Article
Biophysics
Enja Laureen Roesch, Jing Zhong, Aidin Lak, Zhe Liu, Markus Etzkorn, Meinhard Schilling, Frank Ludwig, Thilo Viereck, Birka Lalkens
Summary: This study demonstrates a diagnostic assay for the detection of pathogen-specific nucleic acids based on magnetic nanoparticles, which allows for rapid and accurate detection of various nucleic acids. DNA can be detected at a concentration as low as 500 pM, and RNA, SARS-CoV-2-specific DNA, and saliva can also be used as sample media for accurate testing.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Multidisciplinary
Zeying Zhang, Maoxiong Zhao, Meng Su, Yali Sun, Ekaterina Ponkratova, Shuang-Jie Tan, Qi Pan, Bingda Chen, Zheng Li, Zheren Cai, Huadong Wang, Dongdong Wu, Lei Shi, Yanlin Song
Summary: This study reports a general method for visualizable detection and measurement of nanoscale objects using one-dimensional nanostructures. Large-scale 1D nanostructures, prepared through template-assisted self-assembly of colloidal nanoparticles, can significantly amplify the weak optical signals from nanoscale objects, achieving detection sensitivity down to the single-particle level. The rapid and ultrasensitive testing of different clinical virus samples using a simple optical microscope or a portable cell phone is demonstrated. This work showcases a label-free, simple, and high-efficiency optical detection platform at the nanoscale, with a broad range of applications.
Article
Chemistry, Analytical
Kavya L. Singampalli, Jiran Li, Peter B. Lillehoj
Summary: Protein-based diagnostics are widely used for screening and diagnosing various diseases. The current gold standard method, enzyme-linked immunosorbent assay (ELISA), has high sensitivity but is time-consuming. This study presents a unique magneto-ELISA using labeled magnetic nanoparticles for rapid enrichment and signal amplification. The assay showed superior diagnostic accuracy in detecting malaria parasite biomarker and SARS-CoV-2 nucleocapsid protein, with fast completion time and compatibility with standard equipment.
ANALYTICA CHIMICA ACTA
(2022)
Article
Nanoscience & Nanotechnology
Kai Wu, Vinit Kumar Chugh, Venkatramana D. Krishna, Yongqiang Andrew Wang, Timothy D. Gordon, Maxim C. -J. Cheeran, Jian-Ping Wang
Summary: In this work, a 5-minute bioassay strategy based on magnetic particle spectroscopy (MPS) is reported. By incubating surface-functionalized magnetic nanoparticles with target analytes at 37 degrees C for 3 minutes and taking the MPS reading at the fifth minute, the feasibility of ultrafast detection of SARS-CoV-2 spike protein with a detection limit below 5 nM (0.2 pmol) is demonstrated. The proposed 5-minute bioassay strategy can be applied to reduce the assay time for other liquid-phase, volumetric biosensors such as NMR, quantum dots, and fluorescent biosensors.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jing Zhong, Klaas-Julian Janssen, Sebastian Draack, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Summary: This study demonstrates that a lower MNP concentration can improve the measurement sensitivity of biomolecules with MPS in the frequency range from 180 to 1418 Hz. The ratio of the 3rd to 1st harmonics decreases significantly with increasing IgG concentration at a lower MNP concentration, indicating a higher measurement sensitivity of IgG. The absolute variation in the ratio of 3rd to 1st harmonics of the MNPs can be used as a characterization of the measurement sensitivity of IgG.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Kai Wu, Vinit Kumar Chugh, Venkatramana D. Krishna, Arturo di Girolamo, Yongqiang Andrew Wang, Renata Saha, Shuang Liang, Maxim C-J Cheeran, Jian-Ping Wang
Summary: Amid the ongoing global COVID-19 pandemic, there is a growing demand for accessible, easy-to-use, rapid, inexpensive, and highly accurate diagnostic tools. Traditional diagnostic methods may be too slow and cumbersome for effective disease surveillance and control. Therefore, developing a rapid, one-step, user-friendly, and high-accuracy diagnostic platform is crucial for future epidemic control.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ruben Canton-Vitoria, Kotaro Sato, Yashiro Motooka, Shinya Toyokuni, Zheng Liu, Ryo Kitaura
Summary: We made sensors by modifying MoS2 and WS2 surfaces with COVID-19 antibodies and examined their stability, reusability, sensitivity, and selectivity. Antibodies interact strongly with Mo or W sites, resulting in durable devices that remain stable for several days in air or water. The antibodies remain intact even during aggressive cleaning at pH 3, allowing reuse without significant loss of sensitivity. The nanodevice can be used for different patient samples, with a limit of detection of 1 fg ml(-1) at room temperature and a response time of 1 second, showing selectivity against interferences.
Article
Environmental Sciences
Jinhui Zhu, Huijun Lu, Qiuyuan Lin, Tong Zhang, Guang Chen, Yang Zhou, Guodong Sui
Summary: This study introduced magnetic beads coated with fucoidan and polydopamine as a capture carrier for pretreatment of SARS-CoV-2 samples. The Fuc-PDA-MBs showed better efficiency in virus enrichment compared to traditional methods. By combining with nucleic acid extraction-free Loop-Mediated Isothermal Amplification, the whole procedure of virus detection could be completed within 90 minutes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Materials Science, Multidisciplinary
Matthew J. Fox, Ashlee Aiello, Shize Yang, Paul C. Trulove, David P. Durkin, Elena Cimpoiasu
Summary: Biocomposites containing magnetic nanoparticles have the potential to combine the unique properties of nanoparticles with the strong mechanical and sustainable properties of natural fibers. This study investigates how the structural and magnetic properties of these biocomposite materials are affected by increasing metal loading, finding that higher metal loading enhances nanoparticle heterogeneity and agglomeration.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Article
Chemistry, Analytical
Haodong Cui, Wenxing Song, Xiaoling Ru, Wen Fu, Ling Ji, Wenhua Zhou, Zhen Zhao, Guangbo Qu, Xue-Feng Yu, Guibin Jiang
Summary: A new viral RNA extraction method based on poly-(amino ester) with carboxyl group (PC)-coated magnetic nanoparticles (pcMNPs) is reported for the sensitive detection of SARS-CoV-2. This method combines the lysis and binding steps into one step, and refines multiple washing steps into one step, giving a turnaround time of less than 9 min. The extracted pcMNP-RNA complexes can be directly introduced into subsequent RT-PCR reactions without elution.
Article
Chemistry, Analytical
Valerio G. Barauna, Maneesh N. Singh, Leonardo Leal Barbosa, Wena Dantas Marcarini, Paula Frizera Vassallo, Jose Geraldo Mill, Rodrigo Ribeiro-Rodrigues, Luciene C. G. Campos, Patrick H. Warnke, Francis L. Martin
Summary: There is an urgent need for ultrarapid testing for detecting SARS-CoV-2 infections in real-time to stop its spread. Current testing approaches are time-consuming and inaccurate, but the new ATR-FTIR spectroscopy method offers a fast, reagent-free alternative that can provide results within 2 minutes, suitable for areas with high people traffic.
ANALYTICAL CHEMISTRY
(2021)
Article
Electrochemistry
Ana Luiza Lorenzen, Ariane Moraes dos Santos, Luani Poll dos Santos, Luciano da Silva Pinto, Fabricio Rochedo Conceicao, Franciele Wolfart
Summary: Electrochemical sensors and biosensors are useful for fast, inexpensive, sensitive, and easy detection of various specimens. In this study, a modified electrode was used to detect COVID-19 antibodies, showing a linear selective response. The method has the potential to replace traditional tests due to specific antibody-antigen binding interaction and fast response.
ELECTROCHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Ceren Durmus, Duygu Harmanci, Hichem Moulahoum, Kerem Tok, Faezeh Ghorbanizamani, Serdar Sanli, Figen Zihnioglu, Serap Evran, Candan Cicek, Ruchan Sertoz, Bilgin Arda, Tuncay Goksel, Kutsal Turhan, Suna Timur, Simge Balaban Hanoglu
Summary: An electrochemical immunosensor based on SARS-CoV-2 antibody cocktail-conjugated magnetic nanoparticles has been developed for sensitive and accurate detection of the SARS-CoV-2 virus and its variants. The antibody cocktail showed better performance compared to commercial antibodies, and could detect a wider range of variants.
Article
Biochemistry & Molecular Biology
Yunxiao Feng, Gang Liu, Ming La, Lin Liu
Summary: In this study, a label-free peptide substrate was used to induce the aggregation of AuNPs for visual analysis of Mpro activity. Co-assembly of AuNPs and peptide on an electrode surface allowed for the development of a simple and sensitive electrochemical method for detecting Mpro in serum samples.
Article
Medicine, General & Internal
Sunggyun Park, Do-Hoon Kim
Summary: Due to decreasing trends in COVID-19 cases and tests, a new testing system capable of testing small sample amounts quickly and efficiently is needed. In this study, the testing performance of the Aptima SARS-CoV-2 assay and the Real-Q Direct SARS-CoV-2 detection kit was compared and evaluated. Both systems showed comparable clinical performance for individual and pooled samples, with the Aptima SARS-CoV-2 assay having a lower limit of detection (LoD). The results indicate that these testing systems can effectively detect SARS-CoV-2 in clinical specimens.
Article
Chemistry, Analytical
Wilson Ombati Nyang'au, Tamara Kahmann, Thilo Viereck, Erwin Peiner
Summary: This study introduces a measurement approach for determining the mass and magnetic moment of magnetic particles on a MEMS resonant cantilever balance, using FEMM simulation. Results show varying magnetic moment values for different types of particles compared to nominal values.
Article
Engineering, Multidisciplinary
Klaas-Julian Janssen, Meinhard Schilling, Frank Ludwig, Jing Zhong
Summary: he paper proposes a single harmonic-based narrowband MPI approach for quantitatively visualizing SPIONs. The approach reduces design efforts and noise matching in the MPI scanner, and achieves good spatial resolution and limit of detection. Further improvements can be made by optimizing SPIONs and improving the detection circuitry.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yimeng Li, Hui Hui, Peng Zhang, Jing Zhong, Lin Yin, Haoran Zhang, Bo Zhang, Yu An, Jie Tian
Summary: In this study, a more accurate model called the modified Jiles-Atherton (MJA) model was proposed to describe the dynamic magnetization behavior of superparamagnetic iron-oxide nanoparticles (SPIOs). The MJA model was integrated into the x-space algorithm to improve the spatial resolution of magnetic particle imaging (MPI) technology.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Yuedong Li, Fei Wang, Xi Zhang, Songtao Guo
Summary: This paper proposes IRS-based MEC schemes for delay-constrained QoS provisioning in RF-powered 6G mobile networks. The schemes utilize intelligent reflecting surfaces to enable energy harvesting and data transmission from multiple mobile users to a base station for processing. The joint optimization of phase-shift matrices, resource allocation, detection coefficients, and transmission time and task allocation significantly reduces delay for mobile users. The effectiveness of the proposed schemes is validated through numerical analyses.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Klaas-Julian Janssen, Jing Zhong, Thilo Viereck, Meinhard Schilling, Frank Ludwig
Summary: Magnetic Particle Imaging (MPI) is a promising imaging modality for disease theranostics, enabling visualization of magnetic nanoparticles (MNPs). This study proposes a new approach for temperature imaging using MPI, by measuring the phase lag of the 3rd harmonic of MNP response. Experimental results demonstrate the feasibility of this approach.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mohammad Suman Chowdhury, Enja Laureen Roesch, Daniel Arenas Esteban, Klaas-Julian Janssen, Florian Wolgast, Frank Ludwig, Meinhard Schilling, Sara Bals, Thilo Viereck, Aidin Lak
Summary: Researchers designed monodisperse magnetic nanocubes of different sizes and compositions, and achieved ultrahigh sensitivity by decoupling their physical properties. They found that tricomponent Zn0.06Co0.80Fe2.14O4 particles showed ultrahigh magnetic sensitivity, despite having lower saturation magnetization. These Zn0.06Co0.80Fe2.14O4 particles, coated with catechol-based poly(ethylene glycol) ligands, exhibited 3 orders of magnitude better particle limit of detection than commercial nanoparticles of comparable size.
Article
Engineering, Biomedical
Yanjun Liu, Hui Hui, Sijia Liu, Guanghui Li, Bo Zhang, Jing Zhong, Yu An, Jie Tian
Summary: This study proposes a direct imaging method based on the weighted sum of harmonic signals for magnetic particle imaging (MPI), which can rapidly image the concentration distribution of nanoparticles without prior calibration measurements. Simulation and scanner-based experiments demonstrate the effectiveness of the proposed method, with significant improvements in structural similarity, mean square error, and signal-to-artifact ratio compared to traditional methods. This method has the potential to be implemented as a multi-patch imaging method in MPI.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Peng Zhang, Jie Liu, Yimeng Li, Tao Zhu, Lin Yin, Yu An, Jing Zhong, Hui Hui, Jie Tian
Summary: In this study, a dynamic residual Kaczmarz (DRK) method was proposed as an improved reconstruction method for magnetic particle imaging (MPI) to achieve better reconstruction quality from high-noise signals. The DRK method selects parts of the low-noise equations for reconstruction based on a residual vector, resulting in accurate reconstruction with less noise. The numerical simulation and experimental results demonstrate that the DRK method outperforms classical Kaczmarz-type methods in terms of reconstruction quality at similar noise levels.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Automation & Control Systems
Li Song, Yuguo Dai, Luyao Wang, Wei Zhang, Yiming Ji, Yuqing Cao, Junyi Wei, Fengwu Wang, Jing Zhong, Jiapeng Yang, Lin Feng
Summary: This study presents a new electromagnetic coil system based on adaptive magnetic levitation for the applications of magnetically actuated capsule robot in the diagnoses of human stomach disease. The system enables motion control of the capsule, including levitating translational motion control, and pitch and yaw motion control in levitation. The proposed system compensates for the limitations of previous magnetic levitation systems and has been proven to be stable and adaptable to the environment, providing a new examination method for capsule endoscopy.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Physical
Hajnalka Nadasi, Melvin Kuester, Alenka Mertelj, Nerea Sebastian, Patricija Hribar Bostjancic, Darja Lisjak, Thilo Viereck, Margaret Rosenberg, Alexey O. Ivanov, Sofia S. Kantorovich, Alexey Eremin, Frank Ludwig
Summary: The study investigates the influence of electrostatic interactions on the dynamical response in dispersions of magnetic nanoplatelets, and finds that tuning the interactions with an ionic surfactant leads to new dynamic modes in magnetic response spectra. The collective modes can be induced or suppressed by varying the concentration ratio of the nanoplatelets to the surfactant or increasing the nanoplatelet concentration, reflecting the nanoscale characteristics of this fluid magnet.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Electrical & Electronic
Hui Hui, Jiaojiao Liu, Hui Zhang, Jing Zhong, Jie He, Bo Zhang, Haoran Zhang, Qin Li, Hongjun Li, Jie Tian
Summary: The purpose of this study is to develop a magnetic particle imaging (MPI) technique to directly measure time-varied cerebral superparamagnetic iron oxide nanoparticle (SPIO) concentration in rhesus macaques. A hand-held MPI detector was developed to monitor MPI signal changes at the third harmonics of the drive frequency in resting-state nonhuman primates. The detection limit of the MPI detector is about 125 ng iron.
IEEE MAGNETICS LETTERS
(2023)
Article
Engineering, Electrical & Electronic
Peng Zhang, Jie Liu, Yimeng Li, Lin Yin, Yu An, Jing Zhong, Hui Hui, Jie Tian
Summary: The frequency component compression method (FCCM) has been widely used in magnetic particle imaging (MPI) technology to improve reconstruction efficiency. A dual-feature frequency component compression method (DF-FCCM) was developed to further accelerate the reconstruction by using the signal-to-noise ratio (SNR) feature and a new energy spectral density (ESD) feature. The efficiency and robustness of the proposed method were validated through simulation experiments and real experiments based on the OpenMPI dataset.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2023)
Article
Engineering, Electrical & Electronic
Shuai Wang, Jing Zhong, Wenzhong Liu
Summary: In this study, a highly sensitive temperature measurement approach independent of concentration is proposed using electron paramagnetic resonance. The temperature of MNPs is characterized by measuring the g-value, which is found to be independent of the concentration of MNPs. The influence of particle size and data analysis method on temperature estimation is also investigated.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
