Review
Immunology
Jia Shi, Cheng Cai
Summary: Immunometabolism, particularly the role of itaconate and its derivatives, plays a crucial role in regulating macrophage immune metabolism.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Adil Rasheed, Katey J. Rayner
Summary: Macrophages are a heterogeneous population involved in tissue immunity, with their metabolism and environment-dependent identities regulating their response to external stimuli. The establishment of immunometabolism as a research field has highlighted the interaction between altered metabolism and cellular immunity, with macrophages playing a crucial role in disease progression through immune responses influenced by metabolic changes.
Review
Immunology
Jiaqi Li, Yanjin Wang, Hao Deng, Su Li, Hua-Ji Qiu
Summary: Cellular metabolism plays a crucial role in regulating immune responses, including both innate and adaptive immunity. Viral infections induce metabolic reprogramming, which affects immune cell function, immune molecule expression, and cell fate. It is vital to explore effector molecules involved in immunometabolism, such as metabolites, metabolic enzymes, and other related molecules, for the development of antiviral drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Santiago Mansilla, Veronica Tortora, Florencia Pignataro, Santiago Sastre, Ignacio Castro, Ma. Laura Chiribao, Carlos Robello, Ari Zeida, Javier Santos, Laura Castro
Summary: Mitochondrial aconitase (ACO2) is a redox sensor in the tricarboxylic acid cycle, sensitive to reactive oxygen and nitrogen species due to its labile [4Fe-4S](2+) prosthetic group. It has been implicated in aging and pathologies related to mitochondrial dysfunction. Recombinant human ACO2 was expressed and characterized, showing high yield and determining kinetic parameters. ACO2 reacts with various reactive species with different rate constants, and its thermal stability is lower upon cluster oxidation. It was confirmed that frataxin (FXN) can reactivate [3Fe-4S](+)-ACO2 and directly interact with iron. Molecular dynamics simulations revealed differences in protein dynamics based on the Fe-S cluster redox state.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemical Research Methods
Dylan G. Ryan, Christian Frezza, Luke A. J. O'Neill
Summary: The origin of eukaryotic cell complexity is believed to have emerged from the symbiosis between a proteobacterium and an archaeal host, with contributions from the mitochondrial genome and archaeal histones. Evolutionary communication between the host and symbiont remains unclear, while mitochondrial TCA cycle signaling is proposed to play a crucial role in controlling genome expansion. TCA cycle remodeling serves as an evolutionary strategy for eukaryotic organisms to coordinate stress responses and gene expression, with itaconate as a focus.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liang Han, Jing Zhou, Zhuozhou Hu, Chenggong Fu, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Tongyu Wu, Chun Li, Jia Kang, Jiazhong Li, Xinping Chen
Summary: Lamivudine can significantly decrease serum alcohol concentration, accelerate acetaldehyde metabolism, improve symptoms post drinking, and reduce the death rate.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Olivier Diaz, Pierre-Olivier Vidalain, Christophe Ramiere, Vincent Lotteau, Laure Perrin-Cocon
Summary: Hepatitis viruses actively alter cellular metabolism through molecular interactions, which can have a direct impact on the antiviral immune response. The complex interactions between viral components, innate immunity, and hepatocyte metabolism may explain the progression of chronic hepatitis infections to liver inflammation, fibrosis, and hepatocellular carcinoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafael Franco, Joan Serrano-Marin
Summary: The Krebs cycle in cells plays a crucial role in both energy production and anabolic processes. This study compares closed and linear metabolism and finds that the closed cycle can reach a steady state regardless of disturbances, unlike the linear metabolism. Modeling the cycle in different conditions, including cancer, reveals that reductions in flux are limited, suggesting the presence of an undiscovered regulation mechanism. The findings have important implications for evaluating metabolism-modifying medicines.
Review
Biochemistry & Molecular Biology
Junichi Fujii, Tsukasa Osaki
Summary: When NOS2 expression is induced in M1-polarized macrophages, large amounts of nitric oxide (center dot NO) are produced, which can lead to both inflammation aggravation and elimination of radical-mediated damage. The reaction of center dot NO with superoxide can be toxic, but it can also terminate radical chain reactions and suppress ferroptosis. center dot NO is involved in metabolic remodeling and regulates the defense systems in M1 macrophages.
Article
Engineering, Environmental
Xiang Wu, Huijie Hou, Yao Liu, Shanshan Yin, Shijie Bian, Sha Liang, Chaofan Wan, Shushan Yuan, Keke Xiao, Bingchuan Liu, Jingping Hu, Jiakuan Yang
Summary: The stress response of rice under microplastic exposure involves adjustments in gene expression and metabolic pathways, with distinct responses observed in different rice subspecies. XS123 subspecies can respond to microplastic exposure stress through enhanced metabolite accumulation and energy expenditure pathways, while Y900 subspecies cannot.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana I. Sandlers
Summary: This study investigated the metabolic effects of dodecanedioic acid supplementation on Krebs cycle intermediates, glucose uptake, and acylcarnitine profiles in VLCAD-deficient fibroblasts. The findings suggest that dodecanedioic acid supplementation replenishes the Krebs cycle by increasing the succinate pool, attenuates glycolytic flux, and reduces levels of toxic very long-chain acylcarnitines.
Article
Cell Biology
Mette Trauelsen, Thomas K. Hiron, Da Lin, Jacob E. Petersen, Billy Breton, Anna Sofie Husted, Siv A. Hjorth, Asuka Inoue, Thomas M. Frimurer, Michel Bouvier, Chris A. O'Callaghan, Thue W. Schwartz
Summary: The study identifies that succinate regulates transcription of immune function genes by activating Gq signaling, affecting the phenotype of macrophages M2 and M1. This indicates that SUCNR1 acts as a transcriptional regulator in macrophages.
Review
Medicine, Research & Experimental
Di Wang, Zhenyu Tian, Peng Zhang, Lv Zhen, Qingju Meng, Benteng Sun, Xingli Xu, Tong Jia, Shengqiang Li
Summary: Recently, cuproptosis, a new form of cell death dependent on copper and mitochondrial respiration, has been discovered. It differs from other well-known cell death modes like apoptosis, necrosis, pyroptosis, and ferroptosis. Excessive copper induces cuproptosis by interfering with the tricarboxylic acid cycle and reducing iron-sulfur cluster protein levels. Disturbances to copper homeostasis lead to cuproptosis. Cuproptosis has been found to play a significant role in cardiovascular diseases such as myocardial ischemia/reperfusion injury, heart failure, atherosclerosis, and arrhythmias. Inhibiting cuproptosis through copper chelators and oxidative phosphorylation inhibitors may be a potential treatment for these diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yardena Silas, Esti Singer, Koyeli Das, Norbert Lehming, Ophry Pines
Summary: Class-II fumarases are dual-targeted enzymes found in the mitochondria and cytosol of all eukaryotes, playing a crucial role in protecting cells from DNA double-strand breaks. The gram-positive bacterium Bacillus subtilis' Class-II fumarase participates in both the tricarboxylic acid cycle and DNA damage response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agronomy
Miao Wang, Canying Li, Jiaqi Liu, Shuran Zhang, Yan Guo, Yueruxin Jin, Yonghong Ge
Summary: Quality breakdown caused by high respiration, evaporation, and pigment degradation affects the storage ability and shelf life of pear fruit. Phenylalanine treatment can enhance the quality indicators and maintain the postharvest quality of pears by inhibiting key gene expression and enzyme activity in the TCA cycle and chlorophyll degradation. These findings suggest that phenylalanine can be a potential inducer to delay yellowing and maintain the postharvest quality of fruit.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jea-Hyun Baek, Rui Zeng, Julia Weinmann-Menke, M. Todd Valerius, Yukihiro Wada, Amrendra K. Ajay, Marco Colonna, Vicki R. Kelley
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Review
Cell Biology
Thomas Hieronymus, Martin Zenke, Jea-Hyun Baek, Kristin Sere
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2015)
Article
Pathology
Jea-Hyun Baek, Ivan G. Gomez, Yukihiro Wada, Allie Roach, Don Mahad, Jeremy S. Duffield
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Immunology
Kristin Sere, Jea-Hyun Baek, Julia Ober-Bloebaum, Gerhard Mueller-Newen, Frank Tacke, Yoshifumi Yokota, Martin Zenke, Thomas Hieronymus
Article
Immunology
Jea-Hyun Baek, Carmen Birchmeier, Martin Zenke, Thomas Hieronymus
JOURNAL OF IMMUNOLOGY
(2012)
Review
Physiology
Jea-Hyun Baek
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Environmental Sciences
Woo Seok Byun, Sin Woo Heo, Gunhee Jo, Jae Won Kim, Sarang Kim, Sujie Lee, Hye Eun Park, Jea-Hyun Baek
Summary: The COVID-19 pandemic has lasted for over a year, with researchers conducting numerous empirical and epidemiological studies on a global and local scale to explore whether COVID-19 exhibits any seasonal features.
ENVIRONMENTAL RESEARCH
(2021)
Review
Oncology
Sungmin Jung, Jea-Hyun Baek
Summary: TCF1, a transcription factor, is crucial in promoting T cell proliferation and maintaining stemness, especially in CD8(+) T cells. Its regulatory role in CD8(+) T cells is significant, especially in the context of T cell exhaustion linked to tumor and viral escape. The importance of TCF1 in sustaining cytotoxic T lymphocyte (CTL)-mediated immunity against pathogens and tumors, as well as its necessity in effective anti-tumor immune response in immune checkpoint blockade therapy, makes TCF1 a potentially significant biomarker and therapeutic target for overcoming CD8(+) T cell exhaustion and resistance to ICB therapy.
Article
Medicine, Research & Experimental
Hilda Minerva Gonzalez-Sanchez, Jea-Hyun Baek, Julia Weinmann-Menke, Amrendra Kumar Ajay, Julia Forgan-Farnam Charles, Masaharu Noda, Ruth Anne Franklin, Patricia Rodriguez-Morales, Vicki Rubin Kelley
Summary: Myeloid cell mediated mechanisms regulate synovial joint inflammation. IL-34 and PTPRZ limit arthritis by reducing neutrophil recruitment and intra-synovial neutrophil extracellular traps, thereby alleviating synovial and bone erosion. IL-34 and PTPRZ levels are elevated in rheumatoid arthritis patients and correlate with disease activity.
LABORATORY INVESTIGATION
(2022)
Review
Medicine, General & Internal
Hanna Oh, Hye Eun Park, Min Su Song, HaYoung Kim, Jea-Hyun Baek
Summary: Fibrosis is a pathological process characterized by the stiffening of organs or tissues due to increased synthesis of extracellular matrix components. The coagulation cascade has been found to be directly associated with fibrotic development, and anticoagulation therapy has shown potential as a strategy for treating fibrosis in various organs.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Hye Eun Park, Hanna Oh, Jea-Hyun Baek
Summary: Rheumatoid arthritis is a chronic autoimmune disease with a complex etiology. The cytokine IL-34 has gained interest as a potential driver or modulator of RA pathogenesis. However, the significance and role of IL-34 in RA remains unclear.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Hanna Oh, Ohbin Kwon, Min Jung Kong, Kwon Moo Park, Jea-Hyun Baek
Summary: Macrophages play a fundamental role in the development of kidney fibrosis. A recent study has shown that kidney macrophages express coagulation factors, which contribute to fibrosis during acute kidney injury and chronic kidney disease. The upregulation of coagulation factors in macrophages occurs in a Ca2+ -dependent manner. This study provides insights into a novel effector mechanism of macrophages in kidney fibrosis.
FRONTIERS IN MEDICINE
(2023)
Article
Pathology
Jea-Hyun Baek, Gina M. Many, Frances J. Evesson, Vicki R. Kelley
AMERICAN JOURNAL OF PATHOLOGY
(2017)