Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 199, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111505
Keywords
XPS; Depth-profiling; Biomaterials; Spectroscopy; Thin films; Layer-by-layer
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- CNPq [147536/2016-2]
- Sao Paulo Research Foundation (FAPESP) [2016/10193-9, 2018/20560-4]
- PNPD/FEQ
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The study revealed that polysaccharide-based polyelectrolyte multilayer films loaded with silver ions have a uniform polymer composition and antimicrobial activity, providing insights for engineering advanced materials with controlled spatio-temporal behavior.
This study presents the axial molar composition of polysaccharide-based polyelectrolyte multilayer (PEM) films loaded with silver ions for antimicrobial applications. Individual polymers (chitosan, hyaluronan or alginate) and silver composition were determined using X-Ray Photoelectron Spectroscopy coupled with C-60(+) cluster ion sputtering technique, while the influence of silver loading on film topography was assessed using Atomic Force Microscopy. Despite the use of the layer-by-layer approach for film assembly, these PEM films present a nonstratified, nanoblend-like, polymer composition, with a nearly uniform metal distribution over the axial direction. Results also show surface antimicrobial activity towards Staphylococcus aureus bacteria and Candida albicans fungi over 20 h for hyaluronan/chitosan PEM, which is associated with its higher silver loading capacity. The interplay of bulk film composition and surface properties may provide valuable insights for engineering advanced materials with controlled spatio-temporal behavior.
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