Article
Nutrition & Dietetics
Mamdooh Ghoneum, Shaymaa Abdulmalek, Hewida H. Fadel
Summary: This study examines the efficacy of Biobran/MGN-3 against SARS-CoV-2 and shows that Biobran has potent antiviral activity against SARS-CoV-2 in vitro. It suggests that Biobran may be able to prevent SARS-CoV-2 infection, which warrants further investigation in clinical trials.
Review
Plant Sciences
Nourhan Hisham Shady, Khayrya A. Youssif, Ahmed M. Sayed, Lassaad Belbahri, Tomasz Oszako, Hossam M. Hassan, Usama Ramadan Abdelmohsen
Summary: The COVID-19 outbreak has caused global panic, with no specific treatment available yet. Natural herbal medicines and purified products may offer a rich resource for novel antiviral drugs. This review focuses on sterols and triterpenes as potential candidates derived from natural sources, which could be developed into anti-SARS-CoV-2 therapeutics.
Article
Biochemistry & Molecular Biology
Faizul Azam, Ismail M. Taban, Eltayeb E. M. Eid, Muzaffar Iqbal, Ozair Alam, Shamshir Khan, Danish Mahmood, Md Jamir Anwar, Habibullah Khalilullah, M. U. Khan
Summary: This study investigates the interaction between ivermectin and COVID-19 targets as well as IMP alpha through molecular docking and molecular dynamics simulation. The results show that ivermectin has a strong affinity for the non-structural protein 9 of the virus and moderate affinity for IMP alpha.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biotechnology & Applied Microbiology
Lena Petit, Lea Vernes, Jean-Paul Cadoret
Summary: This study used computational tools to investigate molecules derived from algae, identifying several promising compounds with potential antiviral properties, including phycocyanobilin, phycoerythrobilin, phycourobilin, and folic acid. These compounds showed reliable binding energies and are likely to compete with the SARS-CoV-2/ACE2 complex in further studies.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jyoti Rani, Anasuya Bhargav, Faez Iqbal Khan, Srinivasan Ramachandran, Dakun Lai, Urmi Bajpai
Summary: The study collated known natural antiviral compounds and identified fangchinoline and versicolactone C as compounds that bind to the structural proteins of SARS-CoV-2, causing structural deformation. Experimental validation is recommended to confirm their inhibitory effects.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Physical
Kunal Dutta, Ammar D. Elmezayen, Anas Al-Obaidi, Wei Zhu, Olga Morozova, Sergey Shityakov, Ibrahim Khalifa
Summary: At the beginning of the new decade, the COVID-19 pandemic has severely affected modern human societies, but scientists have discovered three new antiviral peptides to combat SARS-CoV-2. These peptides can block the virus from binding to human cells, potentially serving as effective tools in fighting against the virus in the future.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Genetics & Heredity
Stephanie Portelli, Ruby Heaton, David B. Ascher
Summary: The development and approval of antivirals against SARS-CoV-2 has provided clinicians with treatment strategies against COVID-19, reducing deaths. However, the extensive use of these drugs can lead to antiviral resistance. This study computationally analyzed the effects of mutations on antiviral targets and identified potential resistance in different genome regions, providing insights for drug stewardship and therapeutic design.
Article
Biochemistry & Molecular Biology
Gisele Strieder Philippsen, Flavio Augusto Vicente Seixas
Summary: This study aimed to prospect potential inhibitors of the main protease (M-pro) of SARS-CoV-2 through computational methods. The D449-0032 compound was identified as a promising inhibitor, and molecular dynamics simulations demonstrated the stability of the protein-ligand complex. In vitro and in vivo studies are needed to confirm the M-pro inhibition by D449-0032.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Mehran Alavi, M. R. Mozafari, Saba Ghaemi, Morahem Ashengroph, Fatemeh Hasanzadeh Davarani, Mohammadreza Mohammadabadi
Summary: This study investigated the docking properties of epigallocatechin gallate and quercetin with the transmembrane spike glycoprotein of SARS-CoV-2. The results suggest that these compounds have the potential to be effective therapeutic agents for viral diseases.
Article
Biochemistry & Molecular Biology
Francisca Carvalhal, Ana Cristina Magalhaes, Rita Rebelo, Andreia Palmeira, Diana I. S. P. Resende, Fernando Duraes, Miguel Maia, Cristina P. R. Xavier, Luisa Pereira, Emilia Sousa, Marta Correia-da-Silva, M. Helena Vasconcelos
Summary: This study focuses on the interaction between the spike protein of SARS-CoV-2 and the ACE2 receptor. Through virtual screening and in vitro assays, five synthetic compounds were identified as potential inhibitors of SARS-CoV-2 infection, with xanthene 1 being the most promising. It exhibited antiviral activity without cytotoxicity to human lung cells.
Article
Biochemistry & Molecular Biology
Madeswaran Arumugam, Brahmasundari Shanmugavel, Mohan Sellppan, Parasuraman Pavadai
Summary: Coronavirus has had a harmful effect on the world's population, resulting in millions of deaths and billions of infections. This study aimed to assess the enzyme inhibitory potential of commercially available terpenoids against SARS-CoV-2 using computational docking calculations and molecular dynamic studies. Friedelin showed excellent inhibitory potential against the virus, surpassing the standard drug Remdesivir.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Multidisciplinary Sciences
Jordana Munoz-Basagoiti, Fabio Luis Lima Monteiro, Lauren R. H. Krumpe, Victoria Armario-Najera, Shilpa R. Shenoy, Daniel Perez-Zsolt, Harrison James Westgarth, Gemma Villorbina, Larissa Maciel Bomfim, Dalia Raich-Regue, Lara Nogueras, Curtis J. Henrich, Marcal Gallemi, Filipe Romero Rebello Moreira, Pascual Torres, Jennifer Wilson, Mirela D'arc, Silvia Marfil, Alice Laschuk Herlinger, Edwards Pradenas, Luiza Mendonca Higa, Manuel Portero-Otin, Benjamin Trinite, Richard M. Twyman, Teresa Capell, Amilcar Tanuri, Julia Blanco, Nuria Izquierdo-Useros, Elibio L. Rech, Paul Christou, Barry R. O'Keefe
Summary: SARS-CoV-2 is a coronavirus responsible for the COVID-19 pandemic. Targeting the glycosylated Spike protein on the virus surface can prevent infections. Cyanovirin-N (CV-N), a lectin from cyanobacteria, can selectively target SARS-CoV-2 Spike glycans and inhibit viral infection in vitro and in vivo, showing potential as a broad-spectrum antiviral agent.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Pradeep Kumar Yadav, Amit Jaiswal, Rajiv Kumar Singh
Summary: Researchers conducted in-silico study selecting eighteen well reported antiviral phytochemicals from commonly used spices in Indian kitchen to find out their potential in inhibiting SARS-CoV-2 infection. Among these, bisdemethoxycurcumin (BDMC), carvacrol, and thymol were identified as better inhibitors than camostat, showing stable binding with TMPRSS2 and inducing subtle modification in catalytic triad residues' spatial arrangement. Carvacrol was found to be the most effective inhibitor among the three, followed by BDMC, while thymol was the least effective.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Anshuman Chandra, Meenakshi Chaudhary, Imteyaz Qamar, Nagendra Singh, Vikrant Nain
Summary: In this study, computational methods were used to target the MTase of SARS-CoV-2, identifying four natural antiviral compounds, Amentoflavone, Baicalin, Daidzin, and Luteoloside, as strong inhibitors. The analysis suggested that these compounds have a high potential to inhibit MTase of SARS-CoV-2 and be used in the treatment of COVID-19, providing a quick therapeutic choice.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Nanoscience & Nanotechnology
Valentina Gentili, Daniele Pazzi, Sabrina Rizzo, Giovanna Schiuma, Edoardo Marchini, Stefania Papadia, Andrea Sartorel, Dario Di Luca, Francesca Caccuri, Carlo Alberto Bignozzi, Roberta Rizzo
Summary: The SARS-CoV-2 virus mainly spreads through small airborne aerosol particles and droplets, with contaminated surfaces also recognized as an important route of transmission. Two transparent polymeric compounds synthesized with silver and benzalkonium ions showed effective antimicrobial and antiviral properties against various bacteria and viruses, including SARS-CoV-2.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Rishi Kumar Mishra, Ayushi Datey, Tanweer Hussain
Article
Pharmacology & Pharmacy
Nitin Khandelwal, Yogesh Chander, Ram Kumar, Thachamvally Riyesh, Ramesh Kumar Dedar, Manoj Kumar, Baldev R. Gulati, Shalini Sharma, Bhupendra N. Tripathi, Sanjay Barua, Naveen Kumar
ANTIVIRAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Madhurima Datta, Maalavika Pillai, Mamata Jayant Modak, Aivar Liiv, Faisal Tarique Khaja, Tanweer Hussain, Jaanus Remme, Umesh Varshney
Summary: The study demonstrates that the L48K mutation in uS12 leads to a cold-sensitive phenotype and ribosome biogenesis defect in E. coli, affecting initiation and elongation translation steps, and interacting genetically with RRF and Pth, revealing a novel role of the PNSA loop in ribosome recycling.
MOLECULAR MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Anamika Sahu, Himani Dhanze, Vijayta Singh, Deepa Mehta, Megha Gupta, Mithilesh Singh, V. K. Vinod, B. R. Gulati
Summary: A recombinant NS1 protein-based indirect IgM-ELISA was developed in this study to diagnose recent infection of JEV in equines. The research findings showed a high seropositivity of JEV in the equine population of India, emphasizing the need for vaccination and antiviral therapy research for Indian equines.
Article
Veterinary Sciences
Aarti Kapdi, Himani Dhanze, Anamika Sahu, Vijayata Singh, Murthy Suman Kumar, Kiran Narayan Bhilegaonkar, Baldev Raj Gulati
Summary: A newly developed ELISA method based on NS1 protein was used to assess the sero-positivity of JE virus in the equine population of India. The study revealed an overall sero-positivity of 19.38% for JE virus in horses, and the spread of the virus to nonendemic parts of the country.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jose L. Llacer, Tanweer Hussain, Jinsheng Dong, Laura Villamayor, Yuliya Gordiyenko, Alan G. Hinnebusch
Summary: The study revealed the crucial role of the eukaryotic initiation factor 3 (eIF3) complex in translation initiation, particularly the repositioning of eIF3b and eIF3i contributing to the accuracy of initiation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biology
Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil, Santhosh Kambaiah Nagaraj, Sandeep M. Eswarappa, Shashank Tripathi, Tanweer Hussain
Summary: In this study, it was discovered that montelukast sodium hydrate has a strong binding affinity to the Nsp1 protein of SARS-CoV-2 and can inhibit the inhibitory effect of Nsp1 on host protein synthesis. Additionally, montelukast sodium hydrate also shows antiviral activity against SARS-CoV-2.
Article
Biology
Ipsita Basu, Biswajit Gorai, Thyageshwar Chandran, Prabal K. Maiti, Tanweer Hussain
Summary: Accurate and high-speed scanning and selection of the correct start codon are important events in protein synthesis. Molecular dynamics simulations and energy calculations suggest that the ribosomal 48S pre-initiation complex (PIC) may reject most non-AUG codons, with initiation factor eIF1 playing a crucial role. This study provides insights into the scanning process and the involvement of initiation factors in codon-anticodon-ribosome network stability.
COMMUNICATIONS BIOLOGY
(2022)
Article
Virology
A. Pathak, B. R. Gulati, S. Maan, S. Mor, D. Kumar, R. Soman, S. Punia, D. Chaudhary, S. K. Khurana
Summary: The genomic diversity of equine rotaviruses is still unknown, and this study reveals unusual genomic constellations and bat-related lineages. Extensive surveillance of both animal and human rotaviruses with a one health approach is crucial.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jitendra Singh, Rishi Kumar Mishra, Shreya Ahana Ayyub, Tanweer Hussain, Umesh Varshney
Summary: This study reveals the crucial role of the interaction between the N-terminal domain (NTD) of initiation factor 3 (IF3) and initiator tRNA (i-tRNA) in bacterial translation initiation and growth fitness of Escherichia coli. Specific mutations in NTD disrupt its interaction with i-tRNA, leading to impaired translation fidelity and bacterial growth.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Immunology
Seema R. R. Pegu, Pranab Jyoti Das, Joyshikh Sonowal, Gyanendra Singh Sengar, Rajib Deb, Ajay Kumar Yadav, Swaraj Rajkhowa, Manjisa Choudhury, Baldev R. R. Gulati, Vivek Kumar Gupta
Summary: This study conducted molecular detection and genome sequencing of Japanese encephalitis virus (JEV) isolates from pigs and mosquitoes in Assam, India. The analysis revealed that these isolates belong to genotype III and are closely related to strains from China, indicating the transboundary circulation of JEV genotype III through mosquito-swine transmission cycles.
Article
Biochemistry & Molecular Biology
Greco Hernandez, Alejandra Garcia, Shira Weingarten-Gabbay, Rishi Kumar Mishra, Tanweer Hussain, Mehdi Amiri, Gabriel Moreno-Hagelsieb, Angelica Montiel-Davalos, Paul Lasko, Nahum Sonenberg
Summary: This study analyzed the influence of translation initiation site (TIS) context on mRNA translation across different eukaryotes. It was found that -3A conferred the highest translational efficiency in Drosophila, rabbit, wheat, and yeast. However, there was variability in the optimal translation at the +4 position. The Kozak motif showed weak predictive power for wheat and no predictive power for yeast. Additionally, eight conserved sequences that disfavored translation were discovered.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Infectious Diseases
M. R. Grace, Himani Dhanze, Pranita Pantwane, M. Sivakumar, Baldev Raj Gulati, Ashok Kumar
JOURNAL OF VECTOR BORNE DISEASES
(2019)