Acute Pancreatitis: Genetic Risk and Clinical Implications

Acute pancreatitis (AP) is one of the most common gastroenterological indications for emergency admittance and hospitalization. Gallstones, alcohol consumption or the presence of additional initiating factors give rise to a disease with a diverse clinical appearance and a hard-to predict course of progression. One major challenge in the treatment of AP patients is the early identification of patients at risk for the development of systemic complications and organ failure. In addition, 20%-30% of patients with a first episode of AP later experience progress to recurrent or chronic disease. Complex gene-environment interactions have been identified to play a role in the pathogenesis of pancreatitis, but so far no predictive genetic biomarkers could be implemented into the routine clinical care of AP patients. The current review explains common and rare etiologies of acute pancreatitis with emphasis on underlying genetic aberrations and ensuing clinical management.

Automated summary

Acute pancreatitis, caused by various factors such as gallstones and alcohol consumption, poses challenges in early identification of patients at risk for systemic complications and organ failure. The presence of complex gene-environment interactions plays a role in the pathogenesis of pancreatitis, but predictive genetic biomarkers are not yet implemented into routine clinical care for AP patients.