Article
Biochemistry & Molecular Biology
Fernanda Almeida-Oliveira, Samara Santos-Araujo, Luiz Fernando Carvalho-Kelly, Alessa Macedo-Silva, Jose Roberto Meyer-Fernandes, Katia C. Gondim, David Majerowicz
Summary: ATP synthase plays an important role in mitochondrial metabolism, but recent research suggests it may also be involved in lipophorin binding and lipid metabolism. This study used a functional genetics approach to explore the roles of ATP synthase in lipid metabolism in the kissing bug Rhodnius prolixus. The results showed that knockdown of ATP synthase subunits impaired ovarian development, reduced egg-laying, and increased triacylglycerol accumulation in the fat body, suggesting a direct role of ATP synthase in lipid metabolism and lipophorin physiology.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Agustina Pascual, Rolando Rivera-Pomar
Summary: The study analyzes the maternal gene expression in R. prolixus during oogenesis and early embryogenesis and proposes three times of action for maternal genes.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Bruno Moraes, Valdir Braz, Samara Santos-Araujo, Isadora A. Oliveira, Larissa Bomfim, Isabela Ramos, Katia C. Gondim
Summary: The study demonstrates the significance of de novo fatty acid synthesis in the metabolism of Rhodnius prolixus insects. Acetyl-CoA carboxylase (ACC) plays a central role in digestion, lipid synthesis and storage, as well as reproductive success in these insects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
P. V. P. Nascimento, F. Almeida-Oliveira, A. Macedo-Silva, P. Ausina, C. Motinha, M. Sola-Penna, D. Majerowicz
Summary: 20-hydroxyecdysone plays a crucial role in regulating moulting and metamorphosis in insects, as well as in influencing the physiological regulation and lipid metabolism of adult insects. The genome of Rhodnius prolixus reveals a potential duplication of the HNF4 gene. Treatment with 20-hydroxyecdysone increases the storage of triacylglycerol in the fat bodies of adult female insects.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
A. N. Haddad, J. Leyria, A. B. Lange
Summary: Neuropeptides and their receptors play a crucial role in regulating physiological and behavioral processes in insects. In this study, the tachykinin receptor (Rhopr-TKR) was identified and cloned from Rhodnius prolixus, which is a vector of Chagas disease. The findings suggest that tachykinin signaling regulates lipid and carbohydrate homeostasis via the insulin signaling pathway.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Physiology
Petter F. Entringer, David Majerowicz, Katia C. Gondim
Summary: Insects, such as the kissing bug Rhodnius prolixus, rely on dietary cholesterol for cell membrane composition and hormone production. This study found that both the anterior and posterior midguts of R. prolixus can absorb cholesterol from ingested blood, with the anterior midgut absorbing more. Additionally, the fat body and ovaries of the insects also incorporate and store cholesterol, with active cholesterol transport being indicated at low temperatures.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jimena Leyria, Riya Philip, Ian Orchard, Angela B. Lange
Summary: Insulin-like peptides (ILPs) are crucial hormones found in all organisms, and a newly discovered ILP called gonadulin has been found to be highly expressed in the reproductive system of Rhodnius prolixus insects. In this study, it was observed that impairment of the gonadulin signaling cascade inhibited ovulation and oviposition, leading to egg retention. Understanding the reproductive processes in R. prolixus could provide insights for the development of biopesticides to control insect populations and disease transmission.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Vitor Lima Coelho, Tarcisio Fontenele de Brito, Ingrid Alexandre de Abreu Brito, Maira Arruda Cardoso, Mateus Antonio Berni, Helena Maria Marcolla Araujo, Michael Sammeth, Attilio Pane
Summary: This study presents the stage-specific transcriptomes of Rhodnius prolixus during oogenesis, significantly improving the genome annotations for over 9000 genes and discovering more than 2000 novel genes. The data reveals key genes involved in germline development, genome integrity, and early embryonic development, shedding new light on the biological processes in this medically relevant insect.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jimena Leyria, Ian Orchard, Angela B. Lange
Summary: Insulin signaling in insects, such as the blood-gorging triatomine R. prolixus, plays a crucial role in metabolism, growth, and reproduction, with a direct effect on ovarian follicles and egg production. The up-regulation of insulin/ToR signaling transcripts in unfed insects suggests a heightened sensitivity to respond rapidly to nutrient levels, while the pathway is only activated in fed insects. This study demonstrates a mechanism by which nutritional signaling regulates reproductive performance in insects, offering potential implications for the development of biocontrol methods.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luca Finetti, Jimena Leyria, Ian Orchard, Angela B. Lange
Summary: The study investigates the role of RpTAR1 in reproduction of female R. prolixus and finds that RpTAR1 is highly expressed in tissues associated with egg development. Knockdown of RpTAR1 leads to reduced egg production and increased protein accumulation in the fat body. However, it does not affect the hatching ratio of the eggs. Moreover, the study reveals a potential connection between RpTAR1, Vg synthesis, and the JH pathway.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Anatomy & Morphology
Laure-Alix Clerbaux, Hayley Schultz, Samara Roman-Holba, Dan Fu Ruan, Ronald Yu, Abigail M. Lamb, Guido T. Bommer, Jennifer A. Kennell
Summary: Our study reveals that loss of miR-33 in flies leads to elevated TAG levels and identified genes involved in TAG synthesis as direct targets of miR-33. Mutants of miR-33 showed increased survival upon starvation but greater sensitivity to oxidative stress. Furthermore, miR-33 is a negative regulator of cuticle pigmentation and its deficiency leads to a reduction in interfollicular stalk cells during oogenesis.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Parasitology
Daiene Lopes Moreira Nunes, Maria Fernanda Carvalho-Araujo, Suellen Silva-Cabral, Thamara Rios, Alessandra Catarina Chagas-Lima, Gessica de Sousa, Isabela Ramos, Suzete A. O. Gomes, Georgia C. Atella
Summary: This study investigated the impact of T. rangeli infection on lipid metabolism in R. prolixus. The results showed that infected insects had decreased levels of TAG, MAG, PE, and PC in the fat body, as well as increased levels of free fatty acids in the hemolymph. Additionally, the size of lipid droplets in infected fat bodies decreased, and a significant number of parasites were found adhered to the organ surface. The transcript levels of the acetyl-CoA carboxylase gene were upregulated, while the lipophorin receptor gene was downregulated in response to infection.
Article
Multidisciplinary Sciences
Jessica Coraiola Nevoa, Jose Manuel Latorre-Estivalis, Fabiano Sviatopolk-Mirsky Pais, Newmar Pinto Marliere, Gabriel da Rocha Fernandes, Marcelo Gustavo Lorenzo, Alessandra Aparecida Guarneri
Summary: This study characterized the gene expression profiles in the brain of starved R. prolixus nymphs through RNA sequencing. Neuromodulatory-related genes, such as neuropeptide precursors, neurohormones, and their receptors, as well as enzymes involved in neuropeptide and biogenic amine biosynthesis, were identified and analyzed. Other important genes, including neurotransmitter receptors, nuclear receptors, clock genes, sensory receptors, and takeouts genes, were also identified. The study suggests that further functional characterization of these highly expressed genes in starved R. prolixus brain could lead to the development of bug control tools.
Article
Parasitology
T. Atella, P. R. Bittencourt-Cunha, M. F. C. Araujo, L. Silva-Cardoso, C. M. Maya-Monteiro, G. C. Atella
Summary: This study investigates the interaction between the Chagas disease parasite and its insect vector, revealing that the parasite modifies the lipid flux and metabolism of its host through increased lipid delivery from the fat body to the midgut.
Article
Endocrinology & Metabolism
Areej N. Al-Dailami, Ian Orchard, Angela B. Lange
Summary: Within the blood-gorging insect Rhodnius prolixus, corticotropin-releasing factor/diuretic hormones (CRF/DHs) modulate feeding, diuresis, and reproduction. This study explores the role of Rhopr-CRF/DH in female reproduction and reveals its co-localization with the glycoprotein hormone GPB5. Knockdown of Rhopr-CRF/DH-R2, the receptor for Rhopr-CRF/DH, accelerates egg production and alters the expression of vitellogenin and its receptor, suggesting the involvement of the CRF-signaling pathway in reproduction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Felipe B. Saraiva, Michele Alves-Bezerra, David Majerowicz, Lisvane Paes-Vieira, Valdir Braz, Muriel G. M. D. Almeida, Jose Roberto Meyer-Fernandes, Katia C. Gondim
Summary: In this study, the regulation of R. prolixus ACC expression and de novo lipogenesis activity in adult females under different nutritional and metabolic conditions was investigated. The blood meal induces the utilization of diet-derived amino acids by de novo lipogenesis in the fat body, and the control of this activity does not occur at the RhoprACC gene or protein expression level. These results provide insights into the synthesis and regulation of lipids in insects, particularly in the context of blood feeding and metabolic changes.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Krishanu Saha, Erik J. Sontheimer, P. J. Brooks, Melinda R. Dwinell, Charles A. Gersbach, David R. Liu, Stephen A. Murray, Shengdar Q. Tsai, Ross C. Wilson, Daniel G. Anderson, Aravind Asokan, Jillian F. Banfield, Krystof S. Bankiewicz, Gang Bao, Jeff W. M. Bulte, Nenad Bursac, Jarryd M. Campbell, Daniel F. Carlson, Elliot L. Chaikof, Zheng-Yi Chen, R. Holland Cheng, Karl J. Clark, David T. Curiel, James E. Dahlman, Benjamin E. Deverman, Mary E. Dickinson, Jennifer A. Doudna, Stephen C. Ekker, Marina E. Emborg, Guoping Feng, Benjamin S. Freedman, David M. Gamm, Guangping Gao, Ionita C. Ghiran, Peter M. Glazer, Shaoqin Gong, Jason D. Heaney, Jon D. Hennebold, John T. Hinson, Anastasia Khvorova, Samira Kiani, William R. Lagor, Kit S. Lam, Kam W. Leong, Jon E. Levine, Jennifer A. Lewis, Cathleen M. Lutz, Danith H. Ly, Samantha Maragh, Paul B. McCray, Todd C. McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S. Prather, John A. Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W. Mark Saltzman, Philip J. Santangelo, David J. Segal, Mary Shimoyama, Melissa C. Skala, Alice F. Tarantal, John C. Tilton, George A. Truskey, Moriel Vandsburger, Jonathan K. Watts, Kevin D. Wells, Scot A. Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, Jiangbing Zhou
Summary: The NIH's SCGE Consortium aims to develop safer and more effective methods to edit disease-relevant somatic cell genomes in patients, even in hard-to-reach tissues. Their approach includes rigorous validation of technology through third-party testing in animals to accelerate clinical development of new therapies.
Article
Gastroenterology & Hepatology
Norihiro Imai, Hayley T. Nicholls, Michele Alves-Bezerra, Yingxia Li, Anna A. Ivanova, Eric A. Ortlund, David E. Cohen
Summary: This study revealed the crucial role of skeletal muscle Them2 in the pathogenesis of HS and IR, suggesting it as a potential target for the management of NAFLD.
Article
Physiology
Bruno Moraes, Valdir Braz, Samara Santos-Araujo, Isadora A. Oliveira, Larissa Bomfim, Isabela Ramos, Katia C. Gondim
Summary: The study demonstrates the significance of de novo fatty acid synthesis in the metabolism of Rhodnius prolixus insects. Acetyl-CoA carboxylase (ACC) plays a central role in digestion, lipid synthesis and storage, as well as reproductive success in these insects.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagstrom, Terry T. -K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jorn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: This study aimed to develop a research agenda for fatty liver disease, and 28 priorities were identified to address the individual and societal harms caused by this disease. Adopting this agenda can accelerate global efforts to respond to this public health threat.
JOURNAL OF HEPATOLOGY
(2023)
Article
Entomology
Valdir Braz, Lukas Selim, Geyse Gomes, Manoel Luis Costa, Claudia Mermelstein, Katia C. Gondim
Summary: Rhodnius prolixus is a blood-feeding insect that undergoes molting and develops into a winged adult form after five nymphal stages. After molting, the protein content in the midgut decreases and digestion is completed fifteen days later. Meanwhile, proteins and triacylglycerols in the fat body decrease while increasing in the ovary and flight muscle. Lipogenesis is most efficient in the fat body, while the flight muscle and ovary have low rates of lipid synthesis. The flight muscle develops gradually after molting, with an increase in lipid droplets and muscle fiber size. The fat body shows a different pattern, with a decrease in droplet size followed by an increase. Mobilization of substrates from the midgut and fat body to the ovary and flight muscle prepares R. prolixus adults for feeding and reproduction.
JOURNAL OF INSECT PHYSIOLOGY
(2023)
Article
Infectious Diseases
Allana Faria-Reis, Samara Santos-Araujo, Jessica Pereira, Thamara Rios, David Majerowicz, Katia Gondim, Isabela Ramos
Summary: Insects with high reproductive rates are significant vectors for various vector-borne diseases. Finding molecular targets for insect reproduction is strategically critical. This study discovered the importance of proteasome activity in oogenesis and reproductive success of Rhodnius prolixus, the vector of Chagas Disease.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Quentin M. Anstee, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Amalia Gastaldelli, Hannes Hagstrom, Terry T. K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Norah A. Terrault, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Joern M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: Fatty liver disease is a major public health threat, and focused interventions are urgently needed. A consensus-driven action agenda has been developed, which includes 29 priorities such as early diagnosis, addressing the needs of patients with multiple morbidities, and incorporating fatty liver disease into non-communicable disease strategies and guidance.
Article
Biochemistry & Molecular Biology
Fernanda Almeida-Oliveira, Samara Santos-Araujo, Luiz Fernando Carvalho-Kelly, Alessa Macedo-Silva, Jose Roberto Meyer-Fernandes, Katia C. Gondim, David Majerowicz
Summary: ATP synthase plays an important role in mitochondrial metabolism, but recent research suggests it may also be involved in lipophorin binding and lipid metabolism. This study used a functional genetics approach to explore the roles of ATP synthase in lipid metabolism in the kissing bug Rhodnius prolixus. The results showed that knockdown of ATP synthase subunits impaired ovarian development, reduced egg-laying, and increased triacylglycerol accumulation in the fat body, suggesting a direct role of ATP synthase in lipid metabolism and lipophorin physiology.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jessica Pereira, Samara Santos-Araujo, Larissa Bomfim, Katia Calp B. Gondim, David B. Majerowicz, Attilio B. Pane, Isabela B. Ramos
Summary: This study investigates the role of the autophagy/UPS adaptor protein p62 in Chagas disease vector insects and finds that silencing the p62 gene does not result in any apparent phenotypes.
Editorial Material
Physiology
Katia C. Gondim, Natraj Krishnan, Petros T. Damos, Amr A. Mohamed, Mohammad Mehrabadi, Maria L. Simoes
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Iron F. De Paula, Samara Santos-Araujo, David Majerowicz, Isabela Ramos, Katia C. Gondim
Summary: The energy stored in fatty acids plays a crucial role in important activities of insects. A study on Rhodnius prolixus showed that the CPT1 gene is essential for lipid metabolism and resistance to starvation.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Beatrice Bissig-Choisat, Michele Alves-Bezerra, Barry Zorman, Scott A. Ochsner, Mercedes Barzi, Xavier Legras, Diane Yang, Malgorzata Borowiak, Adam M. Dean, Robert B. York, N. Thao N. Galvan, John Goss, William R. Lagor, David D. Moore, David E. Cohen, Neil J. McKenna, Pavel Sumazin, Karl-Dimiter Bissig
Summary: By transplanting human hepatocytes into mice, researchers have successfully generated a humanized NAFLD mouse model, revealing molecular differences in the development of fatty liver disease between human and mouse hepatocytes. This model provides a new experimental system for studying the pathogenic changes of NAFLD.
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)