Article
Multidisciplinary Sciences
Yan-Zhe Zhang, Qian-Han Zhao, Hong-Wei Duan, Yuan-Jing Zou, Shao-Chen Sun, Lin-Lin Hu
Summary: Our study found that exposure to AFB1 had toxic effects on the distribution of mouse oocyte organelles, leading to a decline in oocyte quality.
Article
Environmental Sciences
Chun-Hua Xing, Yue Wang, Jing-Cai Liu, Zhen-Nan Pan, Hao-Lin Zhang, Shao-Chen Sun, Yu Zhang
Summary: Sudan I, an industrial dye illegally used in food, poses toxic effects on mouse oocytes by disrupting spindle organization and inducing mitochondrial dysfunction. Melatonin supplementation can protect against Sudan I-induced meiotic deteriorations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Tahir Muhammad, Yanling Wan, Qianqian Sha, Jianfeng Wang, Tao Huang, Yongzhi Cao, Mengjing Li, Xiaochen Yu, Yingying Yin, Wai Yee Chan, Zi-Jiang Chen, Li You, Gang Lu, Hongbin Liu
Summary: Advanced maternal age negatively impacts oocyte quality, but supplementation of IGF2 can promote oocyte maturation and reduce defects. IGF2 also enhances mitochondrial function, decreases oxidative stress, and improves overall health of aged mouse oocytes.
Article
Biochemistry & Molecular Biology
Xiuying Jiang, Xiangning Xu, Bicheng Wang, Ke Song, Jiaqi Zhang, Ye Chen, Ying Tian, Jing Weng, Yuanjing Liang, Wei Ma
Summary: 2-Methoxyestradiol (2-ME2), a metabolite of 17 beta-estradiol, is being studied as an antitumor agent. This study found that while 2-ME2 levels remain stable in the ovaries of aging mice, it declines in the serum. Exposure to 2-ME2 affects the meiotic maturation of mouse oocytes, leading to abnormal spindle structure and chromosome alignment. The study suggests that the impairment of oocyte maturation caused by 2-ME2 exposure is due to mitochondrial imbalance, oxidative stress, and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Qingrui Zhuan, Jun Li, Xingzhu Du, Luyao Zhang, Lin Meng, Yuwen Luo, Dan Zhou, Hongyu Liu, Pengcheng Wan, Yunpeng Hou, Xiangwei Fu
Summary: This study reveals the multi-protective roles of the antioxidant PCB2 in response to vitrification stimuli through mitochondria-mediated cortical tension regulation.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Yuan-Jing Zou, Meng-Meng Shan, Zhen-Nan Pan, Meng-Hao Pan, Xiao-Han Li, Shao-Chen Sun
Summary: This study demonstrates that GBF1 is stably expressed in mouse oocytes and plays a role in regulating organelle dynamics. Inhibiting GBF1 activity results in aberrant accumulation of the Golgi apparatus, condensation of GM130, abnormal ER distribution, ER stress, and altered mitochondrial functions.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Agriculture, Dairy & Animal Science
Sicong Yu, Lepeng Gao, Yang Song, Xin Ma, Shuang Liang, Hainan Lan, Xin Zheng, Suo Li
Summary: In this study, a mitochondrial damage model was induced in porcine oocytes with the Bcl-2-specific antagonist ABT-199, and the protective effects of glycine (Gly) against ABT-199-induced mitochondrial dysfunction were investigated. Gly was found to significantly ameliorate mitochondrial dysfunction, oxidative stress, and apoptosis, as well as regulate intracellular calcium levels and IP(3)R1 cellular distribution, thereby protecting oocyte maturation.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Engineering, Environmental
Zheng Zhang, Xin Zhang, Shuangshuang Zhao, Caihong Dong, Wei Feng, Luodan Yu, Li Ding, Yu Chen, Baoding Chen
Summary: Calcium overload can effectively induce inflammatory regulated cell death (RCD) in Gas-dermin E (GSDME)-expressed tumor cells, providing a distinct and effective pathway for treating refractory carcinomas with a strong inflammatory response.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Medicine, Research & Experimental
Xin Su, Mingyang Zhou, Yingjian Li, Jianzhen Zhang, Na An, Fan Yang, Guoxia Zhang, Chao Yuan, Hengwen Chen, Hongjin Wu, Yanwei Xing
Summary: Patients with ischemic heart disease receiving reperfusion therapy are still at risk of left ventricular remodeling and heart failure. However, reperfusion itself can paradoxically lead to further cardiomyocyte death and dysfunction. Mitochondrial dysfunction and structural disorder play a crucial role in the development of ischemia/reperfusion (I/R) injury. This review summarizes the basic relationship and potential mechanisms of mitochondrial injury in I/R injury, and discusses natural products (NPs) that have shown therapeutic effects targeting mitochondria during I/R injury and related cellular signal transduction pathways. The study finds that these NPs mainly protect mitochondrial integrity and improve dysfunction, thus providing potential therapies for cardioprotection during I/R injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Bin Wen, Kai Xu, Rui Huang, Teng Jiang, Jian Wang, Jiehui Chen, Juan Chen, Benhong He
Summary: Ischemic stroke is closely related to mitochondrial dysfunction, with mitochondrial calcium overload playing a key role in the pathophysiological process. Inhibiting GRP75 can effectively ameliorate mitochondrial function and potentially provide evidence for translational studies of ischemic diseases.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cell Biology
Yue Xue, Tie-Gang Meng, Ying-Chun Ouyang, Sai-Li Liu, Jia-Ni Guo, Zhen-Bo Wang, Heide Schatten, Chun-Ying Song, Xing-Ping Guo, Qing-Yuan Sun
Summary: This study found that Miro1 plays a crucial role in the maturation process of mouse oocytes by regulating mitochondrial homeostasis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Shuo Chao, Li -Jun Li, Jun Lu, Shu-Xian Zhao, Ming -Hui Zhao, Gui-An Huang, Shen Yin, Wei Shen, Qing-Yuan Sun, Yong Zhao, Zhao-Jia Ge, Lei Zhao
Summary: This study evaluated the effect of EGCG on the maturation of diabetic oocytes. The results showed that EGCG could reduce the frequency of abnormal spindle assembly and chromosome mismatches in diabetic oocytes. Additionally, EGCG alleviated abnormal mitochondrial membrane potential, regulated the expression of genes involved in mitochondrial fusion and fission, reduced reactive oxygen species levels, and decreased DNA damage in diabetic oocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Jie Jhuo, Yi-Hsiung Lin, I-Hsin Liu, Tsung-Hsien Lin, Bin-Nan Wu, Kun-Tai Lee, Wen-Ter Lai
Summary: SGLT2 inhibitors have a protective effect on cardiomyocyte mitochondria, reducing ROS production and mitochondrial Ca2+ overload caused by high fat diet-induced metabolic disorder. They also increase ATP production, providing evidence and potential mechanisms for the benefit of SGLT2i in heart failure and arrhythmias.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Juan Ge, Na Zhang, Shoubin Tang, Feifei Hu, Xiaojing Hou, Hongzheng Sun, Longsen Han, Qiang Wang
Summary: Maternal diabetes impairs oocyte quality, but controlling the PDK1-mediated Ser232-PDHE1α phosphorylation pathway can partly protect oocytes from the effects of diabetes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Bor-Chyuan Su, Giun-Yi Hung, Yun-Chieh Tu, Wei-Chen Yeh, Meng-Chieh Lin, Jyh-Yih Chen
Summary: Synovial sarcoma is a rare but aggressive soft-tissue sarcoma with limited treatment options. In this study, the marine antimicrobial peptide TP4 showed strong anticancer activity in human synovial sarcoma cells by disrupting oxidative status, promoting mitochondrial hyperpolarization, and causing calcium overload.
Article
Cell Biology
Qingrui Zhuan, Jun Li, Xingzhu Du, Luyao Zhang, Lin Meng, Keren Cheng, Shien Zhu, Yunpeng Hou, Xiangwei Fu
Summary: Maternal aging can affect the quality and developmental competence of ovulated oocytes by compromising germinal vesicle breakdown, increasing reactive oxygen species and mitochondrial Ca2+ levels, and decreasing mitochondrial temperature. The expression and localization changes of FoxO3a and Nampt play crucial roles in regulating cell survival and mitochondrial function in aged oocytes. Suppression of Nampt may further impair mitochondrial function in aged oocytes, as shown by decreased ATP and mitochondrial membrane potential levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Correction
Engineering, Biomedical
Zhankui Zhao, Deqian Liu, Ye Chen, Qingsheng Kong, Dandan Li, Qingxin Zhang, Chuanxin Liu, Yanjun Tian, Chengjuan Fan, Lin Meng, Haizhou Zhu, Honglian Yu
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Dongguang Liu, Peng Zhang, Lin Meng, Chongfei Ruan, Yan Liang, Jiangping Tu
Summary: In this study, nano-multilayer films (MFs) containing sequential sp(3)-C:Ti/sp(2)-C:Ti were deposited on Ti6Al4V and c-Si substrates to improve the adhesive strength and fatigue resistance of amorphous carbon (a-C) films. The results showed that these MFs exhibited excellent mechanical properties and scratch behavior, with lower coefficient of friction and wear rate in both humid air and FBS solution.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Hengyi Li, Zhichen Wang, Xuebin Yue, Wenwen Wang, Hiroyuki Tomiyama, Lin Meng
Summary: This paper conducts a thorough study on the inference workload of DNNs, especially focusing on the advantages of CPUs and the potential improvements in efficiency. The research provides comprehensive details for optimizing DNN efficiency at both hardware and software levels.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Engineering, Electrical & Electronic
Xuebin Yue, Hengyi Li, Lin Meng
Summary: The emergence of empty-dish recycling robots has resolved issues caused by an aging population, such as labor shortages. Nonetheless, traditional object detection models are hindered by limited resources and hamper the development of these robots. Therefore, this article introduces an ultralightweight dish detection model, YOLO-GS, which achieves efficient and intelligent dish detection. By utilizing an optimized architecture and image processing algorithms, the proposed model attains a high mean average precision and real-time performance for the empty-dish recycling robot.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Computer Science, Artificial Intelligence
Hengyi Li, Xuebin Yue, Chengyan Zhao, Lin Meng
Summary: Deep neural networks (DNNs) are overparameterized and demanding of hardware resources, posing challenges for inference applications on resource-constrained edge devices. This study proposes a mechanism called FS-DNN for determining lightweight DNN networks from scratch, which achieves superior performance in computing consumption with competitive or even better accuracy.
APPLIED INTELLIGENCE
(2023)
Article
Reproductive Biology
Lv Zheng, Yuwen Luo, Dan Zhou, Hongyu Liu, Guizhen Zhou, Lin Meng, Yunpeng Hou, Changbin Liu, Jun Li, Xiangwei Fu
Summary: The natural compound Leonurine (LEO) extracted from motherwort, a Chinese herb, has been found to significantly improve the quality of bovine oocytes during in vitro maturation (IVM) by reducing ROS levels and enhancing cellular functions. This study provides a new solution for optimizing the in vitro culture system of bovine embryos.
Article
Computer Science, Information Systems
Qi Li, Hengyi Li, Lin Meng
Summary: Existing compression methods for deep learning models mainly focus on reducing redundant channels and ignore layer-level redundancies, resulting in compressed models that still have significant redundancies. To address this issue, we propose an effective compression algorithm that combines channel-level and layer-level compression techniques to optimize deep learning models. Experimental results show that the proposed algorithm reduces computations by 80.05% with only a 0.72% decrease in accuracy. This demonstrates the efficiency of the algorithm, as 48 convolutional layers can be discarded with no performance loss.
Review
Computer Science, Interdisciplinary Applications
Zhuo Li, Hengyi Li, Lin Meng
Summary: With the rapid development of deep learning, deep neural networks (DNNs) have been widely applied in computer vision tasks. However, advanced DNN models have become complex, leading to high memory usage and computation demands. To address these issues, model compression has become a research focus. This study analyzed various model compression methods to reduce device storage space, speed up model inference, and improve model deployment.
Article
Humanities, Multidisciplinary
Hayata Kaneko, Ryuto Ishibashi, Lin Meng
Summary: Early Japanese books carry significant historical and cultural value, but the old characters in them have suffered from scratching, fading, and loss over time. Restoring these deteriorated books is crucial for cultural revitalization.
Article
Biochemistry & Molecular Biology
Hai-Ping Tao, Teng-Fei Lu, Shuang Li, Gong-Xue Jia, Xiao-Na Zhang, Qi-En Yang, Yun-Peng Hou
Summary: This study found that pancreatic lipase-related protein 2 (Pnliprp2) is specifically expressed in peritubular myoid cells (PTMCs) in the testis, and its genetic ablation causes age-dependent defects in spermatogenesis. Further analysis revealed that Pnliprp2 deletion affects the homeostasis of undifferentiated spermatogonia and severely disrupts the development and function of spermatids. Integrated analysis of RNA-seq and metabolomics data showed that glyceride metabolism was altered in PTMCs from Pnliprp2(-/-) mice, resulting in dysregulated lipid metabolism in the sperm.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Computer Science, Artificial Intelligence
Hengyi Li, Lin Meng
Summary: This paper introduces a hardware-aware mechanism, IHSOpti, which optimizes deep neural networks by utilizing hardware characteristics and parallelism features. It achieves remarkable pruning ratios and improvements in running efficiency, surpassing the latest advances in the field.
Article
Chemistry, Analytical
Jiale Ren, Aihui Wang, Hengyi Li, Xuebin Yue, Lin Meng
Summary: Lower limb exoskeleton robots have significant research value in improving physical motion functions. In this study, a transformer-based neural network was developed to predict hip and knee joint angles using plantar pressure. The model showed improved performance compared to other models in terms of prediction accuracy.
Article
Computer Science, Information Systems
Xiao Xue, Deyu Zhou, Fangyi Chen, Xiangning Yu, Zhiyong Feng, Yucong Duan, Lin Meng, Mu Zhang
Summary: With the advancement of ICT and service economy, service ecosystem has emerged in various fields. The evolution of service ecosystem is influenced by the interaction of three heterogeneous networks - social network, service network, and value network. Traditional analysis models based on Service Oriented Architecture (SOA) are inadequate in this scenario, making the analysis of service ecosystem a challenging task. This paper introduces a value oriented analysis framework (VOA) that utilizes value as a key factor in describing the interaction between the three networks. Additionally, a computational experiment system is developed to test the effectiveness of the VOA framework and explore the impact of different intervention strategies. The results demonstrate that the proposed analysis framework provides new methods and ideas for analyzing service ecosystems.
IEEE TRANSACTIONS ON SERVICES COMPUTING
(2023)
Article
Engineering, Electrical & Electronic
Xuebin Yue, Lin Meng
Summary: As global population ages and labor force decreases, the use of artificial intelligence technology to enhance labor productivity becomes a popular topic. This article proposes a multiscale stereoscopic attention network (YOLO-MSA) to detect postprandial dishes for empty-dish recycling robots, and extensive experiments demonstrate its effectiveness and robustness.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)