Integrity of the Antiviral STING-mediated DNA Sensing in Tumor Cells Is Required to Sustain the Immunotherapeutic Efficacy of Herpes Simplex Oncolytic Virus

Replicative conditioning of Herpes simplex type 1 virus by Survivin promoter, combined to ERBB2 retargeting, improves tumour cell-restricted oncolysis

(2020) Emanuele Sasso et al.   Scientific Reports

Retargeted and multi-cytokine armed herpes virus is a potent cancer endovaccine for local and systemic anti-tumor treatment in combination with anti-PD1

(2020) Maria De Lucia et al.   Molecular Therapy-Oncolytics

The Antiviral Apparatus: STING and Oncolytic Virus Restriction

(2019) Joel Lee et al.   Molecular Therapy-Oncolytics

Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?

(2019) Maria Eugenia Davola et al.   OncoImmunology

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway

(2019) Markus Stempel et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma

(2019) Praveen K. Bommareddy et al.   OncoImmunology

Oncolytic Viruses: Priming Time for Cancer Immunotherapy

(2019) Luke Russell et al.   BIODRUGS

Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds

(2019) Venkatesh Sivanandam et al.   Molecular Therapy-Oncolytics

STING Signaling in Melanoma Cells Shapes Antigenicity and Can Promote Antitumor T-cell Activity

(2019) Rana Falahat et al.   Cancer Immunology Research

STING Restricts Oncolytic HSV Replication and Spread in Resistant Malignant Peripheral Nerve Sheath Tumors but is Dispensable for Basal Interferon Stimulated Gene Upregulation.

(2019) Joel M. Lee et al.   Molecular Therapy-Oncolytics

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

(2018) Jeonghyun Ahn et al.   CANCER CELL

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy

(2018) Dmitriy Zamarin et al.   JOURNAL OF CLINICAL INVESTIGATION

Randomized, Open-Label Phase II Study Evaluating the Efficacy and Safety of Talimogene Laherparepvec in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced, Unresectable Melanoma

(2018) Jason Chesney et al.   JOURNAL OF CLINICAL ONCOLOGY

Extracellular vesicles released by herpes simplex virus 1 infected cells block virus replication in recipient cells in a STING-dependent manner.

(2018) Thibaut Deschamps et al.   JOURNAL OF VIROLOGY

Human MxB protein is a pan-herpesvirus restriction factor

(2018) Mirjam Schilling et al.   JOURNAL OF VIROLOGY

A long non-coding SINEUP RNA boosts semi-stable production of fully human monoclonal antibodies in HEK293E cells

(2018) Emanuele Sasso et al.   mAbs

Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies

(2018) Emanuele Sasso et al.   mAbs

The Immune System in Oncolytic Immunovirotherapy: Gospel, Schism and Heresy

(2018) Richard G. Vile   MOLECULAR THERAPY

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

(2018) Hiroyasu Konno et al.   ONCOGENE

Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies

(2018) Shashi Gujar et al.   TRENDS IN IMMUNOLOGY

Herpes Simplex Virus 1 γ134.5 Protein Inhibits STING Activation That Restricts Viral Replication

(2018) Shuang Pan et al.   JOURNAL OF VIROLOGY

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors

(2018) Valerio Leoni et al.   PLoS Pathogens

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

(2018) Guoxin Ni et al.   PLoS Pathogens

Immune cell gene signatures for profiling the microenvironment of solid tumors

(2018) Ajit J Nirmal et al.   Cancer Immunology Research

Ovarian Cancer Cells Commonly Exhibit Defective STING Signaling Which Affects Sensitivity to Viral Oncolysis

(2018) Nina Marí Gual Pimenta de Queiroz et al.   MOLECULAR CANCER RESEARCH

An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer

(2018) Xiang An et al.   Molecular Therapy-Nucleic Acids

Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity

(2017) Kenji Chamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for the antitumor effect of immune checkpoint blockade

(2017) Hua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells

(2015) Emanuele Sasso et al.   Biomed Research International

Combinatorial Strategies for the Induction of Immunogenic Cell Death

(2015) Lucillia Bezu et al.   Frontiers in Immunology

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs

(2014) Maria Kalamvoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An autophagy-dependent anticancer immune response determines the efficacy of melanoma chemotherapy

(2014) Mickaël Michaud et al.   OncoImmunology

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Herpes Simplex Virus 1 Counteracts Tetherin Restriction via Its Virion Host Shutoff Activity

(2013) H. L. Zenner et al.   JOURNAL OF VIROLOGY

Immunogenic HSV-mediated Oncolysis Shapes the Antitumor Immune Response and Contributes to Therapeutic Efficacy

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition

(2012) A Pellecchia et al.   Oncogenesis

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

(2008) L. Menotti et al.   JOURNAL OF VIROLOGY