Neuron–Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures

Update on Drug Management of Refractory Epilepsy in Tuberous Sclerosis Complex

(2020) Emma van der Poest Clement et al.   PEDIATRIC DRUGS

Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice

(2020) Nabila Haji et al.   Molecular Autism

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: an open-label pilot study

(2020) Dorinde M. van Andel et al.   Molecular Autism

Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation

(2020) Mouhamed Alsaqati et al.   Molecular Autism

Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex

(2019) Jian-Ping Zhao et al.   Molecular Brain

A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex

(2019) Iris E. Overwater et al.   NEUROLOGY

Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter

(2019) Prisca S. Leferink et al.   ANNALS OF NEUROLOGY

Cerebral aquaporin-4 expression is independent of seizures in tuberous sclerosis complex

(2019) Brittany Short et al.   NEUROBIOLOGY OF DISEASE

Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

(2019) Kellen D. Winden et al.   JOURNAL OF NEUROSCIENCE

Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

(2019) Anna K. Prohl et al.   Journal of Neurodevelopmental Disorders

Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation

(2018) Avery J. Zucco et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetically engineered human cortical spheroid models of tuberous sclerosis

(2018) John D. Blair et al.   NATURE MEDICINE

Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro

(2018) Aishwarya G. Nadadhur et al.   Stem Cell Research

Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

(2018) Aishwarya G. Nadadhur et al.   Stem Cell Reports

Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance

(2017) Yuri Bozzi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders

(2017) Yehezkel Ben-Ari   TRENDS IN NEUROSCIENCES

Abnormal Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Partially Mimicked Development of TSC2 Neurological Abnormalities

(2017) Yaqin Li et al.   Stem Cell Reports

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders

(2017) Darcy A. Krueger et al.   Annals of Clinical and Translational Neurology

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

(2017) Aishwarya G. Nadadhur et al.   PLoS One

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Functional aspects of early brain development are preserved in tuberous sclerosis complex (TSC) epileptogenic lesions

(2016) Gabriele Ruffolo et al.   NEUROBIOLOGY OF DISEASE

RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism

(2016) Jihane Soueid et al.   Scientific Reports

Neurological and neuropsychiatric aspects of tuberous sclerosis complex

(2015) Paolo Curatolo et al.   LANCET NEUROLOGY

Anti-EGFR Antibody Reduces Lung Nodules by Inhibition of EGFR-Pathway in a Model of Lymphangioleiomyomatosis

(2015) Elena Lesma et al.   Biomed Research International

TSC2epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival

(2014) Elena Lesma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits

(2013) David M. Feliciano et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Enhanced Epidermal Growth Factor, Hepatocyte Growth Factor, and Vascular Endothelial Growth Factor Expression in Tuberous Sclerosis Complex

(2011) Whitney E. Parker et al.   AMERICAN JOURNAL OF PATHOLOGY

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex

(2011) Kenji Mori et al.   BRAIN & DEVELOPMENT

Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming

(2011) Eva Warlich et al.   MOLECULAR THERAPY

Impaired astrocytic gap junction coupling and potassium buffering in a mouse model of tuberous sclerosis complex

(2009) Lin Xu et al.   NEUROBIOLOGY OF DISEASE

Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex

(2008) Karin Boer et al.   NEUROPATHOLOGY