CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

(2019) Katherine E Bohnsack et al.   EMBO JOURNAL

Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation

(2019) Yangyang Yu et al.   Cell Discovery

Ribosome assembly coming into focus

(2018) Sebastian Klinge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ribosomopathies: There’s strength in numbers

(2017) Eric W. Mills et al.   SCIENCE

How Ribosomes Translate Cancer

(2017) Sergey O. Sulima et al.   Cancer Discovery

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

(2016) X-R Han et al.   ONCOGENE

DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

(2016) Zengli Guo et al.   Nature Communications

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

(2015) Jiangge Zheng et al.   GENES & DEVELOPMENT

CRL4VprBP E3 Ligase Promotes Monoubiquitylation and Chromatin Binding of TET Dioxygenases

(2015) Tadashi Nakagawa et al.   MOLECULAR CELL

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

(2015) A Bailly et al.   ONCOGENE

Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells

(2015) Lukas Badertscher et al.   Cell Reports

Ribosome Assembly Factors Pwp1 and Nop12 Are Important for Folding of 5.8S rRNA during Ribosome Biogenesis in Saccharomyces cerevisiae

(2014) J. Talkish et al.   MOLECULAR AND CELLULAR BIOLOGY

An overview of pre-ribosomal RNA processing in eukaryotes

(2014) Anthony K. Henras et al.   Wiley Interdisciplinary Reviews-RNA

VprBP (DCAF1): a promiscuous substrate recognition subunit that incorporates into both RING-family CRL4 and HECT-family EDD/UBR5 E3 ubiquitin ligases

(2013) Tadashi Nakagawa et al.   BMC MOLECULAR BIOLOGY

Growth control and ribosomopathies

(2013) Teng Teng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

CRL4 Complex Regulates Mammalian Oocyte Survival and Reprogramming by Activation of TET Proteins

(2013) C. Yu et al.   SCIENCE

VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity

(2011) Michele D Kassmeier et al.   EMBO JOURNAL

When ribosomes go bad: diseases of ribosome biogenesis

(2010) Emily F. Freed et al.   Molecular BioSystems

Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis

(2010) S. Yamaji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of Lgl and Mahjong/VprBP in Cell Competition

(2010) Yoichiro Tamori et al.   PLOS BIOLOGY

Targeting protein ubiquitylation: DDB1 takes its RING off

(2009) Sarah Jackson et al.   NATURE CELL BIOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Human Immunodeficiency Virus Type 1 Vpr-Binding Protein VprBP, a WD40 Protein Associated with the DDB1-CUL4 E3 Ubiquitin Ligase, Is Essential for DNA Replication and Embryonic Development

(2008) C. M. McCall et al.   MOLECULAR AND CELLULAR BIOLOGY

Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 Forms a Nuclear E3 Ubiquitin Ligase with DDB1 and CUL4 That Is Involved in Multiple Plant Developmental Processes

(2008) Y. Zhang et al.   PLANT CELL