Article
Oncology
Vincent Crenn, Yonis Quinette, Charlie Bouthors, Gilles Missenard, Brice Viard, Philippe Anract, Stephane Boisgard, Eric Mascard, Francois Gouin
Summary: The study suggests that using a vascularised fibula graft (VFG) in femoral reconstructions can promote bone union and reduce mid- to long-term revision risks. However, irradiated allografts increase the risk of revisions. Therefore, in cases of tumors, it is recommended to choose VFG+ from fresh-frozen allografts.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Orthopedics
Costantino Errani, Patricio A. Alfaro, Virginia Ponz, Marco Colangeli, Davide Maria Donati, Marco Manfrini
Summary: The study aimed to compare the outcomes of children with femoral bone sarcomas undergoing intercalary resection and reconstruction with massive bone allograft alone versus with vascularized free fibula. It analyzed surgical time, complications, Musculoskeletal Tumor Society scores, and survival rate of the reconstructions. The findings suggest that using an allograft alone for femoral intercalary defects reconstruction may be a more conservative approach, with no significant difference in functional outcomes and survival compared to using a vascularized fibula along with the allograft.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2021)
Article
Orthopedics
Domenico Andrea Campanacci, Roberto Scanferla, Matteo Innocenti, Francesco Muratori, Serena Puccini, Guido Scoccianti, Giovanni Beltrami, Rodolfo Capanna, Marco Innocenti
Summary: This retrospective study analyzed the results of intercalary resection of the humeral diaphysis and vascularized fibula graft (VFG) in 127 patients with primary bone tumors. The study found that VFG is an effective reconstructive option after humeral intercalary resection, providing long-term, durable reconstruction with excellent functional results. However, mechanical complications after surgery were relatively high and should be managed by an experienced surgical team.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Health Care Sciences & Services
Alexis Combal, Francois Thuau, Alban Fouasson-Chailloux, Pierre-Paul Arrigoni, Marc Baud'huin, Franck Duteille, Vincent Crenn
Summary: The Capasquelet surgery showed satisfactory bone consolidation and early weight-bearing, with the induced membrane potentially playing a role in osteoinduction of the graft. Further studies with larger cohorts and longer follow-up periods are needed to better assess the implications of this two-stage reconstruction technique.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Orthopedics
Xianhao Shao, Mengmeng Dou, Qiang Yang, Jianmin Li, Ailin Zhang, Yuan Yao, Qing Chu, Ka Li, Zhenfeng Li
Summary: Two novel 3D-printed customized intercalary femoral prostheses were used to reconstruct massive bone defects in oncologic patients, achieving satisfactory postoperative outcomes and increasing the opportunities for joint-preserving tumor resection.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Suman Medda, Matthew A. King, Christopher M. Runyan, John Frino
Summary: The video reviews the technique of using vascularized fibula flap for pediatric tibia reconstruction. A 4-year-old boy with tibial nonunion and bone loss was successfully treated with this method and achieved independent ambulation.
JOURNAL OF ORTHOPAEDIC TRAUMA
(2021)
Article
Pediatrics
Massimiliano Baleani, Paolo Erani, Manon Blaise, Roberta Fognani, Marco Palmas, Marco Manfrini
Summary: This study compared the reconstruction stiffness achieved by three different host-graft junctions and found that the taper junctions can achieve more homogeneous and higher construct stability. However, when associated with a low-stiffness intramedullary nail, there is an increased risk of instability under high torsional loads.
FRONTIERS IN PEDIATRICS
(2022)
Article
Surgery
Alexander F. Mericli, Malke Asaad, Valerae O. Lewis, Patrick P. Lin, Christopher J. Goodenough, David M. Adelman, Scott D. Oates, Matthew M. Hanasono
Summary: This study evaluated outcomes of vascularized bone flap reconstruction for oncologic bony extremity defects and compared union rates based on different insetting methods. A retrospective review of patients who received fibula flap reconstruction after oncologic resection was conducted. The overall union rate was 91.7%, with a mean time to full weightbearing of 16 months for lower extremity reconstructions.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Oncology
Jan Lesensky, Ana C. Belzarena, Martin Masek, Zdenek Matejovsky Jr
Summary: This study retrospectively analyzed data from patients who underwent femoral diaphysis reconstruction surgery in the past ten years and compared the results of combined vascularized fibula-allograft constructs with plain allograft reconstruction. The study also evaluated the accuracy of imaging studies in predicting fibular vitality. The results showed that the combined graft group had higher surgical time, blood loss, and resection length, but lower risk of non-union and infectious complications, as well as shorter healing time. Viable fibula transfer enhances allograft incorporation, reduces the risk of structural failure and infectious complications, and improves the functional status of the recipient.
JOURNAL OF BONE ONCOLOGY
(2023)
Article
Orthopedics
David Graham, Brahman Sivakumar, Francisco del Pinal
Summary: Massive carpal loss following trauma, tumor, or infection is a difficult reconstructive challenge, especially when the metacarpal bases are also lost. This study describes a method of carpal reconstruction using a triangular vascularized free fibular flap and proposes an algorithm for managing metacarpal instability in this setting.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Article
Immunology
Cheng-Hung Lin, Madonna Rica Anggelia, Hui-Yun Cheng, Yun-Huan Hsieh, Wen-Yu Chuang, Huang-Yu Yang, Chih-Hung Lin
Summary: This study demonstrated that VBM transplantation is an efficient strategy to induce and maintain donor-specific tolerance for an osseous-free allograft.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sabina M. Gorski, Chao Dong, Ulrich Lenze, Martin Haug, Andreas H. Krieg
Summary: This study compared the use of vascularized and non-vascularized fibula grafts for reconstructing bone defects after tumor resection. The results showed that both types of grafts were successful in reconstructing segmental bone tumor defects, with lower complication rates observed in the non-vascularized grafts. Chemotherapy was identified as a negative prognostic factor for union time in both techniques.
ANTICANCER RESEARCH
(2022)
Article
Orthopedics
J. Dheenadhayalan, A. Devendra, P. Velmurugesan, T. Shanmukha Babu, P. Ramesh, Mohd Zackariya, S. Raja Sabapathy, S. Rajasekaran
Summary: This study investigated the use of gamma-irradiated intercalary structural allografts combined with autologous cancellous grafts in treating large metaphyseal bone defects of the distal femur. The results showed that 68% of the patients achieved bone union without the need for additional surgery. Infections were the most common complication, requiring additional procedures.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Veterinary Sciences
Radina Vasileva, Tzvetan Chaprazov
Summary: This study investigated the potential of erythropoietin to promote bone regeneration in a rat model. The results showed that applying erythropoietin locally on a collagen scaffold could induce bone healing, and combining it with a bone substitute resulted in faster integration between the xenograft and host bone.
VETERINARY SCIENCES
(2023)
Article
Orthopedics
Amanda N. Goldin, Samuel R. Johnson, Katherine S. Hajdu, Brooke L. Kowalski, Alexander J. Volkmar, Cullen P. Moran, Akhil Rekulapelli, Joshua M. Lawrenz, Jennifer L. Halpern, Herbert S. Schwartz, Ginger E. Holt
Summary: This study compared fixation methods in intercalary allograft reconstruction in the lower extremity and found that intramedullary fixation with nails had higher rates of nonunion, but lower fracture rates and revision surgery rates. Additionally, allograft survival was longer in the intramedullary group.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
