Review
Immunology
Yong Xi, Lijie Chen, Jian Tang, Bentong Yu, Weiyu Shen, Xing Niu
Summary: Immunogenic cell death (ICD) is a unique mode of cell death that triggers long-term protective antitumor immune responses by releasing immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens. Amplifying the "eat me" signal during the tumor ICD cascade is critical for cancer immunotherapy.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Wenpan Li, Yanhao Jiang, Jianqin Lu
Summary: Tumor immunotherapy, specifically tumor immunogenic cell death (ICD), has shown great potential for cancer therapy. Nanoparticles, such as liposomes, nanostructured lipid carriers, and inorganic nanoparticles, have been widely studied as vehicles for delivering ICD inducers. This review summarizes the strategies of different nanoparticles for ICD-induced cancer immunotherapy and discusses their advantages, disadvantages, and potential solutions. It aims to provide insights into the design of effective nanoparticulate systems for the therapeutic delivery of ICD inducers, ultimately promoting the development of ICD-mediated cancer immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyuan Gao, Shaorui Jia, Hanlin Ou, Yuning Hong, Ke Shan, Xianglong Kong, Zhiming Wang, Guangxue Feng, Dan Ding
Summary: In this study, an activatable near-infrared (NIR) afterglow theranostic prodrug was developed to release a cancer drug and monitor tumor transformation through triggering immunogenic cell death (ICD) process. The prodrug induced ICD through photodynamic therapy (PDT) and amplified the ICD process, leading to anti-tumor immune response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Tao Huang, Xiaofan Sun, Yingqiu Qi, Xi Yang, Linyao Fan, Mengdie Chen, Yale Yue, Hong Ge, Yiye Li, Guangjun Nie, Huan Min, Xianfu Sun
Summary: This study develops a targeted nanomedicine for breast cancer chemo-immunotherapy, which can induce immunogenic cell death (ICD) to kill cancer cells and stimulate antitumor immune response. The nanomedicine also competitively relieves the inhibition of serpinb9 (Sb9) to granzyme B (GrB), enhancing the combined antitumor effect.
Article
Immunology
Jun Lei, Zihao Zhou, Jialing Fang, Zaiqiao Sun, Mengting He, Boxiao He, Qian Chen, Chonil Paek, Peng Chen, Jin Zhou, Hongjian Wang, Mingliang Tang, Lei Yin, Yongshun Chen
Summary: In this study, it was found that aspirin can induce immunogenic cell death (ICD) in colon cancer cells, alter tumor cell metabolism, and enhance the efficacy of anti-PD-1 antibody and anti-CTLA-4 antibody. Furthermore, the antitumor activity of aspirin in combination with anti-PD-1 antibody relies on the presence of CD8+ T cells, and aspirin-treated tumor cells combined with vaccines can effectively eradicate tumors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Chemistry, Physical
En Ren, Yanfang Wang, Tingxizi Liang, Hanqi Zheng, Jiaqi Shi, Zesheng Cheng, Hongjun Li, Zhen Gu
Summary: Immunogenic cell death (ICD) is a dying state of the cells that can initiate an adaptive immune response. Local drug delivery systems have gained attention as alternatives to overcome the potential toxicity encountered in intravenous administration. This article provides a brief overview of local drug delivery techniques for ICD inducers and discusses their therapeutic capability, historical context, complexities, potential pitfalls, and opportunities in cancer immunotherapy.
Review
Chemistry, Physical
Teng Liu, Pei Pei, Wenhao Shen, Lin Hu, Kai Yang
Summary: Traditional radiotherapy (RT) is limited by radioresistance, while immunotherapy has low response rate and high cost. The combination of radiotherapy and immunotherapy in radioimmunotherapy shows promise in eliminating cancer cells with specificity, efficiency, and safety. RT-induced immunogenic cell death (ICD) plays a crucial role in stimulating systemic immune response against cancer, and this review discusses the origin, concept, signaling pathways, and enhancing strategies of RT-induced ICD for radioimmunotherapy. It also attempts to forecast future directions for clinical applications based on published research and underlying mechanisms.
Review
Chemistry, Physical
Qian Chen, Chunyan Li, Qiangbin Wang
Summary: Immunotherapy is a promising method to overcome cancer, with immunogenic cell death (ICD) attracting attention for cancer immunotherapy. Nano-biomaterials have unique properties at the nanoscale, providing a prospective approach to overcome obstacles in ICD-mediating immunotherapy.
Review
Immunology
Jumin Huang, Fugang Duan, Chun Xie, Jiahui Xu, Yizhong Zhang, Yuwei Wang, Yu-Ping Tang, Elaine Lai-Han Leung
Summary: Immunogenic cell death (ICD) is a form of cell death that triggers the immune system against cancer cells. It releases molecules called DAMPs to signal immune cells to recognize and attack cancer cells. ICD-based drug development is a new approach in exploring novel therapeutic combinations and personalized strategies in cancer therapy.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Liwen Fu, Xiaojun Zhou, Chuanglong He
Summary: Immunotherapy has shown a promising direction for cancer treatment by regulating the anti-cancer immune system through immunogenic cancer cell death (ICD). Polymer nanoparticles play a critical role in delivering antigens or immune inducers for ICD-based immunotherapy with their controllable size and excellent biocompatibility.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yuan Ding, Zhongquan Sun, Yong Gao, Sitong Zhang, Caixia Yang, Zhefeng Qian, Lulu Jin, Jiaojiao Zhang, Cheng Zeng, Zhengwei Mao, Weilin Wang
Summary: Clinical trials have shown that combining IDO blockade with immunogenic chemotherapy has great potential in cancer therapy. A hybrid nanomedicine was designed to co-deliver an IDO inhibitor and a chemotherapeutic prodrug, effectively activating chemo-immunotherapy and overcoming the immunosuppressive tumor microenvironment, leading to tumor growth suppression.
ADVANCED MATERIALS
(2021)
Review
Immunology
Yichen Guo, Rong Ma, Mengzhe Zhang, Yongjian Cao, Zhenzhong Zhang, Weijing Yang
Summary: This review summarizes the latest studies on nanotechnology-mediated immunogenic cell death for effective cancer immunotherapy and highlights the challenges.
Review
Chemistry, Multidisciplinary
Yue Sun, Ting Lian, Qichao Huang, Yawei Chang, Yuan Li, Xiaoyu Guo, Weirong Kong, Yifang Yang, Kun Zhang, Pan Wang, Xiaobing Wang
Summary: Immunotherapy has shown great potential in cancer treatment, but its response rate is low in most tumors. Recent studies have demonstrated that inducing regulated cell death can enhance immune responses in cancer, and nanotechnology can be used to facilitate this process. Cell death-based immunotherapy provides a new approach for improving cancer treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Physical
Mengyao Yang, Cheng Zhang, Rui Wang, Xiaofeng Wu, Haidong Li, Juyoung Yoon
Summary: Cancer immunotherapy is a revolutionary treatment that not only eliminates tumors but also prevents metastases and recurrent tumors. However, the effectiveness of immunotherapy induced by immunogenic cell death (ICD) is limited due to low accumulation of ICD inducers in tumors and damage to normal tissues. Smart nanomaterials offer a solution to these challenges with their targeted delivery, stability, bioavailability, on-demand release, and biocompatibility. This article summarizes the design of targeted nanomaterials, various ICD inducers, and the applications of nanomaterials responsive to different stimuli, providing insights for designing novel smart nanomaterials for ICD-induced immunotherapy.
Article
Chemistry, Multidisciplinary
Xiang Xiong, Jingya Zhao, Rui Su, Chunping Liu, Xing Guo, Shaobing Zhou
Summary: The study introduces a novel strategy for enhanced tumor immunotherapy by combining different carriers to achieve targeted delivery to tumors and activation of immune response, resulting in improved efficacy in tumor therapy.
Article
Clinical Neurology
Jiwon Kim, Hee Jeong Jang, Dawid Schellingerhout, Su-Kyoung Lee, Ha Kim, Young Dae Kim, Kyung-Yul Lee, Hye-Yeon Choi, Han-Jin Cho, Seong-Soo Jang, Sangmin Jeon, Ick Chan Kwon, Kwangmeyung Kim, Wi-Sun Ryu, Matthias Nahrendorf, Seungbum Choi, Dong-Eog Kim
Summary: The study found that short-term cessation of dabigatran therapy can lead to a rebound prothrombotic state, increasing thrombus volume. This effect can be prevented by single-dose aspirin pretreatment, and cessation of dabigatran increases platelet aggregability for 2 days after drug cessation, which can be significantly attenuated by single-dose aspirin pretreatment.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemical Research Methods
Seungho Lim, Woojun Kim, Sukyung Song, Man Kyu Shim, Hong Yeol Yoon, Byung-Soo Kim, Ick Chan Kwon, Kwangmeyung Kim
Summary: The development of BCN-AuNPs allows for enhanced cellular uptake of nanoparticles through bioorthogonal click chemistry on metabolically engineered stem cells.
BIOCONJUGATE CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Eun Hye Kim, Jongwon Lee, Gijung Kwak, Hochung Jang, Hyosuk Kim, Haeun Cho, Yeongji Jang, Jiwoong Choi, Sung Gil Chi, Kwangmeyung Kim, Ick Chan Kwon, Yoosoo Yang, Sun Hwa Kim
Summary: This study developed a dual-targeting drug delivery system (Pep-21) that can inhibit miR-21 activity in both cancer cells and tumor-associated macrophages (TAMs). The study found that Pep-21 treatment reduced tumor cell migration, reprogrammed immunosuppressive TAMs into immunostimulatory macrophages, and restrained tumor progression.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Analytical
Yurim Kim, Hong Yeol Yoon, Il Keun Kwon, Inchan Youn, Sungmin Han
Summary: Heart rate variability is closely related to cancer pain and can be used as a tool for assessing pain.
Article
Multidisciplinary Sciences
Hyosuk Kim, Byeong-Wook Song, Soon-Jung Park, Seong Woo Choi, Hanbyeol Moon, Ki-Chul Hwang, Sun-Woong Kang, Sung-Hwan Moon, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim
Summary: This study proposes an extracellular vesicle (EV)-guided, nonviral, direct lineage conversion strategy to enhance the transdifferentiation of fibroblasts to induced cardiomyocyte-like cells (iCMs). The resulting iCMs show typical cardiac features and have gene expression profiles similar to cardiomyocytes. This method achieves a high conversion efficiency (>60%) and establishes a more accessible platform for generating specialized somatic cells through direct lineage conversion.
Article
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Suah Yang, Jaewan Lee, Jiwoong Choi, Yujeong Moon, Jinseong Kim, Nayeon Shim, Hanhee Cho, Man Kyu Shim, Sangmin Jeon, Dong-Kwon Lim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: By using DOX as an ICD inducer and PLGA-based nanoparticles for controlled release, continuous ICD induction and reduced cell viability can be achieved. Direct injection of DP-NPs allows DOX to remain in the tumor site for 14 days and enhances antitumor immunity, with minimal toxicities.
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Wan Su Yun, Man Kyu Shim, Seungho Lim, Sukyung Song, Jinseong Kim, Suah Yang, Hee Sook Hwang, Mi Ra Kim, Hong Yeol Yoon, Dong-Kwon Lim, In-Cheol Sun, Kwangmeyung Kim
Summary: In this study, a promising approach of using mesenchymal stem cells (MSCs) for the deep tumor delivery of gold nanorods (AuNRs) has been demonstrated. The AuNRs are modified and chemically conjugated to the MSCs, allowing deep tissue penetration and enhanced photothermal effect against colon tumor growth. This provides a potential method for effective photothermal therapy.
Article
Pharmacology & Pharmacy
Hanhee Cho, Man Kyu Shim, Yujeong Moon, Sukyung Song, Jinseong Kim, Jiwoong Choi, Jeongrae Kim, Youngjoo Lee, Jung Yeon Park, Yongju Kim, Cheol-Hee Ahn, Mi Ra Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This study proposes tumor-specific monomethyl auristatin E (MMAE) prodrug nanoparticles for safe and effective chemotherapy. The nanoparticles efficiently accumulate within tumor tissues and inhibit tumor cell growth by releasing MMAE. Meanwhile, these nanoparticles maintain a non-toxic inactive state in normal tissues, reducing the toxicity of MMAE.
Review
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Dong-Hwee Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This review summarizes recent advances in the use of injectable hydrogels for combination immunotherapy in treating tumors. Injectable hydrogels, with their biocompatibility, degradability, and controllable properties, can effectively encapsulate various immunotherapeutic agents and elicit antitumor immune responses. The review also discusses the application of injectable hydrogels in chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy.
Article
Chemistry, Multidisciplinary
Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee
Summary: A new anticancer strategy exploiting abnormal cancer cell metabolism is reported. An antiglycolytic amphiphilic polymer is synthesized and regulates glucose metabolism to inhibit tumor growth. This strategy highlights the necessity for safe and effective cancer treatment without conventional drugs.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Ashita Nair, Kaila Javius-Jones, Jason Bugno, Michael J. Poellmann, Narsimha Mamidi, In-San Kim, Ick Chan Kwon, Heejoo Hong, Seungpyo Hong
Summary: Nanoscale drug delivery systems combining natural exosomes and synthetic dendrimers have been developed to improve the selectivity and reduce the toxicity of cancer treatment. These hybrid nanoparticles exhibit advantageous biological properties and have shown enhanced delivery and downregulation of gene and protein targets in cancer cells.
CHEMISTRY OF MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Andre-Rene Blaudszun, Woo Jun Kim, Wooram Um, Hong Yeol Yoon, Man Kyu Shim, Kwangmeyung Kim
Summary: This study proposes a combinational photodynamic and cancer immunotherapy using adoptive transfer of photosensitizer-loaded cytotoxic T cells. The loaded T cells efficiently produce reactive oxygen species under visible light irradiation and significantly inhibit tumor growth in a murine lymphoma model.
Article
Materials Science, Biomaterials
Sanghyo Park, Hyungkyu Park, Chaewon Park, Wan Su Yun, Soonjae Hwang, Hong Yeol Yoon, Ick Chan Kwon, Kwangmeyung Kim, Jaehong Key
Summary: A simple method was developed to enhance the delivery efficiency of doxorubicin in a lung metastasis model by manipulating the size, shape, loading content, and biodegradability of the drug delivery system. The system exhibited high drug release and delivered doxorubicin to lung cancer cells with minimal off-target effects, showing comparable anticancer efficacy to the free drug.
BIOMATERIALS SCIENCE
(2022)