Journal
BIOSENSORS-BASEL
Volume 10, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/bios10120210
Keywords
ovarian cancer; nanowire biosensor; nanowire; silicon-on-insulator; CA 125; antibodies
Funding
- Ministry of Science and Higher Education of the Russian Federation [75-15-2020-913]
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The detection of CA 125 protein in a solution using a silicon-on-insulator (SOI)-nanowire biosensor with n-type chip has been experimentally demonstrated. The surface of nanowires was modified by covalent immobilization of antibodies against CA 125 in order to provide the biospecificity of the target protein detection. We have demonstrated that the biosensor signal, which results from the biospecific interaction between CA 125 and the covalently immobilized antibodies, increases with the increase in the protein concentration. At that, the minimum concentration, at which the target protein was detectable with the SOI-nanowire biosensor, amounted to 1.5 x 10(-16) M.
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