Article
Public, Environmental & Occupational Health
Yiping Li, Qinjian Wang, Shu Liang, Chuanteng Feng, Hong Yang, Hang Yu, Dan Yuan, Shujuan Yang
Summary: This study found that a PI-based ART regimen is beneficial for reducing mortality in people living with HIV and HIV-1 drug resistance. Efforts should be made to detect HIV-1 drug resistance earlier and ensure timely adjustment to PI-based ART, maximizing the benefits of early switch treatment for these patients.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Oncology
Jiali Wang, Yixuan Zhang, Xiaoquan Liu, Haochen Liu
Summary: The study introduces a method of evaluating the restoration index based on system reachability to improve the treatment outcome of tumors with aggressive resistant subpopulations, while balancing the benefits of intra-competition and killing sensitive subpopulations. The effectiveness of this method was confirmed through simulation and animal experiments.
Article
Oncology
Renee Brady-Nicholls, Heiko Enderling
Summary: The study investigates the potential benefit of range-bounded adaptive therapy (RBAT) in metastatic castration-resistant prostate cancer (mCRPC). The results show that RBAT can extend time to progression and reduce the cumulative dose received.
Article
Immunology
Kritika Chetty, Iek Cheng, Marios Kaliakatsos, Luis Ignacio Gonzalez-Granado, Dimitra Klapsa, Javier Martin, Alasdair Bamford, Judith Breuer, Claire Booth
Summary: This case report describes the successful treatment of severe enterovirus encephalitis in an immunocompromised child using a novel regimen of favipiravir, fluoxetine, and high-dose IVIg. This is the first reported case of combined therapy with these drugs for enterovirus encephalitis in an immunocompromised individual. The treatment resulted in clinical improvement and excellent immune recovery.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Changjing Cai, Qingqing Luo, Yihan Liu, Yinghui Peng, Xiangyang Zhang, Zhaohui Jiang, Ziyang Feng, Yaru Qi, Yan Gao, Yongting Liu, Ping Liu, Yihong Chen, Cao Guo, Hong Shen, Shan Zeng, Ying Han
Summary: This study conducted a comprehensive analysis of treatment regimens for left-sided RAS wild-type metastatic colorectal cancer (mCRC) and found that the double-drug regimen plus cetuximab/panitumumab was more effective and safer than the double-drug and triple-drug regimens with bevacizumab.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Leilei Sun, Chuanren Liu, Guoqing Chen, Chonghui Guo, Hui Xiong, Yanming Xie
Summary: This paper introduces a novel Extended Jaccard Similarity measure to quantify the similarities between treatment sequences, and develops an efficient clustering algorithm to extract semantic prototypes of treatment regimens. By adopting a matrix factorization framework, the approach is able to predict treatment outcomes by integrating multiple internal and external factors, showing its effectiveness and superiority over state-of-the-art methods through comprehensive experiments on Electronic Medical Records.
IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Yoshiaki Nakamura, Wataru Okamoto, Takeshi Kato, Taito Esaki, Ken Kato, Yoshito Komatsu, Satoshi Yuki, Toshiki Masuishi, Tomohiro Nishina, Hiromichi Ebi, Kentaro Sawada, Hiroya Taniguchi, Nozomu Fuse, Shogo Nomura, Makoto Fukui, Seiko Matsuda, Yasutoshi Sakamoto, Hiroshi Uchigata, Kana Kitajima, Naomi Kuramoto, Takashi Asakawa, Steve Olsen, Justin Odegaard, Akihiro Sato, Satoshi Fujii, Atsushi Ohtsu, Takayuki Yoshino
Summary: The study demonstrated that ctDNA genotyping can identify mCRC patients who benefit from pertuzumab plus trastuzumab treatment and monitor treatment response. The accuracy of ctDNA genotyping in identifying HER2-amplified mCRC patients was similar to tissue genotyping.
Article
Multidisciplinary Sciences
Ben Parker, Tom Ward, Olivia Hayward, Ian Jacob, Erin Arthurs, Debbie Becker, Sarah-Jane Anderson, Vasiliki Chounta, Nicolas Van de Velde
Summary: Long-acting injectable antiretroviral therapy may improve clinical outcomes and cost-effectiveness for HIV patients, reducing HIV transmission risk to some extent and leading to cost-savings in healthcare.
Article
Multidisciplinary Sciences
Md Asaduzzaman, Eric Koetz, Hanwen Wu, Michael Hopwood, Adam Shephard
Summary: The study found that glyphosate-resistant plants generally produced more biomass and had higher spike and seed numbers per plant at higher concentrations of glyphosate. However, in the absence of glyphosate, resistant plants performed worse than susceptible plants. The widespread use of glyphosate in fields may favor the selection of resistant individuals.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Andrea Marino, Antonio Munafo, Aldo Zagami, Manuela Ceccarelli, Rosaria Di Mauro, Giuseppina Cantarella, Renato Bernardini, Giuseppe Nunnari, Bruno Cacopardo
Summary: EFIE is a potentially fatal infectious disease with limited progress in antibiotic therapy, high prevalence of multi-drug resistant strains, and double beta-lactam therapy is considered as a potentially effective treatment method.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Mingming Zhang, Yang Zheng, Xiaohui Li, Shuai Yang, Lin Shi, Aijie Li, Yang Liu
Summary: The study revealed that the modified mPSL regimen as an initial treatment for refractory KD is safe and effective, with the potential to improve the initial response to IVIG and reduce dilation of the left circumflex coronary artery.
PEDIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Andrew J. Kavran, Scott A. Stuart, Kristyn R. Hayashi, Joel M. Basken, Barbara J. Brandhuber, Natalie G. Ahn
Summary: Patients with melanoma often develop resistance to drugs targeting BRAF(V600E) and MEK1/2, but intermittent treatment involving drug withdrawal and rechallenge may delay resistance onset through drug addiction and resensitization mechanisms. Continuous treatment leads to transcriptional changes associated with chemoresistance, while intermittent treatment results in reversible expression of transcripts involved in invasiveness and cellular plasticity. Resensitization during drug removal periods contributes to the beneficial effect of intermittent treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Xiangjie Luo, Ao Li, Xiaoqin Chi, Yaying Lin, Xing Liu, Lifan Zhang, Xinhui Su, Zhenyu Yin, Hongyu Lin, Jinhao Gao
Summary: YC-Dox is a hypoxia-activated prodrug that can release chemotherapy drugs and downregulate HIF-1 alpha under hypoxic conditions, exhibiting significant cytotoxic selectivity for hypoxic cancer cells.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Physics, Fluids & Plasmas
Y. Ma, P. K. Newton
Summary: This study uses evolutionary game theory to design adaptive schedules for two drugs in order to mitigate chemotherapeutic resistance and delay tumor recurrence. The key parameter determines whether the drugs interact synergistically, additively, or antagonistically, with antagonistic interactions being more effective in controlling the evolution of resistance. By shaping the fitness landscape of cell populations and altering dosages and timing of drugs, the study shows that antagonistic drug interactions result in slower rates of adaptation of resistant cells, making them more effective in combatting resistance evolution.
Review
Biochemistry & Molecular Biology
Enrico Celestino Nista, Angelo Del Gaudio, Livio Enrico Del Vecchio, Teresa Mezza, Giulia Pignataro, Andrea Piccioni, Antonio Gasbarrini, Francesco Franceschi, Marcello Candelli
Summary: Pancreatic cancer is a challenging malignancy with high mortality rates. Microbes, particularly certain bacteria, have been found to play a role in therapy resistance and tumor microenvironment, affecting cancer progression and treatment outcomes. Understanding the interactions between microbiota and therapy may lead to improved treatment strategies and survival for patients with pancreatic cancer.
Editorial Material
Biochemistry & Molecular Biology
Lauren A. Richardson, Sandra L. Schmid, Avinash Bhandoola, Christelle Harly, Anders Hedenstrom, Michael T. Laub, Georgina M. Mace, Piali Sengupta, Ann M. Stock, Andrew F. Read, Harmit S. Malik, Mark Estelle, Sally Lowell, Jonathan Kimmelman
Article
Multidisciplinary Sciences
Nina Wale, Matthew J. Jones, Derek G. Sim, Andrew F. Read, Aaron A. King
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Evolutionary Biology
Elsa Hansen, Andrew F. Read
EVOLUTIONARY APPLICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Alita R. Burmeister, Elsa Hansen, Jessica J. Cunningham, E. Hesper Rego, Paul E. Turner, Joshua S. Weitz, Michael E. Hochberg
Summary: Successful therapies for microbial diseases and cancers must incorporate ecological and evolutionary principles. A systems-based approach, drawing upon ecology and evolutionary biology, reveals that successful treatments engage with multiple interactions within the host ecosystem. Leveraging synergies and nonlinear feedbacks is essential for improving pathogenesis research and developing more effective therapies.
Article
Biochemistry & Molecular Biology
Clare L. Kinnear, Elsa Hansen, Valerie J. Morley, Kevin C. Tracy, Meghan Forstchen, Andrew F. Read, Robert J. Woods
Article
Biology
Valerie J. Morley, Clare L. Kinnear, Derek G. Sim, Samantha N. Olson, Lindsey M. Jackson, Elsa Hansen, Grace A. Usher, Scott A. Showalter, Manjunath P. Pai, Robert J. Woods, Andrew F. Read
Article
Virology
Peter J. Kerr, Isabella M. Cattadori, Derek Sim, June Liu, Edward C. Holmes, Andrew F. Read
Summary: This study investigated the virulence and disease phenotypes of recent isolates of myxoma virus in Australian rabbits. The viruses showed different levels of virulence, causing acute death with minimal signs of myxomatosis and bacterial invasions, but no inflammatory response. Some rabbits developed an amyxomatous phenotype. It was also found that certain laboratory rabbits had innate resistance to myxomatosis. The alterations in disease pathogenesis and bacterial invasions suggest that the virulence grades of modern viruses cannot be directly compared with earlier studies.
JOURNAL OF VIROLOGY
(2022)
Article
Evolutionary Biology
Robert J. Woods, Andrew F. Read
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2023)
Article
Evolutionary Biology
Valerie J. Morley, Derek G. Sim, Aline Penkevich, Robert J. Woods, Andrew F. Read
Summary: This study demonstrates that oral administration of cholestyramine can effectively prevent the enrichment of diverse daptomycin-resistant mutations in the gut during daptomycin treatment. Administering cholestyramine prior to the first dose of daptomycin shows the best effectiveness in reducing the frequency of resistant E. faecium.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
David A. Kennedy, Andrew F. Read
Article
Virology
Andrew S. Bell, David A. Kennedy, Matthew J. Jones, Christopher L. Cairns, Utsav Pandey, Patricia A. Dunn, Moriah L. Szpara, Andrew F. Read