Article
Immunology
Fengyuan Qi, Shangrong Fan, Chao Fang, Lan Ge, Jinli Lyu, Zhuoqi Huang, Shaowei Zhao, Yuanqiang Zou, Liting Huang, Xinyang Liu, Yiheng Liang, Yongke Zhang, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Xiaowei Zhang
Summary: This study evaluated the efficacy of oral Chinese-origin Lactobacillus with adjuvant metronidazole in treating Chinese BV patients. The results showed that oral administration of probiotics did not improve cure rates, but it effectively restored vaginal health after cure and mainly acted through the intestine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jacob H. Elnaggar, Caleb M. Ardizzone, Nuno Cerca, Evelyn Toh, Pawel Laniewski, Rebecca A. Lillis, Melissa M. Herbst-Kralovetz, Alison J. Quayle, Christina A. Muzny, Christopher M. Taylor
Summary: Bacterial vaginosis (BV) is the most common vaginal dysbiosis characterized by the formation of a polymicrobial biofilm on vaginal epithelial cells. The standard method for quantifying the bacterial burden of BV biofilm using Escherichia coli as a reference has limitations. A novel qPCR standard using different combinations of vaginal bacteria was proposed to accurately quantify bacterial burden in vaginal microbial communities, which showed superior accuracy compared to the traditional E. coli reference standard.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Xiaodi Chen, Yune Lu, Tao Chen, Rongguo Li
Summary: The vaginal microbiome is crucial for women's health, with bacterial vaginosis (BV) associated with various adverse gynecologic and obstetric outcomes. Research on diagnosis and treatment strategies for BV is making progress.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Maximilien Clabaut, Amine M. Boukerb, Amine Ben Mlouka, Amandine Suet, Ali Tahrioui, Julien Verdon, Magalie Barreau, Olivier Maillot, Agathe Le Tirant, Madina Karsybayeva, Coralie Kremser, Gerard Redziniak, Cecile Duclairoir-Poc, Chantal Pichon, Julie Hardouin, Pascal Cosette, Sylvie Chevalier, Marc G. J. Feuilloley
Summary: The study found that 17 beta -estradiol affects the membrane dynamics and adhesion phenotype of Lactobacillus crispatus strains, especially promoting aggregation potential in the vaginal strain V4. However, there was no significant effect on membrane dynamics in V4 compared to strain CIP104459.
SCIENTIFIC REPORTS
(2021)
Review
Infectious Diseases
Rebecca Jane Joseph, Hooi-Leng Ser, Yi-He Kuai, Loh Teng-Hern Tan, Valliammai Jayanthi Thirunavuk Arasoo, Vengadesh Letchumanan, Lijing Wang, Priyia Pusparajah, Bey-Hing Goh, Nurul-Syakima Ab Mutalib, Kok-Gan Chan, Learn-Han Lee
Summary: Bacterial vaginosis, caused by an imbalance in the vaginal microbiota, affects one-third of women worldwide and is associated with high treatment failure and recurrence rates. Current research is focused on alternative treatments like probiotics and vaginal microbiota transplants to improve treatment outcomes and reduce colonization by pathogenic microbes.
Article
Immunology
Sarah E. Brown, Susan Tuddenham, Michelle D. Shardell, Mark A. Klebanoff, Khalil G. Ghanem, Rebecca M. Brotman
Summary: This study found an association between bacterial vaginosis (BV) and the duration of urogenital Chlamydia trachomatis infection, with BV patients having longer durations and lower rates of spontaneous clearance.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Microbiology
Eric Armstrong, Rupert Kaul
Summary: HIV incidence remains high in Eastern and Southern Africa, particularly affecting women. The prevalence of bacterial vaginosis in African, Caribbean, and other Black (ACB) women is associated with increased risk of HIV acquisition, with Lactobacillus species such as L. crispatus offering better protection compared to the more common species L. iners. Further research is needed to determine the mechanisms behind the varying levels of HIV protection among different Lactobacillus species.
Review
Medicine, General & Internal
Eric Armstrong, Rupert Kaul, Craig R. Cohen
Summary: Bacterial vaginosis (BV) is a genital condition characterized by high vaginal bacterial diversity and lack of Lactobacillus species, which is associated with increased risk of HIV acquisition and transmission. Current BV treatment with antibiotics is not effective in promoting Lactobacillus growth, leading to high recurrence rates. Recent studies have shown that BV treatment strategies incorporating live biotherapeutic lactobacilli can optimize the vaginal microbiome and reduce inflammatory biomarkers associated with HIV susceptibility. Future research is needed to evaluate BV treatment strategies that can promote long-term colonization of H2O2-producing vaginal lactobacilli and assess their effectiveness in reducing the risk of HIV transmission.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Immunology
Bingbing Xiao, A. Disi, Hanyu Qin, Lan Mi, Dai Zhang
Summary: Mixed vaginitis is a condition where different types of vaginal pathogens coexist. Bacterial vaginosis (BV) plus vulvovaginal candidiasis (VVC) is the most common form. There is limited research on the clinical manifestations, pathogenesis, diagnostic criteria, and therapy of mixed vaginitis. This study investigated the effect of combined drug treatment on the vaginal microbiome in BV+VVC mixed vaginitis patients and found that it can alter the composition of the microbiome, with increased abundance of Lactobacillus improving the prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
AbuZar Ansari, Dooheon Son, Young Min Hur, Sunwha Park, Young-Ah You, Soo Min Kim, Gain Lee, Seungbeom Kang, Yusook Chung, Sanghyun Lim, Young Ju Kim
Summary: Administering Lactobacillus probiotics orally can improve vaginal dysbiosis and promote the colonization of Lactobacillus species in asymptomatic women.
Article
Immunology
Rui Zhou, Jingjing Lu, Jun Wang, Bingbing Xiao
Summary: Seven Gardnerella genomospecies were detected in Chinese BV patients, but no association between their distribution and BV occurrence or prognosis was found. The relative abundance of L. iners was higher in cured patients, and its antimicrobial activity against G. vaginalis and F. vaginae was validated.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
David N. Fredricks, Anna Plantinga, Sujatha Srinivasan, Antoinette Oot, Andrew Wiser, Tina L. Fiedler, Sean Proll, Michael C. Wu, Jeanne M. Marrazzo
Summary: This study found that the presence or concentrations of BV-associated bacteria in the mouth, anus, labia, and vagina can predict whether women will develop BV in the future.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Johanna B. Holm, Michael T. France, Pawel Gajer, Bing Ma, Rebecca M. Brotman, Michelle Shardell, Larry Forney, Jacques Ravel
Summary: Metagenomic community state types (mgCSTs) are a novel approach to describe and define vaginal microbiomes based on both composition and functional potential. They enable the investigation of multiple strains and functional diversity within the same species, and may lead to novel hypotheses and therapeutic strategies to improve women's genital health.
Article
Public, Environmental & Occupational Health
Rodman Turpin, Natalie Slopen, Joanna-Lynn C. Borgogna, Carl J. Yeoman, Xin He, Ryan S. Miller, Mark A. Klebanoff, Jacques Ravel, Rebecca M. Brotman
Summary: Psychosocial stress is associated with changes in vaginal microbiota composition, increasing the risk of infection, particularly molecular bacterial vaginosis (BV).
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Food Science & Technology
Yi Zhang, Jingbo Zhang, Xinping Lin, Huipeng Liang, Sufang Zhang, Chaofan Ji
Summary: This study selected two Lactobacillus plantarum strains to reduce biogenic amines accumulation in salted mackerel, and found that they could effectively decrease the levels of biogenic amines and histamine. Additionally, the L. plantarum strains demonstrated antibacterial activity, aiding in the control of biogenic amine production.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Carl J. Yeoman, Christopher J. Fields, Pascale Lepercq, Philippe Ruiz, Evelyne Forano, Bryan A. White, Pascale Mosoni
Summary: This study provides the first evidence of in vivo competitions between F. succinogenes and the two Ruminococcus species. It shows that a simple disequilibrium within the cellulolytic community has repercussions on the rumen metabolome and fermentation end products. This finding will have to be considered in the future when determining strategies aiming at directing rumen fermentations for animal production.
Article
Agriculture, Dairy & Animal Science
A. S. Dankwa, U. Humagain, S. L. Ishaq, C. J. Yeoman, S. Clark, D. C. Beitz, E. D. Testroet
Summary: The study found that including 20% RF-DDGS in the diet of lactating dairy cows did not significantly alter the bacterial composition in the rumen and feces. This suggests that RF-DDGS can be a viable alternative protein source for high-producing dairy cows without adverse consequences on their microbiome within a short-term period.
Article
Biochemistry & Molecular Biology
Stephanie M. Wilson, Adam P. Maes, Carl J. Yeoman, Seth T. Walk, Mary P. Miles
Summary: The study found that postprandial triglyceride responses to a high-fat meal vary between individuals, with factors such as visceral adiposity playing a major role in affecting the response.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Multidisciplinary Sciences
Jesse T. Peach, Stephanie M. Wilson, Logan D. Gunderson, Lizzi Frothingham, Tan Tran, Seth T. Walk, Carl J. Yeoman, Brian Bothner, Mary P. Miles
Summary: Chronic low-grade inflammation is closely associated with the development of diseases, and a study using a high-fat meal challenge found that incorporating temporal response can differentiate inflammatory response phenotypes, create a metabolic signature, improve prediction of inflammation responses, and develop a dynamic biosignature for stratifying disease risk.
Article
Multidisciplinary Sciences
Joanna-Lynn C. Borgogna, Michael Anastario, Paula Firemoon, Elizabeth Rink, Adriann Ricker, Jacques Ravel, Rebecca M. Brotman, Carl J. Yeoman
Summary: The research found that a high proportion of American Indian women suffer from molecular-bacterial vaginosis, and psychosocial stressors such as historical loss and lifetime trauma are associated with the disease.
Article
Infectious Diseases
Sarah Elizabeth Brown, Xin He, Michelle D. Shardell, Jacques Ravel, Khalil G. Ghanem, Jonathan M. Zenilman, Rebecca M. Brotman
Summary: In this pilot study, cessation of douching was not found to have significant effects on the composition and structure of the vaginal microbiota. Additional interventions may be necessary to restore optimal vaginal microbiota among women who practice douching.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Multidisciplinary Sciences
Michael T. France, Sarah E. Brown, Anne M. Rompalo, Rebecca M. Brotman, Jacques Ravel
Summary: While some mother-daughter pairs had similar vaginal microbiota, the degree of similarity did not exceed chance expectations. However, shared bacterial strains were found more often between individuals from different families, suggesting biogeographic patterns in vaginal bacteria. Further studies are needed to demonstrate vertical transmission of the vaginal microbiota.
Article
Medicine, General & Internal
Susan Tuddenham, Pawel Gajer, Anne E. Burke, Catherine Murphy, Sabra L. Klein, Christina A. Stennett, Barbara Wilgus, Jacques Ravel, Khalil G. Ghanem, Rebecca M. Brotman
Summary: This study compared the vaginal microbiota of women using combined oral contraceptives (COCs) with those not using contraceptives. The findings showed that COC users had more stable and Lactobacillus-dominated microbiota. The results have clinical implications for the timing and effectiveness of COC use.
Article
Immunology
Sarah E. Brown, Susan Tuddenham, Michelle D. Shardell, Mark A. Klebanoff, Khalil G. Ghanem, Rebecca M. Brotman
Summary: This study found an association between bacterial vaginosis (BV) and the duration of urogenital Chlamydia trachomatis infection, with BV patients having longer durations and lower rates of spontaneous clearance.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Joanna-Lynn C. Borgogna, Savannah G. Grace, Johanna B. Holm, Tadeo Aviles Zuniga, Herlin Kadriu, Xin He, Sarah R. McCoski, Jacques Ravel, Rebecca M. Brotman, Carl J. Yeoman
Summary: This study investigates the associations between condomless vaginal intercourse and lubricant use on the vaginal metabolome. The results show that both practices lead to higher concentrations of metabolites indicative of epithelial damage and antioxidants. Lubricant use is also associated with an increase in lipids related to cellular damage, antimicrobials, and a cooling agent.
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Review
Infectious Diseases
Johanna B. Holm, Kayla A. Carter, Jacques Ravel, Rebecca M. Brotman
Summary: This review summarizes the role of Lactobacillus iners in the vaginal microbiome, emphasizes the importance of considering strain-level characteristics, and explains how whole metagenome sequencing can aid in understanding this species in genital health. Recent findings suggest that L. iners exists in the vagina as a unique combination of strains, and further research is needed to explore its functional roles and impact on susceptibility to infections.
CURRENT INFECTIOUS DISEASE REPORTS
(2023)
Letter
Urology & Nephrology
Sarah E. Brown, Rebecca M. Brotman
JOURNAL OF SEXUAL MEDICINE
(2023)
Correction
Microbiology
Andres Gomez, Ashok Kumar Sharma, Elizabeth K. Mallott, Klara J. Petrzelkova, Carolyn A. Jost Robinson, Carl J. Yeoman, Franck Carbonero, Barbora Pafco, Jessica M. Rothman, Alexander Ulanov, Klara Vlckova, Katherine R. Amato, Stephanie L. Schnorr, Nathaniel J. Dominy, David Modry, Angelique Todd, Manolito Torralba, Karen E. Nelson, Michael B. Burns, Ran Blekhman, Melissa Remis, Rebecca M. Stumpf, Brenda A. Wilson, H. Rex Gaskins, Paul A. Garber, Bryan A. White, Steven R. Leigh