Article
Immunology
Ying Zhang, He Ren, Chunting Zhang, Haihua Li, Qingzhi Guo, Haitao Xu, Lina Cui
Summary: This study investigates the prognostic value of ferroptosis-related genes (FRGs) in hepatocellular carcinoma (HCC) and their impact on tumor immune function. The findings suggest that these four pivotal FRGs play essential roles in tumor progression and are statistically significantly correlated with tumor-infiltrating immune cells and immune checkpoint expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Dengchuan Wang, Limei Zhang, YingJie Zhang, Yonggang Zhang, Shi Xu
Summary: In this study, a prognostic signature consisting of 7 ferroptosis-related lncRNAs was developed to accurately predict the prognosis of hepatocellular carcinoma. The signature was significantly associated with tumor grade, immune cell infiltration, and expression of methylation regulatory factors.
Article
Biochemistry & Molecular Biology
Dong-Li Liu, Ming-Yao Wu, Tie-Ning Zhang, Chun-Gang Wang
Summary: This study highlights the potential roles of ferroptosis modification patterns in tumor microenvironment immune cell infiltration of hepatocellular carcinoma (HCC). It identifies three distinct ferroptosis modification patterns and constructs a gene signature to evaluate individual tumor's ferroptosis modification pattern. The study shows a close association between ferroptosis modification patterns and immune cell infiltration levels as well as patient survival time.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell Biology
Xin Yang, Minhui Mei, Jingze Yang, Jinlu Guo, Fan Du, Shi Liu
Summary: This study established a prognostic risk model for hepatocellular carcinoma (HCC) based on 17 ferroptosis-related long non-coding RNAs (lncRNAs). The model showed significant prognostic value for HCC and may serve as therapeutic targets associated with ferroptosis in clinical practice.
Article
Cell Biology
Yuanliang Yan, Qiuju Liang, Zhijie Xu, Jinzhou Huang, Xi Chen, Yuan Cai, Bi Peng, Qiaoli Yi
Summary: STEAP3 is significantly downregulated in LIHC tissues and shows favorable prognostic significance in LIHC patients. It is also associated with various clinicopathological parameters and has potential diagnostic biomarker value for LIHC patients. Additionally, STEAP3 might play a role in immune-associated signatures in LIHC pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yingxi Du, Yarui Ma, Qing Zhu, Tongzheng Liu, Yuchen Jiao, Peng Yuan, Xiaobing Wang
Summary: This study constructed a survival prediction model using m6A-associated genes to investigate the molecular and immune characteristics of HCC. It was found that m6A RNA methylation regulators were differentially expressed and associated with immune checkpoint expression in HCC. Additionally, two distinct HCC clusters were identified with different clinical features and immune characteristics.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Jingjuan Zhu, Xiao Xu, Man Jiang, Fangfang Yang, Yingying Mei, Xiaochun Zhang
Summary: This study reveals the existence of three distinct ferroptosis molecular models in hepatocellular carcinoma (HCC) and establishes the predictive value of the ferroptosis score in immunotherapy response, tumor microenvironment (TME) characteristics, and prognosis. Tumors with low ferroptosis scores are associated with poor prognosis and enhanced immunotherapy response.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiuliang Cui, Lu Han, Longjiu Cui, Gongbo Fu, Erdong Liu, Duowei Wang, Bin Song, Yongxiang Zhang, Wenxia Zhou, Hongyang Wang, Jing Fu
Summary: The heterogeneity of tumor immune microenvironment plays important roles in the development and immunotherapy response of hepatocellular carcinoma. Machine learning algorithms were used to introduce immune index (IMI) and gene model (IMIG), which can predict the prognosis, classification, and immune checkpoint blockade treatment response of HCC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anmin Huang, Ting Li, Xueting Xie, Jinglin Xia
Summary: Long non-coding RNAs (lncRNAs) play important roles in various pathophysiological processes, including cancer, with frequent dysregulation in hepatocellular carcinoma (HCC). By combining ferroptosis, immunity, and lncRNA, potential biomarkers for clinical cancer therapy have been identified. The development of an immune- and ferroptosis-related lncRNA risk signature (IFLSig) using bioinformatics methods has shown association with prognosis in HCC patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bo Zhang, Jilong Zhao, Bing Liu, Yanan Shang, Fei Chen, Sidi Zhang, Jiayao He, Yumei Fan, Ke Tan
Summary: This study analyzed the expression pattern of ferroptosis-related genes (FRGs) in hepatocellular carcinoma (HCC) and identified three clusters. Cluster 3 was associated with unfavorable prognosis and higher tumor stage and grade. Different infiltrating levels of immune cells were observed among the clusters, with cluster 3 showing higher expression of immune checkpoint genes. A five FRG-based prognostic risk model was developed and found to be significantly correlated with the infiltrating levels of six major types of immune cells in HCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Qiaoli Yi, Qiuju Liang, Yuanhong Liu, Zhicheng Gong, Yuanliang Yan
Summary: This study analyzed genomic profiles of HCC datasets and identified a gene, CXCL2, that is associated with ferroptosis and positively correlates with patient prognosis. Further investigation revealed that CXCL2 inhibits HCC cell growth and promotes ferroptotic cell death, while being negatively associated with malignant clinical features. Additionally, CXCL2 was found to regulate inflammation and immune-related pathways and positively correlate with tumor-infiltrating immune cells. These findings suggest that CXCL2 may enhance ferroptosis sensitivity and regulate the immune microenvironment in HCC, highlighting its potential as a prognosis biomarker for HCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Lei Yang, Yu Guan, Zhanbing Liu
Summary: Ferroptosis is a newly discovered form of programmed cell death that involves iron-dependent lipid peroxide accumulation and plays a vital role in the tumorigenesis, development, and drug resistance of various tumors such as hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) participate in the initiation and progression of HCC, either as oncogenes or tumor suppressors. Recent studies have shown that ncRNAs can regulate ferroptosis in HCC cells, thereby affecting tumor progression and drug resistance. Clarifying the role of ferroptosis and ncRNA regulation on ferroptosis in HCC could lead to new treatment interventions for this disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Yanlong Shi, Yizhu Wang, Wenning Zhang, Kaiyi Niu, Xinyu Mao, Kun Feng, Yewei Zhang
Summary: This study revealed the dysregulation of N6-methyladenosine (m6A) regulators in hepatocellular carcinoma (HCC) and their interaction with the immune microenvironment. Through analysis of HCC patients and normal individuals, three clusters based on m6A regulator expression were identified, with the second cluster showing a favorable prognosis. Furthermore, HNRNPC was found to be an independent prognostic factor in HCC and positively correlated with PD-L1 expression. These findings highlight the crucial roles of m6A regulators in HCC prognosis and immune infiltration, and suggest HNRNPC as a potential therapeutic target for immunotherapy response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Siqian Wu, Meiliang Liu, Suyang Xiao, Mingshuang Lai, Liling Wei, Deyuan Li, Lijun Wang, Fuqiang Yin, Xiaoyun Zeng
Summary: Novel computational process identified GLMP, SLC38A6, and WDR76 as potential prognostic biomarkers indicating poor prognosis in HCC.
Article
Genetics & Heredity
Wenli Li, Jun Liu, Dangui Zhang, Liming Gu, Hetong Zhao
Summary: By comprehensively analyzing the genetic data of HCC patients, we revealed the heterogeneity of ferroptosis and its association with immune responses. Further investigation identified prognostic gene signatures and developed a diagnostic nomogram. These findings provide guidance for the diagnosis and treatment of HCC.
FRONTIERS IN GENETICS
(2022)