Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway

Green tea extract prevents obesity in male mice by alleviating gut dysbiosis in association with improved intestinal barrier function that limits endotoxin translocation and adipose inflammation

(2019) Priyankar Dey et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice

(2019) Yuchen Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges

(2019) Úrsula Martínez-Garza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal serotonin and fluoxetine exposure modulate bacterial colonization in the gut

(2019) Thomas C. Fung et al.   Nature Microbiology

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

(2019) Xiaoli Sun et al.   Cell Metabolism

Nutritionally Attenuating the Human Gut Microbiome To Prevent and Manage Metabolic Syndrome

(2019) Scarlet Louis-Jean et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

(2018) Xiaojiaoyang Li et al.   PHYTOMEDICINE

The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα

(2018) Meng Zhang et al.   BIOSCIENCE REPORTS

Gut Microbiome in Obesity, Metabolic Syndrome, and Diabetes

(2018) Xinpu Chen et al.   Current Diabetes Reports

Gut microbiota and obesity: An opportunity to alter obesity through faecal microbiota transplant (FMT)

(2018) Patrick Lee et al.   DIABETES OBESITY & METABOLISM

Saikosaponins A, C and D enhance liver-targeting effects of anticancer drugs by modulating drug transporters

(2017) Limin Feng et al.   Oncotarget

miRNA-32 Drives Brown Fat Thermogenesis and Trans-activates Subcutaneous White Fat Browning in Mice

(2017) Raymond Ng et al.   Cell Reports

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells

(2016) Dan He et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

HepG2 cells biospecific extraction and HPLC-ESI-MS analysis for screening potential antiatherosclerotic active components in Bupeuri radix

(2016) Shuqiang Liu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways

(2015) SUNG OK KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties

(2015) Alexei Kharitonenkov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula

(2014) Jia Xu et al.   ISME Journal

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

(2010) Yihai Cao   NATURE REVIEWS DRUG DISCOVERY