The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

Published 2015 View Full Article

Authors

Keywords

Bisphosphonate, Farnesyl pyrophosphate synthase, Inhibition mechanism, Drug binding, Substrate binding, Active site mutant

Journal

BONE

Volume 81, Issue -, Pages 478-486

Publisher

Elsevier BV

Online

2015-08-29

DOI

10.1016/j.bone.2015.08.020

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