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Performance of soluble fms-like tyrosine kinase-1-to-placental growth factor ratio of ≥85 for ruling in preeclampsia within 4 weeks

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Volume 224, Issue 3, Pages 322-323

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MOSBY-ELSEVIER

DOI: 10.1016/j.ajog.2020.11.007

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National Institute for Health Research (NIHR), United Kingdom

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Short-Term Prediction of Preeclampsia in Chinese Women Using the Soluble fms-Like Tyrosine Kinase 1/Placental Growth Factor Ratio: A Sub-Analysis of the PROGNOSIS Asia Study

Jinsong Gao, Xianghua Huang, Wen Di, Xiaojing Dong, Wenli Gou, Hong Shi, Zilian Wang, Angela Dietl, Sonja Grill, Martin Hund

Summary: This study demonstrates that the sFlt-1/PlGF ratio cutoff of 38 has high predictive performance for short-term prediction of preeclampsia in Chinese women, helping to reduce unnecessary hospitalization for low-risk women.

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Real-world data on the clinical use of angiogenic factors in pregnancies with placental dysfunction

Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan

Summary: This real-world data analysis found a correlation between the soluble fms-like tyrosine kinase-1 to placental growth factor ratio and the severity of preeclampsia and placental dysfunction, providing a useful tool for stratifying patients' outcomes.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Interferon y neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats

Olivia K. Travis, Geilda A. Tardo, Chelsea Giachelli, Shani Siddiq, Henry T. Nguyen, Madison T. Crosby, Tyler D. Johnson, Andrea K. Brown, George W. Booz, Alex N. Smith, Jan Michael Williams, Denise C. Cornelius

Summary: In this study, neutralization of IFNy was found to reduce MAP, UARI, and placental ROS levels in RUPP recipients. However, fetal and placental weights in RUPP rats were not improved following anti-IFNy treatment. These findings suggest that IFNy may play a role in the pathophysiology of PE and could be a potential therapeutic target for improving maternal outcomes in PE.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Paeoniflorin alleviates endothelial dysfunction caused by overexpression of soluble fms-like tyrosine kinase 1 and soluble endoglin in preeclampsia via VEGFA upregulation

Jin Zhang, Wei Hua, Xinyuan Zhao, Fan Yang, Ting Guo, Jianhua Zhang, Xuerong Zheng, Wanqi Liang

Summary: This study confirmed the protective effects of paeoniflorin against preeclampsia-related endothelial damage by upregulating VEGFA to alleviate the injury caused by overexpression of sFlt-1 and sEng.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2021)

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Atypical preeclampsia with systemic lupus erythematosus and elevated soluble fms-like tyrosine kinase 1/placental growth factor ratio

Kazuya Mimura, Takuji Tomimatsu, Masayuki Endo, Tadashi Kimura

Summary: In early pregnancy, the sFlt-1/PlGF ratio may be used to differentiate between exacerbation of systemic lupus erythematosus and preeclampsia.

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Article Medicine, Research & Experimental

Human umbilical cord mesenchymal stem cell derived exosomes (HUCMSC-exos) recovery soluble fms-like tyrosine kinase-1 (sFlt-1)-induced endothelial dysfunction in preeclampsia

Xinwen Chang, Qizhi He, Mengtian Wei, Linyan Jia, Yingying Wei, Yiding Bian, Tao Duan, Kai Wang

Summary: Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) have beneficial effects on adverse birth outcomes in a preeclampsia mouse model induced by sFlt-1. They can decrease blood pressure, improve fetal birth weight, and restore placental vascular networks. In addition, HUCMSC-exos partially rescue sFlt-1-induced dysfunction of human umbilical vein endothelial cells.

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Article Biochemistry & Molecular Biology

Pregnancy-Induced High Plasma Levels of Soluble Endoglin in Mice Lead to Preeclampsia Symptoms and Placental Abnormalities

Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho

Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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The clinical value of PlGF and the sFlt1/PlGF ratio in the management of hypertensive pregnancy disorders: A retrospective real-world study in China

Hao Yang, Fang Guo, Qin Guo, Yifei Wang, Ping He, Hongbo Zhang, Shuaiyu Wang

Summary: The sFlt1/PlGF ratio is a useful parameter for the diagnosis of preeclampsia, showing good performance in distinguishing preeclampsia from other hypertensive disorders of pregnancy and predicting adverse outcomes. PlGF and sFlt1/PlGF ratio are worth implementing in the clinical management of women with preeclampsia.

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MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia

Qing Yong, Kyra L. Dijkstra, Carin van der Keur, Jan A. Bruijn, Michael Eikmans, Hans J. Baelde

Summary: Insufficient immune tolerance during pregnancy is associated with pathological conditions such as preeclampsia (PE). The expression of sFLT1 protein in human placenta is regulated by MIF during early pregnancy and preeclampsia. sFLT1 plays an important role in the modulation of inflammation in early pregnancy and preeclampsia.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Peripheral Vascular Disease

Short-term prediction of preeclampsia using the sFlt-1/PlGF ratio: a subanalysis of pregnant Japanese women from the PROGNOSIS Asia study

Akihide Ohkuchi, Shigeru Saito, Tatsuo Yamamoto, Hisanori Minakami, Hisashi Masuyama, Keiichi Kumasawa, Jun Yoshimatsu, Takeshi Nagamatsu, Angela Dietl, Sonja Grill, Martin Hund

Summary: The subanalysis of Japanese women with suspected preeclampsia showed a high predictive value of Elecsys sFlt-1/PlGF ratio cutoff of 38 for short-term prediction of preeclampsia. This ratio can effectively rule out or diagnose preeclampsia within 1 week, helping to accurately determine the condition of pregnant women.

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Article Cardiac & Cardiovascular Systems

Decision Threshold for Kryptor sFlt-1/PlGF Ratio in Women With Suspected Preeclampsia: Retrospective Study in a Routine Clinical Setting

Lise Lotte Torvin Andersen, Annemarie Helt, Lene Sperling, Martin Overgaard

Summary: The study evaluated the predictive performance and decision threshold of Kryptor sFlt-1/PlGF ratio in managing women with symptoms of preeclampsia, showing good predictive value for both early-onset and late-onset preeclampsia. A single threshold of 66 is recommended for clinical use in ruling out and ruling in preeclampsia within 1 week.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Value of soluble fms-like tyrosine kinase-1/placental growth factor test in third trimester of pregnancy for predicting preeclampsia in asymptomatic women

Ele Hanson, Kristiina Rull, Kaspar Ratnik, Pille Vaas, Pille Teesalu, Maris Laan

Summary: The study aimed to evaluate the value of screening for maternal serum sFlt-1/PlGF ratio in predicting the development of preeclampsia during the third trimester. The results showed that testing sFlt-1/PlGF ratio between 180-259 gestational days could detect approximately half of subsequent preeclampsia cases, with the highest detection rate observed at 225-238 gestational days.

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Soluble fms-like tyrosine kinase 1 (sFlt-1): A novel biochemical marker for acute fatty liver of pregnancy

Fabienne Trottmann, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Araceli Jarquin Campos, Franz H. Messerli, Lorenz Risch, Marc U. Baumann

Summary: In this study, pregnant women with AFLP had significantly higher sFlt-1 levels compared to those with HELLP syndrome. PlGF levels were also higher in AFLP patients. The sFlt-1 cutoff value of 31,100 pg/mL showed a sensitivity and specificity of 100% in distinguishing between AFLP and HELLP syndrome.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2021)

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Article Obstetrics & Gynecology

Serum levels of soluble FMS-like tyrosine kinase 1 and endothelial glycocalyx components in early- and late-onset preeclampsia

Jakub Kornacki, Przemyslaw Wirstlein, Ewa Wender-Ozegowska

Summary: Evaluation of serum concentrations of HA in patients with PE was found to be more useful in the assessment of endothelial injury, compared to the assessment of SDC-1. The degree of EG damage was comparable in patients with early- and late-onset PE. The pathomechanism of the damage seems to be more sFlt-1 dependent in patients with early- onset PE than in the case of late-onset disease.

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The Impact of Coexisting Gestational Diabetes Mellitus on the Course of Preeclampsia

Katarzyna Pankiewicz, Ewa Szczerba, Anna Fijalkowska, Janusz Sierdzinski, Tadeusz Issat, Tomasz Mikolaj Maciejewski

Summary: This case-control observational study evaluates the influence of concomitant gestational diabetes mellitus (GDM) on the severity of preeclampsia (PE). The study found that the coexistence of GDM may mitigate the course of PE. Furthermore, there were no differences in serum levels of studied biomarkers between patients with PE with and without GDM, suggesting their usefulness in the diagnosis and management of PE in patients with coexisting GDM.

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The diagnostic value of angiogenic and antiangiogenic factors in differential diagnosis of preeclampsia

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Performance of soluble fms-like tyrosine kinase-1-to-placental growth factor ratio of ≥85 for ruling in preeclampsia within 4 weeks

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