Article
Critical Care Medicine
Julius J. Grunow, Katja Reiher, Niklas M. Carbon, Lilian Jo Engelhardt, Knut Mai, Susanne Koch, Joerg C. Schefold, Werner Z'Graggen, Stefan J. Schaller, Jens Fielitz, Joachim Spranger, Steffen Weber-Carstens, Tobias Wollersheim
Summary: This study investigated the role of muscular protein myostatin in intensive care unit-acquired weakness (ICUAW). The results showed that myostatin levels were reduced in critically ill patients and were associated with muscle strength and insulin sensitivity. However, therapeutic inhibition of myostatin may not have a pathophysiological rationale to improve muscle quality in critically ill patients.
Article
Nutrition & Dietetics
Liliane Barbosa da Silva Passos, Tulio Augusto Alves Macedo, Daurea Abadia De-Souza
Summary: The study aimed to correlate the nutritional status of critically ill patients with 28-day mortality and establish cut-off values for BIA and USG methods. Results showed that RFM sectional area was an independent predictor of 28-day mortality, and patients with higher phase angle and RFM sectional area had better survival rates.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Maria Antonieta Ballesteros Vizoso, Albert Figueras Castilla, Antonia Barcelo, Joan Maria Raurich, Paula Argente del Castillo, Daniel Morell-Garcia, Julio Velasco, Jon Perez-Barcena, Juan Antonio Llompart-Pou
Summary: By analyzing the thyroid profile in critically ill COVID-19 patients, variables associated with mortality and the predictive ability of mortality were identified. The study found that fT4 on day 5 after ICU admission was associated with in-hospital mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yingying Fang, Chao Xiong, Xinghe Wang
Summary: This study found that early use of ondansetron can reduce in-hospital mortality in ICU patients. The daily low-to-moderate dose of ondansetron has a protective effect against in-hospital mortality, especially in patients with circulatory system diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Nutrition & Dietetics
I. A. Osuna-Padilla, N. C. Rodriguez-Moguel, S. Rodriguez-Llamazares, C. E. Orsso, C. M. Prado, M. A. Rios-Ayala, O. Villanueva-Camacho, A. Aguilar-Vargas, L. E. Pensado-Piedra, F. Juarez-Hernandez, C. M. Hernandez-Cardenas
Summary: This study analyzed the prognostic significance of low muscle mass in critically ill COVID-19 patients using CT scans. The study also compared the accuracy and agreement of diverse markers in identifying low muscle mass compared to CT as the gold standard. The results showed that low muscle mass was associated with prolonged length of ICU and hospital stays, and the bedside markers of muscle mass showed poor accuracy compared to CT assessment.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Chao Ren, Yu-xuan Li, De-meng Xia, Peng-yue Zhao, Sheng-yu Zhu, Li-yu Zheng, Li-ping Liang, Ren-qi Yao, Xiao-hui Du
Summary: The presence of sepsis-associated coagulopathy (SAC) was significantly associated with increased risk of in-hospital death and septic shock among postoperative patients with sepsis admitted to the ICU, but there was no statistical difference of hospital length of stay (LOS) between the SAC and no SAC groups.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Lisa Van Dyck, Fabian Guiza, Inge Derese, Lies Pauwels, Michael P. Casaer, Greet Hermans, Pieter J. Wouters, Greet Van den Berghe, Ilse Vanhorebeek
Summary: This study found that critically ill patients have different DNA methylation signatures in skeletal muscle compared to healthy controls, which may provide a biological basis for the long-term persistence of weakness in ICU survivors.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Beong Ki Kim, Chi Young Kim, Sua Kim, Yu Jin Kim, Seung Heon Lee, Je Hyeong Kim
Summary: This study investigated the association between phosphate concentrations and hospital mortality among patients in the intensive care unit. The results showed that Delta P and Pmean values were significantly associated with hospital mortality, highlighting the importance of maintaining stable phosphate concentrations during hospitalization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Dawei Zhou, Chao Wang, Qing Lin, Tong Li
Summary: This study aimed to evaluate the impact of obesity on long-term mortality outcomes after discharge from ICU. The results showed that higher BMI was associated with lower 4-year mortality rate among survivors, indicating the presence of the obesity paradox.
Article
Infectious Diseases
Le Hu, Ying Zhang, Jia Wang, Jingchao Xuan, Jun Yang, Junyu Wang, Bing Wei
Summary: The novel serum biomarker RBP, in combination with CURB-65 score and BUN levels, serves as a valuable predictor for in-hospital mortality of critically ill pneumonia patients. The combination of these factors has a high accuracy in predicting patient outcomes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Bin Zhou, Liang-Ying Lin, Xiao-Ai Liu, Ye-Sheng Ling, Yuan-Yuan Zhang, An-Qi Luo, Meng-Chun Wu, Ruo-Mi Guo, Hua-Li Chen, Qi Guo
Summary: The study found an association between invasive blood pressure (IBP) monitoring and lower in-hospital mortality in critically ill patients with hypertension in the intensive care unit.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Critical Care Medicine
Giacomo Grasselli, Vittorio Scaravilli, Davide Mangioni, Luigia Scudeller, Laura Alagna, Michele Bartoletti, Giacomo Bellani, Emanuela Biagioni, Paolo Bonfanti, Nicola Bottino, Irene Coloretti, Salvatore Lucio Cutuli, Gennaro De Pascale, Daniela Ferlicca, Gabriele Fior, Andrea Forastieri, Marco Franzetti, Massimiliano Greco, Amedeo Guzzardella, Sara Linguadoca, Marianna Meschiari, Antonio Messina, Gianpaola Monti, Paola Morelli, Antonio Muscatello, Simone Redaelli, Flavia Stefanini, Tommaso Tonetti, Massimo Antonelli, Maurizio Cecconi, Giuseppe Foti, Roberto Fumagalli, Massimo Girardis, Marco Ranieri, Pierluigi Viale, Mario Raviglione, Antonio Pesenti, Andrea Gori, Alessandra Bandera
Summary: Critically ill patients with COVID-19 are at high risk for hospital-acquired infections (HAIs), especially ventilator-associated pneumonia (VAP) and bloodstream infections (BSIs) caused by multidrug-resistant organisms. HAIs prolong mechanical ventilation and hospitalization, and those complicated by septic shock nearly double mortality rate.
Article
Nutrition & Dietetics
Inga Tjader, Maria Klaude, Ali Ait Hssain, Christelle Guillet, Inger Nennesmo, Jan Wernerman, Olav Rooyackers
Summary: There is a large variation in muscle protein synthesis rates in critically ill patients, which is not due to heterogeneity in synthesis rates or infiltrating cells. There are differences in the synthesis rates of different proteins, but these do not explain the larger variations.
Article
Biochemistry & Molecular Biology
Xiangning Bai, Aswathy Narayanan, Magdalena Skagerberg, Rafael Cena-Diez, Christian G. Giske, Kristoffer Stralin, Anders Sonnerborg
Summary: This study reveals correlations between the upper respiratory tract microbiome and clinical outcomes in COVID-19 patients, particularly a strong association between Moraxella lincolnii and vitamin K2 biosynthesis pathways with better clinical results.
Article
Multidisciplinary Sciences
Christopher M. Sauer, Josep Gomez, Manuel Ruiz Botella, David R. Ziehr, William M. Oldham, Giovana Gavidia, Alejandro Rodriguez, Paul Elbers, Armand Girbes, Maria Bodi, Leo Anthony Celi
Summary: The study found that patients with normal serum lactate levels had lower mortality rates compared to those with high levels, despite similar physiologic phenotypes. Future research should confirm these findings and establish the underlying pathophysiological mechanisms.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Nobuto Nakanishi, Rie Tsutsumi, Kanako Hara, Masafumi Matsuo, Hiroshi Sakaue, Jun Oto
Summary: Titin, a giant protein functioning as a molecular spring in sarcomeres, can be used as a biomarker for muscle atrophy and weakness, measurable in urine, aiding in the diagnosis of muscle diseases and monitoring patients' conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Sachiyo Fukushima, Nobuto Nakanishi, Kazumichi Fujioka, Kenichi Suga, Taku Shirakawa, Kayo Osawa, Kanako Hara, Rie Tsutsumi, Maki Urushihara, Ryuji Nakagawa, Hiroyuki Awano, Jun Oto, Hiroshi Sakaue, Kazumoto Iijima, Masafumi Matsuo
Summary: This study investigated the changes in urinary titin N-fragment levels in infants with postmenstrual age, revealing an exponential decline with postmenstrual age and a significant increase in catabolic state in preterm infants.
PEDIATRIC RESEARCH
(2022)
Article
Food Science & Technology
Yasuhiro Shikishima, Rie Tsutsumi, Ayuka Kawakami, Hiroyuki Miura, Yoshitaka Nii, Hiroshi Sakaue
Summary: Extracts from Japanese Citrus sudachi peel, including sudachitin, have shown positive effects on lipid and glucose metabolism. In a randomized controlled trial, capsules of sudachi peel extract powder were found to significantly reduce the ratio of visceral fat to subcutaneous fat and moderately decrease waist circumference in individuals at risk for diabetes. Glycemic control and lipid profile were not significantly impacted by consumption of the extract.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Kana Beppu, Rie Tsutsumi, Satoshi Ansai, Nana Ochiai, Mai Terakawa, Marie Mori, Masashi Kuroda, Kazuki Horikawa, Takumi Tomoi, Joe Sakamoto, Yasuhiro Kamei, Kiyoshi Naruse, Hiroshi Sakaue
Summary: This study established an engineered strain of medaka that allows direct visualization of taste receptor expression and identified potential therapeutic agents for dysgeusia. The findings provide new insights and tools for the treatment of taste disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Editorial Material
Medicine, General & Internal
Shigeaki Inoue, Nobuto Nakanishi, Kensuke Nakamura
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Keishi Nawata, Nobuto Nakanishi, Shigeaki Inoue, Keibun Liu, Masafumi Nozoe, Yuko Ono, Isamu Yamada, Hajime Katsukawa, Joji Kotani
Summary: Muscle mass is crucial for surviving illnesses, and ultrasound is a valuable method for assessing muscle mass. However, a survey of healthcare providers in Japan revealed that only 21% of participants performed ultrasound-based muscle mass assessment, and lack of education was identified as the most important barrier to implementation.
Article
Medicine, General & Internal
Shigeaki Inoue, Nobuto Nakanishi, Jun Sugiyama, Naoki Moriyama, Yusuke Miyazaki, Takashi Sugimoto, Yoshihisa Fujinami, Yuko Ono, Joji Kotani
Summary: This study investigated the frequency and clinical characteristics of post-intensive care syndrome (PICS) in sepsis patients, as well as its relationship with 2-year survival. The study found a high incidence of PICS in survivors and a lower 2-year survival rate among those who developed PICS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Nobuto Nakanishi, Shinya Matsushima, Junko Tatsuno, Keibun Liu, Takahiko Tamura, Hiroshi Yonekura, Norimasa Yamamoto, Takeshi Unoki, Yutaka Kondo, Kensuke Nakamura
Summary: This systematic review and meta-analysis compared the effects of energy and protein delivery during the first 4 to 10 days of ICU stay on physical impairments. The results showed that protein delivery within a certain range could attenuate muscle loss and slightly improve activities of daily living (ADL), while energy delivery did not have a significant impact.
Review
Critical Care Medicine
Nobuto Nakanishi, Shodai Yoshihiro, Yusuke Kawamura, Gen Aikawa, Haruka Shida, Motohiro Shimizu, Yoshihisa Fujinami, Ayaka Matsuoka, Shinichi Watanabe, Shunsuke Taito, Shigeaki Inoue
Summary: This study found that neuromuscular electrical stimulation (NMES) may reduce the occurrence of ICU-acquired weakness (ICU-AW) and potentially increase muscle strength and decrease muscle mass change in critical illness patients. However, the effects of NMES on pricking sensation in patients and length of ICU stay require further investigation, and the impact on mortality and quality of life remains uncertain.
CRITICAL CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Yuta Takahashi, Tomoyuki Morisawa, Hiroshi Okamoto, Nobuto Nakanishi, Noriko Matsumoto, Masakazu Saitoh, Tetsuya Takahashi, Toshiyuki Fujiwara
Summary: This study compared the incidence of diaphragm dysfunction and ICU-acquired weakness in patients with septic shock, with and without mechanical ventilation. The incidence of diaphragm dysfunction was higher than that of ICU-acquired weakness in patients with septic shock, regardless of the use of mechanical ventilation. Further studies are needed to assess the association between diaphragm dysfunction and clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ayaka Matsuoka, Shodai Yoshihiro, Haruka Shida, Gen Aikawa, Yoshihisa Fujinami, Yusuke Kawamura, Nobuto Nakanishi, Motohiro Shimizu, Shinichi Watanabe, Kensuke Sugimoto, Shunsuke Taito, Shigeaki Inoue
Summary: Previous systematic review and meta-analysis have shown that rehabilitation within a week of ICU admission can improve physical function in critically ill patients. This updated review aimed to examine the effects of initiating rehabilitation within 72 hours of ICU admission on long-term physical, cognitive, and mental health. The results suggest that early rehabilitation may improve muscle strength and cognitive function, but its impact on mental health remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Nobuto Nakanishi, Shigeaki Inoue, Yuko Ono, Jun Sugiyama, Kazushi Takayama, Yuta Arai, Kensuke Nakamura, Jun Oto, Joji Kotani
Summary: This study aimed to investigate the feasibility of measuring upper limb muscle thickness using ultrasound to assess muscle condition upon ICU admission. The results showed that ultrasound-based measurements of upper limb muscle thickness can effectively screen for low muscle mass. Therefore, ultrasound measurement can be considered as an important method to assess nutritional status in ICU patients upon admission.
CLINICAL NUTRITION ESPEN
(2023)
Article
Medicine, General & Internal
Jun Sugiyama, Shigeaki Inoue, Masami Inada, Yusuke Miyazaki, Nobuto Nakanishi, Yoshihisa Fujinami, Masafumi Saito, Yuko Ono, Kazushige Toyama, Futoshi Toda, Tohru Shirotsuki, Soushi Shiotani, Joji Kotani
Summary: This study investigated the impact of the COVID-19 pandemic on the operational efficiency of emergency medical services (EMS) and the survival rate of out-of-hospital cardiac arrest (OHCA). The results showed that the pandemic led to a decrease in EMS efficiency and a significant decrease in OHCA survival rates. Further research is needed to improve EMS efficiency and OHCA survival rates.
ACUTE MEDICINE & SURGERY
(2023)
Article
Medicine, General & Internal
Ryo Ishizawa, Nobuto Nakanishi, Liu Keibun, Tomohiro Sonoo, Kensuke Nakamura, Tadahiro Goto
Summary: This study aimed to investigate the characteristics of fall-related injuries accompanied by hip fractures. The results showed that 6% of patients with hip fracture had additional injuries, with upper limb and head injuries being the most frequent. This highlights the importance of conducting a whole-body assessment in the emergency department for patients with fall-related hip fractures.
ACUTE MEDICINE & SURGERY
(2022)
Article
Medicine, General & Internal
Yuko Ono, Nobuto Nakanishi, Isamu Yamada, Joji Kotani
OXFORD MEDICAL CASE REPORTS
(2022)