Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma

A Novel Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Activities and Exhibits Potent Growth-Suppressive Activity in Human Cancer Cells

(2015) Li Lin et al.   NEOPLASIA

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3

(2013) Purnachandra Nagaraju Ganji et al.   ANGIOGENESIS

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

(2013) V. W. Y. Lui et al.   Cancer Discovery

Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines

(2012) Jason I Couto et al.   BMC Veterinary Research

Characterization of bone resorption in novel in vitro and in vivo models of oral squamous cell carcinoma

(2012) Chelsea K. Martin et al.   ORAL ONCOLOGY

Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12

(2012) Hemant K. Bid et al.   PLoS One

STAT3 negatively regulates thyroid tumorigenesis

(2012) J. P. Couto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of cell survival after irradiation via clonogenic assay versus multiple MTT Assay - A comparative study

(2012) Karl Buch et al.   Radiation Oncology

The Presence of p16CDKN2A Protein Immunostaining Within Feline Nasal Planum Squamous Cell Carcinomas Is Associated With an Increased Survival Time and the Presence of Papillomaviral DNA

(2012) J. S. Munday et al.   VETERINARY PATHOLOGY

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells

(2011) Suzanne Reed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Studies on the inhibition of feline EGFR in squamous cell carcinoma: Enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors

(2011) Gurå T. Bergkvist et al.   CANCER BIOLOGY & THERAPY

Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice

(2011) Grace-Ifeyinwa Onimoe et al.   INVESTIGATIONAL NEW DRUGS

Treatment of Oral Squamous Cell Carcinoma with Accelerated Radiation Therapy and Concomitant Carboplatin in Cats

(2011) J. Fidel et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells

(2011) P Yue et al.   ONCOGENE

Papillomaviral DNA and increased p16CDKN2A protein are frequently present within feline cutaneous squamous cell carcinomas in ultraviolet-protected skin

(2011) John S. Munday et al.   VETERINARY DERMATOLOGY

Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis

(2010) E. Pectasides et al.   CLINICAL CANCER RESEARCH

Stat3 Orchestrates Tumor Development and Progression: The Achilles Heel of Head and Neck Cancers?

(2010) M. Masuda et al.   CURRENT CANCER DRUG TARGETS

Prognostic significance of nuclear pSTAT3 in oral cancer

(2010) Muzafar A. Macha et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Priming of Signal Transducer and Activator of Transcription Proteins for Cytokine-Triggered Polyubiquitylation and Degradation by the A2A Adenosine Receptor

(2010) M. M. A. Safhi et al.   MOLECULAR PHARMACOLOGY

Evaluation of feline oral squamous cell carcinomas for p16CDKN2A protein immunoreactivity and the presence of papillomaviral DNA

(2010) John S. Munday et al.   RESEARCH IN VETERINARY SCIENCE

Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC)

(2010) G. T. Bergkvist et al.   Veterinary and Comparative Oncology

Bone-Invasive Oral Squamous Cell Carcinoma in Cats

(2010) C. K. Martin et al.   VETERINARY PATHOLOGY

Characterization of STAT3 activation and expression in canine and human osteosarcoma

(2009) Stacey L Fossey et al.   BMC CANCER

STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination

(2009) Joo Eun Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes

(2008) R. R. Seethala et al.   CLINICAL CANCER RESEARCH

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1  RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

(2008) G. Niu et al.   MOLECULAR CANCER RESEARCH

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols