Article
Astronomy & Astrophysics
Sergio R. Santa Maria, Diana B. Marina, Sofia Massaro Tieze, Lauren C. Liddell, Sharmila Bhattacharya
Summary: The biological risks of the deep space environment need to be studied in order to support human exploration and scientific discovery beyond low earth orbit. The lack of deep space biological missions limits our understanding of the harmful effects of prolonged exposure to this environment. NASA's BioSentinel mission, which uses yeast as a biosensor, aims to fill this knowledge gap and provide insights into the DNA damage response to deep space radiation. The study discusses the optimization of conditions for long-term yeast survival and the sensitivity of dried yeast to low doses of deep space-relevant ionizing radiation.
Editorial Material
Astronomy & Astrophysics
Sofia Massaro Tieze, Lauren C. Liddell, Sergio R. Santa Maria, Sharmila Bhattacharya
Summary: BioSentinel is the first CubeSat designed for deep space missions, aiming to assess the effects of deep space radiation on biological systems and gather data from model organisms. This collection of articles describes the extensive optimization of the biological payload system for this long-duration deep space mission, providing insights into the evolution of NASA's previous biological CubeSats.
Article
Astronomy & Astrophysics
Lauren C. Liddell, Diana M. Gentry, Rachel Gilbert, Diana Marina, Sofia Massaro Tieze, Michael R. Padgen, Kylie Akiyama, Kyra Keenan, Sharmila Bhattacharya, Sergio R. Santa Maria
Summary: With the impending human exploration of deep space, it is crucial to understand the biological risks of deep space radiation. The BioSentinel mission, the first biological payload to study radiation effects beyond low Earth orbit in 50 years, uses yeast cells to investigate the long-term effects of low-dose deep space radiation. The study shows that space-like radiation leads to a dose-dependent decrease in yeast cell growth and metabolism, with a more pronounced effect in strains deficient in DNA damage repair.
Article
Biophysics
Ruiyun Zhou, Chen Wang, Yuxin Huang, Kang Huang, Yingli Wang, Wendao Xu, Lijuan Xie, Yibin Ying
Summary: This study investigates the integration of graphene with THz metasurface into a microfluidic cell for sensitive biosensing in liquid environment, demonstrating high sensitivity in detecting DNA sequences of Escherichia coli O157:H7. The results suggest the potential of the proposed graphene-metasurface microfluidic biosensor for label-free biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Ali R. Jalalvand
Summary: A novel biosensor has been developed for detecting DNA damage induced by photoexcited TrC and investigating the protective effect of GSO. Molecular docking techniques were used to study the binding of TrC with DNA, and a biosensor was fabricated with modified GCE for impedimetric investigation. The biosensor showed promising abilities for DNA damage detection and TrC determination.
MICROCHEMICAL JOURNAL
(2022)
Article
Engineering, Aerospace
Andrea Capannolo, Giovanni Zanotti, Michele Lavagna, Elena Mazzotta Epifani, Elisabetta Dotto, Vincenzo Della Corte, Igor Gai, Marco Zannoni, Marilena Amoroso, Simone Pirrotta
Summary: In 2021, NASA will launch the DART spacecraft to intercept the binary system Didymos and impact the moonlet Dimorphos, testing the effectiveness of kinetic impactors on altering hazardous asteroids' trajectories. Observing the cloud of particles generated by the impact could yield valuable data on asteroid properties and impact models. Ground observations of ejecta and plume evolution after impact are possible but of lower quality compared to short-range imaging.
Article
Biochemistry & Molecular Biology
Foroozan Shokri, Abdollah Yari, Ali R. Jalalvand
Summary: A novel electrochemical biosensor was developed with the assistance of multivariate calibration methods for simultaneous estimation of DNA damage rates induced by different drugs and for simultaneous determination of the drugs. The biosensor was able to detect and quantify the rates of DNA damage induced by the drugs simultaneously.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Aerospace
Iaroslav Iakubivskyi, Laurynas Maciulis, Pekka Janhunen, Janis Dalbins, Mart Noorma, Andris Slavinskis
Summary: This paper presents a detailed mechanical and thermal analysis of a stand-alone nanospacecraft, designed for asteroid flybys in the main asteroid belt and one Earth flyby to return gathered data. The spacecraft consists of a main body and a remote unit, using E-sail as primary propulsion for flybys and data transmission.
ADVANCES IN SPACE RESEARCH
(2021)
Article
Biochemical Research Methods
Fei-Fei Guo, Tong Li, Xi-Ping Mu, Xue Zhang, Zhi-Hao Xu, Ping Sun, Ri-Lei Yu, Ya-Mu Xia, Wei-Wei Gao
Summary: In this study, a novel DNA intercalator, PT-MCA, was designed and synthesized as a potential antitumor agent. The redox process of PT-MCA on the electrode surface was investigated through electrochemical analysis. Bioelectrochemical sensors were fabricated by modifying the surface of GCE with different DNA structures, and the oxidative damage of DNA induced by PT-MCA was characterized using various analytical techniques. Moreover, PT-MCA exhibited stronger anti-proliferation activity than mitoxantrone against cancer cells and could be detected in real serums without interference from ions.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Aerospace
Marco Lombardo, Marco Zannoni, Igor Gai, Luis Gomez Casajus, Edoardo Gramigna, Riccardo Lasagni Manghi, Paolo Tortora, Valerio Di Tana, Biagio Cotugno, Simone Simonetti, Silvio Patruno, Simone Pirrotta
Summary: In the framework of the Artemis-1 mission, the ArgoMoon CubeSat will be deployed to capture images of the Interim Cryogenic Propulsion Stage and navigate a highly elliptical orbit around the Earth with encounters with the Moon. Precise orbit determination and flight path control are required for successful navigation.
Article
Multidisciplinary Sciences
Pierre-Alexandre Goyette, Etienne Boulais, Maude Tremblay, Thomas Gervais
Summary: The article introduces the pixelated chemical display (PCD) for highly parallel and reconfigurable liquid handling on open surfaces. It creates microfluidic pixels to display dynamic chemical images on surfaces without the need for physical barriers.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Amira F. El-Yazbi, Eman El-Kimary
Summary: This study introduces a novel, inexpensive fluorescent biosensor based on terbium chloride to directly quantitate DNA damage induced by epirubicin and investigate the underlying molecular mechanisms of damage. The results show that in the presence of dithiothreitol, epirubicin has a slower DNA damage kinetics but more potent damaging effect on DNA compared to when dithiothreitol is not added. This suggests a potential alternative anticancer therapy that requires further investigation.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Catarina R. F. Caneira, Denis R. Santos, Virginia Chu, Joao P. Conde
Summary: Recently, there has been a growing demand for rapid diagnosis of diseases, which has led to the development of new DNA detection platforms. However, the potential risk of misdiagnosis has hindered their market acceptance. In this study, a regenerable bead-based microfluidic device with integrated thin-film photodiodes was developed for real-time monitoring of DNA molecular recognition. The system demonstrated high sensitivity and the potential for reusability, which can reduce costs and improve the accuracy of diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemical Research Methods
Hsiu-Yang Tseng, Jose H. Lizama, Noel A. S. Alvarado, Hsin-Han Hou
Summary: This article discusses the application of printed circuit boards in the field of micro-total analysis systems, exploring the current state of the field, the challenges faced by researchers in implementing these technologies, and potential improvements to meet current demands. It also introduces some trendy innovations and developments that are expected to enhance the functionality and application range of micro-total analysis systems.
Article
Engineering, Aerospace
Janis Dalbins, Kristo Allaje, Hendrik Ehrpais, Iaroslav Iakubivskyi, Erik Ilbis, Pekka Janhunen, Joosep Kivastik, Maido Merisalu, Mart Noorma, Mihkel Pajusalu, Indrek Suenter, Antti Tamm, Hans Teras, Petri Toivanen, Boris Segret, Andris Slavinskis
Summary: Nanosatellites are important in LEO and are commonly built by student teams for educational and technology demonstration purposes. The challenge now is to mature the technology for deep-space missions. The ESTCube-2 mission, developed by the Estonian Student Satellite Program, aims to serve as a technology demonstrator for future deep-space missions using electric solar wind sail (E-sail) technology.
Article
Cell Biology
Jonathan Cowman, Louis Richter, Roisin Walsh, Niamh Keegan, Willard Tinago, Antonio J. Ricco, Bryan T. Hennessy, Dermot Kenny, Eimear Dunne
Article
Biophysics
Qin M. Qi, Eimear Dunne, Irene Oglesby, Ingmar Schoen, Antonio J. Ricco, Dermot Kenny, Eric S. G. Shaqfeh
BIOPHYSICAL JOURNAL
(2019)
Article
Engineering, Aerospace
Michael R. Padgen, Tori N. Chinn, Charlie R. Friedericks, Matthew P. Lera, Matthew Chin, Macarena P. Parra, Matthew E. Piccini, Antonio J. Ricco, Stevan M. Spremo
Article
Electrochemistry
Seamus D. Thomson, Richard C. Quinn, Antonio J. Ricco, Jessica E. Koehne
Article
Astronomy & Astrophysics
Michael R. Padgen, Matthew P. Lera, Macarena P. Parra, Antonio J. Ricco, Matthew Chin, Tori N. Chinn, Aaron Cohen, Charlie R. Friedericks, Michael B. Henschke, Timothy Snyder, Stevan M. Spremo, Wang Jing-Hung, A. C. Matin
LIFE SCIENCES IN SPACE RESEARCH
(2020)
Article
Engineering, Aerospace
Antonio Ricco, Sergio R. Santa Maria, Robert P. Hanel, Sharmila Bhattacharya
IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE
(2020)
Article
Chemistry, Multidisciplinary
Hye Ryoung Lee, Lei Liao, Wang Xiao, Arturas Vailionis, Antonio J. Ricco, Robin White, Yoshio Nishi, Wah Chiu, Steven Chu, Yi Cui
Summary: The global COVID-19 pandemic has changed daily lives, with wearing face masks becoming common. Research shows that the average porosity of filter layers is 89.1%, with fibers less than 1.8 μm in diameter being particularly effective.
Article
Physics, Applied
Hye Ryoung Lee, Naoki Furukawa, Antonio J. Ricco, Eric Pop, Yi Cui, Yoshio Nishi
Summary: Thermoelectric devices, which convert thermal energy to electrical energy, have potential for energy harvesting from waste heat. By using CNT-hydroxypropyl cellulose (HPC) composite thermoelectric films, it is possible to produce CNT-TDs with good electrical conductivity and Seebeck coefficients. The aqueous-solution-based film fabrication process enables low-cost, readily scalable TDs.
APPLIED PHYSICS LETTERS
(2021)
Letter
Astronomy & Astrophysics
Michael R. Padgen, Macarena P. Parra, Antonio J. Ricco, A. C. Matin
LIFE SCIENCES IN SPACE RESEARCH
(2021)
Article
Astronomy & Astrophysics
David Touchette, Ianina Altshuler, Isabelle Raymond-Bouchard, Miguel angel Fernandez-Martinez, Louis-Jacques Bourdages, Brady O'Connor, Antonio J. Ricco, Lyle G. Whyte
Summary: With no direct extant-life detection instrumentation included in a space mission since the 1970s, the development of new technologies for future space missions is crucial. The mu MAMA system, which utilizes metabolism-indicator redox dyes, has shown robustness and sensitivity in detecting extant microbial life in high-Arctic samples under various physiochemical conditions. Its small size and potential for automation make it a promising tool for life detection missions.
Article
Environmental Sciences
J. Homan, T. C. Lusby, A. J. Ricco, J. L. Mintz, L. A. Braby, T. Straume
Summary: The objective of this study is to evaluate the accuracy of the NASA BioSentinel Pixel Dosimeter (BPD) using gamma-ray and neutron sources in a standard calibration lab. The results show that the BPD can accurately measure absorbed dose from low LET charged particles and is insensitive to neutrons.
Article
Chemistry, Multidisciplinary
Nicholas Post, Florian Bender, Fabien Josse, Antonio J. Ricco
Summary: A relatively simple design procedure is presented for new, adaptable chemical sensor coatings made from a single polymer-plasticizer pair to detect single or a mixture of chemical compounds. By optimizing the sensor coatings, target analytes can be identified and quantified, allowing for the detection of previously inseparable mixtures and differentiation of chemical isomers.
Article
Chemistry, Multidisciplinary
Nicholas Post, Florian Bender, Fabien Josse, Edwin E. Yaz, Antonio J. Ricco
Summary: This study reports the isomer-specific detection and quantitation of m-, p-, and o-xylene and ethylbenzene in aqueous solutions using a specifically designed polymer-plasticizer coating on a shear-horizontal surface acoustic wave (SH-SAW) device. By optimizing the affinity of the sensor coating for the four chemical isomers, and using a high-sensitivity coating and an SH-SAW platform, combined with exponentially weighted recursive-least-squares estimation, accurate identification and quantification of the isomers were achieved. This research is significant for applications such as environmental monitoring and chemical manufacturing.
Article
Biology
Wayne L. Nicholson, Antonio J. Ricco