Tuning the efficacy of esterase-activatable prodrug nanoparticles for the treatment of colorectal malignancies

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

(2020) Xuexiang Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent hollow mesoporous carbon spheres for drug loading and tumor treatment through 980-nm laser and microwave co-irradiation

(2020) Xin Gui et al.   BIOMATERIALS

Transforming a toxic drug into an efficacious nanomedicine using a lipoprodrug strategy for the treatment of patient-derived melanoma xenografts

(2020) Linlin Shi et al.   JOURNAL OF CONTROLLED RELEASE

Survey of Clinical Translation of Cancer Nanomedicines—Lessons Learned from Successes and Failures

(2019) Hongliang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Novel strategy for oral peptide delivery in incretin-based diabetes treatment

(2019) Yining Xu et al.   GUT

Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer

(2019) Ana I. Matos et al.   JOURNAL OF CONTROLLED RELEASE

Tumor targeting via EPR: Strategies to enhance patient responses

(2018) Susanne K. Golombek et al.   ADVANCED DRUG DELIVERY REVIEWS

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

(2018) Kshipra Singh et al.   CANCER RESEARCH

Structure-Guided Engineering of Cytotoxic Cabazitaxel for an Adaptive Nanoparticle Formulation: Enhancing the Drug Safety and Therapeutic Efficacy

(2018) Jianqin Wan et al.   ADVANCED FUNCTIONAL MATERIALS

Sequential Versus Combination Therapy of Metastatic Colorectal Cancer Using Fluoropyrimidines, Irinotecan, and Bevacizumab: A Randomized, Controlled Study—XELAVIRI (AIO KRK0110)

(2018) Dominik Paul Modest et al.   JOURNAL OF CLINICAL ONCOLOGY

Revival of a potent therapeutic maytansinoid agent using a strategy that combines covalent drug conjugation with sequential nanoparticle assembly

(2018) Ke Xie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Systematic evaluation of graphene quantum dot toxicity to male mouse sexual behaviors, reproductive and offspring health

(2018) Ding Zhang et al.   BIOMATERIALS

Molecular afterglow imaging with bright, biodegradable polymer nanoparticles

(2017) Qingqing Miao et al.   NATURE BIOTECHNOLOGY

Highly bioavailable silibinin nanoparticles inhibit HCV infection

(2016) Ching-Hsuan Liu et al.   GUT

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials

(2016) Joseph M. Caster et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

(2016) Yiming Zhao et al.   Nature Communications

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers

(2015) Sandy Schmidt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PTH-272 Modulation of NRF2 alters the responsiveness of colorectal cancer cells to irinotecan

(2015) JP Evans et al.   GUT

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy

(2015) Xinpeng Ma et al.   JOURNAL OF CONTROLLED RELEASE

Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer

(2015) Lin Xie et al.   JNCI-Journal of the National Cancer Institute

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer

(2015) Lin Xie et al.   JNCI-Journal of the National Cancer Institute

Structure-Based Rational Design of Prodrugs To Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy

(2014) Hangxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFN 

(2014) A. Textor et al.   CANCER RESEARCH

Old Drug New Use--Amoxapine and Its Metabolites as Potent Bacterial  -Glucuronidase Inhibitors for Alleviating Cancer Drug Toxicity

(2014) R. Kong et al.   CLINICAL CANCER RESEARCH

The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles

(2013) Amalina B. Ebrahim Attia et al.   BIOMATERIALS

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Can Controversial Nanotechnology Promise Drug Delivery?

(2013) Venkat Ratnam Devadasu et al.   CHEMICAL REVIEWS

Cytokines as biomarkers of nanoparticle immunotoxicity

(2013) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38

(2013) Vaskor Bala et al.   JOURNAL OF CONTROLLED RELEASE

Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?

(2012) Sebastien Taurin et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

(2011) Shanta Dhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Cancer Therapies Utilizing the Camptothecins: A Review of thein VivoLiterature

(2010) Vincent J. Venditto et al.   MOLECULAR PHARMACEUTICS

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

(2010) B. D. Wallace et al.   SCIENCE

Synthetic polymeric nanoparticles by nanoprecipitation

(2009) Stephanie Hornig et al.   JOURNAL OF MATERIALS CHEMISTRY