Article
Reproductive Biology
Manman Shen, Mingzhu Wang, Dehui Li, Yuan Feng, Liang Qu, Jinyu Wang
Summary: The study identified miRNAs associated with follicular development in chickens through small RNA sequencing of granulosa cells, and analyzed their target genes and their relationships with signaling pathways, providing basic data and a new theoretical foundation for further research on the role of miRNAs in follicular development in chickens.
Article
Engineering, Environmental
Jing-Cai Liu, Chun-Hua Xing, Yi Xu, Zhen-Nan Pan, Hao-Lin Zhang, Yu Zhang, Shao-Chen Sun
Summary: Exposure to DEHP during lactation reduces follicle numbers in suckling mice, alters gene transcription levels leading to decreased estradiol and increased oxidative stress. DNA damage marker and ovarian apoptosis are increased in DEHP-exposed suckling mice, with inhibition of granulosa cell proliferation. These changes result in abnormal spindle formation and chromosome misalignment during oocyte maturation.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Developmental Biology
E. R. Frost, E. A. Ford, G. Taylor, S. Boeing, E. L. Beckett, S. D. Roman, R. Lovell-Badge, E. A. McLaughlin, J. M. Sutherland
Summary: The need for investigations has driven the development of ovarian cell dissociation techniques, including two methods suitable for different developmental stages of ovarian samples. These methods provide important tools for the study of folliculogenesis and mouse ovarian development.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
S. J. Huang, L. Purevsuren, F. Jin, Y. P. Zhang, C. Y. Liang, M. Q. Zhu, F. Wang, C. L. Jia, Z. H. Wei
Summary: The study elucidated the role of AMH in regulating ovarian follicle development in laying hens by measuring expression of relevant genes and treating hens with AMH. Results showed changes in gene expressions post-follicular selection and significant effects on ovarian morphology and hormone levels after AMH injection.
Article
Virology
Mehmet Resat Ceylan, Nazim Kankilic, Ozlem Oz
Summary: The study investigated the relationship between genetic cardiovascular risk factors and COVID-19 infection, and found that PROCR H1 and PROCR H3 haplotypes may play an important role in contracting COVID-19 disease.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Reproductive Biology
Kenji Vann, Adelaide E. Weidner, Ariana C. Walczyk, Olga Astapova
Summary: Granulosa cell-specific knockout of adaptor protein paxillin in mice increases fecundity and may reduce granulosa cell death. Knockout of paxillin in granulosa cells leads to increased fertility in older reproductive age mice, which is not due to increased numbers of estrous cycles, ovulated oocytes per cycle, or pups per litter, but rather shorter time to pregnancy and increased number of litters.
BIOLOGY OF REPRODUCTION
(2023)
Article
Environmental Sciences
Zhe Zhang, Jiao Tian, Wenwen Liu, Jidong Zhou, Yang Zhang, Lijun Ding, Haixiang Sun, Guijun Yan, Xiaoqiang Sheng
Summary: This study investigated the impact of PFOA on ovarian function and discovered that it impairs follicle development and disrupts oxidative phosphorylation. Resveratrol, a mitochondrial nutrient supplement, was found to restore mitochondrial function and promote normal follicular development by activating FoxO1. These findings highlight the potential therapeutic use of resveratrol for PFOA-induced ovarian dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Reproductive Biology
Yanqin Gong, Dandan Li, Yi Sun, Li Kang, Yunliang Jiang
Summary: This study reveals the important role of Noggin4 in chicken follicle development, particularly in the proliferation of granulosa cells.
Article
Biochemistry & Molecular Biology
Jiaqi Zhou, Lin Lin, Han Cai, Longping Liu, Huarong Wang, Jingwen Zhang, Guoliang Xia, Jianbin Wang, Fengchao Wang, Chao Wang
Summary: This study investigated the role of transcription factor Sp1 in regulating the primordial to primary follicle transition (PPT) in the ovary. Depletion of Sp1 in granulosa cells (GCs) extended mice fertility and reduced PPT, resulting in the preservation of more primordial follicles. Single-cell RNA-seq analysis showed a downregulation of cholesterol metabolism in GC- Sp1 (-/-) mice. Furthermore, promoting PPT by overexpressing ferredoxin-1 (FDX1), a key gene in cholesterol metabolism, or supplementing cholesterol in cultured fetal ovaries.
Article
Agriculture, Dairy & Animal Science
Shunshun Han, Jianping Wang, Can Cui, Chunlin Yu, Yao Zhang, Diyan Li, Menggen Ma, Huarui Du, Xiaosong Jiang, Qing Zhu, Chaowu Yang, Huadong Yin
Summary: This study explores the regulatory molecular mechanisms of follicular atresia in chickens and reveals the role of autophagy and apoptosis in this process. It also highlights the importance of fibromodulin in regulating autophagy and provides insights into broodiness and poultry production improvement.
Article
Cell Biology
G. D. Catandi, D. R. Bresnahan, S. O. Peters, K. J. Fresa, L. J. Maclellan, C. D. Broeckling, E. M. Carnevale
Summary: Many age-related changes in metabolite abundance suggest impaired mitochondrial metabolic function and oxidative stress in oocytes and follicular cells. The results also indicate impaired transfer of carbohydrate and free fatty acid substrates from cumulus cells to the oocytes of old mares, potentially related to disruption of transzonal projections between the cell types. The identification of age-associated alterations in the abundance of specific metabolites and their correlations among cells contribute to our understanding of follicular dysfunction with maternal aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chenfeng Yuan, Zheng Li, Yun Zhao, Xin Wang, Lu Chen, Zijiao Zhao, Maosheng Cao, Tong Chen, Tariq Iqbal, Boqi Zhang, Wenjing Fan, Yameng Wei, Chunjin Li, Xu Zhou
Summary: This study demonstrated that exosomes play a crucial role in regulating the physiological function of granulosa cells by carrying specific microRNAs, promoting cell proliferation and progesterone synthesis. The MAPK/ERK and WNT/B-CATENIN pathways were found to be involved in these processes.
Article
Agriculture, Dairy & Animal Science
Conghao Zhong, Zhansheng Liu, Dandan Li, Li Kang, Yunliang Jiang
Summary: Follicle selection is a crucial process for chicken laying performance and fecundity. In this study, the impacts of follicle-stimulating hormone (FSH) on chicken granulosa cells were investigated through ONT transcriptome sequencing. FSH treatment upregulated the expression of several genes related to steroid biosynthesis and pathways associated with ovarian steroidogenesis. Specifically, TRAF7 was identified as a key regulator in promoting the expression of steroidogenic enzymes and granulosa cell proliferation. This study provides valuable insights into the molecular mechanism of follicle selection in chickens.
Review
Cell Biology
Iman Dilower, Asef J. Niloy, Vishnu Kumar, Ayushi Kothari, Eun Bee Lee, M. A. Karim Rumi
Summary: The hedgehog (HH) signaling pathway plays a crucial role in development and reproductive functions, involving various molecules, receptors, and transcription factors. It has significant roles in the central nervous system, reproductive organs, and skeletal development, as well as essential physiological functions in adult testes and ovaries.
Article
Cell Biology
Yan Wu, Hongwei Xiao, Jinsong Pi, Hao Zhang, Ailuan Pan, Yuejin Pu, Zhenhua Liang, Jie Shen, Jinping Du, Tao Huang
Summary: The study identified 9,551 lncRNAs in duck follicles, with 445 differentially expressed between white and yellow follicles. The results demonstrated that lnc_13814 promotes cell apoptosis in duck GCs and is involved in a lncRNA-miRNA-mRNA coexpression network. Overexpression of lnc_13814 increases DDIT3 expression and up-regulates GCs apoptosis, suggesting potential effects on duck ovarian follicles.
Letter
Biochemistry & Molecular Biology
Leixin Wei, Xiukun Wang, Suming Yang, Wen Yuan, Jinsong Li
JOURNAL OF GENETICS AND GENOMICS
(2017)
Letter
Neurosciences
He Xu, Chunmei Yue, Ting Zhang, Yuanyuan Li, Ao Guo, Jiaoyang Liao, Gang Pei, Jinsong Li, Naihe Jing
NEUROSCIENCE BULLETIN
(2017)
Article
Cell Biology
Xiong-jun Wang, Yunbo Qiao, Minzhe M. Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Li Xu, Yan Li, Yumei Wang, Ming-dian Tan, Chao Huang, Jinsong Li, Ting C. Zhao, Zhaoyuan Hou, Naihe Jing, Y. Eugene Chin
Article
Chemistry, Analytical
Zi-Yi Li, Min Huang, Xiu-Kun Wang, Ying Zhu, Jin-Song Li, Catherine C. L. Wong, Qun Fang
ANALYTICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Chao Qu, Meng Yan, Suming Yang, Lingbo Wang, Qi Yin, Yuan Liu, Yeguang Chen, Jinsong Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Wuqing Liu, Shifeng Li, Yunbin Zhang, Jinsong Li, Yiping Li
Article
Multidisciplinary Sciences
Su Feng, Can Xing, Tingyu Shen, Yunbo Qiao, Ran Wang, Jun Chen, Jiaoyang Liao, Zhuo Lu, Xiong Yang, Saber Mohamed Abd-Allah, Jinsong Li, Naihe Jing, Ke Tang
SCIENTIFIC REPORTS
(2017)
Review
Reproductive Biology
Lingbo Wang, Jinsong Li
BIOLOGY OF REPRODUCTION
(2019)
Review
Genetics & Heredity
Yuanyuan Li, Jinsong Li
Article
Multidisciplinary Sciences
Yanyan Chen, Yan Wang, Juan Chen, Wu Zuo, Yong Fan, Sijia Huang, Yongmei Liu, Guangming Chen, Qing Li, Jinsong Li, Jian Wu, Qian Bian, Chenhui Huang, Ming Lei
Summary: The interaction between telomeres and the LINC complex, specifically between SUN1 and SPDYA, is crucial for homologous pairing during meiosis prophase I. This interaction is essential for the formation of a ring-shaped telomere supramolecular architecture at the nuclear envelope, which is critical for efficient meiotic progression.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yan Jiang, Xing Fu, Yuhan Zhang, Shen-Fei Wang, Hong Zhu, Wei-Kang Wang, Lin Zhang, Ping Wu, Catherine C. L. Wong, Jinsong Li, Jinbiao Ma, Ji-Song Guan, Ying Huang, Jingyi Hui
Summary: Mutations in MeCP2 can lead to Rett syndrome, a severe neurological disorder in children, and this study shows that MeCP2 plays a key role in the higher-order assembly of the large splicing complex Rbfox/LASR, which is disrupted in mouse models of Rett syndrome.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou, Yun Zhao
Summary: Chromosomes occupy discrete spaces in the cell nucleus, called chromosome territories. The structural and functional relevance of chromosome territories remains unclear. In this study, chromosome 15 and 17 were fused in mouse haploid embryonic stem cells, resulting in changes in the territories of the corresponding chromosomes, but with little impact on gene expression and cell functions. These engineered stem cells were successfully used to generate mouse models with different karyotypes. The mice with fused chromosomes were fertile and showed normal development, indicating the resilience of mammalian chromosome architectures.
Article
Multidisciplinary Sciences
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing
Summary: This study constructed a spatiotemporal molecular atlas of cell lineages in the germ-layers of gastrula-stage mouse embryos, and revealed the crucial role of molecular network activity, particularly asymmetric BMP activity, in the differentiation and patterning of the germ-layer tissue lineages during gastrulation.
NATURE COMMUNICATIONS
(2023)
Letter
Cell Biology
Xiaoyu Merlin Zhang, Meng Yan, Zhenhua Yang, Hao Xiang, Wei Tang, Xindong Cai, Qigui Wu, Xin Liu, Gang Pei, Jinsong Li