Article
Medicine, General & Internal
Jean Pastre, Diane Bouvry, Karine Juvin, Amira Benattia, Isabella Annesi-Maesano, Dominique Valeyre, Hilario Nunes, Dominique Israel-Biet
Summary: SLCAG differs from sarcoidosis in clinical presentation and disease course, with SLCAG having a more benign course and higher recovery rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Audrey Melin, Emilie Routier, Severine Roy, Pauline Pradere, Jerome Le Pavec, Thibaut Pierre, Noemie Chanson, Jean-Yves Scoazec, Olivier Lambotte, Caroline Robert
Summary: Granulomatosis triggered by immune checkpoint inhibitors (ICI) is a common side effect in melanoma and other cancer patients. This study investigates the characteristics of this reaction, its relationship with sarcoidosis, its potential mechanisms, and its association with response to immunotherapy.
Article
Immunology
Tamotsu Sagawa, Yasushi Sato, Hiroyuki Nagashima, Kohichi Takada, Mamoru Takahashi, Masahiro Hirakawa, Kyoko Hamaguchi, Fumito Tamura, Koshi Fujikawa, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, Tetsuji Takayama
Summary: This is a case of drug-induced sarcoidosis-like reaction in a patient with metastatic colorectal cancer during immune checkpoint inhibitor treatment. Although the primary lymph node metastasis shrank after treatment, hilar/mediastinal lymph nodes appeared. Histopathological examination revealed multiple epithelioid granulomas, consistent with sarcoidosis-like reaction.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Pascal Seve, Yves Pacheco, Francois Durupt, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Sylvie Isaac, Loic Boussel, Alain Calender, Geraldine Androdias, Dominique Valeyre, Thomas El Jammal
Summary: Sarcoidosis is a multi-system disease characterized by the formation of granulomas in various organs. Diagnosis is based on specific clinical and histological criteria, with certain clinical features considered highly specific of the disease. New diagnostic guidelines have been developed for cardiac, neurological, and ocular sarcoidosis.
Article
Medicine, General & Internal
Yoshimasa Hachisu, Yasuhiko Koga, Shu Kasama, Kyoichi Kaira, Shogo Uno, Masakiyo Yatomi, Haruka Aoki-Saito, Hiroaki Tsurumaki, Asuka Jingu, Noriaki Sunaga, Toshitaka Maeno, Takeshi Hisada
Summary: This study retrospectively analyzed tumor development before and after the diagnosis of sarcoidosis and examined the impact of having a history of tumors on the activity or severity of sarcoidosis. The results suggest that tumor development may be partly associated with the activity or severity of sarcoidosis.
MEDICINA-LITHUANIA
(2022)
Article
Immunology
Lili Cheng, Qi Song, Mengke Liu, Yan Wang, Hongmei Yi, Ying Qian, Pengpeng Xu, Shu Cheng, Chaofu Wang, Li Wang, Weili Zhao
Summary: PBL is a rare and aggressive hematological malignancy that commonly occurs in immune incompetent patients, with no specific standard treatment currently available. In some cases, immune therapy may be a potential treatment option for PBL, providing new insights into its management.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xi Chen, Wanchun Wu, Wenwen Wei, Liqun Zou
Summary: Peripheral T-cell lymphomas (PTCLs) are highly heterogeneous and immune checkpoint therapies, particularly PD-1/PD-L1 blockers, show promise as a treatment option for this disease. The clinical trials of these blockers have demonstrated good efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Alberto Torres-Zurita, Lucia Vazquez-Montero, Laura Gallego-Lopez, Maria Dolores Mediano-Rambla, Luis de la Cruz-Merino
Summary: Immune checkpoint inhibitors have become an important treatment for many tumors, but they are also associated with several new side effects. We present a case of a 41-year-old male patient with advanced hepatocellular carcinoma who developed adverse reactions, including lymphadenopathy and anterior uveitis, after receiving combination therapy with nivolumab and ipilimumab. The diagnosis was confirmed to be a sarcoidosis-like reaction induced by immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Michael P. Randall, Michael A. Spinner
Summary: The treatment landscape of relapsed/refractory classic Hodgkin lymphoma (cHL) has significantly evolved over the past decade and has led to improved cure rates and overall survival. This review discusses the management of first relapse, maintenance therapy after transplant, relapse after transplant, and treatment of older adults and frail patients. Additionally, emerging immunotherapies in clinical trials are highlighted.
Article
Cell Biology
Lynn S. zur Bonsen, Dominika Pohlmann, Anne Ruebsam, Uwe Pleyer
Summary: Ocular involvement is common in sarcoid patients, with uveitis being the main manifestation. This study analyzed the medical records of 84 patients in a tertiary ophthalmology center to determine the incidence and characteristics of ocular sarcoidosis. The diagnosis was supported by specific ocular findings, biopsy, imaging, and laboratory tests. The lungs, skin, and central nervous system were also commonly affected. The findings emphasize the important role of the eye in early detection of sarcoidosis.
Article
Immunology
Chengzhi Zhou, Yilin Yang, Xinqing Lin, Nianxin Fang, Likun Chen, Juhong Jiang, Haiyi Deng, Yu Deng, Minghui Wan, Guihuan Qiu, Ni Sun, Di Wu, Xiang Long, Changhao Zhong, Xiaohong Xie, Zhanhong Xie, Ming Liu, Ming Ouyang, Yinyin Qin, Francesco Petrella, Alfonso Fiorelli, Sara Bravaccini, Yuki Kataoka, Satoshi Watanabe, Taichiro Goto, Piergiorgio Solli, Hitoshi Igai, Yuichi Saito, Nikolaos Tsoukalas, Takeo Nakada, Shiyue Li, Rongchang Chen
Summary: This study conducted a comprehensive analysis of clinical characteristics, radiological features, histologic features, and laboratory tests of patients with checkpoint inhibitor-related pneumonitis (CIP). Based on the analysis, the study proposed the acute, subacute, and chronic phases of CIP and summarized the characteristics of each phase. The results showed that symptoms improved, radiological features changed, histologic features progressed, and levels of certain biomarkers fluctuated as the disease advanced.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yanping Wang, Yi Zhang, Shengchen Su, Patrick Tamukong, Ramachandran Murali, Hyung L. Kim
Summary: CD4+ regulatory T cells (Tregs) are crucial in controlling anti-tumor immune responses. A new PROTAC drug, PF, that targets the transcription factor FoxP3, has been developed. PF effectively decreases FoxP3 expression in Tregs, enhancing CD8+ lymphocyte proliferation and activation, as well as inhibiting tumor growth. PF also synergizes with immune checkpoint inhibitors and mTOR inhibitors to enhance antitumor immunity. This study provides important evidence for the potential use of PF in cancer immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biology
Raffaella Calabretta, Philipp B. Staber, Christoph Kornauth, Xia Lu, Patrick Binder, Verena Pichler, Markus Mitterhauser, Alexander Haug, Xiang Li, Marcus Hacker
Summary: The study demonstrated that immune checkpoint inhibitor therapy may play a critical role in regulating arterial inflammation, potentially increasing the risk of future cardiovascular events in young oncological patients.
Review
Clinical Neurology
Pitcha Chompoopong, Teerin Liewluck
Summary: Non-necrotizing granulomatous inflammation is a rare but easily recognizable histopathological finding in skeletal muscle biopsy. There are limited diseases associated with non-necrotizing granulomatous myopathy, with sarcoid myopathy and inclusion body myositis being the two main causes. Identifying the etiology of granulomatous myopathy is important for guiding appropriate treatment.
Article
Ophthalmology
Frederik Holm, Lauge Hjorth Mikkelsen, Peter Kamper, Peter Kristian Rasmussen, Thomas Stauffer Larsen, Lene Dissing Sjo, Steffen Heegaard
Summary: This study identified an increasing incidence of OAL in the Danish population, with changes in subtype distribution and survival outcomes. The findings provide important insights for the management and prognosis of OAL.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Rheumatology
Flora Magnotti, Tiphaine Malsot, Sophie Georgin-lavialle, Fatima Abbas, Amandine Martin, Alexandre Belot, Maxime Fauter, Muriel Rabilloud, Mathieu Gerfaud-Valentin, Pascal Seve, Agnes Duquesne, Arnaud Hot, Stephane Durupt, Lea Savey, Irina Giurgea, Gilles Grateau, Thomas Henry, Yvan Jamilloux
Summary: In the study, monitoring inflammasome activation in response to UCN-01 was found to differentiate FMF patients from healthy donors and patients with other inflammatory disorders. Combining pyroptosis and IL-1 beta measurement increased the sensitivity and specificity of UCN-01-based assays for accurate FMF diagnosis. The UCN-01-triggered monocyte responses were influenced by MEFV gene dosage and mutations, similarly to clinical phenotypes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Pharmacology & Pharmacy
Thomas El Jammal, Pascal Seve, Mathieu Gerfaud-Valentin, Yvan Jamilloux
Summary: This article reviews the approved and emerging JAK inhibitors for the treatment of RA and provides expert perspectives on the subject area. JAK inhibitors are considered as an interesting alternative when methotrexate fails in treating RA.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Letter
Hematology
Estelle Bourbon, Mael Heiblig, Mathieu Gerfaud Valentin, Thomas Barba, Cecile-Audrey Durel, Jean Christophe Lega, Fiorenza Barraco, Pascal Seve, Yvan Jamilloux, Pierre Sujobert
Editorial Material
Medicine, General & Internal
Y. Jamilloux
REVUE DE MEDECINE INTERNE
(2021)
Article
Medicine, General & Internal
Caroline Borciuch, Mathieu Fauvernier, Mathieu Gerfaud-Valentin, Pascal Seve, Yvan Jamilloux
Summary: Still's disease in France has a mortality rate of 0.13/million person-years, with no difference between men and women. Young Still's disease patients are more likely to die from cardiovascular events, while patients at all ages are more likely to die from infections compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Clement Javaux, Thomas El-Jammal, Pierre-Antoine Neau, Nicolas Fournier, Mathieu Gerfaud-Valentin, Laurent Perard, Marine Fouillet-Desjonqueres, Julie Le Scanff, Emmanuelle Vignot, Stephane Durupt, Arnaud Hot, Alexandre Belot, Isabelle Durieu, Thomas Henry, Pascal Seve, Yvan Jamilloux
Summary: Distinguishing between macrophage activation syndrome (MAS) and a simple flare of Still's disease (SD) may be challenging. This study aimed to clarify the clinical features and outcome of MAS in SD and explore predictive factors for MAS development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Suzanne Bera, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Stephane Durupt, Raphaele Nove-Josserand, Jean-Christophe Lega, Isabelle Durieu, Arnaud Hot, Pascal Seve
Summary: This retrospective study aimed to determine the etiologies and prognosis of inflammation of unknown origin (IUO) and the contribution of complementary examinations. The results showed that more than half of the IUO cases remained undiagnosed and non-infectious inflammatory diseases and hematological malignancies were the most common causes. 18-FDG-PET/CT had the highest diagnostic value. Most IUO without final diagnosis persisted, and the role of empirical treatments needs further exploration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Clara Baverez, Maximilien Grall, Mathieu Gerfaud-Valentin, Sarah De Gail, Alexandre Belot, Thomas Perpoint, Emmanuelle Weber, Quitterie Reynaud, Pascal Seve, Yvan Jamilloux
Summary: Anakinra is an effective and safe treatment for secondary HLH, showing rapid symptom relief and reduction of inflammatory markers. Further prospective randomized clinical trials are needed to confirm its efficacy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Pascal Seve, Thomas El Jammal, Mathieu Gerfaud-Valentin, Laurent Kodjikian, Yvan Jamilloux, Robin Jacquot
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Arthur Guerber, Etienne Garneret, Thomas El Jammal, Sabine Zaepfel, Mathieu Gerfaud-Valentin, Pascal Seve, Yvan Jamilloux
Summary: Glycosylated ferritin (GF) has been found to be a good diagnostic biomarker for adult-onset Still's disease (AOSD), with high diagnostic accuracy and specificity. Setting the GF threshold at 16% can increase the specificity and positive predictive value for AOSD diagnosis. GF is important for ruling out differential diagnoses and classifying AOSD in clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Florence Chaudot, Pascal Seve, Antoine Rousseau, Alexandre Thibault Jacques Maria, Pierre Fournie, Pierre Lozach, Jeremy Keraen, Marion Servant, Romain Muller, Baptiste Gramont, Sara Touhami, Habeeb Mahmoud, Pierre-Antoine Quintart, Stephane Dalle, Olivier Lambotte, Laurent Kodjikian, Yvan Jamilloux
Summary: This study analyzed ocular immunotherapy-related adverse events (IRAEs) diagnosed in France after the marketing of immune checkpoint inhibitors (ICPIs). The results showed that these events were more common in patients undergoing treatment for metastatic melanoma, and local or systemic corticosteroids were effective in controlling them.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Maxime Fauter, Sabine Mainbourg, Thomas El Jammal, Arthur Guerber, Sabine Zaepfel, Thomas Henry, Mathieu Gerfaud-Valentin, Pascal Seve, Yvan Jamilloux
Summary: This study retrospectively analyzed the diagnosis and prognosis of extreme hyperferritinemia, finding that hyperferritinemia is associated with various conditions, but extreme hyperferritinemia is only associated with four causes, with HLH and acute hepatitis being the most common. Patients with extreme hyperferritinemia have a poor prognosis and increased mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Thomas El Jammal, Arthur Guerber, Martin Prodel, Maxime Fauter, Pascal Seve, Yvan Jamilloux
Summary: This study proposes a machine learning approach to build a classification model for HLH in a cohort of patients selected by glycosylated ferritin dosage in a tertiary center in Lyon, France. The model showed good diagnostic performances on a dataset of 207 adult patients, but further studies are needed to improve its performance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Pierre-Antoine Neau, Thomas El-Jammal, Clement Javaux, Nicolas Fournier, Orlane Chol, Leopold Adelaide, Kim Heang Ly, Mathieu Gerfaud-Valentin, Laurent Perard, Marine Fouillet-Desjonqueres, Julie Le Scanff, Emmanuelle Vignot, Arnaud Hot, Alexandre Belot, Isabelle Durieu, Pascal Seve, Yvan Jamilloux
Summary: Still's disease is a heterogeneous autoinflammatory disorder with various phenotypes. The study found that sore throat and myalgia were more common in AOSD patients, while symptoms like fever and skin rash predicted complete remission or recovery.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Solene La Marle, Gaelle Richard-Colmant, Mathieu Fauvernier, Herve Ghesquieres, Arnaud Hot, Pascal Seve, Yvan Jamilloux
Summary: This study used multiple-cause-of-death analysis to investigate the mortality and associated causes of Hemophagocytic lymphohistiocytosis (HLH). Between 2000 and 2016, HLH was mentioned in 2072 death certificates, with 232 cases as the underlying cause of death and 1840 cases as a non-underlying cause of death. The age-standardized mortality rate of HLH was 1.93 per million person-years and showed an increasing trend over the study period. HLH decedents were more likely to have associated CMV infections or hematological diseases compared to the general population.
JOURNAL OF CLINICAL MEDICINE
(2023)