The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans

Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures

(2020) Dilara Ayyildiz et al.   Scientific Reports

Mutational signatures are jointly shaped by DNA damage and repair

(2020) Nadezda V. Volkova et al.   Nature Communications

Hypersensitivity to DNA double‐strand breaks associated with PARG deficiency is suppressed by exo‐1 and polq‐1 mutations in Caenorhabditis elegans

(2019) Woori Bae et al.   FEBS Journal

The role of poly(ADP-ribose) polymerases in manganese exposed Caenorhabditis elegans

(2019) Catherine Neumann et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans

(2018) Henok Kassahun et al.   DNA REPAIR

Polymorphisms of base-excision repair genes and the hepatocarcinogenesis

(2018) Manar-Aleslam M. Mattar et al.   GENE

Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage

(2018) Jana Slyskova et al.   NUCLEIC ACIDS RESEARCH

UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans

(2018) Arturo Papaluca et al.   Scientific Reports

AP endonuclease EXO-3 deficiency causes developmental delay and abnormal vulval organogenesis, Pvl, through DNA glycosylase-initiated checkpoint activation in Caenorhabditis elegans

(2018) Masahiro Miyaji et al.   Scientific Reports

Base excision repair of oxidative DNA damage from mechanism to disease

(2017) Bret D Freudenthal   Frontiers in Bioscience-Landmark

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

(2017) David M. Wilson et al.   NUCLEIC ACIDS RESEARCH

Editor’s Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson’s Disease Risk

(2017) Laurie H. Sanders et al.   TOXICOLOGICAL SCIENCES

Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA

(2016) Modesto Redrejo-Rodríguez et al.   BIOCHIMIE

Associations between DNA Damage, DNA Base Excision Repair Gene Variability and Alzheimer's Disease Risk

(2016) Dominik Kwiatkowski et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression

(2016) Hassan Nassour et al.   Scientific Reports

A Two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways

(2016) Øyvind Fensgård et al.   Aging-US

Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS

(2015) Barbara Crone et al.   Metallomics

Caenorhabditis elegans EXO-3 contributes to longevity and reproduction: Differential roles in somatic cells and germ cells

(2015) Yuichi Kato et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer

(2015) Melania Zauri et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

(2015) Robin van Schendel et al.   Nature Communications

Base excision repair: A critical player in many games

(2014) Susan S. Wallace   DNA REPAIR

The long N-terminus of the C. elegans DNA repair enzyme APN-1 targets the protein to the nucleus of a heterologous system

(2014) Zhiqiang Wang et al.   GENE

C. eleganswhole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

(2014) Bettina Meier et al.   GENOME RESEARCH

Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

(2014) S. F. Roerink et al.   GENOME RESEARCH

Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

(2014) Jae Sung Park et al.   Oxidative Medicine and Cellular Longevity

C. elegans CEP-1/p53 and BEC-1 Are Involved in DNA Repair

(2014) Sandy Hoffman et al.   PLoS One

Genome Instability and Aging

(2013) Jan Vijg et al.   Annual Review of Physiology

Human Apurinic/Apyrimidinic Endonuclease 1

(2013) Mengxia Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response

(2013) Julia Bornhorst et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

(2013) Tanima SenGupta et al.   Nature Communications

Base excision repair and cancer

(2012) Susan S. Wallace et al.   CANCER LETTERS

In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans

(2012) Senyene E. Hunter et al.   DNA REPAIR

Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1

(2012) Xiaoming Yang et al.   DNA REPAIR

A Broad Requirement for TLS Polymerases η and κ, and Interacting Sumoylation and Nuclear Pore Proteins, in Lesion Bypass during C. elegans Embryogenesis

(2012) Sophie F. Roerink et al.   PLoS Genetics

Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase  

(2011) K. Asagoshi et al.   NUCLEIC ACIDS RESEARCH

APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1

(2011) Mark R. Kelley et al.   Current Molecular Pharmacology

Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans

(2010) Andreas Schlotterer et al.   AGING CELL

Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents

(2010) Hanne K. Skjeldam et al.   DNA REPAIR

Manganese inhibits poly(ADP-ribosyl)ation in human cells: a possible mechanism behind manganese-induced toxicity?

(2010) Julia Bornhorst et al.   JOURNAL OF ENVIRONMENTAL MONITORING

The endonuclease IV family of apurinic/apyrimidinic endonucleases

(2010) James M. Daley et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: Essential role of N-terminal region

(2009) Hironobu Morinaga et al.   DNA REPAIR

Interaction with DNA polymerase η is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells

(2009) Jun-ichi Akagi et al.   DNA REPAIR

Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability

(2009) Chadi Zakaria et al.   DNA REPAIR

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans

(2008) N. Nakamura et al.   MUTAGENESIS

DNA polymerases and human disease

(2008) Lawrence A. Loeb et al.   NATURE REVIEWS GENETICS

Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage

(2008) A. Zaky et al.   NUCLEIC ACIDS RESEARCH

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans

(2007) Nate W. Kahn et al.   BIOCHEMICAL JOURNAL

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark