Article
Chemistry, Multidisciplinary
Yiran Zheng, Zhiyuan Zhong
Summary: Cancer vaccines have become powerful and clinically viable therapeutic modalities for reducing tumor burden, eradicating residual cancer cells, and preventing relapse. Recent years have seen rapid advancements in next-generation cancer vaccines, with cutting-edge technologies focused on eliciting robust and durable immune responses specific to cancer, as well as reducing systemic side effects. This perspective highlights innovative strategies such as high-throughput screening for neoantigens and optimal delivery systems, knowledge-based de novo design of effective delivery platforms with tissue-targeting specificity, and synergizing cancer vaccines with clinical immunotherapeutic practices like CAR-T and anti-PD-1 therapies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Qi Liu, Janice B. Schwartz, Patricia W. Slattum, S. W. Johnny Lau, Daphne Guinn, Rajanikanth Madabushi, Gilbert Burckart, Robert Califf, Francesca Cerreta, Carolyn Cho, Jack Cook, Jamie Gamerman, Paul Goldsmith, Piet H. van der Graaf, Jerry H. Gurwitz, Sebastian Haertter, Sarah Hilmer, Shiew-Mei Huang, Sharon K. Inouye, Bindu Kanapuru, Munir Pirmohamed, Phil Posner, Barbara Radziszewska, H. Keipp Talbot, Robert Temple
Summary: In order to better understand and evaluate the safety and effectiveness of drugs in older adults, it is necessary to increase the representation of older adults in clinical trials, eliminate barriers and set enrollment goals, and obtain various relevant data during trials to guide dosing decisions and reduce risks. Additionally, trial data should be analyzed to assess differences caused by age or common conditions, and drug labels should be updated throughout the product lifecycle.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Hanul Choi, Jungmin Chun, Mina Park, Suyeon Kim, Nahyun Kim, Hee-Jung Lee, Minjee Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
Summary: The research team developed a genetic vaccine using a recombinant baculovirus vector that enhances gene delivery efficiency and demonstrated high levels of immune response in mice. In challenge tests using IFN knock-out mice, the vaccine showed complete protection, indicating its potential as a vaccine candidate for human application.
Editorial Material
Chemistry, Physical
Irene Rubia-Rodriguez, Antonio Santana-Otero, Simo Spassov, Etelka Tombacz, Christer Johansson, Patricia De La Presa, Francisco J. Teran, Maria del Puerto Morales, Sabino Veintemillas-Verdaguer, Nguyen T. K. Thanh, Maximilian O. Besenhard, Claire Wilhelm, Florence Gazeau, Quentin Harmer, Eric Mayes, Bella B. Manshian, Stefaan J. Soenen, Yuanyu Gu, Angel Millan, Eleni K. Efthimiadou, Jeff Gaudet, Patrick Goodwill, James Mansfield, Uwe Steinhoff, James Wells, Frank Wiekhorst, Daniel Ortega
Summary: The scientific community has put great efforts in advancing magnetic hyperthermia in the past two decades, with fruitful international cooperation and careful analysis of lessons learned providing better guarantees for the future development of this nanotherapy against cancer.
Article
Energy & Fuels
Dragos Neagu, J. T. S. Irvine, Jiayue Wang, Bilge Yildiz, Alexander K. Opitz, Juergen Fleig, Yuhao Wang, Jiapeng Liu, Longyun Shen, Francesco Ciucci, Brian A. Rosen, Yongchun Xiao, Kui Xie, Guangming Yang, Zongping Shao, Yubo Zhang, Jakob Reinke, Travis A. Schmauss, Scott A. Barnett, Roelf Maring, Vasileios Kyriakou, Usman Mushtaq, Mihalis N. Tsampas, Youdong Kim, Ryan O'Hayre, Alfonso J. Carrillo, Thomas Ruh, Lorenz Lindenthal, Florian Schrenk, Christoph Rameshan, Evangelos I. Papaioannou, Kalliopi Kousi, Ian S. Metcalfe, Xiaoxiang Xu, Gang Liu
Summary: In the past decade, exsolution has become a powerful method for decorating oxide supports with dispersed nanoparticles for energy and catalytic applications. Exsolved nanoparticles have set new standards in terms of activity, durability, and functionality, due to their exceptional anchorage and ability to be produced, transformed, and applied in various ways. When combined with multifunctional supports like perovskite oxides, exsolution becomes a promising platform for advanced energy materials. This review discusses the current status of exsolution and explores future research directions for its application.
JOURNAL OF PHYSICS-ENERGY
(2023)
Article
Public, Environmental & Occupational Health
Elham Maserat, Leila Keikha, Somayeh Davoodi, Zeinab Mohammadzadeh
Summary: The study developed a multidimensional e-health roadmap for responding to the Covod-19 pandemic and investigating the role of IT in improving vaccine distribution in Iran. The technology-based roadmap went through a two-stage Delphi method process, involving 14 e-health experts to confirm 4 conceptual models for vaccine distribution stages.
Review
Biotechnology & Applied Microbiology
Mohammad Shoushtari, Farzin Roohvand, Mostafa Salehi-Vaziri, Arash Arashkia, Hasan Bakhshi, Kayhan Azadmanesh
Summary: Flaviviruses are arthropod-borne viruses that pose significant public health problems. While vaccines have been approved for some flaviviruses, there is a lack of effective vaccines for other hazardous flaviviruses. Adenovirus vector-based vaccines are suggested as a promising approach, as demonstrated by their successful use in the COVID-19 pandemic.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Neil Lin, Daksh Verma, Nikhil Saini, Ramis Arbi, Muhammad Munir, Marko Jovic, Ayse Turak
Summary: Nanoparticles present new opportunities for merging therapeutics and new materials, with metal-based nanoparticles showing promising antiviral capabilities in preventing pathogen transmission; through various mechanisms, they can effectively inactivate viruses and potentially inhibit the pathogenesis of viruses like SARS-CoV-2.
Article
Infectious Diseases
Corey L. Campbell, Trey K. Snell, Susi Bennett, John H. Wyckoff, Darragh Heaslip, Jordan Flatt, Emma K. Harris, Daniel A. Hartman, Elena Lian, Brian H. Bird, Mark D. Stenglein, Richard A. Bowen, Rebekah C. Kading
Summary: The study showed that DDVax had significantly lower infection rates in mosquitoes and could not be transmitted between mosquitoes. Although infectious virus could be isolated from the bodies of mosquitoes fed on goats inoculated with DDVax or MP-12, the number of DDvax-positive mosquitoes was significantly reduced. Furthermore, DDVax did not disseminate to the legs and wings of mosquitoes fed on goats.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Emily E. Coates, Srilatha Edupuganti, Grace L. Chen, Myra Happe, Larisa Strom, Alicia Widge, Maria Burgos Florez, Josephine H. Cox, Ingelise Gordon, Sarah Plummer, Abidemi Ola, Galina Yamshchikov, Charla Andrews, Sharon Curate -Ingram, Patricia Morgan, Shashi Nagar, Matthew H. Collins, Amy Bray, Thuy Nguyen, Judy Stein, Christopher L. Case, Florence Kaltovich, Diane Wycuff, Jason Liang, Kevin Carlton, Sandra Vazquez, John R. Mascola, Julie E. Ledgerwood
Summary: This study evaluated the safety, tolerability, and immunogenicity of an investigational trivalent virus-like particle vaccine for Western, Eastern, and Venezuelan equine encephalitis viruses. The vaccine was found to be safe and well tolerated, and induced an immune response. The results of this study suggest that the WEVEE VLP vaccine deserves further evaluation in advanced-phase clinical trials.
LANCET INFECTIOUS DISEASES
(2022)
Review
Biochemical Research Methods
Esther H. Roh, Catherine A. Fromen, Millicent O. Sullivan
Summary: Global implementation of mRNA vaccines has advanced the treatment of respiratory diseases significantly. These vaccines provide high efficacy and adaptability, but questions regarding immune persistence and formulation stability remain. Developing inhaled mRNA vaccines can generate long-lasting tissue-specific memory responses for rapid recall and immediate local protection. Advances in pulmonary delivery technologies offer potential solutions to overcome translation challenges.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lulu Han, Shuai Song, Huilin Feng, Wenqiang Wei, Fusheng Si
Summary: Venezuelan equine encephalitis (VEE) is a serious zoonotic disease caused by the VEE virus, posing a major threat to both humans and animals. The lack of licensed vaccines or drugs for human use against VEEV has prompted extensive research on vaccine development. This paper provides an overview of VEEV and its infection mechanism, introduces the available vaccine types, and highlights the challenges and potential strategies for vaccine development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Materials Science, Multidisciplinary
Syed Tawab Shah, Zaira Zaman Chowdhury, Khanom Simarani, Wan Jefrey Basirun, Irfan Anjum Badruddin, Mohamed Hussien, Hussein Alrobei, Sarfaraz Kamangar
Summary: Antioxidants work by converting free radicals into harmless chemicals, interfering with potentially hazardous chain reactions. They have limited impact on cellular health and function due to low absorption, inability to cross cellular membrane, and disintegration during delivery. To overcome these challenges, antioxidants have been covalently attached to nanoparticles or encapsulated in particles with a hollow center, providing improved stability, slow sustained release, biocompatibility, and targeted administration.
Review
Pharmacology & Pharmacy
Sihua Wu, Yufei Xia, Yuning Hu, Guanghui Ma
Summary: Bio-mimic particles are developed to mimic the natural traits of pathogens, providing optimal strategies to stimulate immune engagement and increase vaccine efficacy. Design principles include surface characteristics (hydrophobic, nano-pattern, antigen display, charge), properties (size, shape, softness), and delivered components (peptide, protein, nuclear acids, TLR agonist, antibody), along with efficient delivery strategies.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Polymer Science
Nusaiba K. Al-Nemrawi, Ruba S. Darweesh, Lubna A. Al-shriem, Farah S. Al-Qawasmi, Sereen O. Emran, Areej S. Khafajah, Muna A. Abu-Dalo
Summary: This review focuses on the importance of pulmonary delivery of vaccines and the use of polymeric nanoparticles as a delivery tool. The study found that polymeric nanoparticles have adjuvant properties and can induce immune responses. In addition, factors such as particle size, morphology, and charge influence their behavior in vivo.
Article
Chemistry, Applied
Jordano Augusto Carvalho Sousa, Adriana Cotta Cardoso Reis, Cintia Lopes de Brito Magalhaes, Breno de Mello Silva, Geraldo Celio Brandao
Summary: A new flavone compound and four known compounds were isolated from the ethanolic extract of Rauia resinosa leaves. The structures of all compounds were determined through spectroscopic methods. Cytotoxicity evaluation was conducted on the extracts, fractions, and selected compounds.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Thiago M. Santos, Ayrton B. P. Lisboa, Wenderson Rodrigues, Helena Gomes, Jonatas Abrahao, Luiz-Eduardo Del-Bem
Summary: This study investigated the impact of ACE2 protein variations on SARS-CoV-2 Variants Of Concern (VOCs) through molecular simulations. The results showed that VOCs bind more efficiently to human ACE2, and ACE2 protein variations can weaken the interaction and protein stability with SARS-CoV-2.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Adriana Cotta Cardoso Reis, Gabriel Mendonca Valente, Breno de Mello Silva, Cintia Lopes de Brito Magalhaes, Markus Kohlhoff, Geraldo Celio Brandao
Summary: The ethanolic extracts of Millingtonia hortensis leaves and Oroxylum indicum stems showed antiviral activity against Chikungunya, Zika, and Mayaro viruses, and the isolated compound hispidulin from M. hortensis leaves also exhibited antiviral activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Microbiology
Ricardo Lemes Goncalves, Gabriel Augusto Pires de Souza, Mateus de Souza Terceti, Renato Froes Goulart de Castro, Breno de Mello Silva, Romulo Dias Novaes, Luiz Cosme Cotta Malaquias, Luiz Felipe Leomil Coelho
Summary: The rapid spread of SARS-CoV-2 led to the COVID-19 pandemic, prompting research into drugs and vaccines to prevent or treat the infection. Despite two years of efforts, there is still much to be understood about the virus' pathology. Transcriptomics and deep learning algorithms were used to identify differentially expressed targets and potential inhibitors for COVID-19 treatment, offering a helpful tool for personalized screening of molecules.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Virology
Amanda Stephanie Arantes Witt, Giliane de Souza Trindade, Fernanda Gil de Souza, Mateus Sa Magalhaes Serafim, Alana Vitor Barbosa da Costa, Marcos Vinicius Ferreira Silva, Felipe Campos de Melo Iani, Rodrigo Araujo Lima Rodrigues, Erna Geessien Kroon, Jonatas Santos Abrahao
Summary: In May 2022, the first worldwide outbreak of monkeypox virus (MPXV) was reported, showing different clinical aspects compared to previous human monkeypox infections. This study used transmission electron microscopy (TEM) to evaluate the ultrastructural features of MPXV infection in Vero cells. The results revealed various aspects of the MPXV cycle, including the entry of intracellular mature virus particles, reorganization of the endoplasmic reticulum, and distinct regions in the viral factory. The findings also showed viral crescents, different MPXV particle morphotypes, and cellular alterations induced by infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Isabella Luiza Martins de Aquino, Mateus Sa Magalhaes Serafim, Talita Bastos Machado, Bruna Luiza Azevedo, Denilson Eduardo Silva Cunha, Leila Sabrina Ullmann, Joao Pessoa Araujo Jr, Jonatas Santos Abrahao
Summary: This study analyzed different mimivirus isolates and found at least three different patterns of surface fibrils, which may influence viral interaction with host cells. The study also raises questions about the evolution of these structures.
JOURNAL OF VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Julianne Caravita Grisolia, Pedro Luiz Rosalen, Lauana Aparecida Santos, Masaharu Ikegaki, Luiz Cosme Cotta Malaquias, Eva Burger
Summary: PCM is a severe mycosis caused by Paracoccidioides brasiliensis, mainly found in tropical countries. Itraconazole has marked antifungal activity against Pb and can activate both innate and acquired immunity. The effect of Itraconazole on Pb infection varies with different doses, with lower doses enhancing immune response and higher doses not requiring immune response.
Article
Microbiology
Duillio Alves Caixeta, Mariana Araujo Vieira do Carmo, Flavio Guimaraes da Fonseca, Denismar Alves Nogueira, Luiz Felipe Leomil Coelho, Luiz Cosme Cotta Malaquias
Summary: This study aimed to conduct a seroepidemiological survey of SARS-CoV-2 in three hospitals in the south of Minas Gerais state, Brazil. A total of 859 samples were collected between August and December 2020, and Enzyme-linked immunosorbent assays (ELISA) were performed on participants sera. The results showed that 21.6% of participants had positive serological tests, with higher prevalence in women and healthcare professionals.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lienne D'Auria Lima, Adriana Cotta Cardoso Reis, Jordano Augusto Carvalho Sousa, Gabriel Mendonca Valente, Breno de Mello Silva, Cintia Lopes de Brito Magalhaes, Markus Kohlhoff, Luiz Fernando de Medeiros Teixeira, Geraldo Celio Brandao
Summary: The ethanolic extract of Curatella americana showed significant in vitro anti-Zika virus activity. It had no cytotoxicity for MRC-5 cells and moderately cytotoxicity for Vero cells. The ethyl acetate fraction of the extract exhibited potent activity against the Zika virus, and several flavonoids isolated from this fraction also showed antiviral activity.
Article
Chemistry, Medicinal
Lucianna H. Santos, Rafael E. O. Rocha, Diego L. Dias, Beatriz M. R. M. Ribeiro, Mateus Sa M. Serafim, Jonatas S. Abrahao, Rafaela S. Ferreira
Summary: The NS2B-NS3 protease (NS2B-NS3pro) is an important target for drug development against the Zika virus (ZIKV). This study utilized virtual screening and computational methods to target two non-peptide small-molecule scaffolds with inhibitory activity against ZIKV NS2B-NS3pro. While initial results were promising, further assays revealed artificial inhibition of the compounds. However, two compounds were found to exhibit antiviral properties in cellular-based assays.
Review
Medicine, Research & Experimental
Isabella Luiza Martins de Aquino, Matheus Gomes Barcelos, Talita Bastos Machado, Mateus Sa Magalhaes Serafim, Jonatas Santos Abrahao
Summary: The capsid plays a central role in the life cycle of viruses, protecting the viral genome and facilitating host cell interaction and infection. Giant viruses that infect protists have attracted attention for their bacterial-like dimensions and unique features, such as surface fibrils. This mini review compiles important information on the surface fibrils of nucleocytoviruses, including their functions, composition, length, organization, and origins.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Meeting Abstract
Biophysics
Kristin Parent, Jason R. Schrad, Anastasiya A. Lavell, Juliana R. Cortines, Jonatas Abrahao
BIOPHYSICAL JOURNAL
(2022)
Letter
Biochemistry & Molecular Biology
Ricardo Lemes Goncalves, Tulio Cesar Rodrigues Leite, Bruna de Paula Dias, Camila Carla da Silva Caetano, Ana Clara Gomes de Souza, Ubiratan da Silva Batista, Camila Cavadas Barbosa, Arturo Reyes-Sandoval, Luiz Felipe Leomil Coelho, Breno de Mello Silva
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)