Article
Medicine, Research & Experimental
Seon-A Jang, Youn-Hwan Hwang, Hyun Yang, Jin Ah Ryuk, Dong Ryun Gu, Hyunil Ha
Summary: The study found that the extract of Pyrrosia lingua has anti-osteoporotic effects by suppressing the differentiation of osteoclasts and preventing trabecular bone loss in mice. The researchers also identified phytochemicals in the extract that have known anti-osteoclastogenic or anti-osteoporotic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu, Feng Xu
Summary: The study demonstrates that PRI has therapeutic potential in treating osteolytic diseases like osteoporosis by inhibiting osteoclast formation and bone resorption activity both in vitro and in vivo. PRI exerts its effects through the suppression of NF-κB and ERK MAPK signaling pathways, preventing the production of mature osteoclasts.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang, Fengchao Zhao
Summary: Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting TRAIL degradation and promotes osteoblast differentiation, suggesting its potential in anti-osteopenia pharmacotherapy.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yuying Kou, Xing Rong, Rong Tang, Yuan Zhang, Panpan Yang, Hongrui Liu, Wanli Ma, Minqi Li
Summary: ED-71 can prevent bone loss in postmenopausal osteoporosis by regulating the cell senescence of bone mesenchymal stem cells through the SIRT1-Nrf2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Maqsood Ali, Youri Lee, Bin Ha, Jaeeun Jung, Byoung-Ryol Lee, Dae-soo Kim, Mi-Young Lee, Yong-Sik Kim
Summary: This study evaluated the effects of amino-calcium (AC) on bone protection in ovariectomized control group (NC) rats. Results showed that AC increased bone volume fraction in the femoral head and shaft areas, as well as protected bone mass and architecture. The study also found that AC had good biocompatibility with MC3T3-E1 cells and promoted alkaline phosphatase activity. RNA sequencing analysis revealed high expression of osteogenesis-related genes in MC3T3-E1 cells. This study concluded that supplementing with calcium enhanced bone protection in ovariectomized rats.
Article
Food Science & Technology
Tingting Wang, Enjing Luo, Zhenwei Zhou, Jie Yang, Jianyu Wang, Jinghong Zhong, Jingcheng Zhang, Baojin Yao, Xiangyan Li, Haisi Dong
Summary: The lyophilized powder of velvet antler blood (VAB), which is rich in amino acids, fatty acids, trace elements, and vitamins, has anti-osteoporosis effects. In vivo studies showed that VAB can protect against bone tissue degeneration and bone loss. In vitro studies confirmed that VAB can promote the proliferation, migration, and differentiation of primary osteoblasts by regulating the Wnt/beta-catenin signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, Research & Experimental
Qingqing Wang, Delong Chen, Yining Wang, Chenlin Dong, Jian Liu, Kai Chen, Fangming Song, Chao Wang, Jinbo Yuan, Rohan A. Davis, Vincent Kuek, Haiming Jin, Jiake Xu
Summary: This study found that the natural compound TPB derived from the Great Barrier Reef sponge can inhibit the formation and activity of osteoclasts and reduce bone loss in a mouse model. TPB acts by blocking multiple signaling pathways and may serve as a potential therapeutic candidate for the treatment of osteoporosis and osteolysis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sang-Yong Han, June-Hyun Kim, Eun-Heui Jo, Yun-Kyung Kim
Summary: The root bark of Eleutherococcus sessiliflorus inhibits osteoclast differentiation and prevents bone loss in rats, suggesting its potential as a therapeutic agent for bone-related diseases like osteoporosis.
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhenen Lin, Guanshu Yu, Shengren Xiong, Yu Lin, Zhaohui Li
Summary: The purpose of this study was to investigate the effects of leptin and melatonin on bone metabolism in ovariectomized rodents and their potential mechanisms. The results showed that leptin and melatonin can improve trabecular microstructure, enhance bone growth, reduce trabecular damage, and promote bone repair in rats with osteoporosis. The combined effect of the two is more significant.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Chen Yang, Huaqiang Tao, Haifeng Zhang, Yu Xia, Jiaxiang Bai, Gaoran Ge, Wenming Li, Wei Zhang, Long Xiao, Yaozeng Xu, Zhirong Wang, Ye Gu, Huilin Yang, Yu Liu, Dechun Geng
Summary: Increased bone resorption by osteoclasts is the main cause of postmenopausal osteoporosis. This study revealed that TET2 promotes osteoclast differentiation by regulating autophagy. Knockdown of Tet2 inhibits autophagy and osteoclast differentiation. Mechanistically, Tet2 knockdown increases BCL2 expression and negatively regulates autophagy.
Article
Pharmacology & Pharmacy
Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Summary: Mogrol, an active component of Siraitia grosvenorii, exhibits anti-inflammatory, anticancer and neuroprotective effects. This study demonstrated that mogrol dose-dependently inhibited osteoclast formation and function by regulating gene expression and signaling pathway. Furthermore, mogrol reduced bone mass loss in postmenopausal mice, suggesting its promising potential for osteoporosis prevention or therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Huijie Gu, Zhongyue Huang, Kaifeng Zhou, Guangnan Chen, Chong Bian, Jun Xu, Xiaofan Yin
Summary: This study analyzed the differential expressions of lncRNAs and mRNAs in osteoporosis, constructed a coexpression network, and identified key lncRNAs that may modulate adipogenesis in BMSCs via specific signaling pathways. The findings expand understanding of lncRNAs in the pathogenesis of osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)