Article
Chemistry, Analytical
Li Xiong, Long Yu, Shuo Li, Lixiang Feng, Yuxiu Xiao
Summary: A turn-on/off ratiometric fluorescence detection platform using multifunctional Ln-MOF and an enzymatic cascade reaction has been proposed for alkaline phosphatase (ALP) activity assay. The method showed good linear relationship and low detection limit, with successful application in human serum samples for monitoring ALP activity.
Article
Chemistry, Physical
Huifang Wu, Shiying Ju, Yuwei Ling, Haozhe Sun, Yanfeng Tang, Changlun Tong
Summary: This study successfully synthesized four gelatinous Ln(3+) coordination polymers by self-assembly of ciprofloxacin, adenosine monophosphate, and Ln(3+) ions in water medium. It was found that the characteristic fluorescence of Ln(3+) significantly increased and the concentration of ciprofloxacin decreased with the increasing concentration of Ln-CPs, which was attributed to the aggregation-enhanced antenna effect due to the large aggregates formed by self-assembly.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Food Science & Technology
Shixiang Wu, Xingping Zhang, Wang Chen, Guohao Zhang, Qian Zhang, Hualin Yang, Yu Zhou
Summary: Inspired by the strong binding capacity of pyrophosphate (ppi) and copper ion (Cu2+), a ratiometric fluorescence immunoassay triggered by alkaline phosphatase (ALP) was developed for the detection of zearalenone (ZEN). This method exhibited high accuracy and reliability, with a limit of detection (LOD) of 0.014 ng/mL and a linear detection range of 3.51-17.78 ng/mL. It provides a new approach for efficient and accurate detection of ZEN.
Article
Chemistry, Analytical
Ruihong Yao, Zhijian Li, Gang Liu, Congbin Fan, Shouzhi Pu
Summary: A ratiometric fluorometric method based on luminol-Europium complex was developed for the detection of tetracycline, showing quenching of fluorescence at 453 nm due to inner filter effect in the presence of TC and observation of Eu3+ emission peak at 626 nm thanks to antenna effect. This strategy is fast, sensitive, and visual for TC detection, allowing for detection from 0.5 to 80 mu M with a detection limit of 39 nM, and demonstrating color change from blue to red in real samples using luminol-Eu-based test paper under 365 nm ultraviolet light.
Article
Chemistry, Analytical
Luxuan Yao, Shan He, Yiyu Chen, Huiting Lian, Bin Liu, Chengcai Lai, Xiaofeng Wei
Summary: Abnormal expression of alkaline phosphatase (ALP) in serum is important for health monitoring and disease diagnosis. A ratiometric approach using a carbon dot/cobalt-metal organic framework nanocoral mediated fluorescence-scattering sensor has been developed for simple and highly sensitive detection of ALP. The sensor effectively converted ALP into a ratio signal of fluorescence-scattering dual emission with a wide linear range of detection and improved sensitivity in serum.
Article
Chemistry, Analytical
Sameera Sh Mohammed Ameen, Nidhal M. Sher Mohammed, Khalid M. Omer
Summary: In this study, ultra-small and highly fluorescent zinc-based metal-organic frameworks (FMOF-5) were synthesized, which have the characteristics of stability, low cost, and robustness, making them highly desirable in bioanalytical applications. By selectively tuning the emission color and enhancing the fluorescence intensity of FMOF-5 through aggregation induced emission (AIE), tetracycline (TC) was successfully detected with high sensitivity. The integration of a smartphone and a visual platform enabled quantitative point-of-care testing. The results of this study have promising implications for practical applications.
Article
Chemistry, Analytical
Jie-Yu Yue, Li-Ping Song, Xiu-Li Ding, Peng Yang, Yu Ma, Bo Tang
Summary: By employing a multivariate strategy, this study synthesized a series of novel three-component covalent organic frameworks (COF-COOHX) and achieved ratiometric pH detection performance with selectivity and repeatability. The fluorescent properties, linear pH responsive ranges, and pKa values of the COF-COOHX were regulated by tuning the molar ratio of the components. Additionally, the constructed sensors exhibited satisfactory results in pH detection in drug solutions and carbonated drinks.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuanjin Zhan, Shuangting Yang, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo, Wei Xu
Summary: A ratiometric fluorescence sensor based on FRET strategy was developed for detecting ALP activity and its inhibitor Na3VO4. The sensor showed high FRET efficiency, ratiometric change in fluorescence intensity, and dual-emission self-correction ability, enabling quantitative detection and visual analysis of ALP activity. This biosensor provides a promising alternative for evaluating ALP-related diseases and can also be utilized for assessing Cu2+, PPi, and Na3VO4 levels, as well as screening ALP inhibitors.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Spectroscopy
Yu Ding, Tianxia Lin, Jiwei Shen, Yinmao Wei, Chaozhan Wang
Summary: In this study, a reaction-based ratiometric fluorescence assay was proposed for the detection of alkaline phosphatase (ALP). The method demonstrated high sensitivity, good selectivity, cost efficiency, and easy operation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Yanyun Cui, Jun Zhao, Huidan Li
Summary: In this study, a label-free composite nanoprobe was constructed by combining inorganic nanomaterials and aggregation-induced emission (AIE) molecule for highly sensitive and selective detection of alkaline phosphatase (ALP). The proposed method is simple, low-cost, and overcomes the quenching effect caused by the aggregation of traditional organic dyes.
Article
Chemistry, Applied
Ling Dai, Weilin Mao, Lianzhe Hu, Jiaxing Song, Yan Zhang, Ting Huang, Min Wang
Summary: This study proposes a bifunctional material with aggregation induced emission (AIE) character and catalytic activity by integrating Zr(IV) ions and tetraphenyl ethylene (TPE) derivatives. The TPE-Zr4+ aggregates exhibit typical AIE effect and retain the phosphatase-like catalytic activity of Zr4+ ions, with high sensitivity to pH values. This material shows promise for ratiometric pH sensing and intracellular imaging.
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jialin Wen, Yuxuan Hu, Na Li, Dan Li, Guangfan Zheng, Yongjian Zou, Minmin Zhang, Lingling Shui
Summary: In this study, a novel ratiometric fluorescent probe based on in situ fluorogenic reaction was developed for alkaline phosphatase (ALP) activity sensing. The probe showed high sensitivity for ALP activity with a detection limit of 0.08 U/L.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Di Shen, Wenhan Jin, Yulong Bai, Yanan Huang, Haochen Lyu, Lianggang Zeng, Mengdie Wang, Yuqi Tang, Wang Wan, Xuepeng Dong, Zhenming Gao, Hai-Long Piao, Xiaojing Liu, Yu Liu
Summary: This study developed sensors for amorphous protein aggregation from aggregation-induced-emission probes (AIEgens) with controllable sensitivity, spectral coverage, and cellular performance through rational design.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Jasvir Kaur, Prabhat K. Singh
Summary: The study introduced a fluorescence turn-on probing system for monitoring ALP activity by utilizing the unique phenomenon of aggregation induced emission (AIE), demonstrating rapid, easy, sensitive and highly selective detection. The sensor showed remarkable specificity for ALP and successfully displayed potential application in human serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Xiong, Yingting Zeng, Tian Gan, Feifei Yan, Jiao Bai, Yanbin Shi, Xiaoyue Zhou, Yu Wu, Xiaochun Zhang
Summary: This study demonstrates that coronary computed tomographic angiography (CCTA) has high accuracy and reproducibility in assessing patent foramen ovale (PFO) compared to transesophageal echocardiography (TEE). CCTA could be a practical and efficient alternative to TEE for PFO diagnosis.
JAPANESE JOURNAL OF RADIOLOGY
(2022)
Article
Chemistry, Analytical
Yanhan Li, Lian Zou, Li Xiong, Fen Yu, Hao Jiang, Cien Fan, Mofan Cheng, Qi Li
Summary: This paper proposes a novel deep learning network FRDD-Net with feature remapping modules and a new dense decoding mechanism for automatic carotid plaque segmentation, while also introducing a compound loss function to enhance the network's robustness. The proposed architecture shows superior performance compared to other state-of-the-art methods in multiple carotid plaque ultrasound datasets.
Article
Clinical Neurology
Zhe Huang, Xue-Qing Cheng, Hong-Yun Liu, Xiao-Jun Bi, Ya-Ni Liu, Wen-Zhi Lv, Li Xiong, You-Bin Deng
Summary: By utilizing ultrasonography and clinical features, a nomogram was developed to identify symptomatic carotid plaques, demonstrating higher diagnostic performance compared to traditional clinical and conventional ultrasound models through analysis and evaluation of data.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Chemistry, Analytical
Shuo Li, Long Yu, Li Xiong, Yuxiu Xiao
Summary: The study introduced a novel method for detecting GCU activity using both fluorescence and chromaticity signals. This method allows for sensitive detection of GCU activity and can aid in early disease diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Long Yu, Qutong Zheng, Li Xiong, Lixiang Feng, Yuxiu Xiao
Summary: A rapid and sensitive sensor for decoding organic solvents and detecting water content is developed. The sensor is based on a dual-lanthanide metal-organic framework and utilizes innovative response mechanisms to precisely regulate the energy transfer. The sensor achieves ultra-low limit of detection, broad response range, and high-fluorescence color changing. A logic device based on the sensor is designed for easy water detection, similar to a smart traffic light sensor. Additionally, a paper microsensor is constructed for real-time detection of trace water in organic solvents.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Long Yu, Zhanheng Gao, Qi Xu, Xiangyu Pan, Yuxiu Xiao
Summary: A dual-response biosensor for sensitive detection of TYR monophenolase activity was proposed by integrating fluorescent polymer dots and a luminescent lanthanide metal-organic framework. The sensor achieves sensitive and selective detection of TYR monophenolase activity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Environmental
Long Yu, Lixiang Feng, Li Xiong, Shuo Li, Shuo Wang, Zhongyu Wei, Yuxiu Xiao
Summary: This study established a dual-emission Ln-MOF fluorescent sensor based on single-functionalized ligands single-Ln(3+) for the detection of dipicolinic acid (DPA) and proposed a new sensing mechanism and a triple gates selectivity mechanism towards DPA. Through prediction models and experimental verification, Tb-PTA-OH was determined to be a highly sensitive and specific sensor for DPA detection.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Analytical
Shuo Li, Zhongyu Wei, Li Xiong, Qi Xu, Long Yu, Yuxiu Xiao
Summary: A dual-mode assay method combining fluorescence and photothermal was developed to detect AChE activity. Utilizing metal-organic frameworks and o-phenylenediamine cascade polymers, the method accurately measures AChE activity in human serum.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Long Yu, Lixiang Feng, Zhongyu Wei, Shuo Wang, Yumin Feng, Yongjin Shen, Junlong Cai, Jianyuan Wu, Yuxiu Xiao
Summary: A modular fluorescent artificial receptor design strategy based on multiple parameters programming engineering is proposed for highly selective and sensitive detection of neurotransmitters. The artificial receptor based on lanthanide metal-organic frameworks (Ln-MOFs) can selectively recognize dopamine with a low limit of detection. Ln-MOFs have the potential for label-free detection, imaging and diagnosis, providing new solutions to personalized medicine.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Analytical
Zhongyu Wei, Shuo Wang, Qi Xu, Shuo Li, Long Yu, Yuxiu Xiao
Summary: Researchers have developed a biomimetic integrated three-step workflow, named MIDAS, for the detection of haloacetic acids in aqueous samples. This system allows for rapid, ultrasensitive, and accurate quantification of specific haloacetic acids, as well as the discrimination of mixed haloacetic acids on site.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Shuo Wang, Zhongyu Wei, Long Yu, Jinxuan Hou, Gaosong Wu, Yuxiu Xiao
Summary: In this study, we successfully synthesized double-side SiO2-coated CsPbX3 nanoparticles, which exhibited high water stability, fast anion exchange activity and significantly enhanced fluorescence properties. These nanoparticles were used to construct a multicolor sensing platform for small molecule metabolites, and were applied for uric acid detection in serum, showing consistent results with the commercial method.
CHEMICAL ENGINEERING JOURNAL
(2023)
