Review
Pharmacology & Pharmacy
Sevket Balta, Ilknur Balta
Summary: This review assesses the relationship between inflammatory markers and COVID-19 infection, including both known and emerging markers. These markers play important roles in follow-up, treatment response assessment, and risk stratification.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Nathaly Limon-de la Rosa, Eduardo Cervantes-Alvarez, Osvely Mendez-Guerrero, Miguel A. Gutierrez-Gallardo, David Kershenobich, Nalu Navarro-Alvarez
Summary: This study identified clinical and laboratory parameters that distinguish between survivors and non-survivors of COVID-19 and have independent ability to predict mortality. Some of these parameters, such as C-reactive protein, ferritin, and neutrophil count, were elevated upon admission and remained high in non-survivors during hospital stay, while they decreased in survivors. The study highlights the importance of evaluating these markers to monitor and predict patients' outcome after hospitalization.
Article
Cardiac & Cardiovascular Systems
Kevin K. Manocha, Jared Kirzner, Xiaohan Ying, Ilhwan Yeo, Bradley Peltzer, Bryan Ang, Han A. Li, Bruce B. Lerman, Monika M. Safford, Parag Goyal, Jim W. Cheung
Summary: Elevated troponin and other biomarker levels are commonly observed in patients with COVID-19. High troponin levels serve as a strong predictor for 30-day in-hospital mortality. A simple risk score can help stratify patients at risk for COVID-19-associated mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Oscar M. Peiro, Anna Carrasquer, Raul Sanchez-Gimenez, Nisha Lal-Trehan, Victor del-Moral-Ronda, Gil Bonet, Isabel Fort-Gallifa, Ester Pico-Plana, Natalia Baston-Paz, Cristina Gutierrez, Alfredo Bardaji
Summary: The study found that increased concentrations of cTnI, D-dimer, CRP, and LDH are associated with short-term mortality in COVID-19 patients. Among these biomarkers, cTnI provides better mortality risk prediction, with non-significant differences with D-dimer.
Review
Immunology
Ying-yi Luan, Cheng-hong Yin, Yong-ming Yao
Summary: High levels of CRP in severe COVID-19 and other viral infections can indicate disease progression and guide clinical diagnosis and antibiotic therapy. Understanding the role of CRP in these diseases may lead to more effective prevention and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mohamed Zakaria Bouayed, Ilyass Laaribi, Charaf Eddine Mohammed Chatar, Iliass Benaini, Mohammed Amine Bouazzaoui, Younes Oujidi, Samia Berrichi, Ghizlane El Aidouni, Houssam Bkiyar, Naima Abda, Brahim Housni
Summary: This study aimed to investigate whether CRP levels at admission could predict the progression of COVID-19 patients, showing that patients with CRP levels >= 100mg/L were more likely to have severe lung involvement, require mechanical ventilation, and had a significantly higher mortality rate compared to those with CRP levels < 100mg/L.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Nathaniel R. Smilowitz, Dennis Kunichoff, Michael Garshick, Binita Shah, Michael Pillinger, Judith S. Hochman, Jeffrey S. Berger
Summary: Elevated CRP levels at initial hospital presentation in COVID-19 patients are associated with an increased risk of venous thromboembolism, acute kidney injury, critical illness, and mortality. There is a dose-response relationship between CRP concentration and adverse outcomes, with patients with high levels of both CRP and D-dimer showing the greatest risk of adverse outcomes. Systemic inflammation, as measured by CRP, plays a significant role in predicting clinical outcomes in COVID-19.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Nathaniel R. Smilowitz, Dennis Kunichoff, Michael Garshick, Binita Shah, Michael Pillinger, Judith S. Hochman, Jeffrey S. Berger
Summary: Elevated CRP levels upon hospital admission in COVID-19 patients are associated with increased risks of VTE, AKI, critical illness, and mortality, suggesting a crucial role of systemic inflammation in the clinical course of COVID-19.
EUROPEAN HEART JOURNAL
(2021)
Review
Cell Biology
Christoph C. Kaufmann, Amro Ahmed, Achim Leo Burger, Marie Muthspiel, Bernhard Jager, Johann Wojta, Kurt Huber
Summary: COVID-19 is a complex multi-system disease that can affect various organs, including the cardiovascular system. Early reports have shown excessive myocardial injury in COVID-19 patients, making cardiovascular involvement an important topic of discussion. Cardiac biomarkers, such as high-sensitive cardiac troponin and N-terminal pro-B-type natriuretic peptide, can provide valuable prognostic information and aid in the management of patients with atypical presentations.
Article
Hematology
Chaymae Miri, Hajar Charii, Mohammed-Amine Bouazzaoui, Falmata Laouan Brem, Soumia Boulouiz, Naima Abda, Hatim Kouismi, Zakaria Bazid, Nabila Ismaili, Noha El Ouafi
Summary: This study found that diabetic patients with COVID-19 have significantly higher levels of D-dimer compared to non-diabetic patients; A high D-dimer level (>2885 ng/mL) is an important predictor of mortality in diabetic patients; The study suggests that diabetic patients with COVID-19 are likely to develop hypercoagulation with a poor prognosis.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Ankeet S. Bhatt, Lori B. Daniels, James de Lemos, Erica Goodrich, Erin A. Bohula, David A. Morrow
Summary: This study analyzed the association between multiple blood biomarkers and in-hospital death and cardiovascular events in COVID-19 patients. The study found significant associations between the levels of D-dimer, C-reactive protein, ferritin, cardiac troponin, and natriuretic peptides with in-hospital death and cardiovascular events. Natriuretic peptides had the highest risk of death, while D-dimer had the highest risk of thrombotic events.
AMERICAN HEART JOURNAL
(2023)
Review
Immunology
Denise Battaglini, Miqueias Lopes-Pacheco, Hugo C. Castro-Faria-Neto, Paolo Pelosi, Patricia R. M. Rocco
Summary: This article summarizes the commonly used biomarkers in COVID-19, which play important roles in predicting disease severity, hospitalization, ICU admission, and mortality. It also discusses how novel analytical strategies can be applied in clinical practice, emphasizing the need for future research to focus on identifying a limited but essential number of laboratory biomarkers for predicting prognosis and outcomes in severe COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D. Donnelly, Juan Carlos Kaski, Anthony R. M. Coates
Summary: The ferritin-lymphocyte ratio (FLR) has prognostic value in COVID-19 patients and is unrelated to other inflammatory markers. FLR exhibits high sensitivity and negative predictive values for adverse clinical outcomes in COVID-19, making it a potentially good rule-out test. Further research is needed to improve the sensitivity of FLR and validate its role in prospective studies for clinical management.
Article
Medicine, General & Internal
Juan Carlos Ayus, Armando Luis Negri, Michael L. Moritz, Kyung Min Lee, Daniel Caputo, Maria Elena Borda, Alan S. Go, Carlos Eghi
Summary: Mild hyponatremia at admission is common in COVID-19 patients, associated with systemic inflammation, and an independent risk factor for hospital mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Health Care Sciences & Services
Verity Schaye, Louis Miller, David Kudlowitz, Jonathan Chun, Jesse Burk-Rafel, Patrick Cocks, Benedict Guzman, Yindalon Aphinyanaphongs, Marina Marin
Summary: The study aimed to develop a valid and reliable assessment tool for clinical reasoning documentation to improve the documentation quality of residents and fellows. The tool, with detailed descriptive prompts and a new scoring range, enhanced the quality assessment standard of clinical reasoning documentation, with results showing that less than half of the notes were classified as high-quality.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Cardiac & Cardiovascular Systems
Nina Talmor, Michael Gurin, Nathaniel Smilowitz, Dana Gossett, Bruria Eisner, Mitchell Pleasure, Harmony R. Reynolds
Summary: This case report describes a 37-year-old woman with recurrent non-ST elevation myocardial infarction (NSTEMI) during her menstrual periods. Intracoronary acetylcholine provocation testing revealed coronary spasm in the left anterior descending artery (LAD) that was relieved with nitroglycerine. Initiating calcium channel blockade and suppressing cyclical variation in sex hormones improved her symptoms and prevented monthly NSTEMI events caused by coronary spasm.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Priya Panday, Anais Hausvater, Mitchell Pleasure, Nathaniel R. Smilowitz, Harmony R. Reynolds
Summary: Women with myocardial infarction (MI) are more likely to have nonobstructive coronary artery disease (MINOCA), spontaneous coronary artery dissection (SCAD), and takotsubo syndrome (TS) than men. This study aims to determine the prevalence of cancer in women with MI and investigate its association with the mechanism of MI presentation.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Milla Arabadjian, Zoe T. Duberstein, Sarah H. Sperber, Kiranjot Kaur, Jolaade Kalinowski, Yuhe Xia, Anais Hausvater, Olivia O'Hare, Nathaniel R. Smilowitz, Victoria Vaughan Dickson, Hua Zhong, Jeffrey S. Berger, Judith S. Hochman, Harmony R. Reynolds, Tanya M. Spruill
Summary: Psychological well-being is crucial for individuals with myocardial infarction. Women are more likely to experience stress and depressive disorders after myocardial infarction compared to men. Resilience may protect against these psychological issues. This study examines the role of resilience in the psychological recovery of women post myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Scott D. J. Solomon, Charles J. S. Lowenstein, Ankeet S. Bhatt, Alexander Peikert, Orly N. Vardeny, Mikhail N. S. Kosiborod, Jeffrey S. R. Berger, Harmony R. Reynolds, Stephanie Mavromichalis, Anya D. Barytol, Andrew D. F. Althouse, James F. S. Luther, Eric S. L. Leifer, Andrei L. Kindzelski, Mary N. Cushman, Michelle N. Z. Gong, Lucy Z. Kornblith, Pooja S. Khatri, Keri S. Kim, Lisa Baumann Kreuziger, Lana Wahid, Bridget-Anne W. Kirwan, Mark W. D. Geraci, Matthew D. S. Neal, Judith S. Hochman
Summary: This study aimed to evaluate the efficacy of using the P-selectin inhibitor crizanlizumab in reducing mortality and disease progression in COVID-19 patients. However, the results showed that the drug did not improve organ support-free days in patients hospitalized with COVID-19.
Article
Cardiac & Cardiovascular Systems
Daniel Y. Choi, Dena Hayes, Samuel D. Maidman, Nehal Dhaduk, Jill E. Jacobs, Anna Shmukler, Jeffrey S. Berger, Germaine Cuff, David Rehe, Mitchell Lee, Robert Donnino, Nathaniel R. Smilowitz
Summary: Preoperative cardiovascular risk stratification before noncardiac surgery is a common clinical challenge. Coronary calcium obtained from nongated chest CT imaging can improve preoperative clinical risk stratification before noncardiac surgery.
Editorial Material
Cardiac & Cardiovascular Systems
Sunil V. Rao, Harmony R. Reynolds, Judith S. Hochman
Article
Cardiac & Cardiovascular Systems
Robert S. Zhang, Usman Alam, Muhammad H. Maqsood, Yuhe Xia, Rafael Harari, Norma Keller, Lindsay Elbaum, Sunil V. Rao, Carlos L. Alviar, Sripal Bangalore
Summary: In this study, percutaneous vegetation debulking was found to be a feasible, effective, and safe treatment option for patients with tricuspid valve infective endocarditis refractory to medical therapy.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Peripheral Vascular Disease
Muhammad Haisum Maqsood, Franz H. Messerli, Adam H. Skolnick, Jonathan D. Newman, Jeffrey S. Berger, Sripal Bangalore
Summary: This study compared the efficacy of morning versus evening dosing of antihypertensive drugs and found that evening dosing significantly reduced ambulatory blood pressure parameters and cardiovascular events, but this effect was mainly driven by trials by the Hermida group. Therefore, the timing of antihypertensive drug administration should be chosen based on convenience and minimizing undesirable effects.
Letter
Cardiac & Cardiovascular Systems
Sharine Wittkopp, Elle Anastasiou, Jiyuan Hu, Mengling Liu, Aisha T. T. Langford, Robert D. D. Brook, Terry Gordon, Lorna E. E. Thorpe, Jonathan D. D. Newman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
