Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis

Structure and mechanisms of ROS generation by NADPH oxidases

(2019) Francesca Magnani et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

(2018) Xingfeng Qiu et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

(2018) Zhentao Yang et al.   NATURE CELL BIOLOGY

Insane in the membrane: a structural perspective of MLKL function in necroptosis

(2017) Emma J Petrie et al.   IMMUNOLOGY AND CELL BIOLOGY

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Understanding and preventing mitochondrial oxidative damage

(2016) Michael P. Murphy   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of necroptosis signaling and cell death by reactive oxygen species

(2016) Simone Fulda   BIOLOGICAL CHEMISTRY

Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis

(2016) Timothy J. LaRocca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis

(2015) T J LaRocca et al.   Cell Death & Disease

Role of necroptosis in the pathogenesis of solid organ injury

(2015) H Zhao et al.   Cell Death & Disease

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis

(2014) W Chen et al.   CELL DEATH AND DIFFERENTIATION

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human-Specific Bacterial Pore-Forming Toxins Induce Programmed Necrosis in Erythrocytes

(2014) T. J. LaRocca et al.   mBio

Necroptosis in Immunity and Ischemia-Reperfusion Injury

(2013) A. Linkermann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation

(2013) Ryodai Shindo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

The Molecular Mechanism of the Catalase Reaction

(2009) Mercedes Alfonso-Prieto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria

(2008) Jan Trnka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY