Article
Biotechnology & Applied Microbiology
Yiyang Cong, Bo Sun, Jianlun Hu, Xiaoyang Li, Yanan Wang, Jingyi Zhang, Dongzhi Yang, Weifei Lu, Zhi Ding, Xiaofeng Wang, Hao Hong
Summary: This study developed a metal-organic framework nanoplatform that can produce carbon monoxide in a controllable manner and adjust tumor microenvironment during cancer therapy, providing a new therapeutic strategy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Ningning Song, Bo Li, Dandan Li, Yunwen Yan
Summary: In this study, a Zr-based metal-organic framework (MOF) modified with hyaluronic acid (HA) was developed for two-photon activated photodynamic therapy (PDT) in triple negative breast cancer (TNBC). The composite ZrTc@HA exhibited significant two-photon activity and excellent light-triggered reactive oxygen species generation ability. It can serve as a diagnostic probe for fluorescence imaging and a therapeutic agent for PDT, showing great potential for monotherapy and synergistic phototherapy in TNBC.
Article
Engineering, Biomedical
Wenyu Chen, Huixin He, Pengfei Jiao, Lefei Han, Jianchun Li, Xiu Wang, Xuliang Guo
Summary: A triple-responsive metal-organic framework is designed to release photosensitizers under low oxygen, reactive oxygen species, and low pH conditions, enhancing the efficacy of photodynamic therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Bin Zhao, Zhili Ma, Shuaishuai Ding, Yuhua Cao, Jiangfeng Du, Lijuan Zeng, Yunping Hu, Jingrong Zhou, Xiao Zhang, Xiu-wu Bian, Gan Tian
Summary: Nanomedicine-based synergy of chemodynamic therapy (CDT) and radiotherapy (RT) modulated by tumor microenvironment enables rapid tumor ablation, which holds great hope for the refractory and recurrent cancers, such as triple negative breast cancer (TNBC). The single-component MnWO4 is first reported as a new kind of Fenton-like agent yet radiosensitizer for TNBC treatment undergoing the synergistic CDT/RT mechanism. Mn-triggered chemodynamic effect delays RT-induced DNA damage repair and sorts cell cycles distribution toward radiosensitive phases, while W-mediated radiosensitization improves the tumoral H2O2 overexpression to enhance CDT, remarkably amplifying of the intracellular oxidative stress to boost 4T1 cell apoptosis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Jiangsheng Li, Zhu You, Shiyi Zhai, Junxuan Zhao, Kuangda Lu
Summary: In this study, a multifunctional nanosystem was developed for radiodynamic therapy (RDT) and chemodynamic therapy (CDT), which could efficiently generate reactive oxygen species and center dot OH upon X-ray irradiation and achieve strong anticancer efficacy. The nanosystem could successfully treat radioresistant tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Han Bi Ji, Cho Rim Kim, Chang Hee Min, Jae Hoon Han, Se-Na Kim, Cheol Lee, Young Bin Choy
Summary: Chemodynamic therapy (CDT) utilizes Fe-containing metal-organic framework (MOF) NH2-MIL-101(Fe) as a carrier for Cu-chelating agent d-penicillamine (d-pen) and a catalyst for Fenton reaction. NH2-MIL-101(Fe)/d-pen entered cancer cells and released d-pen in a sustained manner. The released d-pen chelated Cu in cancer environments, producing extra H2O2, which was decomposed by Fe in NH2-MIL-101(Fe) to generate cytotoxic *OH. A combination of NH2-MIL-101(Fe)/d-pen and NH2-MIL-101(Fe) loaded with chemotherapeutic drug CPT-11 showed the most prominent anticancer effects in vivo.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Physical
Jintao Fu, Yixian Zhou, Ting Liu, Wenhao Wang, Yiting Zhao, Ying Sun, Yiming Zhang, Wenxuan Qin, Zhongwei Chen, Chao Lu, Guilan Quan, Chuanbin Wu, Xin Pan
Summary: The rapid evolution of bacterial resistance has outpaced the development of new antibiotics, making chemodynamic therapy a promising alternative. In this study, antibacterial nanoreactors were constructed using zeolitic imidazolate framework-8 nanoparticles coated with a metal polyphenol network. These nanoreactors overcame pH and H2O2 limitations, generating hyperthermia and achieving high-efficiency sterilization. Furthermore, the nanoreactors combined chemodynamic therapy with photothermal therapy and photodynamic therapy, enhancing bactericidal efficiency and addressing antibiotic resistance.
Article
Chemistry, Physical
Jintao Fu, Yixian Zhou, Ting Liu, Wenhao Wang, Yiting Zhao, Ying Sun, Yiming Zhang, Wenxuan Qin, Zhongwei Chen, Chao Lu, Guilan Quan, Chuanbin Wu, Xin Pan
Summary: The research team constructed antibacterial nanoreactors that achieved efficient sterilization by overcoming the limitations of pH and H2O2, and combined photothermal therapy and photodynamic therapy to enhance bactericidal efficiency and broaden the antibacterial spectrum, alleviating antibiotic resistance issues.
Article
Nanoscience & Nanotechnology
Liyan Ming, Liang Song, Jixuan Xu, Ruoping Wang, Junpeng Shi, Min Chen, Yun Zhang
Summary: This study developed a smart manganese dioxide-based lanthanide nanoprobe therapeutic nanoplatform for tumor imaging and precise gene therapy in TNBC, combined with chemodynamic therapy. The nanoplatform exhibited high siRNA delivery efficiency and GSH-responsive precise siRNA releasing ability, with enhanced CDT effect due to GSH depletion, showing excellent NIR-II precise tumor imaging therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Xiaoyan Liang, Min Mu, Bo Chen, Rangrang Fan, Haifeng Chen, Bingwen Zou, Bo Han, Gang Guo
Summary: The study explored the treatment of triple-negative breast cancer (TNBC) using a combination of photodynamic therapy (PDT) and immunotherapy with the help of metal-organic frameworks (MOFs) loaded with PD-L1 inhibitors. The results showed that this treatment strategy effectively inhibited tumor growth and prevented metastasis by promoting immune cell activation and reshaping the tumor immune microenvironment.
BIOMATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Mengyao Chen, Jingxian Yang, Lulu Zhou, Xiaochun Hu, Chunhui Wang, Keke Chai, Ruihao Li, Lei Feng, Yanting Sun, Chunyan Dong, Shuo Shi
Summary: The study presents a smart pH/ROS-responsive nanoplatform Fe2+@UCM-BBD for tumor combination therapy, which exhibits excellent capability of inducing tumor apoptosis through DNA damage, promoting H2O2 production for CDT, and achieving CDT through ROS-responsive mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Lulu Zhou, Jinjin Chen, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang, Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li, Tianming Yao, Hui Li, Chunyan Dong, Shuo Shi
Summary: The self-amplified nanocatalytic system (ZIF67/Ola/Lapa) effectively delivers the PARP inhibitor and NQO1-bioactivatable drug, offering a new paradigm for tumor-specific self-amplified chemodynamic therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Hongliu Yu, Panpan Si, Wenwen Lu, Bing Wang, Junkuo Gao, Wenxin Lin, Quan Hu
Summary: The core-shell MOF CSMnP with enzyme-like activity was designed and synthesized for chemodynamic therapy and promotion of catalytic processes in the tumor microenvironment. The loading capacity of the MOF for the cationic drug DOX was significantly higher than that of Mn(III)-PBC, and the release of DOX showed a characteristic response. It has potential applications for tumor combination therapy.
INORGANIC CHEMISTRY
(2023)
Article
Biophysics
Zhaoyu Han, Yue Qian, Xiyue Gao, Dutao Yang, Yanfei Cai, Yun Chen, Jian Jin, Zhaoqi Yang
Summary: In recent years, laser-mediated photodynamic therapy and photothermal therapy have received significant attention due to their minimally invasive characteristics and high specificity. However, traditional photodynamic or photothermal therapy has certain limitations such as the hypoxic microenvironment and complex operation. This study developed a drug delivery system using covalent organic framework (COF) as a carrier for the photosensitizer indocyanine green (ICG) and the hypoxia-activating prodrug AQ4N, with hyaluronic acid (HA) modified on the surface of COF. The HA-COF@ICG/AQ4N system can target tumor cells through recognizing CD44, which is overexpressed in the surface of tumor cells membrane. Under the irradiation of a single NIR laser, the nanoplatform simultaneously produces a combined effect of photodynamic and photothermal, enhancing the antitumor effect.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Xinshuo Zhao, Xiaojun He, Aidi Hou, Chunhua Cheng, Xingnan Wang, Yuanjing Yue, Zhikang Wu, Haixia Wu, Baozhong Liu, Hai Li, Jianliang Shen, Chaoliang Tan, Zhan Zhou, Lufang Ma
Summary: This study demonstrates the growth of Cu2O nanoparticles on 2D Zr-ferrocene-MOF nanosheets to prepare 2D composites for photothermally enhanced chemodynamic antibacterial therapy. The Cu2O/Zr-Fc-MOF composite shows higher chemodynamic activity than the pristine Zr-Fc-MOF nanosheets, and this activity can be further enhanced by NIR laser irradiation.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chi Yao, Hedong Qi, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang
Summary: The study demonstrates a DNA nanocomplex containing cascade DNAzymes and promoter-like Zn-Mn-Ferrite (ZMF) for combined gene/chemo-dynamic therapy inside cells. By releasing metal ions, the ZMF decomposed in response to glutathione, promoting sequential DNA/RNA cleavage and free radical generation, leading to efficient chemo-dynamic therapy. The administration of this DNA nanocomplex in a breast cancer mouse model resulted in significant therapeutic efficacy in suppressing tumor growth.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Xiaohui Ding, Zhaoyue Lv, Nuo Xu, Feng Li, Dayong Yang
Summary: DNA nanostructures that respond to intracellular signals have potential applications as artificial functional structures in living cells. This review summarizes and discusses the development and dynamic transformation properties of these DNA nanostructures. Challenges and prospects in instructing dynamic DNA nanostructures in living cells are also discussed.
Editorial Material
Chemistry, Physical
Dayong Yang
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Pin Hu, Yuhang Dong, Chi Yao, Dayong Yang
Summary: This review focuses on the construction of branched DNA-based nanostructures for biological and biomedical applications. It discusses the molecular design, synthesis methods, and construction strategies. The review provides guidance for the further development of branched DNA-based nanomaterials in the field of biomedicine.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Feng Li, Yujie Liu, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang
Summary: This study develops a dynamic assembly of DNA tetrahedrons inside cells which mediate K+ and efficiently interfere with mitochondria, leading to a regulation of cell energy metabolism. The developed method significantly inhibits cell migration and holds great potential for biomedical applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Multidisciplinary
Yang Sen, Pan XiaoRui, Tang JianPu, Yao Chi, Yang DaYong
Summary: A luminescent supramolecular hydrogel containing Ln(3+) ions was successfully synthesized by employing coordination and electrostatic interactions with linear single-stranded DNA. The luminescent intensity and color of the hydrogel were finely tuned, and it exhibited reversible luminescent stimulation response. This study enriches the strategies of constructing DNA hydrogels and promotes the development of stimuli-responsive supramolecular materials.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Qingyi Han, Dingding Zhang, Rui Zhang, Jianpu Tang, Keying Xu, Mingzheng Shao, Yuyan Li, Peiyao Du, Ruizhong Zhang, Dayong Yang, Libing Zhang, Xiaoquan Lu
Summary: A DNA-functionalized metal-organic framework (MOF)-based ratiometric fluorescent probe was developed for sensitive detection and imaging of miRNA-21 in living cells. The probe achieved picomolar limit detection without signal amplification and allowed imaging of intracellular miRNA-21 through strand-displacement reaction, enabling discrimination between cancer cells and normal cells. This work presents a new approach for intracellular molecular analysis and has significant implications for early disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Shuai Li, Feng Li, Yuhang Dong, Nachuan Song, Li Pan, Dayong Yang
Summary: Carbon dots synthesized from ribonucleosides can mimic artificial enzymes and regulate the structure and oxidative cleavage of DNA.
Review
Chemistry, Multidisciplinary
Chi Yao, Junhan Ou, Jianpu Tang, Dayong Yang
Summary: Facing the increasing demand for precision medicine, materials chemistry systems with accurate molecular design, controllable structure, and adjustable biological activity are required for bioanalysis. In recent years, DNA has been considered a potential biomaterial for analysis and has been applied in various fields. DNA supramolecular assembly on micro/nanointerfaces is an effective strategy to concentrate functional DNA modules and enhance their functions in bioanalysis. This research direction is expected to guide the construction of more bioanalytical materials and promote the development of precision medicine.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Materials Science, Biomaterials
Gang Shu, Huaixin Zhao, Xuening Zhang
Summary: Molecular imaging-guided therapy is essential for precise cancer intervention, but designing an imaging platform for autofluorescence-free dual-modal imaging-guided drug delivery remains a challenge. In this study, a persistent luminescent metal-organic framework (PLNPs@MIL-100(Fe)) was prepared for dual-modal imaging-guided drug delivery. The PLNPs@MIL-100(Fe) exhibited near-infrared persistent luminescence and T-2-weighted signal, enabling precise in vivo dual-modal imaging of tumor-bearing mice. The porous MIL-100(Fe) shell provided high drug loading capacity and acid-triggered drug release for drug delivery.
BIOMATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Fengqin Li, Junru Li, Weiqiang Yang, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang, Xiaolei Zuo, Peifeng Liu
Summary: The trans-cleavage property of CRISPR-Cas12a system is utilized for disease diagnosis. The effect of different local densities of Framework-Hotspot reporters (FHRs) on the cleavage activity of Cas12a is investigated. A modular sensing platform is constructed with target recognition by CRISPR-Cas12a and signal transduction by FHR. This platform enables sensitive and rapid detection of pathogen nucleic acids and tumor protein markers without pre-amplification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Analytical
Jiawen Li, Franco Centurion, Rouyan Chen, Zi Gu
Summary: Atherosclerosis is a major cause of disease and death, often leading to myocardial infarction, stroke, or sudden death. Various imaging techniques, including the use of nanoparticles, have been developed to accurately detect high-risk atherosclerotic plaques inside blood vessels. Nanoparticles not only enhance image contrast, but also provide therapeutic functions for atherosclerosis.
Article
Multidisciplinary Sciences
Jianpu Tang, Xuemei Jia, Qian Li, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang, Chi Yao
Summary: In this study, a DNA-based hydrogel was developed for the specific and nondestructive separation of exosomes from complex biological media. The separated exosomes were used for breast cancer detection and the therapeutics of myocardial infarction. The DNA hydrogel showed promising potential in the classification of breast cancer patients and the repair of infarcted myocardium in rat models.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Materials Science, Biomaterials
Yuwei Xu, Zhaoyue Lv, Chi Yao, Dayong Yang
Summary: DNA-based materials have great potential in biomedical applications due to their programmability and designability. Rolling circle amplification (RCA) is a highly efficient enzymatic amplification strategy that produces long single-stranded DNA with customized functional groups. The rational design of templates and introduction of other functional components enable the production of RCA-based DNA materials with dynamic responsiveness and diverse biological functions, facilitating their use in biomedical applications.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chi Yao, Yuwei Xu, Pin Hu, Junhan Ou, Dayong Yang
Summary: Developing a new system of material chemistry is crucial for the design and preparation of functional materials, with DNA molecules serving as bioactive macromolecules that can encode genetic information and act as building blocks. The precise control of DNA assembly behaviors and topological structures is essential for constructing a wider variety of functional DNA materials following a gene-like paradigm. This work aims to promote the development of materials genome by exemplifying the gene-like precise construction of functional materials.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
