Mitochondrial Dysfunction in Parkinson’s Disease: Focus on Mitochondrial DNA

Clues of in vivo nuclear gene regulation by mitochondrial short non-coding RNAs

(2020) Marco Passamonti et al.   Scientific Reports

Mitochondrial DNA: the common confusions

(2020) Mikhail Alexeyev   Mitochondrial DNA Part A

ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation

(2020) Jinshan Qin et al.   Nature Communications

Identification of Molecular Network Associated with Neuroprotective Effects of Yashtimadhu (Glycyrrhiza glabra L.) by Quantitative Proteomics of Rotenone-Induced Parkinson’s Disease Model

(2020) Gayathree Karthikkeyan et al.   ACS Omega

TEFM regulates both transcription elongation and RNA processing in mitochondria

(2019) Shan Jiang et al.   EMBO REPORTS

LRPPRC: A Multifunctional Protein Involved in Energy Metabolism and Human Disease

(2019) Jie Cui et al.   Frontiers in Physiology

Organization of DNA in Mammalian Mitochondria

(2019) Géraldine Farge et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects

(2019) Amica C. Müller-Nedebock et al.   NEUROCHEMISTRY INTERNATIONAL

Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease

(2019) Petar Podlesniy et al.   EBioMedicine

Mitochondrial transcription and translation: overview

(2018) Aaron R. D’Souza et al.   Essays in Biochemistry

Mitochondrial DNA replication in mammalian cells: overview of the pathway

(2018) Maria Falkenberg   Essays in Biochemistry

An overview of mammalian mitochondrial DNA replication mechanisms

(2018) Takehiro Yasukawa et al.   JOURNAL OF BIOCHEMISTRY

Ultradeep mapping of neuronal mitochondrial deletions in Parkinson's disease

(2018) Gonzalo S. Nido et al.   NEUROBIOLOGY OF AGING

The Effect of Neurotoxin MPTP and Neuroprotector Isatin on the Profile of Ubiquitinated Brain Mitochondrial Proteins

(2018) Olga Buneeva et al.   Cells

Novel Lines of Evidence for the Asymmetric Strand Displacement Model of Mitochondrial DNA Replication

(2018) Chih-Lin Hsieh   MOLECULAR AND CELLULAR BIOLOGY

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

(2017) Wei Wei et al.   Acta Neuropathologica Communications

Mitochondrial Iron Metabolism and Its Role in Neurodegeneration

(2017) Maxx P. Horowitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Structure and Function of the Mitochondrial Ribosome

(2016) Basil J. Greber et al.   Annual Review of Biochemistry

Human Mitochondrial Transcription Factor B2 Is Required for Promoter Melting during Initiation of Transcription

(2016) Viktor Posse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery

(2015) Xiangmin Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The subunit composition and function of mammalian cytochrome c oxidase

(2015) Bernhard Kadenbach et al.   MITOCHONDRION

Association of the mt-ND2 5178A/C polymorphism with Parkinson’s disease

(2015) Aaron M. Gusdon et al.   NEUROSCIENCE LETTERS

Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype

(2015) Mikalai Lapkouski et al.   NUCLEIC ACIDS RESEARCH

The mitochondrial side of epigenetics

(2015) Alessandra Castegna et al.   PHYSIOLOGICAL GENOMICS

Replication-transcription switch in human mitochondria

(2015) K. Agaronyan et al.   SCIENCE

In vivolevels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice

(2014) Angela Logan et al.   AGING CELL

In D-loop: 40years of mitochondrial 7S DNA

(2014) Thomas J. Nicholls et al.   EXPERIMENTAL GERONTOLOGY

Architecture of mammalian respiratory complex I

(2014) Kutti R. Vinothkumar et al.   NATURE

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

(2014) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

(2014) Ying Dai et al.   NEUROTOXICOLOGY AND TERATOLOGY

Post-Translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain

(2014) David N. Hauser et al.   PLoS One

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

(2014) Javier Miralles Fusté et al.   PLoS Genetics

Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System: Implications for Health, Fitness, and Fertility

(2014) Won-Hee Song et al.   Biomed Research International

Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies

(2014) Heather M. Wilkins et al.   Redox Biology

To be or not to be a nucleoid protein: A comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins

(2013) Fenna Hensen et al.   BIOCHIMIE

Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease

(2013) G. Hudson et al.   NEUROLOGY

The Mitochondrial Nucleoid: Integrating Mitochondrial DNA into Cellular Homeostasis

(2013) R. Gilkerson et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

The History of Parkinson's Disease: Early Clinical Descriptions and Neurological Therapies

(2013) C. G. Goetz   Cold Spring Harbor Perspectives in Medicine

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

(2012) Renato X. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural analysis of cytochrome bc1 complexes: Implications to the mechanism of function

(2012) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Nuclear miRNA Regulates the Mitochondrial Genome in the Heart

(2012) Samarjit Das et al.   CIRCULATION RESEARCH

Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis

(2012) J. He et al.   NUCLEIC ACIDS RESEARCH

Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes

(2012) B. G. Kopek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does Mitochondrial DNA Play a Role in Parkinson's Disease? A Review of Cybrid and Other Supportive Evidence

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

(2011) Benedetta Ruzzenente et al.   EMBO JOURNAL

Neutral mitochondrial heteroplasmy and the influence of aging

(2011) Neal Sondheimer et al.   HUMAN MOLECULAR GENETICS

Mitochondrial ATP synthase: architecture, function and pathology

(2011) An I. Jonckheere et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial DNA and disease

(2011) Laura C Greaves et al.   JOURNAL OF PATHOLOGY

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond

(2011) Knut H. Lauritzen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Shot-gun proteomic analysis of mitochondrial D-loop DNA binding proteins: identification of mitochondrial histones

(2011) Yon-Sik Choi et al.   Molecular BioSystems

Human Mitochondrial Transcription Revisited

(2010) Dmitry Litonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson’s subject mitochondrial transfer

(2010) A. Raquel Esteves et al.   JOURNAL OF NEUROCHEMISTRY

Region-Specific Protein Abundance Changes in the Brain of MPTP-Induced Parkinson’s Disease Mouse Model

(2010) Xu Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial DNA alterations and reduced mitochondrial function in aging

(2010) Sadie L. Hebert et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior

(2010) K. H. Lauritzen et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

(2010) Javier Miralles Fusté et al.   MOLECULAR CELL

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

Unique features of animal mitochondrial translation systems

(2010) Kimitsuna WATANABE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Microtubule depolymerization potentiates alpha-synuclein oligomerization

(2010) A. Raquel Esteves   Frontiers in Aging Neuroscience

Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice

(2009) Daniel Edgar et al.   Cell Metabolism

Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases

(2009) Lokendra Sharma et al.   CURRENT MEDICINAL CHEMISTRY

Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships

(2009) Paula M. Keeney et al.   EXPERIMENTAL NEUROLOGY

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

(2009) A. Raquel Esteves et al.   NEUROBIOLOGY OF DISEASE

Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach

(2009) Oliver Rothfuss et al.   NUCLEIC ACIDS RESEARCH

Oxidative Stress Involvement in α-Synuclein Oligomerization in Parkinson's Disease Cybrids

(2008) A. Raquel Esteves et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis Revealed by Proteomic and Transcriptomic Analyses of the Striata in Two Mouse Models of Parkinson’s Disease

(2008) Mark H. Chin et al.   JOURNAL OF PROTEOME RESEARCH

Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background

(2008) A. Raquel F. Esteves et al.   MITOCHONDRION

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

(2008) Ricardo Gredilla et al.   NEUROBIOLOGY OF AGING