Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Editorial Material
Multidisciplinary Sciences
Peter Hotez
Summary: To halt the spread of the coronavirus, a high-level counteroffensive against new destructive forces is necessary.
News Item
Multidisciplinary Sciences
Elie Dolgin
Summary: In the scramble to combat the pandemic, vaccine dosing decisions relied on past experience and best guesses, with modelling tools potentially playing a role.
News Item
Multidisciplinary Sciences
Heidi Ledford
Summary: Safety concerns have led to delays in the use of two COVID-19 vaccines, prompting scientists to seek answers to important questions.
News Item
Multidisciplinary Sciences
Heidi Ledford
Summary: Nature explores important questions about vaccines being rushed out by countries as viral variants continue to spread globally at a crucial moment in the pandemic.
Article
Immunology
Atefeh Vaezi, Alipasha Meysamie
Summary: This study investigated the cost-effectiveness of various COVID-19 vaccines compared to no vaccination. The results showed varying incremental cost-effectiveness ratios (ICER) among different vaccines, with Ad26.COV2.S having the lowest cost and CoronaVac having the highest cost. The recommended vaccines for Iran include ad26.cov2.s, chadox1-S, rAd26-S + rAd5-S, and BNT162b2 in that order.
News Item
Multidisciplinary Sciences
Smriti Mallapaty
Summary: Although studies show vaccines reduce the spread of SARS-CoV-2 by more than 80%, the Delta variant is introducing fresh uncertainties.
Review
Virology
Maria M. Plummer, Charles S. Pavia
Summary: HIV infects and destroys helper T cells to suppress the immune system, reproducing itself via a unique mechanism. HIV/AIDS patients are at higher risk of SARS-CoV-2 infection during the COVID-19 pandemic, but current vaccines have shown to be effective for them as well.
Review
Immunology
Jang Hyun Park, Heung Kyu Lee
Summary: The development of COVID-19 vaccines includes various types such as subunit vaccines, inactivated vaccines, and nucleic acid vaccines, but currently only intramuscular vaccination is available. Research suggests that mucosal vaccination may enhance local immune responses, but the lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in the limited delivery options available at present.
News Item
Multidisciplinary Sciences
Philip Ball
Summary: The rapid approach used to address SARS-CoV-2 has the potential to revolutionize the future of vaccine science.
Article
Chemistry, Medicinal
Swapna Ponnampalli, Naga Venkata Suryanarayana Birudukota, Ahmed Kamal
Summary: COVID-19, caused by SARS-CoV-2, has become the leading cause of death globally. Despite protective measures, vaccines, and therapeutics, the virus continues to have a long-term impact. Scientists are working tirelessly to develop efficient vaccines and effective treatments. Understanding the current situation and available options is crucial in combating the COVID-19 pandemic.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Immunology
Masayuki Miyasaka
Summary: Understanding the mechanism of vaccine-induced protection and immune correlates is crucial for developing next-generation COVID-19 vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hazel M. Dockrell, Helen McShane
Summary: Despite active research and vaccine development plans, there are still no licensed new tuberculosis vaccines. This viewpoint discusses the reasons why it is taking a long time to develop new tuberculosis vaccines, especially when compared to the rapid development of COVID-19 vaccines.
Review
Biochemistry & Molecular Biology
Haneen Imad Abufares, Leen Oyoun Alsoud, Mohammad A. Y. Alqudah, Mohd Shara, Nelson C. Soares, Karem H. Alzoubi, Waseem El-Huneidi, Yasser Bustanji, Sameh S. M. Soliman, Mohammad H. Semreen
Summary: The COVID-19 pandemic has caused global crises, and the development of vaccines has become a collaborative effort worldwide. WHO-approved vaccines have been shown to be safe and effective, enhancing immune response and reducing the risk of infection. However, the type of vaccine and individual health status have significant impacts on immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Allergy
Ioana Agache, Vanitha Sampath, Juan Aguilera, Cezmi Akdis, Mubeccel Akdis, Michele Barry, Aude Bouagnon, Sharon Chinthrajah, William Collins, Coby Dulitzki, Barbara Erny, Jason Gomez, Anna Goshua, Marek Jutel, Kenneth W. Kizer, Olivia Kline, A. Desiree LaBeaud, Isabella Pali-Schoell, Kirsten P. Perrett, Rachel L. Peters, Maria Pilar Plaza, Mary Prunicki, Todd Sack, Renee N. Salas, Sayantani B. Sindher, Susanne H. Sokolow, Cassandra Thiel, Erika Veidis, Brittany Delmoro Wray, Claudia Traidl-Hoffmann, Christian Witt, Kari C. Nadeau
Summary: This review brings together international experts to describe the direct and indirect health impacts of climate change and expands on potential longer-term impacts on global health. It explores these issues in relation to global health in urban and rural settings in developed and developing countries, and concludes with a discussion of actions that health professionals can take.
Review
Immunology
Natalija Novak, Leticia Tordesillas, Beatriz Cabanillas
Summary: T cells in the skin play a crucial role in immune surveillance and maintaining tissue homeostasis. Different subsets of T cells, including memory regulatory T cells, contribute to immune responses and skin pathologies. Non-classical T cells have also been shown to have a role in skin homeostasis, response to pathogens, as well as allergic skin inflammation and allergen sensitization.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Review
Dermatology
Beatriz Cabanillas
Summary: Dupilumab is the first approved targeted biological therapy for moderate-to-severe atopic dermatitis (AD), and it functions by blocking the downstream signaling of interleukin-4 and interleukin-13 receptors. The clinical improvements induced by dupilumab are associated with remission of dysregulated immune mechanisms and improved epidermal barrier defects in AD. This review provides an overview of the development of dupilumab, clinical trials in different age groups, outcomes, and reported adverse effects, as well as summarizing the current knowledge on its molecular and cellular mechanisms.
Article
Allergy
Magdalena Zemelka-Wiacek, Anna Kosowska, Ewa Winiarska, Ewa Sobanska, Marek Jutel
Summary: This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions. The results showed that in a constant environment, the concentration of HDM remained stable within the targeted values, and the severity of symptoms and other endpoints were reproducible. A concentration of 5000 particles/m³ and a challenge duration of 120 minutes were found to be optimal.
Review
Allergy
Beatriz Cabanillas, Giuseppe Murdaca, Amir Guemari, Maria Jose Torres, Ahmet Kursat Azkur, Emel Aksoy, Joana Vitte, Leticia de las Vecillas, Mattia Giovannini, Ruben Fernandez-Santamaria, Riccardo Castagnoli, Andrea Orsi, Rosa Amato, Irene Giberti, Alba Catala, Dominika Ambrozej, Bianca Schaub, Gerdien A. A. Tramper-Stranders, Natalija Novak, Kari C. C. Nadeau, Ioana Agache, Mubeccel Akdis, Cezmi A. A. Akdis
Summary: The current monkeypox disease outbreak is a new and significant threat to society, with over 55,000 confirmed cases in 103 countries. It is the largest and most serious outbreak since the initial diagnosis in 1970. While monkeypox is usually self-limiting, severe clinical manifestations and complications have been observed, particularly in vulnerable populations. The extensive spread of the current outbreak raises important questions that require investigation to better understand and prevent such threats in the future. A review addressing 50 questions about monkeypox virus and the current outbreak aims to provide up-to-date scientific information and explore the potential causes and consequences of this public health emergency.
Editorial Material
Allergy
Celine Galleani, Rafael Valdelvira, M. Carmen Dieguez, Jesus F. Crespo, Beatriz Cabanillas
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Letter
Allergy
Rafael Valdelvira, Guadalupe Garcia-Medina, Celine Galleani, Vera Kralova, Jesus F. F. Crespo, Beatriz Cabanillas
Review
Chemistry, Applied
Jesus F. Crespo, Beatriz Cabanillas
Summary: Food allergy is a growing public health issue, and recent research has shed light on the molecular and cellular mechanisms behind IgE-mediated food allergy. These discoveries have highlighted the important roles of specific cell types, such as T follicular helper cells, in the production of high-affinity IgE. Additionally, it has been found that not only mast cells and basophils, but also other cell types like neutrophils and macrophages, contribute to food anaphylaxis. Understanding the mechanisms of sensitization through organs like the skin is crucial for comprehending the dual exposure hypothesis and uncovering new approaches to anaphylaxis pathophysiology.
Article
Food Science & Technology
Carmen Cuadrado, Africa Sanchiz, Claudia Arribas, Mercedes M. Pedrosa, Pedro Gamboa, Diana Betancor, Carlos Blanco, Beatriz Cabanillas, Rosario Linacero
Summary: This study evaluates the allergenic features of peanuts after being subjected to heat, pressure, and enzymatic digestion. The combination of pressured heating treatments and enzymatic hydrolysis was found to be the most efficient method in reducing the allergenic potential of peanuts. These findings are important for patients who may undergo allergy treatment using processed peanuts, as well as for the food industry and regulatory agencies.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Allergy
Laura Marin, Beatriz Moya, Maria Jose Penalver, Beatriz Cabanillas, Ruth Barranco, Ismael Garcia-Moguel, Ruth Mielgo, Jesus Fernandez-Crespo
Summary: This study demonstrates that bedside meropenem allergy assessment in hospitalized patients with a labeled 'penicillin allergy' who require a broad-spectrum antibiotic for empiric coverage is a safe and effective procedure, avoiding the use of second-line antimicrobial agents.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Allergy
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Juergen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
Summary: This guideline from the European Academy of Allergy and Clinical Immunology provides recommendations for diagnosing IgE-mediated food allergy, including clinical history, tests for determining IgE sensitization, and the use of oral food challenges for confirmation.
Article
Allergy
Marek Jutel, Ioana Agache, Magdalena Zemelka-Wiacek, Mubeccel Akdis, Tomas Chivato, Stefano del Giacco, Pawel Gajdanowicz, Ibon Eguiluz Gracia, Ludger Klimek, Antti Lauerma, Markus Ollert, Liam O'Mahony, Jurgen Schwarze, Mohamed H. Shamji, Isabel Skypala, Oscar Palomares, Oliver Pfaar, Maria Jose Torres, Jonathan A. Bernstein, Alvaro A. Cruz, Stephen R. Durham, Stephen J. Galli, R. Maximiliano Gomez, Emma Guttman-Yassky, Tari Haahtela, Stephen T. Holgate, Kenji Izuhara, Kenji Kabashima, Desiree E. Larenas-Linnemann, Erica von Mutius, Kari C. Nadeau, Ruby Pawankar, Tomas A. E. Platts-Mills, Scott H. Sicherer, Hae-Sim Park, Stefan Vieths, Gary Wong, Luo Zhang, M. Beatrice Bilo, Cezmi A. Akdis
Summary: The exponential growth of precision diagnostic tools has led to vast amounts of data enabling in-depth disease characterization. New disease endotypes have been identified, moving from symptom-focused descriptions to identifying biomarkers and intricate pathways. The current disease taxonomy must be revised for better categorization.
Article
Allergy
Christina M. Kronfel, Hsiaopo Cheng, Jane K. McBride, Jacqueline B. Nesbit, Rebecca Krouse, Preston Burns, Beatriz Cabanillas, Jesus F. Crespo, Robert Ryan, Reyna J. Simon, Soheila J. Maleki, Barry K. Hurlburt
Summary: The goal of this study is to determine the differences in allergic reactions between the US and Spain. It found that certain regions of Ara h 9, Jug r 3, and Pru p 3 are recognized more frequently by peanut-allergic individuals in the US, indicating potential cross-reactivity. These findings are important for the development of diagnostic and therapeutic tools for food allergies.
FRONTIERS IN ALLERGY
(2023)
Article
Chemistry, Applied
Rafael Valdelvira, Joana Costa, Jesus F. Crespo, Beatriz Cabanillas
Summary: This study investigated the impact of hydration on the release of major and minor allergens from peanut kernels. The results showed that hydration played a crucial role in the release of peanut allergens, with major allergen Ara h 1 being quickly released and minor allergens Ara h 8 and Ara h 9 diffusing into the water. The ratio of peanut to water and stirring had a significant impact on allergen release.
Review
Immunology
Ya-dong Gao, Ioana Agache, Mubeccel Akdis, Kari Nadeau, Ludger Klimek, Marek Jutel, Cezmi A. Akdis
Summary: Studies suggest that asthma and allergic diseases do not significantly affect susceptibility to or severity of COVID-19, but type 2 inflammation-related allergic diseases may impact susceptibility and progression. Current research is also exploring the impact and prevalence of allergic asthma and other allergic diseases in COVID-19 patients.
INTERNATIONAL IMMUNOLOGY
(2022)
