Article
Biochemistry & Molecular Biology
Zhen Pan, Shi-jie Li, Hua Guo, Zhao-hui Li, Xiang Fei, Shi-min Chang, Qing-cheng Yang, Dong-dong Cheng
Summary: Numerous studies have shown that anti-inflammatory agents can have antitumor effects in cancer therapy by directly increasing apoptosis and sensitivity to therapies, and decreasing invasion and metastasis. In this study, ebastine, a H1-histamine receptor antagonist, was screened and found to have antitumor effects in osteosarcoma cells. Ebastine treatment induced cell cycle arrest, inhibited metastasis, and induced apoptosis and autophagy both in vitro and in vivo. Mechanistically, ebastine activated the AMPK/ULK1 signaling pathway, triggering proapoptotic autophagy. IPMK was identified as a positive regulator of AMPK in osteosarcoma cells, and IPMK knockdown reversed the effects of ebastine on autophagy and AMPK/ULK1 signaling. This study suggests that ebastine has potential as a therapeutic candidate for osteosarcoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ran Guo, Shan-Shan Wang, Xiao-You Jiang, Ye Zhang, Yang Guo, Hong-Yan Cui, Qi-Qiang Guo, Liu Cao, Xiao-Chen Xie
Summary: This study reveals that reactive oxygen species (ROS) initiate autophagy through the ATM/CHK2/ULK1 axis to maintain cellular homeostasis and protect cells from metabolic stress-induced damage.
Article
Medicine, Research & Experimental
Prajna Paramita Naik, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Kewal Kumar Mahapatra, Srimanta Patra, Sarbari Saha, Aditya Kumar Panda, Krupasindhu Panda, Subhankar Paul, Palok Aich, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Clusterin induces autophagy in oral cancer through the AMPK/Akt/mTOR signaling pathway, protecting cells from apoptosis, interacts with ULK1 to induce autophagy, and promotes mitophagy in nutrient deprivation conditions. High CLU expression is associated with therapy resistance and clusterin-mediated mitophagy inhibits cell death by cisplatin in cancer cells.
Article
Medicine, Research & Experimental
Xuejie Jiang, Ling Jiang, Jiaying Cheng, Fang Chen, Jinle Ni, Changxin Yin, Qiang Wang, Zhixiang Wang, Dan Fang, Zhengshan Yi, Guopan Yu, Qingxiu Zhong, Bing Z. Carter, Fanyi Meng
Summary: The study investigated the antileukemia effects of HDAC inhibitor chidamide in AML cells and its synergistic activity with the cytotoxic agent adriamycin. Chidamide suppressed EZH2, H3K27me3, and DNMT3A levels, exerted potential antileukemia activity, and increased sensitivity to adriamycin by disrupting the Smo/Gli-1 pathway and downstream signaling target p-AKT. Inhibition of EZH2 by chidamide or shEZH2 enhanced the antileukemia activity of adriamycin in vitro and in vivo.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Virology
Chenlong Jiang, Feifei Diao, Zicheng Ma, Jie Zhang, Juan Bai, Hans Nauwynck, Ping Jiang, Xing Liu
Summary: PRRSV enhances its replication through the Rab1a-ULK1 complex and the autophagy pathway.
Article
Cell Biology
Angela Ianniciello, G. Vignir Helgason
Summary: Minimal residual disease (MRD) is the main cause of relapse in solid cancers and leukemias. In chronic myeloid leukemia (CML), autophagy plays a crucial role in maintaining the survival of drug resistant leukemic stem cells. Inhibition of autophagy-initiating kinase ULK1 could lead to stress-induced differentiation of leukemic stem cells, making them sensitive to drug treatment, providing a promising strategy for selective eradication of leukemic stem cells in CML patients.
Article
Environmental Sciences
Yinyue Luo, Dongxin Da, Qingqing Weng, Shuran Yao, Hao Zhang, Xinxin Han, Ying Zhang
Summary: This study found that overexpression of miR-296-5p can accelerate autophagy in fluoride-induced dental fluorosis, while its underexpression has an inhibitory effect on autophagy. MiR-296-5p may improve the secretion of autophagic mediators by activating AMPK/ULK1 expression, suggesting it as a potential therapeutic target under high fluoride stimulation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Lopez-Bailon Luis, Gonzalez-Telona Ana, Galan-Enriquez Carlos, Garcia-Gil Abraham, Estrada-Garcia Iris, Moreno-Lafont Martha, Ortiz-Navarrete Vianney
Summary: Following infection of B cells, Salmonella activates mTORC1 through SopB, inhibiting autophagy and promoting bacterial survival within the cells.
Article
Immunology
Xiaonan Qiu, Lin Zheng, Xiuting Liu, Dan Hong, Mintong He, Zengqi Tang, Cuicui Tian, Guozhen Tan, Sam Hwang, Zhenrui Shi, Liangchun Wang
Summary: This study found that impairment of ULK1 in the epidermis of psoriasis patients can alleviate symptoms of psoriasis-like dermatitis, affecting proliferation and apoptosis of keratinocytes as well as their interaction with neutrophils, possibly through both autophagy-dependent and independent mechanisms. ULK1 might be a potential target for preventing or treating psoriasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Vinicius Toledo Ribas, Bjorn Friedhelm Vahsen, Lars Tatenhorst, Veronica Estrada, Vivian Dambeck, Raquel Alves Almeida, Mathias Baehr, Uwe Michel, Jan Christoph Koch, Hans Werner Mueller, Paul Lingor
Summary: Inhibition of ULK1 promotes axonal regeneration and neurite outgrowth, increases neuronal survival, and enhances axonal protection after optic nerve and spinal cord injuries. Additionally, it leads to increased sprouting of serotonergic and dopaminergic axons after spinal cord injury by activating ERK1 and reducing RhoA and ROCK2 expression. ULK1 is identified as a key regulator for axonal degeneration and regeneration, and a promising target for neuroprotection and regeneration in the CNS.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Sisi Zhao, Shiqi Wang, Luxi Cao, Hai Zeng, Shujun Lin, Zhuowen Lin, Minan Chen, Mingmin Zhu, Zhao Pang, Yimin Zhang
Summary: This study aims to investigate the autophagy mediating mechanism underlying the neuroprotective effect of acupuncture in traumatic brain injury (TBI) rats. The results showed that acupuncture promoted neuronal autophagy on Day 3 after TBI, but inhibited it on Day 7 and Day 14, alleviating nerve damage. The mTOR/ULK1 pathway may be involved in the regulatory effect of acupuncture on autophagy in different stages of TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biotechnology & Applied Microbiology
Chao Song, Hanping Qi, Yongsheng Liu, Yunping Chen, Pilong Shi, Shu Zhang, Jing Ren, Lixin Wang, Yonggang Cao, Hongli Sun
Summary: The study identified a novel regulatory axis involving lncRNA Gm15834/miR-30b-3p/ULK1/autophagy in cardiac hypertrophy, providing a potential therapeutic target for the condition.
Article
Cell Biology
Yuhan Shu, Xin Sun, Guiqin Ye, Mengting Xu, Zhipan Wu, Caixia Wu, Shouxin Li, Jingkui Tian, Haote Han, Jianbin Zhang
Summary: DHOK, a novel diterpene from the roots of Eurycoma longifolia Jack, exhibits cytotoxic effect on cancer cells. It activates the mTOR signaling pathway, reduces autophagy level, and inhibits colorectal cancer tumorigenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, Mary Scott, Amy Dawson, Karen Dunn, Zuzana Brabcova, Eric R. Kalkman, Colin Nixon, Alison M. Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G. Vignir Helgason
Summary: Inhibition of autophagy has shown to reduce growth of CML cells and induce differentiation of CML LSCs by enhancing mitochondrial respiration and loss of quiescence. This suggests a potential alternative strategy for treating patients with CML by combining autophagy inhibition with TKI treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Jie-yu Yue, Ying-jie Wang, Jin-lan Jiao, Hua-zhong Wang
Summary: Salt stress enhances autophagy and induces programmed cell death in wheat seedlings, potentially through disrupting the balance of cellular death and element elements. Silencing of ATG2 or ATG7 inhibits autophagy and impairs salt tolerance, leading to oxidative stress, decreased antioxidant activity, and altered gene expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Chong Zhang, Yiqin Luo, Qiaoling He, Shuai Liu, Andong He, Jie Yan
Article
Gastroenterology & Hepatology
Chong Zhang, Honglv Chen, Qiaoling He, Yiqin Luo, Andong He, Ailin Tao, Jie Yan
Summary: The study found that fibrinogen is upregulated in the colon of DSS-treated mice and in patients with ulcerative colitis. Inhibition of fibrinogen significantly alleviated DSS-induced colitis. Fibrinogen regulates colitis by modulating vascular permeability through activating AKT and depolymerizing microfilament, suggesting it as a potential target for anti-colitis treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
