Article
Chemistry, Multidisciplinary
Marie Kuehne, Henry Lindemann, Christian Grune, Daniel Schroeder, Zoltan Cseresnyes, Maren Godmann, Andreas Koschella, Marc Thilo Figge, Christian Eggeling, Dagmar Fischer, Thomas Heinze, Thorsten Heinzel
Summary: Bio-based nanoparticles (NPs) as drug carriers have rapid cellular uptake, no cytotoxicity, and ability to induce histone H3 hyperacetylation, making them suitable for treating inflammation, sepsis, and cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Biochemistry & Molecular Biology
Li-Ching Liu, Yi-Hao Chen, Da-Wen Lu
Summary: Ocular diseases have a significant impact on patients' vision and quality of life worldwide, but the unique anatomical and physiological barriers in the eye make effective drug delivery challenging. This comprehensive review provides an overview of various nano-based drug delivery systems for ocular applications, discussing their biology, methodology, clinical applications, and recent studies highlighting advantages and challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Physical
Doaa S. R. Khafaga, Mohamed G. Radwan, Ghazala Muteeb, Mohammad Aatif, Mohd Farhan
Summary: Nanobiocatalysts (NBCs) are a new class of biocatalysts that combine the advantages of enzymes and nanomaterials, improving stability, activity, and selectivity. They address the need for sustainable and environmentally friendly bioprocessing methods, providing a reusable platform for enzymes. The key challenge in NBCs development is enzyme immobilization, which protects enzymes and enables easy recovery and reuse. This review explores the effective role of NBCs in the pharmaceutical and biomedical fields.
Review
Chemistry, Multidisciplinary
Yang Xing, Feroza Yasinjan, Mei Yang, Yajie Du, Huayue Geng, Minghua He, Yingtong Wang, Jicheng Sun, Wei Jiang, Ling Zhang, Baofeng Guo, Kelong Fan
Summary: This paper provides a comprehensive understanding of the advancements in nano-based drug delivery systems for glioblastoma treatment through a systematic scientometric analysis. China and the United States have made significant contributions to this field. The analysis identifies research trends and hot spots through keyword analysis and recognizes the main types of nanocarriers used in this field, laying the foundation for further research.
Article
Chemistry, Applied
Min Li, Yinan Zhao, Wenjun Zhang, Shufen Zhang, Shubiao Zhang
Summary: Polysaccharide-based biomaterials, such as chitosan and hyaluronic acid, are naturally abundant and biocompatible, making them ideal for drug delivery and tumor therapy. These materials can be easily modified and have shown great potential in enhancing various cancer treatments, including chemotherapy and phototherapy. This review provides insights into the design and utilization of polysaccharide-based nanoparticles for advanced cancer therapies.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Mingxiao Cui, Min Zhang, Kehai Liu
Summary: Polysaccharide-based nanocarriers can help reduce the side effects of drugs used for treating inflammatory bowel disease (IBD) by targeting the colon and enhancing their bioavailability. Polysaccharides also play a role in alleviating IBD through their anti-inflammatory and intestinal microecological regulatory effects.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Multidisciplinary
Min Zhang, He Ma, Xijie Wang, Bing Yu, Hailin Cong, Youqing Shen
Summary: Polysaccharide-based nanocarriers (PBNs) have gained significant attention due to their biocompatibility, cost-effectiveness, availability, and versatility in loading anticancer agents. However, the heterogeneous tumor structures compromise the enhanced permeability and retention (EPR) effect, hindering efficient drug delivery. Overcoming the biological barriers for extravasation from tumor vessels is crucial for optimizing PBNs. Various strategies, including nanocarrier property regulation and tumor structure remodeling, have been developed to enhance the EPR effect. This review summarizes recent advances in the design of PBNs with enhanced transvascular transport and discusses the challenges in understanding the transendothelial mechanism of PBNs and their interactions with other drug delivery steps.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biotechnology & Applied Microbiology
Poonam Banthia, Lokesh Gambhir, Asha Sharma, Dhiraj Daga, Neha Kapoor, Rishabh Chaudhary, Gaurav Sharma
Summary: This review discusses the breakthrough of nanotechnology in targeted drug delivery for breast cancer treatment. Nanomedicines using nanoenabled carriers offer advantages like targeted delivery, stability, biocompatibility, and enhanced efficacy. Various nanoassemblies have revolutionized targeted therapeutic delivery by improving drug solubility, reducing dose and toxicity. However, challenges such as identifying appropriate biomarkers, understanding biological processes, ensuring batch uniformity and nanomaterial toxicity and stability still exist.
Review
Biochemistry & Molecular Biology
Nisha Yadav, Deeksha Mudgal, Ritesh Anand, Simran Jindal, Vivek Mishra
Summary: This article summarizes the current developments in nano/micro-encapsulation techniques, with a focus on the encapsulation of natural bioactives using chitosan as a carrier. Polysaccharide-based nano/micro-formulations have emerged as a new trend in scientific research and development, with potential applications in drug delivery systems and nanocarrier formulations.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Chemistry, Multidisciplinary
Ranjit De, Manoj Kumar Mahata, Kyong-Tai Kim
Summary: This article comprehensively investigates the effects of structural design-based varieties of PNCs on drug delivery profiles, with perspectives highlighting the inevitability of incorporating both multi-stimuli-responsive and multi-drug delivery properties in a single carrier.
Review
Chemistry, Medicinal
He Ma, Zhenxiang Pan, Bingjie Lai, Chunfang Zan, He Liu
Summary: From a clinical perspective, local anesthetics have widespread application in various medical procedures. However, traditional local anesthetic agents have limitations such as neurotoxicity and short duration of action. Nanotechnology-based drug delivery systems have emerged as a promising solution to enhance drug release and prolong the effects of local anesthetics with reduced systemic toxicity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mingxiao Cui, Zhou Fang, Mengdi Song, Taidi Zhou, Yongjie Wang, Kehai Liu
Summary: This study constructed nano-drug delivery systems based on Phragmites rhizoma polysaccharide, which effectively alleviated ulcerative colitis, and explored the significant roles of the Phragmites rhizoma polysaccharide-based nanocarriers in the drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Arian Farokh, Erfan Rahmani, Mohammad Mahdi Eshaghi, Ali Aslani, Abbas Rahdar, Luiz Fernando Romanholo Ferreira
Summary: Hydrogels are important materials in medical research, particularly in the field of drug delivery systems. Polyacrylic acid (PAA) is a notable polymer in this regard, due to its biodegradability and pH-sensitivity. PAA's potential in cancer therapy and oral drug delivery has led to extensive research, with a focus on target-specific carriers based on PAA and its derivatives. This review provides an overview of the formation, properties, and recent developments of PAA-contained drug carriers for cancer therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Polymer Science
Siphokazi B. K. Dludla, Leshasha T. Mashabela, Brian Ng'andwe, Pedzisai A. Makoni, Bwalya A. Witika
Summary: The application of nanotechnology in ophthalmic drug delivery systems shows great potential to overcome barriers faced by traditional ophthalmic formulations. Stimuli-responsive nano drug carriers have attracted significant attention due to their unique functionalities and therapeutic efficacy, playing a crucial role in the treatment and alleviation of ocular diseases.
Article
Chemistry, Physical
Seyithan Kansiz, Yasar Murat Elcin
Summary: Liposomes and polymersomes are self-assembled vesicles that can encapsulate hydrophilic and hydrophobic therapeutics, making them important in drug delivery research. They have versatile designs for different drug delivery applications. This review article discusses the physical and biological barriers to efficient drug delivery and explores the design approaches, properties, targeting strategies, and stimuli response of liposomes and polymersomes. The challenges, recent clinical developments, and future perspectives are also addressed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Ophthalmology
Yan Ma, Yuhe Tian, Xia Chen, Rupesh Agrawal, Yun Feng
Summary: Herpes zoster ophthalmicus (HZO) is traditionally considered as a unilateral disease, but subclinical involvements in the contralateral eye structures are evidence. Our study using a pupillometer and an esthesiometer found significantly abnormal features in both affected and contralateral eyes of HZO patients.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Yue Li, Louis Tong, Chrystie Quek, Yun Feng
Summary: This review focuses on novel research in immunology of herpes zoster ophthalmicus (HZO) and aims to formulate hypotheses of spread of lesions through the central nervous system (CNS).
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Zhen Yang, Shuo Yu, Chun Zhang, Rupesh Agrawal, Yun Feng
Summary: This case series provides important insights for the management strategy of severe viral keratitis. Evaluation of characteristics of retrocorneal plaques by ASOCT and reduced corneal sensation are valuable aids in diagnosis. Conservative medical management may be a viable option, and IVIG may have a role in speedy resolution of severe cases.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Yujie Cen, Mingzhou Zhang, Yao Lu, Yun Feng
Summary: This study summarizes the benefits of the double-deck viscoelastic technique in aphakic and SO-dependent eyes, which can effectively inhibit SO-corneal endothelium interaction and reduce the rate of corneal endothelial cell density loss.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Agricultural Engineering
Jihua Zhao, Hongzhi Ma, Wenyu Wu, Mohammed Ali Bacar, Qunhui Wang, Ming Gao, Chuanfu Wu, Changlei Xia, Dayi Qian, William Woei Fong Chong, Su Shiung Lam
Summary: Two fermentation modes, electro-fermentation (EF) and traditional fermentation (TF), were used to produce medium-chain fatty acids (MCFAs) from different concentrations of liquor fermentation waste. EF mode at 40% substrate concentration resulted in the highest caproate (4.04 g/L) and butyrate (13.96 g/L) concentrations. TF experiments showed inhibition of ethanol oxidation and products formation above 40% substrate concentration. Compared to TF mode, EF mode significantly increased total substrates consumption by 2.6%-43.5% and product yields by 54.0%-83.0%. EF effectively alleviated substrate toxicity and enriched chain elongation bacteria, promoting ethanol oxidation and products formation. This study offers a new approach for producing MCFAs from high concentration wastewater.
BIORESOURCE TECHNOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Ruikai Wu, Wenyu Klingler Wu, Lucas Stieglitz, Sabyasachi Gaan, Bernhard Rieger, Manfred Heuberger
Summary: This review discusses the application and recent progress in the development of oc-diimine Ni and Pd complexes in catalyzed ethylene (co)polymerization. The effect of structural modifications on the catalytic behaviors and polymer properties is highlighted, as well as the heterogenization study on solid supports. The review provides valuable insights into the coordination-insertion chemistry and potential applications of these complexes.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Energy & Fuels
Jihua Zhao, Hongzhi Ma, Wenyu Wu, Mohammed Ali Bacar, Qunhui Wang, Ming Gao, Chuanfu Wu, Changlei Xia, Dayi Qian
Summary: Chinese liquor brewing wastewater (CLBW) can be upgraded to biofuels, specifically medium chain fatty acids (MCFAs), using microbial electrosynthesis (MES). The study found that under-1.0 V/CO2 condition, CLBW had the highest concentration and selectivity of caproate, which was 32.6% and 31.9% higher than the control group. The pH and electrochemical analysis supported the superiority of-1.0 V/CO2 condition. This study provides a new pathway for MCFAs production.
Article
Environmental Sciences
Qiang Yang, Yan Feng, Li Guan, Wenyu Wu, Sichen Wang, Qiangyu Li
Summary: X-band weather radar provides high-resolution data for precipitation observation and prediction, but it is susceptible to precipitation attenuation. This paper presents and validates an X-band attenuation correction method based on the LightGBM algorithm (the XACL method). The XACL method shows a significant correction effect and reduces the anomalous correction phenomenon compared to other methods. It achieves a 39.88% reduction in average error in precipitation estimation over 1204 meteorological stations.
Article
Plant Sciences
Xin Song, Baiquan Song, Jialu Huo, Huajun Liu, Muhammad Faheem Adil, Qiue Jia, Wenyu Wu, Abudukadier Kuerban, Yan Wang, Wengong Huang
Summary: Boron deficiency affects sugar beet production, and the use of nutrient-efficient varieties is an important solution. This study aimed to determine the effects of B deficiency on leaf phenotype and photosynthetic functions in B-efficient and B-inefficient sugar beet cultivars. The results showed that B-efficient cultivar had better adaptability to morphological changes and photosynthetic functions under B deficiency, providing theoretical basis for the selection of efficient sugar beet cultivars.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Lulu Zhang, Siqi Zhang, Wenyu Wu, Xingkai Wang, Jieting Shen, Dongyuan Wang, Kuan Hu, Ming-Rong Zhang, Feng Wang, Rui Wang
Summary: The development of immune checkpoint blockade therapy has revolutionized cancer therapies, but the heterogeneous expression of PD-L1 in tumor cells hinders its effectiveness. To enhance treatment efficacy, there is a need for better methods to stratify patients and visualize PD-L1 expression. This study designed a new method using a radiolabeled tracer to detect PD-L1 expression in tumors through PET imaging.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Chemistry, Physical
Shuo Li, Wenyu Wu, Huaxin Ma, Zhao Zhang, Yu Gu, Jingjie Zhang, Ruijun Zhang
Summary: A newly-developed strategy for preparing layer-tunable graphene has overcome the poor service life issue of graphene oxide (GO)-based membranes in water purification. The assembled graphene membrane with an average layer number of 3 exhibits a high rejection rate of 99.9% for Rhodamine B and a water flux of up to 3452.6 L m-2 h-1 bar-1, thanks to its unique hierarchically nanochannel structure. The membrane also demonstrates superior service performance with the rejection rate of RB maintained at 99.9% even after 24 cycles of filtrations.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Environmental
Wenyu Wu Klingler, Valentin Rougier, Zhenyu Huang, Dambarudhar Parida, Sandro Lehner, Andri Casutt, Daniel Rentsch, Karin Brandli Hedlund, Gion Andrea Barandun, Veronique Michaud, Sabyasachi Gaan
Summary: The development of reusable fire-safe polymers with a prolonged lifetime is important for transitioning towards a circular economy. A novel phosphonated thermoset was synthesized using a two-step methodology, showing good flame retardancy and reprocessability at phosphorus concentrations above 5%. This thermoset exhibited high Tg, good thermal stability, and demonstrated its potential for application as a polymer matrix in composite materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Multidisciplinary
Wenyu Wu Klingler, Aurelio Bifulco, Carolina Polisi, Zhenyu Huang, Sabyasachi Gaan
Summary: This article introduces the difficulty of recycling thermosets and two major challenges in designing next-generation thermosets: embedded fire safety and reprocessability/recyclability. The research progress in designing fire-safe and thermomechanically reprocessable/recyclable thermosets is detailed in this review, including the categorization based on the chemistry of labile bonds and the use of bio-based raw materials.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Fei Yu, Wenyu Wu, Liuting Zhang, Shaohua Li, Xiaochen Yao, Jun Wang, Yudan Ni, Qingle Meng, Rui Yang, Feng Wang, Liang Shi
Summary: This study aimed to develop a nomogram for predicting residual and recurrent cervical lymph node metastasis (CLNM) in postoperative papillary thyroid carcinoma (PTC) patients before I-131 therapy. Univariate and multivariate logistic regression analyses were performed to determine the risk factors of CLNM based on clinical and ultrasound features. Two nomograms were constructed based on models with high AUC, and their discrimination, calibration, and clinical usefulness were assessed through internal validation, calibration curves, and decision curves.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Automation & Control Systems
Renjie Zhu, Dongliang Fan, Wenyu Wu, Chongshan He, Guojie Xu, Jian S. Dai, Hongqiang Wang
Summary: By studying the combined softness-rigidity hybrid property of desert iguanas' skin, an anisotropic stiffness structure is developed, leading to the development of novel soft robots capable of various actions.
ADVANCED INTELLIGENT SYSTEMS
(2023)
