information for further research in biotechnology and pharmaceutical domains.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Polymer Science
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polymeric micelles, as carriers for therapeutic compounds, have attracted attention due to their ability to solubilize poorly water-soluble drugs, biocompatibility, and accumulation in tumors. Additional functionality can be achieved through surface modification and stimuli-sensitive groups. This review highlights the development of multifunctional polymeric micelles in cancer therapy, including applications in tumor imaging and theragnosis.
Article
Materials Science, Multidisciplinary
Ivana Jarak, Miguel Pereira-Silva, Ana Claudia Santos, Francisco Veiga, Horacio Cabral, Ana Figueiras
Summary: PMs are efficient NA delivery platforms that can manipulate gene expression and have enormous potential for treating life-threatening diseases. The facile manipulation of polymeric building blocks allows for tuning crucial parameters for NA protection and targeted delivery.
APPLIED MATERIALS TODAY
(2021)
Article
Pharmacology & Pharmacy
Anand Gupta, Antonio P. Costa, Xiaoming Xu, Diane J. Burgess
Summary: A continuous polymeric micelle processing platform was developed to eliminate batch-to-batch variation in critical quality attributes. By controlling polymer molecular weight and concentration, precise particle size and low polydispersity were achieved. The optimized conditions produced paclitaxel polymeric micelles equivalent to commercial Genexol PM, with similar quality attributes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Environmental
Amani Deghiche, Nacerddine Haddaoui, Ali Zerriouh, Seif Eddine Fenni, Dario Cavallo, Alessandro Erto, Yacine Benguerba
Summary: A route was developed to synthesize nanocomposites based on PLA and stearic acid-modified TiO2 nanoparticles, and the properties of the synthesized materials were characterized through various analyses. The functionalization of TiO2 by stearic acid was confirmed, and the nanoparticles acted as nucleating agents in reducing Tg and increasing crystallinity. Additionally, stearic acid played a role in enhancing the miscibility between PLA and TiO2.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Construction & Building Technology
Lin Yang, Yuyang Pang, Xiaohui Chen, Qun Tang, Haoran Cui, Danying Gao, Mingke Chen
Summary: A stearic acid modified metakaolin (MMK) was developed to improve the sulfate resistance of cement-based materials, and it effectively avoided the adverse effects of traditional hydrophobic modifier on the mechanical properties of cement mortar itself. The optimal water contact angle of MMK was achieved with 5% stearic acid content and 20 min grinding time. The MMK reduced the capillary water absorption height of the specimens, thus enhancing the sulfate resistance of the mortar.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Multidisciplinary Sciences
Gholamhossein Sodeifian, Chandrasekhar Garlapati, Fariba Razmimanesh, Hassan Nateghi
Summary: The solubility of empagliflozin in supercritical carbon dioxide was measured for the first time in this study. A new solubility model was derived and compared with existing models, with the Bian et al. model showing the best fit. The enthalpies of empagliflozin were also calculated.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Gholamhossein Sodeifian, Loubna Nasri, Fariba Razmimanesh, Mohammadamin Abadian
Summary: This study aims to experimentally measure the solubility of teriflunomide in supercritical carbon dioxide and describe the solubility using mathematical models. The results show that the solubility of teriflunomide is strongly dependent on pressure and has a complex relationship with temperature. The model proposed by Sodeifian et al. achieves the lowest deviation.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Chemistry, Multidisciplinary
Gholamhossein Sodeifian, Chieh-Ming Hsieh, Reza Derakhsheshpour, Yu-Ming Chen, Fariba Razmimanesh
Summary: Understanding the solubility of drugs in supercritical carbon dioxide is crucial for producing nanoparticles and microparticles using supercritical fluid technology. This study measured the solubility of metoclopramide hydrochloride in SC-CO2 and estimated the enthalpy changes during the solvation process. Additionally, different models were investigated to expand the use of the obtained data.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Gholamhossein Sodeifian, Ratna Surya Alwi, Fariba Razmimanesh, Fatemeh Sodeifian
Summary: The solubility of prazosin hydrochloride (PRH) in supercritical CO2 was measured and correlated using different models, with Sodeifian et al.'s model and a new modified EoS model performing well in fitting the solubility data.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Sahar Daneshyan, Gholamhossein Sodeifian
Summary: This study presents the first synthesis of cyclic polystyrene (cPS) in supercritical carbon dioxide (SC-CO2) media. The results show that the SC-CO2 pressure has a significant influence on the yield and properties of the product. The use of environmentally friendly solvents allows for the production of polymers with lower molecular weight and higher environmental compatibility.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Biochemistry & Molecular Biology
Elham Saleh Jalali, Seyed Abbas Shojaosadati, Sepideh Hamedi
Summary: A safe drug carrier was synthesized using albumin (BSA) and oxidized gum arabic (OGA), and piperine (PIP) was loaded into the carrier successfully. The optimized carrier, PIP2-BSA/OGA5, showed smaller size (<300 nm), higher loading efficiency (1.5 +/- 0.2 %), and sustained drug release. The cell viability study demonstrated that PIP2-BSA/OGA5 exhibited greater cytotoxicity against MCF-7 cells compared to BSA/OGA5 and free PIP. Molecular docking study confirmed the acceptable stability of the prepared drug carrier.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Mechanics
Sara Tarashi, Hossein Nazockdast, Alireza Bandegi, Saeid Shafaghsorkh, Gholamhossein Sodeifian, Reza Foudazi
Summary: Double network hydrogels have precise structural platforms and significant properties, making them new tough materials. This study used large amplitude oscillatory shear technique to investigate their nonlinear response, revealing strain stiffening and shear thickening behaviors. The presence of graphene oxide nanosheets and temperature also influenced the viscoelastic properties of the hydrogels.
JOURNAL OF RHEOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Gholamhossein Sodeifian, Mohammad Mahdi Behvand Usefi, Fariba Razmimanesh, Armin Roshanghias
Summary: This study investigated the solubility of the anticoagulant drug rivaroxaban in supercritical carbon dioxide and examined the correlation of the drug solubility data using different models and equations.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Chemical
Gholamhossein Sodeifian, Mohammad Mahdi Behvand Usefi
Summary: Supercritical carbon dioxide is a crucial supercritical fluid widely used in chemical, food, and pharmaceutical industries. Understanding its solubility is vital for designing material and drug production processes.
CHEMBIOENG REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Esmaeil Rasooly Garmaroody, Niloufar Davoodi PahnehKolaei, Omid Ramezani, Sepideh Hamedi
Summary: The potential of bagasse pith for bio-xylitol production was investigated using sulfuric acid hydrolysis and detoxification methods. The highest sugar yield of 20% was achieved after acid hydrolysis, while detoxification methods using overliming, active carbon, and their combination increased the reducing sugar content and decreased the concentration of inhibitors. The addition of detoxified hydrolysate resulted in higher xylitol productivity compared to non-detoxified hydrolysate.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Thermodynamics
Samane Zarei Mahmoudabadi, Mohammadamin Abadian, Gholamhossein Sodeifian, Fariba Razmimanesh
Summary: This study measured the solubility of Riluzole in supercritical carbon dioxide for the first time and evaluated the data using various methods and models. The results showed that the models used provided a good fit to the experimental data and were suitable for correlating solubility.
FLUID PHASE EQUILIBRIA
(2023)
Article
Polymer Science
Sahar Daneshyan, Gholamhossein Sodeifian
Summary: This study successfully synthesized cyclic poly(N-isopropyl acrylamide) (cPNIPAAM) using a new method. The synthesis involved the generation of an alpha\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\alpha$$\end{document}, omega-difunctionalized precursor through a free radical polymerization process with methanol solvent and the use of hydroxy-TEMPO as the terminator. The cyclization reaction was achieved through end-to-end equilibrium using a suitable coupling agent in water and dimethylformamide (DMF) solvents. The use of a terminator resulted in controlled molecular weight polymers, leading to smaller rings with improved water solubility and LCST temperature, making them ideal for medicinal purposes. The study also compared the morphology and molecular weight of the synthesized polymers with previous techniques, confirming the formation of polymers with lower molecular weight and higher solubility in water compared to DMF.
Article
Multidisciplinary Sciences
Gholamhossein Sodeifian, Chieh-Ming Hsieh, Amirmuhammad Tabibzadeh, Hsu-Chen Wang, Maryam Arbab Nooshabadi
Summary: In this research, the solubility of Palbociclib in supercritical carbon dioxide (ScCO2) was measured for the first time. The results showed that the solubility ranged from 8.1 x 10(-7) to 2.03 x 10(-5) at different equilibrium conditions. Bian's model and PR equation of state using van der Waals mixing rules (PR + vdW) were found to accurately describe the experimental solubility data. The total and vaporization enthalpies of Palbociclib solubility in ScCO2 were calculated to be 40.41 and 52.67 kJ/mol, respectively.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Abolfazl Heydari, Milad KhajeHassani, Haniyeh Daneshafruz, Sepideh Hamedi, Faeze Dorchei, Mario Kotlar, Fahimeh Kazeminava, Samahe Sadjadi, Farideh Doostan, Ivan Chodak, Hassan Sheibani
Summary: This study developed a nanocomposite material consisting of thermoplastic starch (TPS) reinforced with bentonite clay (BC) and encapsulated with vitamin B2 (VB). The study investigated the effects of VB on the physicochemical properties of TPS/BC films, including mechanical and thermal properties, water uptake, and weight loss in water. The addition of VB significantly increased the tensile strength and Young's modulus of TPS/BC films, with the highest values observed for nanocomposites containing 5 php of VB and 3 php of BC. The release of VB was controlled by the BC content, with higher BC content leading to lower VB release. These findings demonstrate the potential of TPS/BC/VB nanocomposites as environmentally friendly materials with improved mechanical properties and controlled release of VB, which can have significant applications in the biopolymer industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Multidisciplinary
Armin Roshanghias, Gholamhossein Sodeifian, Ali Asghar Javidparvar, Sara Tarashi
Summary: This study introduced an innovative formulation for PTFE-based sealant paste to improve sealing performance. The chemical composition, thermal properties, and hydrophobicity of the prepared paste were investigated. The results showed that the addition of PVB and nano-alumina significantly improved the sealing performance of the paste.
RESULTS IN ENGINEERING
(2022)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)