In Situ Potentiostatic Deposition of Calcium Phosphate with Gentamicin-Loaded Chitosan Nanoparticles on Titanium Alloy Surfaces

Bone implants must be biocompatible and are usually built to promote osseointegration, e.g. by application of plasma spray calcium phosphate (CaP) coating. The risk of infection and biofilm formation on implant surfaces is a well-known problem. The combination of electrochemically deposited CaP coating with antibiotics may offer significant benefits. Here, we demonstrate an innovative in situ electrodeposition of gentamicin encapsulated in chitosan nanoparticles along with CaP. The deposition of the coating was observed and studied at several temperatures. A high drug loading into the coating and a controlled release of the drug over two days were demonstrated. (C) 2016 Elsevier Ltd. All rights reserved.