Journal
ELECTROCHIMICA ACTA
Volume 211, Issue -, Pages 611-618Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2016.06.079
Keywords
Nanopore; Atomic Layer Deposition; protein sensor; current rectification
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Funding
- French government
- European Institute of Membrane [PS2-2014]
- GANIL (Caen, France) in the framework of an EMIR project [P-973-M]
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Single nanopore technology permits to design a biosensor, able to detect proteins without the use of specific probe. In this work, we have fashioned cylindrical nanopore by track-etched technique and atomic layer deposition. The nanopore was then decorated by the asymmetric tethering of biotin. From the rectification of the I-V response induced by the asymmetry of the nanopore, we demonstrate the potentiality of this strategy to detect and to discriminate avidin and streptavidin with respect to their global charge. Based on the nanopore decorated with avidin and streptavidin, we show the possible detection layer by layer of biotinylated protein (IgG and BSA) as well as antibody. (C) 2016 Elsevier Ltd. All rights reserved.
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