Journal
CHEMMEDCHEM
Volume 16, Issue 12, Pages 1861-1877Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202100004
Keywords
benzimidazole; biological activity; drug discovery; multitarget; patents
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Funding
- School of Science, Monash University Malaysia
- Graduate Research Merit Scholarship from Monash University Malaysia
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Benzimidazole derivatives have been widely studied in the pharmaceutical field for their wide range of pharmacological activities. This review outlines their biological effects and mechanisms of action, highlighting their potential for clinical drug development. Additionally, the study discusses novel therapeutic approaches for different target diseases using patented benzimidazoles.
Benzimidazole is a heterocyclic ring system that has been widely studied in the pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been synthesized and evaluated for their wide range of pharmacological activities, which are beneficial for drug development. This article presents the biological effects of benzimidazole derivatives in each invention from 2015 to 2020. Two patent databases, Google Patents and Lens, were used to locate relevant granted patent applications. Specifically, this review delineates the role of patented benzimidazoles from a disease-centric perspective and examines the mechanisms of action of these compounds in related diseases. Most of the benzimidazoles have shown good activities against various target proteins. Whilst several of them have progressed into clinical trials, most patents presented novel therapeutic approaches for respective target diseases. Hence, their potential in being developed into clinical drugs are also discussed.
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