Article
Medicine, General & Internal
Abdallah Damin Abukhalil, Hiba Falana, Rawan Hamayel, Fatima Yasser, Aleen Nasser, Hani Naseef, Ni'meh Al-Shami, Abdullah Rabba
Summary: This study investigated the prevalence of vitamin D deficiency and its associated comorbidities in Palestine, revealing a high and alarming prevalence of vitamin D deficiency as well as significant associations with symptoms such as back pain, arthritis, and hypothyroidism. Health initiative programs are needed to increase awareness and further research should be conducted to confirm the relationship between vitamin D supplementation and the reduced risk of comorbid diseases.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Pediatrics
Inbal Golan-Tripto, Neta Loewenthal, Asher Tal, Yotam Dizitzer, Yael Baumfeld, Aviv Goldbart
Summary: Children with acute bronchiolitis exhibited significantly lower levels of vitamin D compared to those with non-respiratory febrile illnesses, and deficiency of vitamin D was more prevalent in bronchiolitis patients.
Article
Nutrition & Dietetics
Aleksandra Kapala, Malgorzata Szlendak, Ewelina Grochowska
Summary: The study revealed a high prevalence of vitamin D deficiency in Caucasian cancer patients, especially in those who were older, male, diagnosed with head and neck cancer or squamous cell carcinoma, and experienced weight loss. The dose of vitamin D supplementation required to prevent deficiencies in cancer patients may need to be higher than that in the general population.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Maham Babar, Maryam Fatima, Ahmad Nawaz, Muhammad Amjad Bashir, Wajahat Ali Khan, Shujaat Ali Khan, A. H. Sneharani, Jawahir Ahmad Mokhtar, Shaymaa Abdalal, Steve Harakeh, Muhammad Essa
Summary: The occurrence of vitamin D deficiency is higher in children with urinary tract infections.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Nursing
Yanghee Pang, Oksoo Kim, Jung-Ah Choi, Heeja Jung, Jui Kim, Haeok Lee, Hyangkyu Lee
Summary: This study found a high prevalence of vitamin D deficiency among Korean female nurses, which was associated with age and season. Vitamin D deficiency should be recognized as one of the primary health concerns among young women, and proactive actions are needed to address it.
Article
Psychiatry
Hongfei Mo, Jipeng Zhang, Chiwei Huo, Mengying Zhang, Jiang Xiao, Junge Peng, Guirong Wang, Changhong Wang, Yan Li
Summary: The study finds that there is a negative correlation between vitamin D levels and depression, and a positive correlation between age and depression. Additionally, vitamin D deficiency and older age both increase the risk of depression.
Article
Public, Environmental & Occupational Health
Saba Arshad, Syed Jaffar Abbas Zaidi
Summary: This study observed the levels of vitamin D deficiency, insufficiency, and sufficiency among different age groups in the Pakistani population. The findings highlight the high prevalence of vitamin D deficiency among children and adolescents, calling for immediate action from the public health sector to screen, intervene, and educate high-risk populations.
Article
Nutrition & Dietetics
Yi-Chuan Chen, Wen-Cheng Li, Pin-Hsuan Ke, I-Chun Chen, Wei Yu, Hsiung-Ying Huang, Xue-Jie Xiong, Jau-Yuan Chen
Summary: This study investigated the risk of vitamin D deficiency in a relatively healthy Asian population, finding that metabolically unhealthy obesity is associated with vitamin D deficiency in women of all ages and men aged > 50 years, while metabolically healthy obesity has the highest risk for vitamin D deficiency in men aged < 50 years.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Gyung-Mee Kim, Gyun-Ho Jeon
Summary: This study examined the relationship between vitamin D deficiency and depressive symptoms in secondary amenorrhea patients. The findings showed that low serum 25(OH)D levels were associated with the severity of depressive symptoms in these patients.
Article
Endocrinology & Metabolism
Chang Shan, Yu-chen Zhu, Jie Yu, Yi Zhang, Yu-ying Wang, Nan Lu, Jie Cai, Wei Liu, Tao Tao
Summary: This study found that Chinese women with PCOS have lower levels of vitamin D compared to controls, especially in those with hyperandrogenemia. Higher levels of 25(OH)D were independently associated with lower risks of hyperandrogenemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Johanna Oberg, Rolf Jorde, Bjorg Almas, Christopher Sivert Nielsen, Thomas Alexander Gerds, Kevin D. Cashman, Guri Grimnes
Summary: This study presents population-based data from an Arctic adolescent population, investigating the changes in vitamin D status during adolescence and the potential impact of lifestyle changes on vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Yogesh Sharma, Alexandra Popescu, Chris Horwood, Paul Hakendorf, Campbell Thompson
Summary: Frailty is common in older hospitalized patients and may be associated with micronutrient malnutrition. Vitamin C deficiency is common and is associated with a greater severity of frailty in older hospitalised patients.
Article
Public, Environmental & Occupational Health
Su H. Chu, Mengna Huang, Rachel S. Kelly, Priyadarshini Kachroo, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su
Summary: This study found that higher levels of maternal vitamin D in the third trimester are associated with a lower risk of ADHD in offspring, with a stronger effect observed in male offspring.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Myriam Calle Rubio, Jose Luis alvarez-Sala, Gianna Vargas Centanaro, Ana Maria Humanes Navarro, Juan Luis Rodriguez Hermosa
Summary: In outpatient respiratory clinics in Spain, testing of vitamin D levels in high-risk COPD patients is infrequent, but when tested, one in four patients is found to have a severe deficiency.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jirayu Visuthranukul, Phenphop Phansuea, Pantat Buranakityanon, Prapawan Lerdrungroj, Eakkawit Yamasmith
Summary: This study aimed to determine the prevalence and risk factors of vitamin D deficiency (VDD) in HIV-infected adults receiving antiretroviral therapy (ART) in a tropical area. The study found that increasing age, efavirenz use, male gender, low BMI, protease inhibitors use, and CD4 count lower than 200 cells/mm(3) were associated with vitamin D deficiency.
Article
Nutrition & Dietetics
Miyuki Hori, Norie Sawada, Kumiko Kito, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: This study aimed to investigate the associations between vegetable and fruit intake and CRC risk by smoking status.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Paramita Khairan, Tomotaka Sobue, Ehab Salah Eshak, Tetsuhisa Kitamura, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Hiroyasu Iso, Shoichiro Tsugane, Norie Sawada
Summary: This study aimed to investigate the association between consumption of sugary drinks and gastric cancer (GC) risk in a Japanese population. The study found no association between sugary drink consumption and GC risk.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Transplantation
Yoshihisa Miyamoto, Ryoko Katagiri, Taiki Yamaji, Manami Inoue, Atsushi Goto, Motoki Iwasaki, Mitsuhiko Noda, Shoichiro Tsugane, Norie Sawada
Summary: This study investigated the association between chronic kidney disease (CKD) and cancer incidence. The findings suggest that a low estimated glomerular filtration rate (eGFR) is not significantly associated with an increased risk of total cancer incidence in patients with CKD, possibly due to the underpowered sample size and shared risk factors between CKD and cancer.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Kenta Tanaka, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane
Summary: This study analyzed data from 30,381 middle-aged Japanese adults and found that fecal occult blood test (FOBT) and colonoscopy both reduced the risk of death and incidence of colorectal cancer (CRC).
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Rei Otsuka, Shu Zhang, Hikaru Ihira, Norie Sawada, Manami Inoue, Kazumasa Yamagishi, Nobufumi Yasuda, Shoichiro Tsugane
Summary: This study aimed to investigate the potential effect of dietary diversity on the risk of disabling dementia in a nationwide large-scale cohort of the Japanese population. The study found that dietary diversity was inversely associated with disabling dementia among women, but there was no significant association among men.
CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Rieko Kanehara, Atsushi Goto, Maki Goto, Toshiaki Takahashi, Motoki Iwasaki, Mitsuhiko Noda, Hikaru Ihira, Shoichiro Tsugane, Norie Sawada
Summary: We evaluated the validity of diabetes definitions using disease codes and antidiabetic drug prescriptions in the Japanese DPC data via medical chart review. The results showed that DPC data can accurately identify diabetes among inpatients using either diabetes codes alone or diabetes codes and/or prescriptions.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Noriko Fujiwara, Naoki Shimada, Masanori Nojima, Keisuke Ariyoshi, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane
Summary: This study identified factors associated with home death in Japan, including being unmarried, unemployed male, and having a high drinking level in male. Cardiovascular disease, cerebrovascular disease, and external factors were significantly associated with home death, while the risk of home death for cancer patients tended to be lower.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Oncology
Makiko Naka Mieno, Maria Yamasaki, Aya Kuchiba, Taiki Yamaji, Keigo Ide, Noriko Tanaka, Norie Sawada, Manami Inoue, Shoichiro Tsugane, Motoji Sawabe, Motoki Iwasaki
Summary: This study investigated the association between SNPs in the LPA region and cancer incidence and mortality in Japanese individuals. The results showed that none of the 25 SNPs in the LPAL2-LPA region were significantly associated with overall cancer incidence or mortality. However, some SNPs were found to be associated with stomach cancer incidence and mortality in men, as well as colorectal cancer incidence in men and prostate cancer incidence in carriers of certain SNPs. Further analysis using different cohorts is needed to confirm these findings.
CANCER EPIDEMIOLOGY
(2023)
Article
Oncology
Michiko Takahashi, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane, Norie Sawada
Summary: This study found a positive association between high consumption of n-3 PUFA and RCC risk in a Japanese population with higher fish intake compared to Western populations.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Public, Environmental & Occupational Health
Nao Yamamoto, Keisuke Ejima, Luis M. Mestre, Arthur H. Owora, Manami Inoue, Shoichiro Tsugane, Norie Sawada
Summary: This study found that stable underweight and weight loss were strongly associated with a high risk of mortality in the Japanese population.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Tomokazu Tajima, Ai Ikeda, Takeshi Tanigawa, Hiroyasu Iso, Kazumasa Yamagishi, Takumi Matsumura, Nobufumi Yasuda, Manami Inoue, Shoichiro Tsugane, Norie Sawada, Japan Public Hlth Ctr Based Study Grp
Summary: This prospective cohort study found that a higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low-medium mental stress group. This finding highlights the importance of managing mental stress and increasing life enjoyment in reducing the risk of disabling dementia.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Article
Oncology
Giulia Collatuzzo, Claudio Pelucchi, Eva Negri, Manolis Kogevinas, Jose Maria Huerta, Jesus Vioque, Manoli Garcia de la Hera, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Zuo-Feng Zhang, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Carlo La Vecchia, Paolo Boffetta
Summary: The association between sleep duration and stress with gastric cancer (GC) was examined. Long sleep duration (=9 h) was found to be associated with GC, while stress was associated with noncardia GC.
Article
Public, Environmental & Occupational Health
Hiroshi Yatsuya, Kazumasa Yamagishi, Yuanying Li, Isao Saito, Yoshihiro Kokubo, Isao Muraki, Manami Inoue, Shoichiro Tsugane, Hiroyasu Iso, Norie Sawada
Summary: This study examined the associations of major risk factors for stroke with different types of stroke and subtypes of ischemic stroke. The results showed that hypertension is the most crucial risk factor for stroke prevention in Japan.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Juan Xu, Atsushi Goto, Maki Konishi, Masayuki Kato, Tetsuya Mizoue, Yasuo Terauchi, Shoichiro Tsugane, Norie Sawada, Mitsuhiko Noda
Summary: This study aimed to develop and validate models to predict the 5-year incidence of T2DM in a Japanese population. The risk scores were developed using data from two different cohorts, and both non-invasive and invasive predictors were considered. The invasive model with HbA1c and FPG showed the highest discriminative ability.
JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
