Hydrogen peroxide-generating nanomedicine for enhanced chemodynamic therapy

Chemodynamic therapy (CDT) is an emerging endogenous stimulation activated tumor treatment approach that exploiting iron-containing nanomedicine as catalyst to convert hydrogen peroxide (H2O2) into toxic hydroxyl radical ((OH)-O-center dot) through Fenton reaction. Due to the unique characteristics (weak acidity and the high H2O2 level) of the tumor microenvironment, CDT has advantages of high selectivity and low side effect. However, as an important substrate of Fenton reaction, the endogenous H2O2 in tumor is still insufficient, which may be an important factor limiting the efficacy of CDT. In order to optimize CDT, various H2O2-generating nanomedicines that can promote the production of H2O2 in tumor have been designed and developed for enhanced CDT. In this review, we summarize recently developed nanomedicines based on catalytic enzymes, nanozymes, drugs, metal peroxides and bacteria. Finally, the challenges and possible development directions for further enhancing CDT are prospected. (C) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Automated summary

Chemodynamic therapy (CDT) utilizes iron-containing nanomedicine as a catalyst to convert hydrogen peroxide into toxic hydroxyl radical, showing high selectivity and low side effects. However, the insufficient endogenous H2O2 in tumors limits the efficacy of CDT. To enhance CDT, various nanomedicines promoting H2O2 production in tumors have been developed.