Article
Biochemistry & Molecular Biology
Wei-Chung Chen, Chun-Chieh Wu, Yi-Hsun Chen, Jui-Ying Lee, Yao-Kuang Wang, Nian-Siou Wu, Ming-Tsang Wu, I-Chen Wu
Summary: This study aimed to investigate the expression of PD-L1 in esophageal squamous cell carcinoma (ESCC) tissues before and after concurrent chemoradiation therapy (CCRT). The results showed a decrease in PD-L1 expression after CCRT, and high pre-CCRT PD-L1 expression was associated with poor prognosis.
Article
Multidisciplinary Sciences
Haruto Nishida, Yoshihiko Kondo, Takahiro Kusaba, Kazuhiro Kawamura, Yuzo Oyama, Tsutomu Daa
Summary: In recent years, several immune checkpoint inhibitors targeting programmed death-ligand 1 (PD-L1) or PD-1 have been developed for cancer therapy. The genetic background of tumors and factors that influence PD-L1 expression in tumor tissues are not yet elucidated in cutaneous squamous cell carcinoma (cSCC).
Article
Medicine, Research & Experimental
I-Tsang Chiang, Yuan-Hao Lee, Zhao-Lin Tan, Fei-Ting Hsu, Hsi-Feng Tu
Summary: Combination therapy with regorafenib and anti-PD-L1 can enhance anti-tumor immune response and suppress immunosuppression in oral squamous cell carcinoma (OSCC). This finding contributes to the development of more effective treatment strategies for OSCC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Si-Rui Ma, Jian-Feng Liu, Rong Jia, Wei-Wei Deng, Jun Jia
Summary: ITGB4 plays an important role in mediating cell adhesion and has been implicated in tumorigenesis and metastasis. This study examined the expression of ITGB4 in oral squamous cell carcinoma (OSCC) and its relationship with other markers. The results showed that ITGB4 was significantly increased in OSCC, and a subgroup with high expression of ITGB4/PD-L1 and CD8/PD-1 had a better prognosis. These findings shed light on the potential role of ITGB4 in OSCC and provide a basis for further investigation.
Article
Multidisciplinary Sciences
Kit Kitichotkul, Nirush Lertprasertsuke, Sompid Kintarak, Surawut Pongsiriwet, Warit Powcharoen, Anak Iamaroon
Summary: This study investigated the expression of PD-L1 and its associations with HPV infection, p16 expression, and other clinical characteristics in patients with OSCC. The results showed that approximately one-fourth of OSCC patients were PD-L1-positive, and there was no association between HPV infection or p16 expression and PD-L1 expression.
Article
Biochemistry & Molecular Biology
Yutaro Kondo, Susumu Suzuki, Shoya Ono, Mitsuo Goto, Satoru Miyabe, Tetsuya Ogawa, Hiromi Tsuchida, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Ryuzo Ueda, Toru Nagao
Summary: The expression of PD-L1 is regulated by complex mechanisms. This study focused on the mechanisms of PD-L1 expression in OSCCs and found that EGF and IFN-gamma upregulate PD-L1 through different signaling pathways. Moreover, the phosphorylation pattern of related molecules in PD-L1-positive cells varied among different cases. These findings suggest that choosing the appropriate combination drugs for PD-1 blockade cancer treatment should consider the tissue environment and molecular alterations affecting PD-L1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rocio Garcia-Marin, Sara Reda, Cristina Riobello, Virginia N. Cabal, Laura Suarez-Fernandez, Blanca Vivanco, Cesar Alvarez-Marcos, Fernando Lopez, Jose L. Llorente, Mario A. Hermsen
Summary: Sinonasal squamous cell carcinoma (SNSCC) is an aggressive tumor with a poor prognosis. Immunotherapy may be a new therapeutic option for SNSCC patients, especially for the subgroup with high CD8(+) TILs and PD-L1 positivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paloma Lequerica-Fernandez, Julian Suarez-Canto, Tania Rodriguez-Santamarta, Juan Pablo Rodrigo, Faustino Julian Suarez-Sanchez, Veronica Blanco-Lorenzo, Francisco Dominguez-Iglesias, Juana Maria Garcia-Pedrero, Juan Carlos de Vicente
Summary: This study found that TILs in OSCC patients were associated with PD-L1 expression and CSC markers. CD4(+) and CD8(+) TILs were related to smoking and alcohol habits. High infiltration of CD4(+) and CD8(+) TILs was significantly associated with tumors harboring positive PD-L1 expression.
Article
Immunology
Tiantian Wu, Caijin Tang, Renchuan Tao, Xiangzhi Yong, Qiaozhi Jiang, Cong Feng
Summary: The research found that PD-L1 is highly expressed in oral squamous cell carcinoma (OSCC), correlated with worse survival, and related to macrophage infiltration and EMT process. Patients with high PD-L1 expression may benefit from ICI treatment and show higher sensitivity to certain chemical drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Jia-Ying Zhou, Qing-Hua Shen, Xiao-Jing Hong, Wu-Ya Zhang, Qiao Su, Wu-Guo Li, Bin Cheng, Cai-Ping Tan, Tong Wu
Summary: This study demonstrates the potential of photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC) by designing two iridium(III) photosensitizers that target the endoplasmic reticulum (ER). The Ir1-mediated PDT treatment adaptively upregulates the expression of programmed death-ligand 1 (PD-L1) and stimulates dendritic cell maturation and T lymphocyte infiltration. It also synergizes with a PD-L1 inhibitor to transform an immune-suppressive cold tumor into an immune-responsive hot tumor.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Sebastian Blatt, Maximilian Krueger, Constantin Rump, Stefanie Zimmer, Keyvan Sagheb, Julian Kuenzel
Summary: PD-L1 expression varies between oral and oropharyngeal squamous cell carcinoma, but does not affect patient survival. The status of p16 is also unrelated to PD-L1 expression.
Article
Oncology
Jiyun Lee, Binnari Kim, Hyun Ae Jung, Yoon La Choi, Jong-Mu Sun
Summary: Nivolumab showed a valuable option as subsequent treatment lines for patients with advanced ESCC, with an objective response rate of 19.3% and a median response duration of 6.5 months. Patients with a combined positive score (CPS) ≥1 demonstrated a significantly longer progression-free survival (PFS).
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shuang-Bo Xu, Meng-Yao Wang, Xin-Zhan Shi, Qiong Wang, Miao Yu, Wei Zhang, Xiao-Hui Xu, Lai-Kui Liu
Summary: The study found that PD-1 and PD-L1 may induce immune suppression in oral leukoplakia (OLK) and accelerate the progress of malignant transformation.
Review
Oncology
Antian Gao, Xiao Pan, Xudong Yang, Zitong Lin
Summary: This review discusses the advantages of anti-PD-1/PD-L1 therapy for oral squamous cell carcinoma (OSCC) patients, and identifies three aspects currently available for predicting treatment efficacy.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Immunology
Juan Wang, Limin Lun, Xin Jiang, Yi Wang, Xiaopeng Li, Guoqiang Du, Jin Wang
Summary: Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) significantly impact patients' quality of life, and immunotherapy plays a crucial role in cancer treatment. Studies have shown that the upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis, while PD-1 and PD-L1 are overexpressed in LSCC and HSCC tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Chanjuan Shi, Fleur Webster, Iris D. Nagtegaal
Article
Dentistry, Oral Surgery & Medicine
Bin Qiao, Zhuo Chen, Junwen Huang, Alfred King-yin Lam, Zi Mei, Yang Li, Jie Qiao
Summary: This study demonstrates that the expression of lipopolysaccharide-binding protein (LBP) is significantly elevated in oral and maxillofacial tumors (OMTs) and is associated with clinical stage, T classification, and lymph node metastasis. LBP could potentially serve as a biomarker for screening and predicting metastasis in patients with OMTs.
Article
Dentistry, Oral Surgery & Medicine
Wen Li, Yang Li, Zhuo Chen, Alfred King-yin Lam, Zeping Li, Xiaoling Liu, Baoyu Zhu, Bin Qiao
Summary: This study aims to investigate the clinical roles of metabolic alterations in head and neck squamous cell carcinoma (HNSCC). By analyzing the differential metabolites and metabolism-related genes, potential biomarkers with clinical applications were identified. These findings provide new insights for the treatment, intervention, and diagnosis of HNSCC.
Review
Oncology
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K-Y Lam, Vinod Gopalan, Farhadul Islam
Summary: This study highlights the significant role of estrogens and their receptors, particularly ERβ, in the pathogenesis of colorectal carcinoma (CRC). Understanding the underlying mechanisms of estrogen and its receptors in CRC pathogenesis could offer new insights for therapeutic development.
Article
Oncology
Justin Curtin, Peter Thomson, Gordon Wong, Alfred Lam, Siu-Wai Choi
Summary: This study found that surgery increases the presence of circulating malignant cells in patients with oral squamous cell carcinoma. These cells persist in the circulation even after surgery. The results suggest that surgical management of oral squamous cell carcinoma can lead to the systemic dissemination of cancer cells.
Review
Medicine, General & Internal
Louise Clarkson, Laura Hart, Alfred K. K. Lam, Tien K. K. Khoo
Summary: This review examined the effectiveness of deprescribing interventions within specialist outpatient clinics for patients aged 60 and older. Nineteen studies showed that implementing deprescribing interventions in certain clinic settings can significantly reduce medication load, but with limited study quality and the need for further research.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Biophysics
Md Sajedul Islam, Vinod Gopalan, Alfred K. Lam, Muhammad J. A. Shiddiky
Summary: Colorectal carcinoma (CRC) is a common cancer with high mortality rates, and various biomarkers and detection methods have been developed for its diagnosis and prognosis assessment. However, a gold standard method that is inexpensive, simple, and time-efficient and a critical review of the advantages and limitations of existing techniques are still lacking. This article provides an overview of the commonly used genetic and epigenetic biomarkers for CRC, discusses their detection methods, and presents the major challenges and advantages/limitations of current techniques.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Biochemistry & Molecular Biology
Ghazaleh Pourali, Nima Zafari, Hamid Fiuji, Jyotsna Batra, Elham Nazari, Majid Khazaei, Seyed Mahdi Hassanian, Mahrou Vahabi, MohammadAli Kiani, Majid Ghayour-Mobarhan, Godefridus J. Peters, Gordon A. Ferns, Alfred King-yin Lam, Elisa Giovannetti, Amir Avan
Summary: There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials and play a vital role in the communication between tumour cells and non-tumour cells. This review summarizes recent findings regarding the involvement of EVs in the metabolic reprogramming of gastrointestinal cancers and highlights potential therapeutic approaches.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Genetics & Heredity
Sharmin Aktar, Farhadul Islam, Tracie Cheng, Sujani Madhurika Kodagoda Gamage, Indra Neil Choudhury, Md Sajedul Islam, Cu Tai Lu, Faysal Bin Hamid, Hirotaka Ishida, Ichiro Abe, Nan Xie, Vinod Gopalan, Alfred K. Lam
Summary: This study investigated the genomic variations of KRAS in circulating tumour cells (CTCs) and matched colorectal carcinoma (CRC) tissues. The results showed differences in KRAS mutations between CTCs and CRC tissues. Patients with KRAS mutations in CTCs were more likely to have poorly differentiated tumors and lymph node metastasis. These findings suggest the genetic basis of KRAS as a potential target for immunotherapy.
Article
Oncology
Maryam Alaei, Seyedeh Elnaz Nazari, Ghazaleh Pourali, AliReza Asadnia, Mehrdad Moetamani-Ahmadi, Hamid Fiuji, Hamid Tanzadehpanah, Fereshteh Asgharzadeh, Fatemeh Babaei, Fatemeh Khojasteh-Leylakoohi, Ibrahim Saeed Gataa, Mohammad Ali Kiani, Gordon A. Ferns, Alfred King-yin Lam, Seyed Mahdi Hassanian, Majid Khazaei, Elisa Giovannetti, Amir Avan
Summary: In this study, the potential of targeting the enzyme cytochrome P450 (CYP450) using lopinavir/ritonavir in colorectal cancer (CRC) was explored. Experimental methods were employed to assess the effects of lopinavir/ritonavir on CRC, and it was found that inhibiting CYP450 reduced cell proliferation, induced cell death, and suppressed cell migration. Lopinavir/ritonavir also inhibited tumor growth and fibrosis. These findings suggest that targeting CYP450 with lopinavir/ritonavir has therapeutic potential in CRC and further research in this area is needed.
Article
Oncology
Alireza Asadnia, Elham Nazari, Ladan Goshayeshi, Nima Zafari, Mehrdad Moetamani-Ahmadi, Lena Goshayeshi, Haneih Azari, Ghazaleh Pourali, Ghazaleh Khalili-Tanha, Mohammad Reza Abbaszadegan, Fatemeh Khojasteh-Leylakoohi, Mohammadjavad Bazyari, Mir Salar Kahaei, Elnaz Ghorbani, Majid Khazaei, Seyed Mahdi Hassanian, Ibrahim Saeed Gataa, Mohammad Ali Kiani, Godefridus J. Peters, Gordon A. Ferns, Jyotsna Batra, Alfred King-yin Lam, Elisa Giovannetti, Amir Avan
Summary: This study identified genetic variants and differentially expressed genes in colorectal cancer patients using genome-wide DNA and RNA sequencing. ASPHD1 and ZBTB12 genes were identified as potential prognostic markers, and two novel genetic variants were found to potentially regulate gene expression. These findings provide a proof of concept for the evaluation of emerging biomarkers in colorectal cancer.
Meeting Abstract
Transplantation
Ken Chau, Shu Kay Ng, Alfred Lam, Tien Khoo, Dwarakanathan Ranganathan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Meeting Abstract
Transplantation
Louise Clarkson, Tien Khoo, Alfred Lam, Anthony Griffiths
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Meeting Abstract
Transplantation
Zaw Thet, Thin Han, Leo Francis, Nyi Aung, Ken Chau, Shu Kay Ng, Mar Myint, Jennifer Borg, Alfred Lam, Tien Khoo, Dwarakanathan Ranganathan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Hirotaka Ishida, Atsuko Kasajima, Takuro Yamauchi, Ryujiro Akaishi, Shunsuke Ueki, Yusuke Taniyama, Fumiyoshi Fujishima, Tomoyuki Koike, Takashi Kamei, Alfred King-yin Lam, Hironobu Sasano
Summary: Esophageal basaloid squamous cell carcinoma can resemble small cell carcinoma biopsy specimens and cause difficulties in pathology diagnosis. Small cell carcinoma-like features are frequent in biopsies but do not impact patients' outcome. Immunohistochemically, synapto-physin and chromogranin A are consistently negative, while CD56 is expressed in some cases. p16 expression may also be detected in basaloid squamous cell carcinoma.
HISTOLOGY AND HISTOPATHOLOGY
(2023)