Article
Clinical Neurology
Anette-Eleonore Schrag, Davide Martino, Hanyuying Wang, Gareth Ambler, Noa Benaroya-Milstein, Maura Buttiglione, Francesco Cardona, Roberta Creti, Androulla Efstratiou, Tammy Hedderly, Isobel Heyman, Chaim Huyser, Pablo Mir, Astrid Morer, Natalie Moll, Norbert E. Muller, Kirsten R. Muller-Vahl, Kerstin J. Plessen, Cesare Porcelli, Renata Rizzo, Veit Roessner, Markus Schwarz, Zsanett Tarnok, Susanne Walitza, Andrea Dietrich, Pieter J. Hoekstra
Summary: This study aimed to investigate the association between group A streptococcal (GAS) infections and tic incidence among unaffected children with a family history of chronic tic disorders (CTDs). Findings showed a strong association between sex and tic onset, with girls having a lower risk of developing tics compared to boys. However, there was no statistical evidence to suggest an association between GAS exposure and tic onset.
Review
Clinical Neurology
Antonella Gagliano, Alessandra Carta, Marcello G. Tanca, Stefano Sotgiu
Summary: Pediatric acute-onset neuropsychiatric syndrome (PANS) is characterized by a constellation of acute symptoms followed by a chronic course. Recent research has focused on clinical and pathophysiological aspects of PANS, as well as strategies for disease management. The importance of a comprehensive approach to treatment and the role of neuro-inflammation in psychiatric disorders are highlighted. This article is rated 7 out of 10 in terms of importance.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Psychiatry
Giuseppe Fanelli, Barbara Franke, Ward De Witte, I. Hyun Ruisch, Jan Haavik, Veerle van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Lars Lind, Jan K. Buitelaar, Tobias Banaschewski, Soren Dalsgaard, Alessandro Serretti, Nina Roth Mota, Geert Poelmans, Janita Bralten
Summary: The prevalence of somatic insulinopathies, such as metabolic syndrome, obesity, and type 2 diabetes mellitus, is higher in Alzheimer's disease, autism spectrum disorder, and obsessive-compulsive disorder. There is a genetic overlap between these neuropsychiatric disorders and insulin-related diseases/traits, indicating a potential shared genetic mechanism.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Francesco Demaria, Paolo Alfieri, Maria Cristina Digilio, Maria Pontillo, Cristina Di Vincenzo, Federica Alice Maria Montanaro, Valentina Ciullo, Giuseppe Zampino, Stefano Vicari
Summary: KBG syndrome is a rare disease characterized by short stature, facial dysmorphism, and other symptoms. This study found that a subset of patients with KBGS exhibited peculiar behaviors related to paper handling, reminiscent of symptoms seen in obsessive compulsive disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Medicine, General & Internal
Lilach Rachamim, Hila Mualem-Taylor, Osnat Rachamim, Michael Rotstein, Sharon Zimmerman-Brenner
Summary: This study found that in children and adolescents with tic disorders, both the presence of ADHD and the absence of comorbid ADHD were associated with similar reductions in tic symptoms after internet-delivered, self-help comprehensive behavioral intervention for tics (ICBIT). However, the presence of OCD comorbidity was associated with a lesser response to intervention. Furthermore, the intervention also led to significant reductions in parental reports of inattention, hyperactivity, and impulsivity. Larger studies are needed to further optimize the application of ICBIT in children and teens with both tic disorders and comorbid ADHD and OCD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Nicolas Lamanna-Rama, Diego Romero-Miguel, Manuel Desco, Maria Luisa Soto-Montenegro
Summary: Curcumin, a therapeutic compound with antioxidant, anti-inflammatory, and neuroprotective properties, has been studied in preclinical and clinical trials for psychiatric disorders. While there are some positive results reported, the limited number of trials and protocol heterogeneity make it difficult to draw solid conclusions about the real efficacy of curcumin in psychiatric disorders.
Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Article
Genetics & Heredity
Dima Qu'd, Lauren. M. M. Schmitt, Amber Leston, Jacqueline. R. R. Harris, Anne Slavotinek, Ilka Riddle, Diana. S. S. Brightman, Brittany. N. N. Simpson
Summary: This study investigated the neurocognitive and behavioral challenges faced by individuals with Rubinstein-Taybi syndrome (RSTS) and found a high prevalence of neuropsychiatric and behavioral issues, particularly in school-age individuals. Furthermore, differences were observed between the two types of RSTS, with type 2 exhibiting better adaptive behavior and living skills but higher social phobia compared to type 1. The study highlights the importance of early screening for neuropsychiatric and behavioral issues in RSTS patients.
FRONTIERS IN GENETICS
(2023)
Article
Chemistry, Analytical
Sinem Burcu Erdogan, Gulnaz Yukselen
Summary: This study proposes a machine learning-based classification approach for objective diagnosis of three neuropsychiatric or neurological disorders using functional near-infrared spectroscopy (fNIRS) derived biomarkers. The results show that all algorithms achieved accuracies above 81% and specificities above 94% in four-class classification, with support vector machines (SVM) performing the best.
Review
Clinical Neurology
Natalia Szejko, Kirsten R. Muller-Vahl
Summary: Tourette syndrome (TS) is characterized by vocal and motor tics, often accompanied by psychiatric comorbidities. Differential diagnosis between tics and OCD-related phenomena can be challenging, as some symptoms may overlap. "Just right" phenomena are common in patients with TS, showing similarities with both tics and OCD. Treatment strategies for tics and OCD in TS patients should take into consideration these complexities.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Nevena V. Radonjic, Jonathan L. Hess, Paula Rovira, Ole Andreassen, Jan K. Buitelaar, Christopher R. K. Ching, Barbara Franke, Martine Hoogman, Neda Jahanshad, Carrie McDonald, Lianne Schmaal, Sanjay M. Sisodiya, Dan J. Stein, Odile A. van den Heuvel, Theo G. M. van Erp, Daan van Rooij, Dick J. Veltman, Paul Thompson, Stephen V. Faraone
Summary: Genomewide association studies have shown significant genetic correlations among neuropsychiatric disorders. The study found substantial similarities in structural brain alterations among disorders, hinting at a shared genetic etiology. These similarities in brain alterations appear to be partially explained by common genetic variants.
MOLECULAR PSYCHIATRY
(2021)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
Keyoumars Ashkan, Asfand Baig Mirza, Kantharuby Tambirajoo, Luciano Furlanetti
Summary: The use of DBS in the management of psychiatric conditions has progressed steadily in the adult population but at a slower pace in the pediatric population; main indications for surgery in pediatric patients included Tourette Syndrome, aggressive behavior, self-harm, and eating disorders; future studies should focus on rigorous and standardized trials, as well as research on personalized DBS therapy.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2021)
Article
Psychiatry
Parisa Hajjari, Malin Huldt Oldmark, Elisabeth Fernell, Klara Jakobsson, Ingrid Vinsa, Max Thorsson, Mehran Monemi, Lotta Stenlund, Anders Fasth, Catrin Furuhjelm, Jakob Asberg Johnels, Christopher Gillberg, Mats Johnson
Summary: This study found that significant and pervasive improvements in symptoms and clinical impairments were observed in ten children with PANS after three months of IVIG treatment. The PANS scale, CGI-S scale, and CY-BOCS scale scores significantly decreased after three treatments.
Letter
Hematology
Klara M. Benninghoven-Frey, Nina Neuhaus, Atte K. Lahtinen, Claudia Krallmann, Joana M. D. Portela, Andrea Jarisch, Verena Nordhoff, Armin Soave, Hajar A. M. Ba Omar, Mikael Sundin, Cecilia Langenskiold, Sabine Kliesch, Jan-Bernd Stukenborg, Kirsi Jahnukainen
Article
Allergy
Arjan C. Lankester, Benedicte Neven, Nizar Mahlaoui, Erik G. J. von Asmuth, Virginie Courteille, Mikael Alligon, Michael H. Albert, Isabelle Badell Serra, Peter Bader, Dmitry Balashov, Rita Beier, Yves Bertrand, Stephane Blanche, Victoria Bordon, Robbert G. Bredius, Andrew Cant, Marina Cavazzana, Cristina Diaz-de-Heredia, Figen Dogu, Karoline Ehlert, Natacha Entz-Werle, Anders Fasth, Francesca Ferrua, Alina Ferster, Renata Formankova, Wilhelm Friedrich, Marta Gonzalez-Vicent, Jolanta Gozdzik, Tayfun Gungor, Manfred Hoenig, Aydan Ikinciogullari, Krzysztof Kalwak, Savas Kansoy, Alphan Kupesiz, Arnalda Lanfranchi, Caroline A. Lindemans, Roland Meisel, Gerard Michel, Nuno A. A. Miranda, Jose Moraleda, Despina Moshous, Herbert Pichler, Kanchan Rao, Petr Sedlacek, Mary Slatter, Elena Soncini, Carsten Speckmann, Mikael Sundin, Amos Toren, Kim Vettenranta, Austen Worth, Mehmet A. Yesilipek, Marco Zecca, Fulvio Porta, Ansgar Schulz, Paul Veys, Alain Fischer, Andrew R. Gennery
Summary: This comprehensive multicenter analysis examined the outcomes of hematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency (SCID) and analyzed the factors affecting immune reconstitution (IR) and long-term clinical outcomes. The results showed improved overall survival (OS) and event-free survival (EFS) in all genotypes and donor types. Pretransplantation infections and the use of mismatched related donors were associated with less favorable OS and EFS. The study also identified factors such as specific genetic mutations, conditioning regimen, matched donor HSCT, and levels of naive CD4 T lymphocytes as independent predictors of favorable clinical and immunologic outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biophysics
Hannes Lindahl, Sofie Vonlanthen, Davide Valentini, Andreas T. Bjorklund, Mikael Sundin, Stephan Mielke, Dan Hauzenberger
Summary: Recipient-donor chimerism analysis is crucial after HSCT for monitoring engraftment and graft rejection, and can also be used to predict relapse in certain diseases. For AML patients, achieving early complete donor chimerism can help in risk stratification.
BONE MARROW TRANSPLANTATION
(2022)
Article
Pediatrics
Fredrik Sundquist, Kleopatra Georgantzi, Kirsten Brunsvig Jarvis, Jesper Brok, Minna Koskenvuo, Jelena Rascon, Max van Noesel, Per Grybaeck, Joachim Nilsson, Arthur Braat, Mikael Sundin, Sandra Wessman, Nikolas Herold, Lars Hjorth, Per Kogner, Dan Granberg, Mark Gaze, Jakob Stenman
Summary: This article introduces a new trial for the treatment of high-risk neuroblastoma, which uses a new dosing schedule and has been approved by the European Medicines Agency. The trial is currently ongoing and recruitment is estimated to be completed within 3-5 years.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Emilie W. Borgstrom, Marie Edvinsson, Lucia P. Perez, Anna C. Norlin, Sara L. Enoksson, Susanne Hansen, Anders Fasth, Vanda Friman, Olle Kampe, Robert Mansson, Hernando Y. Estupinan, Qing Wang, Tan Ziyang, Tadepally Lakshmikanth, Carl Inge E. Smith, Petter Brodin, Peter Bergman
Summary: This study investigated the clinical effects and biomarker alterations in three patients with chronic mucocutaneous candidiasis (CMC) caused by gain-of-function mutations in the STAT1 gene during treatment with Janus kinase (JAK) inhibitors. The results showed that JAK inhibitors improved clinical symptoms of CMC, but also caused side effects. The treatment had a sustained effect on the populations of neutrophils, T cells, B cells, and NK cells. Additionally, the treatment enhanced cellular reactivity against Candida albicans and altered plasma biomarkers.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Psychiatry
Lisa Dinkler, Marie-Louis Wronski, Paul Lichtenstein, Sebastian Lundstrom, Henrik Larsson, Nadia Micali, Mark J. Taylor, Cynthia M. Bulik
Summary: The study aims to estimate the extent to which genetic and environmental factors contribute to Avoidant Restrictive Food Intake Disorder (ARFID). The results show that ARFID is highly heritable, encouraging future twin and molecular genetic studies.
Article
Biophysics
Dina Averbuch, Rafael de la Camara, Gloria Tridello, Nina Simone Knelange, Tatiana A. Bykova, Marianne Ifversen, Veronika Dobsinska, Mouhab Ayas, Amir Ali Hamidieh, Herbert Pichler, Antonio Perez-Martinez, Simone Cesaro, Mikael Sundin, Isabel Badell, Peter Bader, Jan-Erik Johansson, Oana Mirci-Danicar, Petr Sedlacek, Catherine Paillard, Brenda Gibson, Sarah Lawson, Nicolaus Kroeger, Selim Corbacioglu, Malgorzata Mikulska, Jose Luis Pinana, Jan Styczynski, Per Ljungman
Summary: This international study analyzed risk factors for severe SARS-Cov-2 infection in children following hematopoietic cell transplantation. The study found that although the infection is often asymptomatic, 10% of children required ICU care and 8% died. Hematopoietic cell transplantation, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.
BONE MARROW TRANSPLANTATION
(2023)
Article
Neurosciences
Max Thorsson, Martyna A. Galazka, Parisa Hajjari, Elisabeth Fernell, Jonathan Delafield-Butt, Christopher Gillberg, Mats Johnson, Jakob Asberg Johnels, Nouchine Hadjikhani
Summary: This study used a bespoke tablet-based motor coordination test called SpaceSwipe to assess motor coordination in children with PANS. It found that SpaceSwipe can accurately predict motor coordination scores from the Beery-Buktenica Developmental Test of Visual-Motor Integration.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Psychology, Clinical
Lisa Dinkler, Elin Hedlund, Cynthia M. Bulik
Summary: The self-reported knowledge and confidence of Swedish clinicians from various disciplines in diagnosing and treating avoidant restrictive food intake disorder (ARFID) is generally low. Although most participants gave correct responses to three basic knowledge-based items about ARFID, the majority reported never having received education about ARFID and few reported feeling confident in their ability to diagnose and treat ARFID. Nearly half the sample either did not know which ARFID treatments their unit offered or reported no treatment being offered. This highlights the pressing need for resources, clearer organization and structure, and additional education and training opportunities for clinicians encountering individuals with ARFID.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Article
Pediatrics
Kahoko Yasumitsu-Lovell, Lucy Thompson, Elisabeth Fernell, Masamitsu Eitoku, Narufurmi Suganuma, Christopher Gillberg, Japan Environm Children's Study Grp
Summary: This study found an association between vitamin D deficiency and neurodevelopmental problems in children, particularly affecting boys. The results for girls were inconclusive.
Meeting Abstract
Hematology
Soheir Beshara, Nickolaus Fotiadis, Mikael Sundin
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Clinical Neurology
Rajna Knez, Dejan Stevanovic, Elisabeth Fernell, Christopher Gillberg
Summary: ESSENCE is an umbrella term covering a wide range of neurodevelopmental difficulties and disorders. This article suggests that dysfunction of the orexin/hypocretin system (Orx-S) may have an important role in various neurodevelopmental symptom domains in ESSENCE, such as arousal, sleep, mood regulation, attention, and sociability. Further research is needed to explore the involvement of Orx-S in ESSENCE.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Meeting Abstract
Behavioral Sciences
Lisa Dinkler, Paul Lichtenstein, Sebastian Lundstrom, Henrik Larsson, Nadia Micali, Mark Taylor, Cynthia Bulik
Article
Clinical Neurology
Valdemar Landgren, Leif Svensson, Rajna Knez, Michail Theodosiou, Christopher Gillberg, Elisabeth Fernell, Magnus Landgren, Mats Johnson
Summary: This study examines the prevalence of parent-rated developmental concerns using the ESSENCE-Q in 11-year-old children, and suggests that it may be an acceptable instrument for screening neurodevelopmental problems in middle school students, optimally in combination with other methods.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)